FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1334, 377 aa 1>>>pF1KE1334 377 - 377 aa - 377 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3813+/-0.000379; mu= 16.5632+/- 0.023 mean_var=79.5201+/-16.207, 0's: 0 Z-trim(113.7): 79 B-trim: 34 in 1/53 Lambda= 0.143825 statistics sampled from 23107 (23197) to 23107 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.65), E-opt: 0.2 (0.272), width: 16 Scan time: 6.340 The best scores are: opt bits E(85289) NP_001216 (OMIM: 602664) caspase-4 isoform alpha p ( 377) 2531 534.9 1.1e-151 NP_150649 (OMIM: 602664) caspase-4 isoform gamma p ( 321) 2168 459.6 4.7e-129 XP_011541321 (OMIM: 602664) PREDICTED: caspase-4 i ( 286) 1933 410.8 2e-114 XP_016873886 (OMIM: 602664) PREDICTED: caspase-4 i ( 286) 1933 410.8 2e-114 NP_001129581 (OMIM: 602665) caspase-5 isoform b pr ( 376) 1860 395.7 9.2e-110 NP_004338 (OMIM: 602665) caspase-5 isoform a precu ( 434) 1843 392.2 1.2e-108 NP_001129584 (OMIM: 602665) caspase-5 isoform f pr ( 447) 1843 392.2 1.2e-108 NP_001129582 (OMIM: 602665) caspase-5 isoform c [H ( 292) 1577 336.9 3.6e-92 NP_001244048 (OMIM: 147678) caspase-1 isoform beta ( 383) 1236 266.2 8.8e-71 NP_001214 (OMIM: 147678) caspase-1 isoform beta pr ( 383) 1236 266.2 8.8e-71 XP_011541323 (OMIM: 602665) PREDICTED: caspase-5 i ( 319) 1207 260.2 5e-69 XP_016873884 (OMIM: 147678) PREDICTED: caspase-1 i ( 380) 1184 255.4 1.5e-67 XP_016873885 (OMIM: 147678) PREDICTED: caspase-1 i ( 374) 1134 245.1 2e-64 XP_016873883 (OMIM: 147678) PREDICTED: caspase-1 i ( 401) 1134 245.1 2.1e-64 XP_016873882 (OMIM: 147678) PREDICTED: caspase-1 i ( 401) 1134 245.1 2.1e-64 NP_150634 (OMIM: 147678) caspase-1 isoform alpha p ( 404) 1134 245.1 2.2e-64 NP_001244047 (OMIM: 147678) caspase-1 isoform alph ( 404) 1134 245.1 2.2e-64 NP_150635 (OMIM: 147678) caspase-1 isoform gamma [ ( 311) 1126 243.3 5.6e-64 NP_001177945 (OMIM: 608633) inactive caspase-12 [H ( 341) 1015 220.3 5.1e-57 NP_150636 (OMIM: 147678) caspase-1 isoform delta [ ( 263) 695 153.9 4.1e-37 NP_116764 (OMIM: 600639) caspase-2 isoform 1 prepr ( 452) 314 75.0 3.9e-13 NP_001215 (OMIM: 600639) caspase-2 isoform 2 [Homo ( 312) 295 70.9 4.5e-12 NP_150637 (OMIM: 147678) caspase-1 isoform epsilon ( 88) 287 68.8 5.3e-12 NP_116756 (OMIM: 601762,603909,605027,613659) casp ( 521) 249 61.5 5e-09 NP_116759 (OMIM: 601762,603909,605027,613659) casp ( 522) 249 61.5 5e-09 XP_005246964 (OMIM: 601762,603909,605027,613659) P ( 521) 248 61.3 5.8e-09 XP_006712859 (OMIM: 601762,603909,605027,613659) P ( 272) 230 57.4 4.6e-08 XP_011526163 (OMIM: 605848) PREDICTED: caspase-14 ( 230) 227 56.7 6.3e-08 NP_036246 (OMIM: 605848) caspase-14 precursor [Hom ( 242) 227 56.7 6.5e-08 NP_001193471 (OMIM: 601762,603909,605027,613659) c ( 478) 230 57.6 7.2e-08 NP_001221 (OMIM: 601762,603909,605027,613659) casp ( 479) 230 57.6 7.2e-08 NP_001217 (OMIM: 601532) caspase-6 isoform alpha p ( 293) 218 54.9 2.8e-07 XP_005246946 (OMIM: 114480,114550,211980,601763,60 ( 479) 194 50.1 1.3e-05 XP_006712852 (OMIM: 114480,114550,211980,601763,60 ( 479) 194 50.1 1.3e-05 XP_005246948 (OMIM: 114480,114550,211980,601763,60 ( 479) 194 50.1 1.3e-05 XP_005246945 (OMIM: 114480,114550,211980,601763,60 ( 479) 194 50.1 1.3e-05 XP_005246944 (OMIM: 114480,114550,211980,601763,60 ( 479) 194 50.1 1.3e-05 XP_006712853 (OMIM: 114480,114550,211980,601763,60 ( 479) 194 50.1 1.3e-05 XP_005246947 (OMIM: 114480,114550,211980,601763,60 ( 479) 194 50.1 1.3e-05 NP_203519 (OMIM: 114480,114550,211980,601763,60727 ( 479) 194 50.1 1.3e-05 XP_005246943 (OMIM: 114480,114550,211980,601763,60 ( 479) 194 50.1 1.3e-05 XP_011540575 (OMIM: 602234) PREDICTED: caspase-9 i ( 421) 193 49.9 1.3e-05 NP_001073594 (OMIM: 114480,114550,211980,601763,60 ( 538) 194 50.1 1.4e-05 XP_011510271 (OMIM: 114480,114550,211980,601763,60 ( 334) 191 49.4 1.5e-05 NP_001193453 (OMIM: 601762,603909,605027,613659) c ( 455) 185 48.2 4.5e-05 XP_005246951 (OMIM: 114480,114550,211980,601763,60 ( 280) 182 47.4 4.7e-05 NP_116787 (OMIM: 601532) caspase-6 isoform beta [H ( 204) 180 46.9 4.9e-05 NP_203520 (OMIM: 114480,114550,211980,601763,60727 ( 464) 182 47.6 7e-05 NP_001073593 (OMIM: 114480,114550,211980,601763,60 ( 464) 182 47.6 7e-05 XP_005246949 (OMIM: 114480,114550,211980,601763,60 ( 464) 182 47.6 7e-05 >>NP_001216 (OMIM: 602664) caspase-4 isoform alpha precu (377 aa) initn: 2531 init1: 2531 opt: 2531 Z-score: 2844.0 bits: 534.9 E(85289): 1.1e-151 Smith-Waterman score: 2531; 100.0% identity (100.0% similar) in 377 aa overlap (1-377:1-377) 10 20 30 40 50 60 pF1KE1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP 310 320 330 340 350 360 370 pF1KE1 TIERLSMTRYFYLFPGN ::::::::::::::::: NP_001 TIERLSMTRYFYLFPGN 370 >>NP_150649 (OMIM: 602664) caspase-4 isoform gamma precu (321 aa) initn: 2168 init1: 2168 opt: 2168 Z-score: 2438.0 bits: 459.6 E(85289): 4.7e-129 Smith-Waterman score: 2168; 100.0% identity (100.0% similar) in 321 aa overlap (57-377:1-321) 30 40 50 60 70 80 pF1KE1 DNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNK :::::::::::::::::::::::::::::: NP_150 MADSMQEKQRMAGQMLLQTFFNIDQISPNK 10 20 30 90 100 110 120 130 140 pF1KE1 KAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 KAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEF 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE1 DHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 DHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLV 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE1 LMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 LMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGEL 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE1 WVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 WVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQL 220 230 240 250 260 270 330 340 350 360 370 pF1KE1 ITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 ITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 280 290 300 310 320 >>XP_011541321 (OMIM: 602664) PREDICTED: caspase-4 isofo (286 aa) initn: 1933 init1: 1933 opt: 1933 Z-score: 2175.1 bits: 410.8 E(85289): 2e-114 Smith-Waterman score: 1933; 100.0% identity (100.0% similar) in 286 aa overlap (92-377:1-286) 70 80 90 100 110 120 pF1KE1 QEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKER :::::::::::::::::::::::::::::: XP_011 MEAGPPESGESTDALKLCPHEEFLRLCKER 10 20 30 130 140 150 160 170 180 pF1KE1 AEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTA 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE1 RDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNR 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE1 NCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFI 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE1 AFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPT 220 230 240 250 260 270 370 pF1KE1 IERLSMTRYFYLFPGN :::::::::::::::: XP_011 IERLSMTRYFYLFPGN 280 >>XP_016873886 (OMIM: 602664) PREDICTED: caspase-4 isofo (286 aa) initn: 1933 init1: 1933 opt: 1933 Z-score: 2175.1 bits: 410.8 E(85289): 2e-114 Smith-Waterman score: 1933; 100.0% identity (100.0% similar) in 286 aa overlap (92-377:1-286) 70 80 90 100 110 120 pF1KE1 QEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKER :::::::::::::::::::::::::::::: XP_016 MEAGPPESGESTDALKLCPHEEFLRLCKER 10 20 30 130 140 150 160 170 180 pF1KE1 AEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTA 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE1 RDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNR 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE1 NCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFI 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE1 AFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPT 220 230 240 250 260 270 370 pF1KE1 IERLSMTRYFYLFPGN :::::::::::::::: XP_016 IERLSMTRYFYLFPGN 280 >>NP_001129581 (OMIM: 602665) caspase-5 isoform b precur (376 aa) initn: 1645 init1: 1645 opt: 1860 Z-score: 2091.6 bits: 395.7 E(85289): 9.2e-110 Smith-Waterman score: 1860; 74.0% identity (88.9% similar) in 377 aa overlap (1-377:1-376) 10 20 30 40 50 60 pF1KE1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS ::: ::.:: .:.:: :::: : ::.. :....::. ::::::::::.: :::. ...:: NP_001 MAEDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE .. :.:.: ::. ::..:.:: . : ..:::::::.:::. :::::.::::::::. NP_001 LR-KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKK 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT .::::::.:..: :::::::::.::::: :::: .::.:::.::.:: :.: :.::: NP_001 NHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLT 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN ::::::.:::::.::::::::::::::::::::::::::.: .::::::::::::::::: NP_001 ARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNN 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE1 RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF :::::::::::::::::::: ..:::::::::::: . ::::::::: :.: : : :::: NP_001 RNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDF 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE1 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP ::::::::::::::: : ::::::.::::::::: :::: :.:::::.:::.:.:::::: NP_001 IAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMP 300 310 320 330 340 350 370 pF1KE1 TIERLSMTRYFYLFPGN :::: ..:: ::::::: NP_001 TIERATLTRDFYLFPGN 360 370 >>NP_004338 (OMIM: 602665) caspase-5 isoform a precursor (434 aa) initn: 1700 init1: 1645 opt: 1843 Z-score: 2071.7 bits: 392.2 E(85289): 1.2e-108 Smith-Waterman score: 1843; 74.0% identity (89.0% similar) in 373 aa overlap (5-377:63-434) 10 20 30 pF1KE1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNV ::.:: .:.:: :::: : ::.. :....: NP_004 HMLKNNVAGQTSIQTLVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDV 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 LNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEA :. ::::::::::.: :::. ...::.. :.:.: ::. ::..:.:: . : ..:: NP_004 LTLKEEEKKKYYDTKIEDKALILVDSLR-KNRVAHQMFTQTLLNMDQKITSVKPLLQIEA 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 GPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNG :::::.:::. :::::.::::::::. .::::::.:..: :::::::::.::::: ::: NP_004 GPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNG 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE1 ADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILE : .::.:::.::.:: :.: :.:::::::::.:::::.::::::::::::::::::::: NP_004 AHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILE 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE1 GICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPAS :::::.: .::::::::::::::::::::::::::::::::::::: ..::::::::::: NP_004 GICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPAS 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE1 LEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYS : . ::::::::: :.: : : ::::::::::::::::::: : ::::::.::::::::: NP_004 LALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYS 340 350 360 370 380 390 340 350 360 370 pF1KE1 WCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN :::: :.:::::.:::.:.:::::::::: ..:: ::::::: NP_004 CCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 400 410 420 430 >>NP_001129584 (OMIM: 602665) caspase-5 isoform f precur (447 aa) initn: 1681 init1: 1645 opt: 1843 Z-score: 2071.5 bits: 392.2 E(85289): 1.2e-108 Smith-Waterman score: 1843; 74.0% identity (89.0% similar) in 373 aa overlap (5-377:76-447) 10 20 30 pF1KE1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNV ::.:: .:.:: :::: : ::.. :....: NP_001 HMLKNNVAGQTSIQTLVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDV 50 60 70 80 90 100 40 50 60 70 80 90 pF1KE1 LNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEA :. ::::::::::.: :::. ...::.. :.:.: ::. ::..:.:: . : ..:: NP_001 LTLKEEEKKKYYDTKIEDKALILVDSLR-KNRVAHQMFTQTLLNMDQKITSVKPLLQIEA 110 120 130 140 150 160 100 110 120 130 140 150 pF1KE1 GPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNG :::::.:::. :::::.::::::::. .::::::.:..: :::::::::.::::: ::: NP_001 GPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNG 170 180 190 200 210 220 160 170 180 190 200 210 pF1KE1 ADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILE : .::.:::.::.:: :.: :.:::::::::.:::::.::::::::::::::::::::: NP_001 AHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILE 230 240 250 260 270 280 220 230 240 250 260 270 pF1KE1 GICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPAS :::::.: .::::::::::::::::::::::::::::::::::::: ..::::::::::: NP_001 GICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPAS 290 300 310 320 330 340 280 290 300 310 320 330 pF1KE1 LEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYS : . ::::::::: :.: : : ::::::::::::::::::: : ::::::.::::::::: NP_001 LALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYS 350 360 370 380 390 400 340 350 360 370 pF1KE1 WCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN :::: :.:::::.:::.:.:::::::::: ..:: ::::::: NP_001 CCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 410 420 430 440 >>NP_001129582 (OMIM: 602665) caspase-5 isoform c [Homo (292 aa) initn: 1577 init1: 1577 opt: 1577 Z-score: 1775.8 bits: 336.9 E(85289): 3.6e-92 Smith-Waterman score: 1577; 81.1% identity (92.0% similar) in 286 aa overlap (92-377:7-292) 70 80 90 100 110 120 pF1KE1 QEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKER .:::::::.:::. :::::.::::::::. NP_001 MAALLQIEAGPPESAESTNILKLCPREEFLRLCKKN 10 20 30 130 140 150 160 170 180 pF1KE1 AEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTA .::::::.:..: :::::::::.::::: :::: .::.:::.::.:: :.: :.:::: NP_001 HDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTA 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE1 RDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNR :::::.:::::.::::::::::::::::::::::::::.: .:::::::::::::::::: NP_001 RDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNR 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE1 NCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFI ::::::::::::::::::: ..:::::::::::: . ::::::::: :.: : : ::::: NP_001 NCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFI 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE1 AFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPT :::::::::::::: : ::::::.::::::::: :::: :.:::::.:::.:.::::::: NP_001 AFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPT 220 230 240 250 260 270 370 pF1KE1 IERLSMTRYFYLFPGN ::: ..:: ::::::: NP_001 IERATLTRDFYLFPGN 280 290 >>NP_001244048 (OMIM: 147678) caspase-1 isoform beta pre (383 aa) initn: 1228 init1: 1109 opt: 1236 Z-score: 1391.7 bits: 266.2 E(85289): 8.8e-71 Smith-Waterman score: 1236; 51.0% identity (73.4% similar) in 384 aa overlap (1-377:1-383) 10 20 30 40 50 60 pF1KE1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS ::. ..: ..:.:. ..:.::.:.. ::: .: :: : .: . ::.:.. :: NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 MQEKQRMAGQMLLQTFFNIDQ-------ISPNKKAHPNMEAGPPESGESTDALKLCPHEE . : .: :. . . . :. .: .: . : : :: : .::: :: NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSG-SEGNVKLCSLEE 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 FLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSV :. :... ::::: ....:::::::::: ::: .: :.::. ::::: ::..: ::: NP_001 AQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 DVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDT ::..:::: :: . :.::: :::::.:::::::.::::: ::::: :.:. ::.: .. NP_001 DVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 IFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYK ::...:..:: ::::::::::.::::: . : .: .:: . : ..:..:.::. : NP_001 IFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKK 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 THVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETP .:.:::::::::::: ::::: ::::.:: .:: .:.:. : .::.::::. ::: : NP_001 AHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQP 300 310 320 330 340 350 360 370 pF1KE1 RAKAQMPTIERLSMTRYFYLFPGN ..::::: ::...:: ::::::. NP_001 DGRAQMPTTERVTLTRCFYLFPGH 360 370 380 >>NP_001214 (OMIM: 147678) caspase-1 isoform beta precur (383 aa) initn: 1228 init1: 1109 opt: 1236 Z-score: 1391.7 bits: 266.2 E(85289): 8.8e-71 Smith-Waterman score: 1236; 51.0% identity (73.4% similar) in 384 aa overlap (1-377:1-383) 10 20 30 40 50 60 pF1KE1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS ::. ..: ..:.:. ..:.::.:.. ::: .: :: : .: . ::.:.. :: NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 MQEKQRMAGQMLLQTFFNIDQ-------ISPNKKAHPNMEAGPPESGESTDALKLCPHEE . : .: :. . . . :. .: .: . : : :: : .::: :: NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSG-SEGNVKLCSLEE 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 FLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSV :. :... ::::: ....:::::::::: ::: .: :.::. ::::: ::..: ::: NP_001 AQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 DVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDT ::..:::: :: . :.::: :::::.:::::::.::::: ::::: :.:. ::.: .. NP_001 DVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 IFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYK ::...:..:: ::::::::::.::::: . : .: .:: . : ..:..:.::. : NP_001 IFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKK 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 THVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETP .:.:::::::::::: ::::: ::::.:: .:: .:.:. : .::.::::. ::: : NP_001 AHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQP 300 310 320 330 340 350 360 370 pF1KE1 RAKAQMPTIERLSMTRYFYLFPGN ..::::: ::...:: ::::::. NP_001 DGRAQMPTTERVTLTRCFYLFPGH 360 370 380 377 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 00:58:39 2016 done: Mon Nov 7 00:58:41 2016 Total Scan time: 6.340 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]