FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4492, 512 aa 1>>>pF1KE4492 512 - 512 aa - 512 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1666+/-0.000379; mu= 18.5505+/- 0.023 mean_var=66.4618+/-14.135, 0's: 0 Z-trim(112.7): 176 B-trim: 50 in 1/51 Lambda= 0.157322 statistics sampled from 21562 (21752) to 21562 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.255), width: 16 Scan time: 8.750 The best scores are: opt bits E(85289) NP_001093242 (OMIM: 124075) cytochrome P450 4B1 is ( 512) 3554 815.9 0 NP_000770 (OMIM: 124075) cytochrome P450 4B1 isofo ( 511) 3537 812.1 0 NP_001306090 (OMIM: 124075) cytochrome P450 4B1 is ( 497) 2702 622.5 8.6e-178 XP_016855955 (OMIM: 124075) PREDICTED: cytochrome ( 496) 2685 618.7 1.2e-176 NP_001306091 (OMIM: 124075) cytochrome P450 4B1 is ( 349) 2420 558.4 1.2e-158 NP_001306092 (OMIM: 124075) cytochrome P450 4B1 is ( 348) 2403 554.6 1.7e-157 XP_011539134 (OMIM: 124075) PREDICTED: cytochrome ( 296) 2033 470.6 2.9e-132 NP_000769 (OMIM: 601310) cytochrome P450 4A11 isof ( 519) 1804 418.7 2e-116 NP_001010969 (OMIM: 615341) cytochrome P450 4A22 i ( 519) 1686 391.9 2.3e-108 NP_828847 (OMIM: 614999) cytochrome P450 4X1 isofo ( 509) 1657 385.4 2.2e-106 XP_016856462 (OMIM: 614999) PREDICTED: cytochrome ( 470) 1543 359.5 1.3e-98 XP_016855954 (OMIM: 601310) PREDICTED: cytochrome ( 415) 1536 357.8 3.4e-98 XP_011539135 (OMIM: 124075) PREDICTED: cytochrome ( 278) 1513 352.5 9.3e-97 NP_001307218 (OMIM: 614999) cytochrome P450 4X1 is ( 508) 1516 353.4 9.4e-97 NP_001307219 (OMIM: 614999) cytochrome P450 4X1 is ( 444) 1512 352.4 1.6e-96 NP_001073 (OMIM: 604426) phylloquinone omega-hydro ( 520) 1425 332.7 1.6e-90 NP_009184 (OMIM: 611545) cytochrome P450 4F8 precu ( 520) 1413 330.0 1e-89 NP_067010 (OMIM: 611517) phylloquinone omega-hydro ( 524) 1412 329.8 1.2e-89 NP_001122404 (OMIM: 611517) phylloquinone omega-hy ( 524) 1412 329.8 1.2e-89 NP_001186137 (OMIM: 601270) docosahexaenoic acid o ( 520) 1396 326.1 1.5e-88 XP_016882303 (OMIM: 601270) PREDICTED: docosahexae ( 520) 1396 326.1 1.5e-88 NP_001186138 (OMIM: 601270) docosahexaenoic acid o ( 520) 1396 326.1 1.5e-88 NP_000887 (OMIM: 601270) docosahexaenoic acid omeg ( 520) 1391 325.0 3.3e-88 XP_011525995 (OMIM: 611495) PREDICTED: cytochrome ( 531) 1388 324.3 5.4e-88 XP_011525994 (OMIM: 611495) PREDICTED: cytochrome ( 531) 1388 324.3 5.4e-88 NP_775754 (OMIM: 611495) cytochrome P450 4F22 [Hom ( 531) 1388 324.3 5.4e-88 NP_076433 (OMIM: 611485) cytochrome P450 4F12 [Hom ( 524) 1373 320.9 5.7e-87 XP_005259968 (OMIM: 601270) PREDICTED: docosahexae ( 371) 1237 289.9 8.4e-78 XP_011526316 (OMIM: 601270) PREDICTED: docosahexae ( 371) 1237 289.9 8.4e-78 XP_011526504 (OMIM: 611485) PREDICTED: cytochrome ( 375) 1214 284.7 3.2e-76 XP_006722913 (OMIM: 611485) PREDICTED: cytochrome ( 375) 1214 284.7 3.2e-76 XP_011526510 (OMIM: 611485) PREDICTED: cytochrome ( 375) 1214 284.7 3.2e-76 NP_001306084 (OMIM: 601310) cytochrome P450 4A11 i ( 487) 1137 267.3 7.2e-71 XP_011526505 (OMIM: 611485) PREDICTED: cytochrome ( 352) 1107 260.4 6.2e-69 XP_011526507 (OMIM: 611485) PREDICTED: cytochrome ( 352) 1107 260.4 6.2e-69 XP_011526506 (OMIM: 611485) PREDICTED: cytochrome ( 352) 1107 260.4 6.2e-69 XP_011526509 (OMIM: 611485) PREDICTED: cytochrome ( 334) 1059 249.5 1.1e-65 XP_016881721 (OMIM: 611545) PREDICTED: cytochrome ( 418) 999 236.0 1.7e-61 NP_997235 (OMIM: 210370,608614) cytochrome P450 4V ( 525) 877 208.3 4.4e-53 XP_005262992 (OMIM: 210370,608614) PREDICTED: cyto ( 524) 874 207.7 7.1e-53 XP_016882661 (OMIM: 611485) PREDICTED: cytochrome ( 411) 861 204.6 4.5e-52 XP_016882304 (OMIM: 601270) PREDICTED: docosahexae ( 391) 859 204.2 5.9e-52 XP_016863526 (OMIM: 210370,608614) PREDICTED: cyto ( 393) 784 187.1 7.9e-47 XP_005270596 (OMIM: 601310) PREDICTED: cytochrome ( 357) 644 155.3 2.7e-37 XP_016855953 (OMIM: 601310) PREDICTED: cytochrome ( 421) 644 155.4 3.1e-37 XP_005270827 (OMIM: 615341) PREDICTED: cytochrome ( 261) 563 136.9 7.1e-32 NP_001295031 (OMIM: 615341) cytochrome P450 4A22 i ( 357) 563 137.0 9.2e-32 XP_005270824 (OMIM: 615341) PREDICTED: cytochrome ( 421) 563 137.0 1e-31 NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo ( 503) 540 131.8 4.5e-30 NP_059488 (OMIM: 124010) cytochrome P450 3A4 isofo ( 503) 538 131.4 6.2e-30 >>NP_001093242 (OMIM: 124075) cytochrome P450 4B1 isofor (512 aa) initn: 3554 init1: 3554 opt: 3554 Z-score: 4357.8 bits: 815.9 E(85289): 0 Smith-Waterman score: 3554; 100.0% identity (100.0% similar) in 512 aa overlap (1-512:1-512) 10 20 30 40 50 60 pF1KE4 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD 430 440 450 460 470 480 490 500 510 pF1KE4 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK :::::::::::::::::::::::::::::::: NP_001 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK 490 500 510 >>NP_000770 (OMIM: 124075) cytochrome P450 4B1 isoform b (511 aa) initn: 2106 init1: 2106 opt: 3537 Z-score: 4337.0 bits: 812.1 E(85289): 0 Smith-Waterman score: 3537; 99.8% identity (99.8% similar) in 512 aa overlap (1-512:1-511) 10 20 30 40 50 60 pF1KE4 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL :::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: NP_000 FCDVGHMALNTLMKCTFGRGDTGLGH-RDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE4 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD 420 430 440 450 460 470 490 500 510 pF1KE4 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK :::::::::::::::::::::::::::::::: NP_000 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK 480 490 500 510 >>NP_001306090 (OMIM: 124075) cytochrome P450 4B1 isofor (497 aa) initn: 2702 init1: 2702 opt: 2702 Z-score: 3312.9 bits: 622.5 E(85289): 8.6e-178 Smith-Waterman score: 3398; 97.1% identity (97.1% similar) in 512 aa overlap (1-512:1-497) 10 20 30 40 50 60 pF1KE4 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRG------------- 70 80 90 100 130 140 150 160 170 180 pF1KE4 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 --GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE4 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE4 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD 410 420 430 440 450 460 490 500 510 pF1KE4 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK :::::::::::::::::::::::::::::::: NP_001 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK 470 480 490 >>XP_016855955 (OMIM: 124075) PREDICTED: cytochrome P450 (496 aa) initn: 2830 init1: 2106 opt: 2685 Z-score: 3292.1 bits: 618.7 E(85289): 1.2e-176 Smith-Waterman score: 3381; 96.9% identity (96.9% similar) in 512 aa overlap (1-512:1-496) 10 20 30 40 50 60 pF1KE4 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRG------------- 70 80 90 100 130 140 150 160 170 180 pF1KE4 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 --GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL :::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: XP_016 FCDVGHMALNTLMKCTFGRGDTGLGH-RDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE4 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE4 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD 410 420 430 440 450 460 490 500 510 pF1KE4 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK :::::::::::::::::::::::::::::::: XP_016 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK 470 480 490 >>NP_001306091 (OMIM: 124075) cytochrome P450 4B1 isofor (349 aa) initn: 2420 init1: 2420 opt: 2420 Z-score: 2969.2 bits: 558.4 E(85289): 1.2e-158 Smith-Waterman score: 2420; 100.0% identity (100.0% similar) in 349 aa overlap (164-512:1-349) 140 150 160 170 180 190 pF1KE4 WLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLM :::::::::::::::::::::::::::::: NP_001 MLDKWEEKAREGKSFDIFCDVGHMALNTLM 10 20 30 200 210 220 230 240 250 pF1KE4 KCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQV 40 50 60 70 80 90 260 270 280 290 300 310 pF1KE4 AHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTF 100 110 120 130 140 150 320 330 340 350 360 370 pF1KE4 MFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKE 160 170 180 190 200 210 380 390 400 410 420 430 pF1KE4 SFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFST 220 230 240 250 260 270 440 450 460 470 480 490 pF1KE4 ENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVL 280 290 300 310 320 330 500 510 pF1KE4 RSKNGFHLHLKPLGPGSGK ::::::::::::::::::: NP_001 RSKNGFHLHLKPLGPGSGK 340 >>NP_001306092 (OMIM: 124075) cytochrome P450 4B1 isofor (348 aa) initn: 2106 init1: 2106 opt: 2403 Z-score: 2948.4 bits: 554.6 E(85289): 1.7e-157 Smith-Waterman score: 2403; 99.7% identity (99.7% similar) in 349 aa overlap (164-512:1-348) 140 150 160 170 180 190 pF1KE4 WLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLM :::::::::::::::::::::::::::::: NP_001 MLDKWEEKAREGKSFDIFCDVGHMALNTLM 10 20 30 200 210 220 230 240 250 pF1KE4 KCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQV ::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::: NP_001 KCTFGRGDTGLGH-RDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQV 40 50 60 70 80 260 270 280 290 300 310 pF1KE4 AHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTF 90 100 110 120 130 140 320 330 340 350 360 370 pF1KE4 MFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKE 150 160 170 180 190 200 380 390 400 410 420 430 pF1KE4 SFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFST 210 220 230 240 250 260 440 450 460 470 480 490 pF1KE4 ENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVL 270 280 290 300 310 320 500 510 pF1KE4 RSKNGFHLHLKPLGPGSGK ::::::::::::::::::: NP_001 RSKNGFHLHLKPLGPGSGK 330 340 >>XP_011539134 (OMIM: 124075) PREDICTED: cytochrome P450 (296 aa) initn: 2033 init1: 2033 opt: 2033 Z-score: 2495.6 bits: 470.6 E(85289): 2.9e-132 Smith-Waterman score: 2033; 100.0% identity (100.0% similar) in 294 aa overlap (1-294:1-294) 10 20 30 40 50 60 pF1KE4 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARGR 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD >>NP_000769 (OMIM: 601310) cytochrome P450 4A11 isoform (519 aa) initn: 1810 init1: 1537 opt: 1804 Z-score: 2211.1 bits: 418.7 E(85289): 2e-116 Smith-Waterman score: 1804; 52.6% identity (76.3% similar) in 506 aa overlap (1-506:6-509) 10 20 30 40 50 pF1KE4 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLF . :: : . :.. :: :::.: ..: ..: :.:: : ::...:: ::.:::: NP_000 MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 GHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVY :: :.:. :... .:.. :: : : :. ...:.::: :.. .:.:::. : NP_000 GHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 DFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREG :. ::: :::.:.: :.:::..:::.::::.:::::.....:.:.::::::: . NP_000 RFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 KSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHND . ...: :. :.:.:.:::.:.. . ..:: :.:::. :. .:. . ..:: NP_000 SPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQND 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARD :: :: :: ::::.::.::::::. ::: :: : .::. .:::::::::: :. NP_000 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE4 EDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF :. ::: :::::::::::::::::.:::::.:: .: .:.::.:::::.. .::: NP_000 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGAS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE4 FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHR . :. : .: : ::::::..::::::: . :.:: :::: :::::: : .. . ::.::. NP_000 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 NSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF : :::.::::: .::. .: .: ::.:::.: :::::.::::.:.::.::. :::: NP_000 NPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRF 430 440 450 460 470 480 490 500 510 pF1KE4 EFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK :. ::.:.:: . .:::.::::.::.:. : NP_000 ELLPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL 480 490 500 510 >>NP_001010969 (OMIM: 615341) cytochrome P450 4A22 isofo (519 aa) initn: 1692 init1: 1424 opt: 1686 Z-score: 2066.4 bits: 391.9 E(85289): 2.3e-108 Smith-Waterman score: 1686; 51.9% identity (74.8% similar) in 489 aa overlap (18-506:23-509) 10 20 30 40 50 pF1KE4 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLF : :::.: ..: .: :.:: : ::...:: ::.:::: NP_001 MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 GHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVY :: :.:. :... .. :: : : :. ...:.::: :.. .:.:::. : NP_001 GHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 DFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREG :. :: :::.:.: :.:::..:::.:: :.:::::.....:.:.::::::: . NP_001 KFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 KSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHND . ...: :. :.:.:.:: .:.. . ..:: :.:::. :. . . ..:: NP_001 SPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHEND 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARD :: :: :: ::::.::.::::::. ::: :: : .::. .:::::::::: :. NP_001 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE4 EDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF :. ::: :::::::::::::::::.:::::.:: .: .:.::.:::::.. .::: NP_001 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGAS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE4 FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHR . :. : .: : ::::::..::::::: . :.:: :::: :::::: : .. . ::.::. NP_001 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 NSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF : :::. :::: ::. .: .: ::.:::.: :::::.::::...::. :. :::: NP_001 NPKVWPNLEVFDPSRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRF 430 440 450 460 470 480 490 500 510 pF1KE4 EFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK :. ::.:.:: : .:::.::::.::.:. : NP_001 ELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL 480 490 500 510 >>NP_828847 (OMIM: 614999) cytochrome P450 4X1 isoform 1 (509 aa) initn: 1494 init1: 1121 opt: 1657 Z-score: 2030.9 bits: 385.4 E(85289): 2.2e-106 Smith-Waterman score: 1657; 48.0% identity (77.2% similar) in 487 aa overlap (22-506:22-506) 10 20 30 40 50 60 pF1KE4 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE :.::.:. :.: :::: : . . ::.:::::..:: NP_828 MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ ::. ...:. ...: : :.:.: : .:. ::.:::::.. :: :::. . : NP_828 IQDD-NMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPP 70 80 90 100 110 130 140 150 160 170 pF1KE4 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEK-AREGKSFD .:.:: .:.::::.:::.:::::::...:: :. :...:...::::::. . . : . NP_828 LLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 IFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYW .. .. :.:. .:::.:.. . .: . : :. .:. .. .:: :. ::.:.:. NP_828 VYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 LTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDI :.:.: :: . .: ...:: .:.::: .:: . . .:.. :::::.:.:.::. NP_828 LSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGS 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWD ..:: :...::.::.. :::: ...:::.:::.:: ::::.::::::: :::: . . :: NP_828 SFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWD 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 DLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAV .::.:.: ::::::. :: : ::.. :.::::.:: :: .:::: . . :..::.: :: NP_828 QLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAV 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 WPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSL : .:.::: :::: ::...:::.:..::::: ::::::.::: :.::. :. ::.:. . NP_828 WKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTP 420 430 440 450 460 470 480 490 500 510 pF1KE4 DPSRLPIKMP-QLVLRSKNGFHLHLKPLGPGSGK ::.: :. .: ...:. :::..:::: : NP_828 DPTR-PLTFPNHFILKPKNGMYLHLKKLSEC 480 490 500 512 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:46:40 2016 done: Sun Nov 6 00:46:42 2016 Total Scan time: 8.750 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]