FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6702, 758 aa 1>>>pF1KE6702 758 - 758 aa - 758 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5169+/-0.000445; mu= 19.4573+/- 0.028 mean_var=81.5762+/-16.529, 0's: 0 Z-trim(111.1): 55 B-trim: 0 in 0/51 Lambda= 0.142001 statistics sampled from 19552 (19601) to 19552 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.589), E-opt: 0.2 (0.23), width: 16 Scan time: 9.530 The best scores are: opt bits E(85289) NP_599025 (OMIM: 610068) solute carrier family 26 ( 758) 4887 1011.8 0 NP_075062 (OMIM: 610068) solute carrier family 26 ( 759) 4875 1009.3 0 NP_001035544 (OMIM: 610068) solute carrier family ( 738) 4745 982.7 0 NP_602298 (OMIM: 610068) solute carrier family 26 ( 740) 3879 805.3 0 NP_001268662 (OMIM: 610068) solute carrier family ( 651) 3249 676.2 1.2e-193 NP_001268661 (OMIM: 610068) solute carrier family ( 723) 3222 670.7 6e-192 NP_996766 (OMIM: 604943,613865) prestin isoform b ( 685) 1769 373.0 2.3e-102 XP_011514472 (OMIM: 604943,613865) PREDICTED: pres ( 744) 1769 373.0 2.5e-102 NP_945350 (OMIM: 604943,613865) prestin isoform a ( 744) 1769 373.0 2.5e-102 NP_443166 (OMIM: 608481) solute carrier family 26 ( 791) 1726 364.2 1.2e-99 NP_599152 (OMIM: 608481) solute carrier family 26 ( 887) 1726 364.3 1.3e-99 XP_011507423 (OMIM: 608481) PREDICTED: solute carr ( 702) 1544 326.9 1.8e-88 NP_996767 (OMIM: 604943,613865) prestin isoform c ( 516) 1536 325.2 4.4e-88 XP_011507424 (OMIM: 608481) PREDICTED: solute carr ( 627) 1342 285.5 4.7e-76 NP_001308716 (OMIM: 604943,613865) prestin isoform ( 653) 1291 275.0 6.8e-73 NP_001161434 (OMIM: 604943,613865) prestin isoform ( 712) 1291 275.1 7.2e-73 NP_000432 (OMIM: 274600,600791,605646) pendrin [Ho ( 780) 1261 268.9 5.5e-71 XP_005250482 (OMIM: 274600,600791,605646) PREDICTE ( 780) 1261 268.9 5.5e-71 XP_011507426 (OMIM: 608481) PREDICTED: solute carr ( 466) 1247 265.9 2.7e-70 NP_000102 (OMIM: 126650,214700) chloride anion exc ( 764) 1212 258.9 5.7e-68 XP_011514169 (OMIM: 126650,214700) PREDICTED: chlo ( 764) 1212 258.9 5.7e-68 NP_439897 (OMIM: 608479) anion exchange transporte ( 656) 1047 225.1 7.6e-58 NP_001269285 (OMIM: 608479) anion exchange transpo ( 656) 1047 225.1 7.6e-58 NP_599028 (OMIM: 608479) anion exchange transporte ( 663) 1047 225.1 7.6e-58 NP_071325 (OMIM: 167030,610130) sulfate anion tran ( 701) 990 213.4 2.6e-54 NP_998778 (OMIM: 167030,610130) sulfate anion tran ( 701) 990 213.4 2.6e-54 XP_016864680 (OMIM: 222600,226900,256050,600972,60 ( 739) 979 211.2 1.3e-53 NP_000103 (OMIM: 222600,226900,256050,600972,60671 ( 739) 979 211.2 1.3e-53 NP_443193 (OMIM: 606766,608480) testis anion trans ( 970) 879 190.8 2.4e-47 XP_016865724 (OMIM: 606766,608480) PREDICTED: test ( 970) 879 190.8 2.4e-47 NP_001180405 (OMIM: 606766,608480) testis anion tr ( 970) 879 190.8 2.4e-47 NP_996768 (OMIM: 604943,613865) prestin isoform d ( 335) 855 185.5 3.1e-46 XP_016867807 (OMIM: 274600,600791,605646) PREDICTE ( 754) 792 172.9 4.5e-42 XP_006716088 (OMIM: 274600,600791,605646) PREDICTE ( 423) 783 170.8 1e-41 NP_619732 (OMIM: 606766,608480) testis anion trans ( 865) 648 143.4 3.8e-33 NP_775897 (OMIM: 610117) sodium-independent sulfat ( 606) 585 130.4 2.2e-29 NP_001159819 (OMIM: 610117) sodium-independent sul ( 606) 585 130.4 2.2e-29 NP_001159820 (OMIM: 610117) sodium-independent sul ( 606) 585 130.4 2.2e-29 NP_001159821 (OMIM: 610117) sodium-independent sul ( 606) 585 130.4 2.2e-29 NP_001269286 (OMIM: 608479) anion exchange transpo ( 355) 448 102.1 4.1e-21 XP_006721896 (OMIM: 610117) PREDICTED: sodium-inde ( 630) 445 101.7 9.8e-21 XP_016879996 (OMIM: 610117) PREDICTED: sodium-inde ( 630) 445 101.7 9.8e-21 XP_016879995 (OMIM: 610117) PREDICTED: sodium-inde ( 677) 445 101.7 1e-20 XP_016879994 (OMIM: 610117) PREDICTED: sodium-inde ( 696) 445 101.7 1.1e-20 NP_602297 (OMIM: 167030,610130) sulfate anion tran ( 224) 343 80.5 8.5e-15 XP_011522955 (OMIM: 610117) PREDICTED: sodium-inde ( 441) 336 79.3 3.9e-14 XP_011522956 (OMIM: 610117) PREDICTED: sodium-inde ( 441) 336 79.3 3.9e-14 XP_011522954 (OMIM: 610117) PREDICTED: sodium-inde ( 465) 336 79.3 4.1e-14 XP_011512596 (OMIM: 606766,608480) PREDICTED: test ( 944) 324 77.1 3.9e-13 >>NP_599025 (OMIM: 610068) solute carrier family 26 memb (758 aa) initn: 4887 init1: 4887 opt: 4887 Z-score: 5410.2 bits: 1011.8 E(85289): 0 Smith-Waterman score: 4887; 100.0% identity (100.0% similar) in 758 aa overlap (1-758:1-758) 10 20 30 40 50 60 pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 AASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAPDGSTLKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 AASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAPDGSTLKAL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE6 GLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 GLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHF 670 680 690 700 710 720 730 740 750 pF1KE6 FDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL :::::::::::::::::::::::::::::::::::::: NP_599 FDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL 730 740 750 >>NP_075062 (OMIM: 610068) solute carrier family 26 memb (759 aa) initn: 4048 init1: 4048 opt: 4875 Z-score: 5396.9 bits: 1009.3 E(85289): 0 Smith-Waterman score: 4875; 99.9% identity (99.9% similar) in 759 aa overlap (1-758:1-759) 10 20 30 40 50 60 pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ 550 560 570 580 590 600 610 620 630 640 650 pF1KE6 AASPKGASVSINVNTSLEDMRSNNVEDCKMM-VSSGDKMEDATANGQEDSKAPDGSTLKA ::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::: NP_075 AASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKA 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE6 LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH 670 680 690 700 710 720 720 730 740 750 pF1KE6 FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL ::::::::::::::::::::::::::::::::::::::: NP_075 FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL 730 740 750 >>NP_001035544 (OMIM: 610068) solute carrier family 26 m (738 aa) initn: 3918 init1: 3918 opt: 4745 Z-score: 5253.2 bits: 982.7 E(85289): 0 Smith-Waterman score: 4745; 99.9% identity (99.9% similar) in 738 aa overlap (22-758:1-738) 10 20 30 40 50 60 pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL ::::::::::::::::::::::::::::::::::::::: NP_001 MDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL 10 20 30 70 80 90 100 110 120 pF1KE6 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE6 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE6 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE6 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE6 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE6 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE6 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE6 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE6 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ 520 530 540 550 560 570 610 620 630 640 650 pF1KE6 AASPKGASVSINVNTSLEDMRSNNVEDCKMM-VSSGDKMEDATANGQEDSKAPDGSTLKA ::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::: NP_001 AASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKA 580 590 600 610 620 630 660 670 680 690 700 710 pF1KE6 LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH 640 650 660 670 680 690 720 730 740 750 pF1KE6 FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL ::::::::::::::::::::::::::::::::::::::: NP_001 FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL 700 710 720 730 >>NP_602298 (OMIM: 610068) solute carrier family 26 memb (740 aa) initn: 4681 init1: 3856 opt: 3879 Z-score: 4294.3 bits: 805.3 E(85289): 0 Smith-Waterman score: 4646; 96.2% identity (97.0% similar) in 758 aa overlap (1-758:1-740) 10 20 30 40 50 60 pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_602 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_602 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_602 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_602 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_602 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_602 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_602 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_602 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_602 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_602 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 AASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAPDGSTLKAL :. .: .. ..::::::::::::::::::::::::::::: NP_602 AGPLLSACLA------------------PQQVSSGDKMEDATANGQEDSKAPDGSTLKAL 610 620 630 640 670 680 690 700 710 720 pF1KE6 GLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_602 GLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHF 650 660 670 680 690 700 730 740 750 pF1KE6 FDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL :::::::::::::::::::::::::::::::::::::: NP_602 FDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL 710 720 730 740 >>NP_001268662 (OMIM: 610068) solute carrier family 26 m (651 aa) initn: 3239 init1: 3239 opt: 3249 Z-score: 3597.6 bits: 676.2 E(85289): 1.2e-193 Smith-Waterman score: 4005; 85.9% identity (85.9% similar) in 758 aa overlap (1-758:1-651) 10 20 30 40 50 60 pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR :::::::::::::::::::::::: NP_001 FGLYSSFYPVFIYFLFGTSRHISV------------------------------------ 130 140 190 200 210 220 230 240 pF1KE6 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS NP_001 ------------------------------------------------------------ 250 260 270 280 290 300 pF1KE6 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -----------VLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL 150 160 170 180 190 310 320 330 340 350 360 pF1KE6 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI 200 210 220 230 240 250 370 380 390 400 410 420 pF1KE6 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA 260 270 280 290 300 310 430 440 450 460 470 480 pF1KE6 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT 320 330 340 350 360 370 490 500 510 520 530 540 pF1KE6 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV 380 390 400 410 420 430 550 560 570 580 590 600 pF1KE6 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ 440 450 460 470 480 490 610 620 630 640 650 660 pF1KE6 AASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAPDGSTLKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAPDGSTLKAL 500 510 520 530 540 550 670 680 690 700 710 720 pF1KE6 GLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHF 560 570 580 590 600 610 730 740 750 pF1KE6 FDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL :::::::::::::::::::::::::::::::::::::: NP_001 FDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL 620 630 640 650 >>NP_001268661 (OMIM: 610068) solute carrier family 26 m (723 aa) initn: 3378 init1: 2394 opt: 3222 Z-score: 3567.0 bits: 670.7 E(85289): 6e-192 Smith-Waterman score: 4128; 87.3% identity (90.7% similar) in 761 aa overlap (1-758:1-723) 10 20 30 40 50 60 pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMV--GSVTESLAPQALNDSMINETARDA ::::::::::::::::::::::::.: . . ... : : . .:. : : NP_001 FGLYSSFYPVFIYFLFGTSRHISVATPGPLPLLTAPGRPTGGAGPDPL---------RLR 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 ARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLH ... : .. : : : . : .: : :. . . ... NP_001 GHLPVRTSCPRL------------------YHSCSCA-GLRLTAQVCVWPPSEQPLWA-- 180 190 200 210 240 250 260 270 280 290 pF1KE6 LSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGE .. . .:::::::::::::::::::::::::::::::::::::::::::::: NP_001 --------TVPHLLLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGE 220 230 240 250 260 300 310 320 330 340 350 pF1KE6 LLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAI 270 280 290 300 310 320 360 370 380 390 400 410 pF1KE6 AISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVA 330 340 350 360 370 380 420 430 440 450 460 470 pF1KE6 GAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWL 390 400 410 420 430 440 480 490 500 510 520 530 pF1KE6 VTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVR 450 460 470 480 490 500 540 550 560 570 580 590 pF1KE6 GVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLR 510 520 530 540 550 560 600 610 620 630 640 650 pF1KE6 KQAASPKGASVSINVNTSLEDMRSNNVEDCKMM-VSSGDKMEDATANGQEDSKAPDGSTL ::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::: NP_001 KQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTL 570 580 590 600 610 620 660 670 680 690 700 710 pF1KE6 KALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEA 630 640 650 660 670 680 720 730 740 750 pF1KE6 GHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL ::::::::::::::::::::::::::::::::::::::::: NP_001 GHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL 690 700 710 720 >>NP_996766 (OMIM: 604943,613865) prestin isoform b [Hom (685 aa) initn: 1731 init1: 1330 opt: 1769 Z-score: 1958.6 bits: 373.0 E(85289): 2.3e-102 Smith-Waterman score: 1833; 41.6% identity (75.5% similar) in 687 aa overlap (29-707:16-679) 10 20 30 40 50 pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWR :..:::.... :.: : ..: . . . NP_996 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLK 10 20 30 40 60 70 80 90 100 110 pF1KE6 TWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGL . :. . .. . ::. ::: : ....::::.::.:....:::::::.:.::.. NP_996 QAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAV 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 PPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET-- ::.::::::::::..: ..:::::::.: :::.:.:.:.:. :.:. . . .: : NP_996 PPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNG 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 --ARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLK :::: ::.:: ....: :..: ::. .::::. ::.::::::.::::::.::.:.:: NP_996 TEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLK 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 YVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLP :.::.. . .:: .:..:... : .. . .: .. .. .. .:. : .:......:: NP_996 YLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLP 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE6 MPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIA ::: :..... .:::: :..::. ..:::::..: ::.::. :.:.:: . .:..:: NP_996 APIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIA 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE6 VVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTG .:::...::..: .: .:::.::.::::.:::: : ::..:: : .:::.:::::::.:: NP_996 IVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTG 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE6 GNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRA :..:.:: ..::.:::.:. : ::..::.:::.::.:::::::. :.::. .:.... NP_996 GKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKI 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE6 DLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYS .: :::.::.....:.:: ::..:::..:: :. ::: : :.:::..:.::.: :. : NP_996 ELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYE 470 480 490 500 510 520 540 550 560 570 580 590 pF1KE6 EAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQ :.::. :.:.:. .: .:.::...::.:::.. ::. ... ..: ..: NP_996 EVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYA-------- 530 540 550 560 570 600 610 620 630 640 650 pF1KE6 KEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAP : .: ... :. ..... :: . . :: .. :. . . : : NP_996 ---KEVGNANMANATVVKADAEVDGEDATKPEEEDGEV------KYPPIVIK----STFP 580 590 600 610 620 660 670 680 690 700 710 pF1KE6 DGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVV . .. . : . :..:::. ..:.:.: .:.: .: ... .. . ::.:.: NP_996 E--EMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAFIQ 630 640 650 660 670 680 720 730 740 750 pF1KE6 SQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL NP_996 R >>XP_011514472 (OMIM: 604943,613865) PREDICTED: prestin (744 aa) initn: 1908 init1: 1330 opt: 1769 Z-score: 1958.1 bits: 373.0 E(85289): 2.5e-102 Smith-Waterman score: 1902; 41.5% identity (75.1% similar) in 718 aa overlap (29-738:16-710) 10 20 30 40 50 pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWR :..:::.... :.: : ..: . . . XP_011 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLK 10 20 30 40 60 70 80 90 100 110 pF1KE6 TWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGL . :. . .. . ::. ::: : ....::::.::.:....:::::::.:.::.. XP_011 QAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAV 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 PPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET-- ::.::::::::::..: ..:::::::.: :::.:.:.:.:. :.:. . . .: : XP_011 PPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNG 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 --ARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLK :::: ::.:: ....: :..: ::. .::::. ::.::::::.::::::.::.:.:: XP_011 TEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLK 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 YVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLP :.::.. . .:: .:..:... : .. . .: .. .. .. .:. : .:......:: XP_011 YLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLP 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE6 MPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIA ::: :..... .:::: :..::. ..:::::..: ::.::. :.:.:: . .:..:: XP_011 APIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIA 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE6 VVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTG .:::...::..: .: .:::.::.::::.:::: : ::..:: : .:::.:::::::.:: XP_011 IVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTG 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE6 GNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRA :..:.:: ..::.:::.:. : ::..::.:::.::.:::::::. :.::. .:.... XP_011 GKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKI 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE6 DLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYS .: :::.::.....:.:: ::..:::..:: :. ::: : :.:::..:.::.: :. : XP_011 ELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYE 470 480 490 500 510 520 540 550 560 570 580 590 pF1KE6 EAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQ :.::. :.:.:. .: .:.::...::.:::.. ::. ... ..: ..: XP_011 EVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYA-------- 530 540 550 560 570 600 610 620 630 640 650 pF1KE6 KEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAP : .: ... :. ..... :: . . :: .. :. . . : : XP_011 ---KEVGNANMANATVVKADAEVDGEDATKPEEEDGEV------KYPPIVIK----STFP 580 590 600 610 620 660 670 680 690 700 710 pF1KE6 DGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVV . .. . : . :..:::. ..:.:.: .:.: .: ... .. . ::.:.: . :: XP_011 E--EMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVV 630 640 650 660 670 680 720 730 740 750 pF1KE6 SQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL ..: ..::. . :: :.:::: XP_011 NDLTRNRFFENPALWELLFHSIHDAVLGSQLREALAEQEASAPPSQEDLEPNATPATPEA 690 700 710 720 730 740 >>NP_945350 (OMIM: 604943,613865) prestin isoform a [Hom (744 aa) initn: 1908 init1: 1330 opt: 1769 Z-score: 1958.1 bits: 373.0 E(85289): 2.5e-102 Smith-Waterman score: 1902; 41.5% identity (75.1% similar) in 718 aa overlap (29-738:16-710) 10 20 30 40 50 pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWR :..:::.... :.: : ..: . . . NP_945 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLK 10 20 30 40 60 70 80 90 100 110 pF1KE6 TWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGL . :. . .. . ::. ::: : ....::::.::.:....:::::::.:.::.. NP_945 QAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAV 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 PPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET-- ::.::::::::::..: ..:::::::.: :::.:.:.:.:. :.:. . . .: : NP_945 PPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNG 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 --ARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLK :::: ::.:: ....: :..: ::. .::::. ::.::::::.::::::.::.:.:: NP_945 TEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLK 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 YVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLP :.::.. . .:: .:..:... : .. . .: .. .. .. .:. : .:......:: NP_945 YLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLP 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE6 MPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIA ::: :..... .:::: :..::. ..:::::..: ::.::. :.:.:: . .:..:: NP_945 APIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIA 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE6 VVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTG .:::...::..: .: .:::.::.::::.:::: : ::..:: : .:::.:::::::.:: NP_945 IVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTG 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE6 GNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRA :..:.:: ..::.:::.:. : ::..::.:::.::.:::::::. :.::. .:.... NP_945 GKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKI 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE6 DLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYS .: :::.::.....:.:: ::..:::..:: :. ::: : :.:::..:.::.: :. : NP_945 ELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYE 470 480 490 500 510 520 540 550 560 570 580 590 pF1KE6 EAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQ :.::. :.:.:. .: .:.::...::.:::.. ::. ... ..: ..: NP_945 EVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYA-------- 530 540 550 560 570 600 610 620 630 640 650 pF1KE6 KEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAP : .: ... :. ..... :: . . :: .. :. . . : : NP_945 ---KEVGNANMANATVVKADAEVDGEDATKPEEEDGEV------KYPPIVIK----STFP 580 590 600 610 620 660 670 680 690 700 710 pF1KE6 DGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVV . .. . : . :..:::. ..:.:.: .:.: .: ... .. . ::.:.: . :: NP_945 E--EMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVV 630 640 650 660 670 680 720 730 740 750 pF1KE6 SQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL ..: ..::. . :: :.:::: NP_945 NDLTRNRFFENPALWELLFHSIHDAVLGSQLREALAEQEASAPPSQEDLEPNATPATPEA 690 700 710 720 730 740 >>NP_443166 (OMIM: 608481) solute carrier family 26 memb (791 aa) initn: 1316 init1: 1178 opt: 1726 Z-score: 1910.2 bits: 364.2 E(85289): 1.2e-99 Smith-Waterman score: 1726; 37.3% identity (73.1% similar) in 713 aa overlap (51-748:32-744) 30 40 50 60 70 80 pF1KE6 AMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVW : .. :. ..:: :. :... :::: : NP_443 SQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLSW 10 20 30 40 50 60 90 100 110 120 130 140 pF1KE6 LPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSR ::.: ..:... :::.::: . .:.:::.:.::::.:: : ::::::.:.. ::..: . NP_443 LPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVH 70 80 90 100 110 120 150 160 170 180 190 pF1KE6 HISVGTFAVMSVMVGSVTESLAPQ--------ALNDSMINETARDAARVQVASTLSVLVG .. :::::.:..::.. .:::. : :.:... .: .: :..:..::. :.. NP_443 QMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLTA 130 140 150 160 170 180 200 210 220 230 240 250 pF1KE6 LFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTV ..:.:::...::::. :::: ..::. :::..:...: :::.::: . :..:: :...: NP_443 IIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTF 190 200 210 220 230 240 260 270 280 290 300 310 pF1KE6 LEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGM ...: .::........ : ..:. ::.:: :: . .... .::: :..... ::.:: : NP_443 IDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGC 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE6 GLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGY . .......::.: :. ::.: .. .. ..:.::..:.:...: ...:. .: .::: NP_443 KMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGY 310 320 330 340 350 360 380 390 400 410 420 430 pF1KE6 RVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVK ::::::..::: ::..:..:. . :..: .:. ...::.::::. :: ... .. NP_443 DVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLV 370 380 390 400 410 420 440 450 460 470 480 490 pF1KE6 LGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLG :: .. :::.::.:.: ::::. :.::.: ::. .. : ::.:.: ....:.: : NP_443 LGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYG 430 440 450 460 470 480 500 510 520 530 540 550 pF1KE6 LVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFA ..:.: ::.:.:: .::. . .:.:: ::::: . :..:....:.:.. . .::: NP_443 VAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFA 490 500 510 520 530 540 560 570 580 590 600 610 pF1KE6 NAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSIN :.:.. . . . :.: . .. :.: :::::. ... :....: .. . . .. . NP_443 NSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQD 550 560 570 580 590 600 620 630 640 650 660 pF1KE6 V-NTSLEDMRSNNVEDCKMMVS----SGDKMEDATANGQEDSKAP-DGSTLKALGLPQPD :. : .:.. :: : :. : .. ...:: . : . : : NP_443 FENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE6 FHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFF-DASI ::.::::....:::: . .:.: .. . .: :.:... :. : ... : : :.:. NP_443 FHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSL 670 680 690 700 710 720 730 740 750 pF1KE6 TKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL ::.: :.:::: :: . : : NP_443 ECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFGS 730 740 750 760 770 780 758 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 15:30:26 2016 done: Tue Nov 8 15:30:27 2016 Total Scan time: 9.530 Total Display time: 0.190 Function used was FASTA [36.3.4 Apr, 2011]