FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4456, 475 aa 1>>>pF1KE4456 475 - 475 aa - 475 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7198+/-0.000461; mu= 15.4043+/- 0.028 mean_var=65.8514+/-13.473, 0's: 0 Z-trim(109.4): 49 B-trim: 33 in 1/49 Lambda= 0.158049 statistics sampled from 17508 (17552) to 17508 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.564), E-opt: 0.2 (0.206), width: 16 Scan time: 8.270 The best scores are: opt bits E(85289) XP_011531105 (OMIM: 143450,609015) PREDICTED: trif ( 474) 3068 708.9 7.6e-204 NP_000174 (OMIM: 143450,609015) trifunctional enzy ( 474) 3068 708.9 7.6e-204 XP_016859428 (OMIM: 143450,609015) PREDICTED: trif ( 481) 2993 691.8 1.1e-198 NP_001268442 (OMIM: 143450,609015) trifunctional e ( 452) 2834 655.5 8.4e-188 NP_001268441 (OMIM: 143450,609015) trifunctional e ( 459) 2531 586.5 5.4e-167 XP_016873172 (OMIM: 203750,607809) PREDICTED: acet ( 301) 345 87.9 4.1e-17 XP_016873171 (OMIM: 203750,607809) PREDICTED: acet ( 301) 345 87.9 4.1e-17 XP_006713186 (OMIM: 604054) PREDICTED: 3-ketoacyl- ( 272) 331 84.7 3.4e-16 XP_011531952 (OMIM: 604054) PREDICTED: 3-ketoacyl- ( 279) 331 84.7 3.5e-16 NP_000010 (OMIM: 203750,607809) acetyl-CoA acetylt ( 427) 257 67.9 6.1e-11 NP_005882 (OMIM: 100678,614055) acetyl-CoA acetylt ( 397) 199 54.7 5.5e-07 NP_006102 (OMIM: 604770) 3-ketoacyl-CoA thiolase, ( 397) 197 54.2 7.6e-07 NP_001290182 (OMIM: 100678,614055) acetyl-CoA acet ( 426) 194 53.6 1.3e-06 NP_001123882 (OMIM: 604054) 3-ketoacyl-CoA thiolas ( 331) 192 53.1 1.4e-06 XP_006713185 (OMIM: 604054) PREDICTED: 3-ketoacyl- ( 364) 189 52.4 2.5e-06 NP_001598 (OMIM: 604054) 3-ketoacyl-CoA thiolase, ( 424) 189 52.4 2.8e-06 XP_006718898 (OMIM: 203750,607809) PREDICTED: acet ( 337) 163 46.5 0.00014 XP_016873170 (OMIM: 203750,607809) PREDICTED: acet ( 337) 163 46.5 0.00014 XP_005271160 (OMIM: 184755,613724) PREDICTED: non- ( 463) 155 44.7 0.00066 NP_001180546 (OMIM: 184755,613724) non-specific li ( 466) 155 44.7 0.00067 NP_001180529 (OMIM: 184755,613724) non-specific li ( 503) 155 44.7 0.00071 NP_001180528 (OMIM: 184755,613724) non-specific li ( 523) 155 44.7 0.00074 NP_002970 (OMIM: 184755,613724) non-specific lipid ( 547) 155 44.7 0.00077 XP_011540237 (OMIM: 184755,613724) PREDICTED: non- ( 399) 139 41.0 0.0073 >>XP_011531105 (OMIM: 143450,609015) PREDICTED: trifunct (474 aa) initn: 3068 init1: 3068 opt: 3068 Z-score: 3780.6 bits: 708.9 E(85289): 7.6e-204 Smith-Waterman score: 3068; 100.0% identity (100.0% similar) in 473 aa overlap (3-475:2-474) 10 20 30 40 50 60 pF1KE4 MTTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDG 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 VRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 ALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 RKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 YGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNN 360 370 380 390 400 410 430 440 450 460 470 pF1KE4 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK 420 430 440 450 460 470 >>NP_000174 (OMIM: 143450,609015) trifunctional enzyme s (474 aa) initn: 3068 init1: 3068 opt: 3068 Z-score: 3780.6 bits: 708.9 E(85289): 7.6e-204 Smith-Waterman score: 3068; 100.0% identity (100.0% similar) in 473 aa overlap (3-475:2-474) 10 20 30 40 50 60 pF1KE4 MTTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDG 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 VRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 ALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 RKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 YGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNN 360 370 380 390 400 410 430 440 450 460 470 pF1KE4 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK 420 430 440 450 460 470 >>XP_016859428 (OMIM: 143450,609015) PREDICTED: trifunct (481 aa) initn: 2993 init1: 2993 opt: 2993 Z-score: 3688.1 bits: 691.8 E(85289): 1.1e-198 Smith-Waterman score: 2993; 100.0% identity (100.0% similar) in 462 aa overlap (3-464:2-463) 10 20 30 40 50 60 pF1KE4 MTTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDG 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 VRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 ALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 RKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 YGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNN 360 370 380 390 400 410 430 440 450 460 470 pF1KE4 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK :::::::::::::::::::::::::::::::::::::::::::: XP_016 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQVRYSGVIGPSRESFSW 420 430 440 450 460 470 XP_016 ND 480 >>NP_001268442 (OMIM: 143450,609015) trifunctional enzym (452 aa) initn: 2834 init1: 2834 opt: 2834 Z-score: 3492.6 bits: 655.5 E(85289): 8.4e-188 Smith-Waterman score: 2834; 100.0% identity (100.0% similar) in 438 aa overlap (38-475:15-452) 10 20 30 40 50 60 pF1KE4 PFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDGVRTPFLL :::::::::::::::::::::::::::::: NP_001 MTLVSGWLLYGWIIAVQTKTKKTLAKPNIRNVVVVDGVRTPFLL 10 20 30 40 70 80 90 100 110 120 pF1KE4 SGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFS 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE4 DKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDL 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 NKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYAL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE4 RSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKPYGTVTAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKPYGTVTAA 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 NSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPKVLEKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPKVLEKA 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 GLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWGGSLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWGGSLSL 350 360 370 380 390 400 430 440 450 460 470 pF1KE4 GHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK 410 420 430 440 450 >>NP_001268441 (OMIM: 143450,609015) trifunctional enzym (459 aa) initn: 2531 init1: 2531 opt: 2531 Z-score: 3119.1 bits: 586.5 E(85289): 5.4e-167 Smith-Waterman score: 2929; 96.8% identity (96.8% similar) in 473 aa overlap (3-475:2-459) 10 20 30 40 50 60 pF1KE4 MTTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDG 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 VRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREA ::::::::::: :::::::::::::::::::::::::::::::::: NP_001 VRTPFLLSGTS---------------GLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREA 60 70 80 90 100 130 140 150 160 170 180 pF1KE4 ALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 RKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE4 EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKP 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 YGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNN 350 360 370 380 390 400 430 440 450 460 470 pF1KE4 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK 410 420 430 440 450 >>XP_016873172 (OMIM: 203750,607809) PREDICTED: acetyl-C (301 aa) initn: 464 init1: 118 opt: 345 Z-score: 428.3 bits: 87.9 E(85289): 4.1e-17 Smith-Waterman score: 469; 33.5% identity (59.6% similar) in 319 aa overlap (159-471:20-299) 130 140 150 160 170 180 pF1KE4 KTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLN ::.::::.: ::.:: .: . XP_016 MFYKEVKDKLLQGRQYWVQDVMVAGGMESMSNVPYVMNR---------G 10 20 30 40 190 200 210 220 230 240 pF1KE4 KAKSMGQRL-SLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYAL .. : .: .:: : .... .. :: :. : . ..: ::: ::. XP_016 STPYGGVKLEDLIVK----------DGLTDVYNKIHMGSCAENTAKKLNIARNEQDAYAI 50 60 70 80 90 250 260 270 280 290 300 pF1KE4 RSHSLAKKAQDEGLL-SDVVPFKVPGK---DTVTK-DNGIRPSSLEQMAKLKPAFIKPYG :.. .: : . : . ..:.: : : :.:.: :. . .. .. ::: .: : : XP_016 NSYTRSKAAWEAGKFGNEVIPVTVTVKGQPDVVVKEDEEYKRVDFSKVPKLKTVFQKENG 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE4 TVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPK ::::::.: :.:::.:...:. . : .. : : . : .. .: : . ..:.::. XP_016 TVTAANASTLNDGAAALVLMTADAAKRLNVTPLARIVAFADAAVEPID-FPIAPVYAASM 160 170 180 190 200 370 380 390 400 410 420 pF1KE4 VLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWG ::. .:: .:: .: .:::: .:::.: .. : : .: : : XP_016 VLKDVGLKKEDIAMWEVNEAFSLVVLANIKMLEID----------------P-QKVNING 210 220 230 240 250 430 440 450 460 470 pF1KE4 GSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK :..:::::.: .: :.: .. :.. :.:::.. : .:: . ::... XP_016 GAVSLGHPIGMSGARIVGHLTHALKQ--GEYGLASICNGGGGASAMLIQKL 260 270 280 290 300 >>XP_016873171 (OMIM: 203750,607809) PREDICTED: acetyl-C (301 aa) initn: 464 init1: 118 opt: 345 Z-score: 428.3 bits: 87.9 E(85289): 4.1e-17 Smith-Waterman score: 469; 33.5% identity (59.6% similar) in 319 aa overlap (159-471:20-299) 130 140 150 160 170 180 pF1KE4 KTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLN ::.::::.: ::.:: .: . XP_016 MFYKEVKDKLLQGRQYWVQDVMVAGGMESMSNVPYVMNR---------G 10 20 30 40 190 200 210 220 230 240 pF1KE4 KAKSMGQRL-SLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYAL .. : .: .:: : .... .. :: :. : . ..: ::: ::. XP_016 STPYGGVKLEDLIVK----------DGLTDVYNKIHMGSCAENTAKKLNIARNEQDAYAI 50 60 70 80 90 250 260 270 280 290 300 pF1KE4 RSHSLAKKAQDEGLL-SDVVPFKVPGK---DTVTK-DNGIRPSSLEQMAKLKPAFIKPYG :.. .: : . : . ..:.: : : :.:.: :. . .. .. ::: .: : : XP_016 NSYTRSKAAWEAGKFGNEVIPVTVTVKGQPDVVVKEDEEYKRVDFSKVPKLKTVFQKENG 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE4 TVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPK ::::::.: :.:::.:...:. . : .. : : . : .. .: : . ..:.::. XP_016 TVTAANASTLNDGAAALVLMTADAAKRLNVTPLARIVAFADAAVEPID-FPIAPVYAASM 160 170 180 190 200 370 380 390 400 410 420 pF1KE4 VLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWG ::. .:: .:: .: .:::: .:::.: .. : : .: : : XP_016 VLKDVGLKKEDIAMWEVNEAFSLVVLANIKMLEID----------------P-QKVNING 210 220 230 240 250 430 440 450 460 470 pF1KE4 GSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK :..:::::.: .: :.: .. :.. :.:::.. : .:: . ::... XP_016 GAVSLGHPIGMSGARIVGHLTHALKQ--GEYGLASICNGGGGASAMLIQKL 260 270 280 290 300 >>XP_006713186 (OMIM: 604054) PREDICTED: 3-ketoacyl-CoA (272 aa) initn: 538 init1: 148 opt: 331 Z-score: 411.7 bits: 84.7 E(85289): 3.4e-16 Smith-Waterman score: 550; 40.5% identity (67.2% similar) in 262 aa overlap (224-474:29-270) 200 210 220 230 240 250 pF1KE4 GQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLA :: ... .: :..:: .:: .:: :.. : XP_006 MSLADRGNPGNITSRLMEKEKARDCLIPMGITSENVAERFGISREKQDTFALASQQKA 10 20 30 40 50 260 270 280 290 300 pF1KE4 KKAQDEGLL-SDVVPFKVPGKD--------TVTKDNGIRPSS-LEQMAKLKPAFIKPYGT .::..: . ...:: . .: :::.:.:::::. .: .::::::: : :. XP_006 ARAQSKGCFQAEIVPVTTTVHDDKGTKRSITVTQDEGIRPSTTMEGLAKLKPAFKKD-GS 60 70 80 90 100 110 310 320 330 340 350 360 pF1KE4 VTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPKV .::.::: ..:::.:.:. . :: .: . ::.. :. : : . .::.:: : . XP_006 TTAGNSSQVSDGAAAILLARRSKAEELGLPILGVLRSYAVVGVPP-DIMGIGPAYAIPVA 120 130 140 150 160 170 370 380 390 400 410 420 pF1KE4 LEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWGG :.:::::..:.: ::..:::..: . . .: :. ::: :: : :: XP_006 LQKAGLTVSDVDIFEINEAFASQ---------AAYCVE-------KLRLPP-EKVNPLGG 180 190 200 210 430 440 450 460 470 pF1KE4 SLSLGHPFGATGCRLVMAAANRLRKEGGQ-YGLVAACAAGGQGHAMIVEAYPK ...::::.: :: : :.. :.:...: . ::.:. : . :.: : . : :: XP_006 AVALGHPLGCTGARQVITLLNELKRRGKRAYGVVSMCIGTGMGAAAVFE-YPGN 220 230 240 250 260 270 >>XP_011531952 (OMIM: 604054) PREDICTED: 3-ketoacyl-CoA (279 aa) initn: 538 init1: 148 opt: 331 Z-score: 411.5 bits: 84.7 E(85289): 3.5e-16 Smith-Waterman score: 550; 40.5% identity (67.2% similar) in 262 aa overlap (224-474:36-277) 200 210 220 230 240 250 pF1KE4 GQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLA :: ... .: :..:: .:: .:: :.. : XP_011 ESMSLADRGNPGNITSRLMEKEKARDCLIPMGITSENVAERFGISREKQDTFALASQQKA 10 20 30 40 50 60 260 270 280 290 300 pF1KE4 KKAQDEGLL-SDVVPFKVPGKD--------TVTKDNGIRPSS-LEQMAKLKPAFIKPYGT .::..: . ...:: . .: :::.:.:::::. .: .::::::: : :. XP_011 ARAQSKGCFQAEIVPVTTTVHDDKGTKRSITVTQDEGIRPSTTMEGLAKLKPAFKKD-GS 70 80 90 100 110 120 310 320 330 340 350 360 pF1KE4 VTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPKV .::.::: ..:::.:.:. . :: .: . ::.. :. : : . .::.:: : . XP_011 TTAGNSSQVSDGAAAILLARRSKAEELGLPILGVLRSYAVVGVPP-DIMGIGPAYAIPVA 130 140 150 160 170 180 370 380 390 400 410 420 pF1KE4 LEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWGG :.:::::..:.: ::..:::..: . . .: :. ::: :: : :: XP_011 LQKAGLTVSDVDIFEINEAFASQ---------AAYCVE-------KLRLPP-EKVNPLGG 190 200 210 220 430 440 450 460 470 pF1KE4 SLSLGHPFGATGCRLVMAAANRLRKEGGQ-YGLVAACAAGGQGHAMIVEAYPK ...::::.: :: : :.. :.:...: . ::.:. : . :.: : . : :: XP_011 AVALGHPLGCTGARQVITLLNELKRRGKRAYGVVSMCIGTGMGAAAVFE-YPGN 230 240 250 260 270 >>NP_000010 (OMIM: 203750,607809) acetyl-CoA acetyltrans (427 aa) initn: 640 init1: 250 opt: 257 Z-score: 317.4 bits: 67.9 E(85289): 6.1e-11 Smith-Waterman score: 649; 31.9% identity (60.9% similar) in 445 aa overlap (34-471:21-425) 10 20 30 40 50 60 pF1KE4 ILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDGVRT : . .. .. ..::....::.:...:: NP_000 MAVLAALLRSGARSRSPLLRRLVQEIRYVERSYVSKPTLKEVVIVSATRT 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 PFLLSGTSYKDLMPHD-LARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAAL : . : . .:.: :. :. : ......::: : .:.:.: . . .:.:.: NP_000 P-IGSFLGSLSLLPATKLGSIAIQGAIEKAGIPKEEVKEAYMGNVLQGGEGQAPTRQAVL 60 70 80 90 100 130 140 150 160 170 180 pF1KE4 GAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRK :::. .:: :.. .: :. .:. . . :. ::.::::.: ::.:: .: NP_000 GAGLPISTPCTTINKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMNR---- 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 LMLDLNKAKSMGQRL-SLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLE ... : .: .:: : .... .. :: :. : . ..: : NP_000 -----GSTPYGGVKLEDLIVK----------DGLTDVYNKIHMGSCAENTAKKLNIARNE 170 180 190 200 210 250 260 270 280 290 pF1KE4 QDEYALRSHSLAKKAQDEGLL-SDVVPFKVPGK---DTVTK-DNGIRPSSLEQMAKLKPA :: ::. :.. .: : . : . ..:.: : : :.:.: :. . .. .. ::: . NP_000 QDAYAINSYTRSKAAWEAGKFGNEVIPVTVTVKGQPDVVVKEDEEYKRVDFSKVPKLKTV 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE4 FIKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGP : : :::::::.: :.:::.:...:. . : .. : : . : .. .: : . ..: NP_000 FQKENGTVTAANASTLNDGAAALVLMTADAAKRLNVTPLARIVAFADAAVEPID-FPIAP 280 290 300 310 320 360 370 380 390 400 410 pF1KE4 TYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLE .::. ::. .:: .:: .: .:::: .:::.: .. : : . NP_000 VYAASMVLKDVGLKKEDIAMWEVNEAFSLVVLANIKMLEID---------------P--Q 330 340 350 360 370 420 430 440 450 460 470 pF1KE4 KFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK : : ::..:::::.: .: :.: .. :.. :.:::.. : .:: . ::... NP_000 KVNINGGAVSLGHPIGMSGARIVGHLTHALKQ--GEYGLASICNGGGGASAMLIQKL 380 390 400 410 420 475 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:59:50 2016 done: Sun Nov 6 00:59:52 2016 Total Scan time: 8.270 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]