Result of FASTA (omim) for
pFN21AE1411
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1411, 199 aa
1>>>pF1KE1411 199 - 199 aa - 199 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7804+/-0.000329; mu= 11.0829+/- 0.020
mean_var=72.4005+/-14.412, 0's: 0 Z-trim(115.5): 49 B-trim: 42 in 1/52
Lambda= 0.150731
statistics sampled from 25956 (26005) to 25956 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.692), E-opt: 0.2 (0.305), width: 16
Scan time: 6.000
The best scores are: opt bits E(85289)
NP_003796 (OMIM: 603454,614499) death domain-conta ( 199) 1308 293.2 1.9e-79
NP_001307028 (OMIM: 603454,614499) death domain-co ( 199) 1308 293.2 1.9e-79
XP_016875634 (OMIM: 603454,614499) PREDICTED: deat ( 102) 644 148.7 3e-36
XP_016875632 (OMIM: 603454,614499) PREDICTED: deat ( 105) 642 148.2 4.2e-36
XP_016875633 (OMIM: 603454,614499) PREDICTED: deat ( 103) 636 146.9 1e-35
NP_001317055 (OMIM: 603454,614499) death domain-co ( 130) 636 147.0 1.3e-35
NP_001307030 (OMIM: 603454,614499) death domain-co ( 115) 628 145.2 3.8e-35
NP_001307029 (OMIM: 603454,614499) death domain-co ( 121) 628 145.2 3.9e-35
NP_116765 (OMIM: 600639) caspase-2 isoform 3 [Homo ( 108) 140 39.1 0.0031
NP_001215 (OMIM: 600639) caspase-2 isoform 2 [Homo ( 312) 146 40.6 0.0032
NP_116764 (OMIM: 600639) caspase-2 isoform 1 prepr ( 452) 146 40.7 0.0044
>>NP_003796 (OMIM: 603454,614499) death domain-containin (199 aa)
initn: 1308 init1: 1308 opt: 1308 Z-score: 1547.5 bits: 293.2 E(85289): 1.9e-79
Smith-Waterman score: 1308; 100.0% identity (100.0% similar) in 199 aa overlap (1-199:1-199)
10 20 30 40 50 60
pF1KE1 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGDRLTGIPSHILNSSPSDRQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGDRLTGIPSHILNSSPSDRQI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 NQLAQRLGPEWEPMVLSLGLSQTDIYRCKANHPHNVQSQVVEAFIRWRQRFGKQATFQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NQLAQRLGPEWEPMVLSLGLSQTDIYRCKANHPHNVQSQVVEAFIRWRQRFGKQATFQSL
130 140 150 160 170 180
190
pF1KE1 HNGLRAVEVDPSLLLHMLE
:::::::::::::::::::
NP_003 HNGLRAVEVDPSLLLHMLE
190
>>NP_001307028 (OMIM: 603454,614499) death domain-contai (199 aa)
initn: 1308 init1: 1308 opt: 1308 Z-score: 1547.5 bits: 293.2 E(85289): 1.9e-79
Smith-Waterman score: 1308; 100.0% identity (100.0% similar) in 199 aa overlap (1-199:1-199)
10 20 30 40 50 60
pF1KE1 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGDRLTGIPSHILNSSPSDRQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGDRLTGIPSHILNSSPSDRQI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 NQLAQRLGPEWEPMVLSLGLSQTDIYRCKANHPHNVQSQVVEAFIRWRQRFGKQATFQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQLAQRLGPEWEPMVLSLGLSQTDIYRCKANHPHNVQSQVVEAFIRWRQRFGKQATFQSL
130 140 150 160 170 180
190
pF1KE1 HNGLRAVEVDPSLLLHMLE
:::::::::::::::::::
NP_001 HNGLRAVEVDPSLLLHMLE
190
>>XP_016875634 (OMIM: 603454,614499) PREDICTED: death do (102 aa)
initn: 644 init1: 644 opt: 644 Z-score: 771.7 bits: 148.7 E(85289): 3e-36
Smith-Waterman score: 644; 100.0% identity (100.0% similar) in 101 aa overlap (1-101:1-101)
10 20 30 40 50 60
pF1KE1 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGDRLTGIPSHILNSSPSDRQI
:::::::::::::::::::::::::::::::::::::::::
XP_016 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGDY
70 80 90 100
130 140 150 160 170 180
pF1KE1 NQLAQRLGPEWEPMVLSLGLSQTDIYRCKANHPHNVQSQVVEAFIRWRQRFGKQATFQSL
>>XP_016875632 (OMIM: 603454,614499) PREDICTED: death do (105 aa)
initn: 642 init1: 642 opt: 642 Z-score: 769.1 bits: 148.2 E(85289): 4.2e-36
Smith-Waterman score: 642; 99.0% identity (99.0% similar) in 102 aa overlap (1-102:1-102)
10 20 30 40 50 60
pF1KE1 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGDRLTGIPSHILNSSPSDRQI
:::::::::::::::::::::::::::::::::::::::: :
XP_016 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGKRQLC
70 80 90 100
130 140 150 160 170 180
pF1KE1 NQLAQRLGPEWEPMVLSLGLSQTDIYRCKANHPHNVQSQVVEAFIRWRQRFGKQATFQSL
>>XP_016875633 (OMIM: 603454,614499) PREDICTED: death do (103 aa)
initn: 636 init1: 636 opt: 636 Z-score: 762.2 bits: 146.9 E(85289): 1e-35
Smith-Waterman score: 636; 100.0% identity (100.0% similar) in 100 aa overlap (1-100:1-100)
10 20 30 40 50 60
pF1KE1 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGDRLTGIPSHILNSSPSDRQI
::::::::::::::::::::::::::::::::::::::::
XP_016 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGCWP
70 80 90 100
130 140 150 160 170 180
pF1KE1 NQLAQRLGPEWEPMVLSLGLSQTDIYRCKANHPHNVQSQVVEAFIRWRQRFGKQATFQSL
>>NP_001317055 (OMIM: 603454,614499) death domain-contai (130 aa)
initn: 636 init1: 636 opt: 636 Z-score: 760.6 bits: 147.0 E(85289): 1.3e-35
Smith-Waterman score: 636; 100.0% identity (100.0% similar) in 100 aa overlap (1-100:1-100)
10 20 30 40 50 60
pF1KE1 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGDRLTGIPSHILNSSPSDRQI
::::::::::::::::::::::::::::::::::::::::
NP_001 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGLEEKGRTGRRMGWGAGEEKG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 NQLAQRLGPEWEPMVLSLGLSQTDIYRCKANHPHNVQSQVVEAFIRWRQRFGKQATFQSL
NP_001 QKCQTVGMRT
130
>>NP_001307030 (OMIM: 603454,614499) death domain-contai (115 aa)
initn: 628 init1: 628 opt: 628 Z-score: 752.1 bits: 145.2 E(85289): 3.8e-35
Smith-Waterman score: 628; 100.0% identity (100.0% similar) in 99 aa overlap (1-99:1-99)
10 20 30 40 50 60
pF1KE1 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGDRLTGIPSHILNSSPSDRQI
:::::::::::::::::::::::::::::::::::::::
NP_001 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAVAIIRLPRELSLPTLL
70 80 90 100 110
130 140 150 160 170 180
pF1KE1 NQLAQRLGPEWEPMVLSLGLSQTDIYRCKANHPHNVQSQVVEAFIRWRQRFGKQATFQSL
>>NP_001307029 (OMIM: 603454,614499) death domain-contai (121 aa)
initn: 628 init1: 628 opt: 628 Z-score: 751.7 bits: 145.2 E(85289): 3.9e-35
Smith-Waterman score: 628; 100.0% identity (100.0% similar) in 99 aa overlap (1-99:1-99)
10 20 30 40 50 60
pF1KE1 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGDRLTGIPSHILNSSPSDRQI
:::::::::::::::::::::::::::::::::::::::
NP_001 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAEMRKLRPKDSVTCLASQLTWR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 NQLAQRLGPEWEPMVLSLGLSQTDIYRCKANHPHNVQSQVVEAFIRWRQRFGKQATFQSL
NP_001 F
>>NP_116765 (OMIM: 600639) caspase-2 isoform 3 [Homo sap (108 aa)
initn: 92 init1: 92 opt: 140 Z-score: 179.0 bits: 39.1 E(85289): 0.0031
Smith-Waterman score: 140; 31.2% identity (76.6% similar) in 77 aa overlap (1-77:32-107)
10 20 30
pF1KE1 MEARDKQVLRSLRLELGAEVLVEGLVLQYL
:. . ...:.. :. :. ..:. : :..:
NP_116 AAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSEL-LEHL
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE1 YQEGILTENHIQEINAQTTGLRKTMLLLDILPSRGPKAFDTFLDSLQEFPWVREKLKKAR
.. :.: . . :.:.. .. ... ::..::.:::.:::.: ..:.
NP_116 LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALHS
70 80 90 100
100 110 120 130 140 150
pF1KE1 EEAMTDLPAGDRLTGIPSHILNSSPSDRQINQLAQRLGPEWEPMVLSLGLSQTDIYRCKA
>>NP_001215 (OMIM: 600639) caspase-2 isoform 2 [Homo sap (312 aa)
initn: 98 init1: 98 opt: 146 Z-score: 178.8 bits: 40.6 E(85289): 0.0032
Smith-Waterman score: 146; 32.1% identity (76.9% similar) in 78 aa overlap (1-78:1-77)
10 20 30 40 50 60
pF1KE1 MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDI
:. . ...:.. :. :. ..:. : :..: .. :.: . . :.:.. .. ... ::..
NP_001 MHPHHQETLKKNRVVLAKQLLLSEL-LEHLLEKDIITLEMRELIQAKVGSFSQNVELLNL
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 LPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGDRLTGIPSHILNSSPSDRQI
::.:::.:::.: ..:.:
NP_001 LPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPL
60 70 80 90 100 110
199 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 01:06:55 2016 done: Mon Nov 7 01:06:56 2016
Total Scan time: 6.000 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]