FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5611, 492 aa 1>>>pF1KE5611 492 - 492 aa - 492 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0866+/-0.000366; mu= 18.8887+/- 0.023 mean_var=61.8564+/-13.213, 0's: 0 Z-trim(113.5): 42 B-trim: 1502 in 2/51 Lambda= 0.163073 statistics sampled from 22860 (22901) to 22860 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.64), E-opt: 0.2 (0.269), width: 16 Scan time: 7.920 The best scores are: opt bits E(85289) NP_037511 (OMIM: 610537) dipeptidyl peptidase 2 pr ( 492) 3381 804.2 0 XP_011516902 (OMIM: 610537) PREDICTED: dipeptidyl ( 484) 2945 701.6 1.3e-201 XP_011516901 (OMIM: 610537) PREDICTED: dipeptidyl ( 514) 2945 701.6 1.3e-201 XP_016870141 (OMIM: 610537) PREDICTED: dipeptidyl ( 436) 2599 620.2 3.7e-177 XP_005266132 (OMIM: 610537) PREDICTED: dipeptidyl ( 565) 2298 549.4 9.6e-156 XP_016870140 (OMIM: 610537) PREDICTED: dipeptidyl ( 458) 2163 517.6 2.9e-146 XP_006717146 (OMIM: 610537) PREDICTED: dipeptidyl ( 509) 1516 365.4 2.1e-100 NP_005031 (OMIM: 176785) lysosomal Pro-X carboxype ( 496) 1267 306.8 8.9e-83 NP_955450 (OMIM: 176785) lysosomal Pro-X carboxype ( 517) 1218 295.3 2.7e-79 XP_005274150 (OMIM: 176785) PREDICTED: lysosomal P ( 391) 1020 248.7 2.3e-65 NP_001306143 (OMIM: 176785) lysosomal Pro-X carbox ( 391) 1020 248.7 2.3e-65 NP_005856 (OMIM: 607169) thymus-specific serine pr ( 514) 632 157.5 8.6e-38 XP_016865651 (OMIM: 607169) PREDICTED: thymus-spec ( 454) 485 122.8 2e-27 XP_016865653 (OMIM: 607169) PREDICTED: thymus-spec ( 357) 381 98.3 3.8e-20 XP_016865652 (OMIM: 607169) PREDICTED: thymus-spec ( 417) 381 98.3 4.3e-20 XP_016865650 (OMIM: 607169) PREDICTED: thymus-spec ( 488) 307 81.0 8.6e-15 XP_016865654 (OMIM: 607169) PREDICTED: thymus-spec ( 257) 233 63.4 8.8e-10 >>NP_037511 (OMIM: 610537) dipeptidyl peptidase 2 prepro (492 aa) initn: 3381 init1: 3381 opt: 3381 Z-score: 4295.0 bits: 804.2 E(85289): 0 Smith-Waterman score: 3381; 99.8% identity (100.0% similar) in 492 aa overlap (1-492:1-492) 10 20 30 40 50 60 pF1KE5 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 DRFWVRGEGPIFFYTGNEGDVWAFANNSGFVAELAAERGALLVFAEHRYYGKSLPFGAQS ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: NP_037 DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ 430 440 450 460 470 480 490 pF1KE5 QPALRGGPRLSL :::::::::::: NP_037 QPALRGGPRLSL 490 >>XP_011516902 (OMIM: 610537) PREDICTED: dipeptidyl pept (484 aa) initn: 2945 init1: 2945 opt: 2945 Z-score: 3740.7 bits: 701.6 E(85289): 1.3e-201 Smith-Waterman score: 2945; 99.8% identity (100.0% similar) in 430 aa overlap (63-492:55-484) 40 50 60 70 80 90 pF1KE5 ERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSGFVA ::::::::::::::::::::::::::.::: XP_011 PGALLPAASGPLQLRALRQQDLPSALPGVGFWVRGEGPIFFYTGNEGDVWAFANNSAFVA 30 40 50 60 70 80 100 110 120 130 140 150 pF1KE5 ELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQ 90 100 110 120 130 140 160 170 180 190 200 210 pF1KE5 DAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQ 150 160 170 180 190 200 220 230 240 250 260 270 pF1KE5 SPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMM 210 220 230 240 250 260 280 290 300 310 320 330 pF1KE5 DYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSC 270 280 290 300 310 320 340 350 360 370 380 390 pF1KE5 ADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRP 330 340 350 360 370 380 400 410 420 430 440 450 pF1KE5 DWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHP 390 400 410 420 430 440 460 470 480 490 pF1KE5 EDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL :::::::::::::::::::::::::::::::::::::::: XP_011 EDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 450 460 470 480 >>XP_011516901 (OMIM: 610537) PREDICTED: dipeptidyl pept (514 aa) initn: 3080 init1: 2945 opt: 2945 Z-score: 3740.4 bits: 701.6 E(85289): 1.3e-201 Smith-Waterman score: 3049; 89.9% identity (91.8% similar) in 514 aa overlap (1-492:1-514) 10 20 30 40 50 pF1KE5 MGSAPWAPVLLLALGLRGLQAGA--RRAPD----PGFQERFFQQRLDHFNFERFGNKTFP ::::::::::::::::::::::. :: : :. :: . . . :. . .: XP_011 MGSAPWAPVLLLALGLRGLQAGGEWRRPPAHSPVPAPPLRFASPHSPQGPGPRLPGALLP 10 20 30 40 50 60 60 70 80 90 pF1KE5 ------------QRFLVSDR----FWVRGEGPIFFYTGNEGDVWAFANNSGFVAELAAER :. : : ::::::::::::::::::::::::::.::::::::: XP_011 AASGPLQLRALRQQDLPSALPGVGFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAER 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE5 GALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIA 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE5 FGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQ 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE5 GVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPT 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE5 DFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGC 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE5 GTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTS 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE5 FWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASV 430 440 450 460 470 480 460 470 480 490 pF1KE5 VEARKLEATIIGEWVKAARREQQPALRGGPRLSL :::::::::::::::::::::::::::::::::: XP_011 VEARKLEATIIGEWVKAARREQQPALRGGPRLSL 490 500 510 >>XP_016870141 (OMIM: 610537) PREDICTED: dipeptidyl pept (436 aa) initn: 2599 init1: 2599 opt: 2599 Z-score: 3301.5 bits: 620.2 E(85289): 3.7e-177 Smith-Waterman score: 2599; 99.7% identity (100.0% similar) in 380 aa overlap (1-380:1-380) 10 20 30 40 50 60 pF1KE5 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 DRFWVRGEGPIFFYTGNEGDVWAFANNSGFVAELAAERGALLVFAEHRYYGKSLPFGAQS ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: XP_016 DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW :::::::::::::::::::: XP_016 SNNVTDMFPDLPFTDELRQRSQSRQQHHLLQREPGPLGRGRDSEEPECLSHRRHHPGGSA 370 380 390 400 410 420 >>XP_005266132 (OMIM: 610537) PREDICTED: dipeptidyl pept (565 aa) initn: 2292 init1: 2292 opt: 2298 Z-score: 2917.1 bits: 549.4 E(85289): 9.6e-156 Smith-Waterman score: 2939; 85.9% identity (86.1% similar) in 524 aa overlap (42-492:42-565) 20 30 40 50 60 70 pF1KE5 LALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPI :::::::::::::::::::::::::::::: XP_005 LALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPI 20 30 40 50 60 70 80 90 100 110 120 130 pF1KE5 FFYTGNEGDVWAFANNSGFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTV :::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::: XP_005 FFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTV 80 90 100 110 120 130 140 150 160 pF1KE5 EQALADFAELLRALRRDLGAQDAPAIAFGG------------------------------ :::::::::::::::::::::::::::::: XP_005 EQALADFAELLRALRRDLGAQDAPAIAFGGRKPSHLSSQPPAQLGCAATLAAFPSESCTR 140 150 160 170 180 190 170 pF1KE5 -------------------------------------------SYGGMLSAYLRMKYPHL ::::::::::::::::: XP_005 TWPRVGICGSQKCRPPCGTCGPLRRKRGNGVLGAAALTLCPSPSYGGMLSAYLRMKYPHL 200 210 220 230 240 250 180 190 200 210 220 230 pF1KE5 VAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDT 260 270 280 290 300 310 240 250 260 270 280 290 pF1KE5 VRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLS 320 330 340 350 360 370 300 310 320 330 340 350 pF1KE5 EAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLT 380 390 400 410 420 430 360 370 380 390 400 410 pF1KE5 FASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLD 440 450 460 470 480 490 420 430 440 450 460 470 pF1KE5 PWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARR 500 510 520 530 540 550 480 490 pF1KE5 EQQPALRGGPRLSL :::::::::::::: XP_005 EQQPALRGGPRLSL 560 >-- initn: 286 init1: 286 opt: 286 Z-score: 358.9 bits: 76.1 E(85289): 3e-13 Smith-Waterman score: 286; 100.0% identity (100.0% similar) in 41 aa overlap (1-41:1-41) 10 20 30 40 50 60 pF1KE5 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS ::::::::::::::::::::::::::::::::::::::::: XP_005 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 DRFWVRGEGPIFFYTGNEGDVWAFANNSGFVAELAAERGALLVFAEHRYYGKSLPFGAQS XP_005 DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS 70 80 90 100 110 120 >>XP_016870140 (OMIM: 610537) PREDICTED: dipeptidyl pept (458 aa) initn: 2298 init1: 2163 opt: 2163 Z-score: 2746.8 bits: 517.6 E(85289): 2.9e-146 Smith-Waterman score: 2267; 87.1% identity (89.6% similar) in 402 aa overlap (1-380:1-402) 10 20 30 40 50 pF1KE5 MGSAPWAPVLLLALGLRGLQAGA--RRAPD----PGFQERFFQQRLDHFNFERFGNKTFP ::::::::::::::::::::::. :: : :. :: . . . :. . .: XP_016 MGSAPWAPVLLLALGLRGLQAGGEWRRPPAHSPVPAPPLRFASPHSPQGPGPRLPGALLP 10 20 30 40 50 60 60 70 80 90 pF1KE5 ------------QRFLVSDR----FWVRGEGPIFFYTGNEGDVWAFANNSGFVAELAAER :. : : ::::::::::::::::::::::::::.::::::::: XP_016 AASGPLQLRALRQQDLPSALPGVGFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAER 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE5 GALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIA 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE5 FGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQ 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE5 GVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPT 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE5 DFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGC 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE5 GTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTS :::::::::::::::::::::::::::::::::::::::::: XP_016 GTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRSQSRQQHHLLQREPGPLG 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE5 FWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASV XP_016 RGRDSEEPECLSHRRHHPGGSAPPRPQSLPPRRSCFRG 430 440 450 >>XP_006717146 (OMIM: 610537) PREDICTED: dipeptidyl pept (509 aa) initn: 1510 init1: 1510 opt: 1516 Z-score: 1923.5 bits: 365.4 E(85289): 2.1e-100 Smith-Waterman score: 2157; 82.0% identity (82.3% similar) in 412 aa overlap (42-380:42-453) 20 30 40 50 60 70 pF1KE5 LALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPI :::::::::::::::::::::::::::::: XP_006 LALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPI 20 30 40 50 60 70 80 90 100 110 120 130 pF1KE5 FFYTGNEGDVWAFANNSGFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTV :::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::: XP_006 FFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTV 80 90 100 110 120 130 140 150 160 pF1KE5 EQALADFAELLRALRRDLGAQDAPAIAFGG------------------------------ :::::::::::::::::::::::::::::: XP_006 EQALADFAELLRALRRDLGAQDAPAIAFGGRKPSHLSSQPPAQLGCAATLAAFPSESCTR 140 150 160 170 180 190 170 pF1KE5 -------------------------------------------SYGGMLSAYLRMKYPHL ::::::::::::::::: XP_006 TWPRVGICGSQKCRPPCGTCGPLRRKRGNGVLGAAALTLCPSPSYGGMLSAYLRMKYPHL 200 210 220 230 240 250 180 190 200 210 220 230 pF1KE5 VAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDT 260 270 280 290 300 310 240 250 260 270 280 290 pF1KE5 VRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLS 320 330 340 350 360 370 300 310 320 330 340 350 pF1KE5 EAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLT 380 390 400 410 420 430 360 370 380 390 400 410 pF1KE5 FASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLD :::::::::::::::::::::: XP_006 FASNNVTDMFPDLPFTDELRQRSQSRQQHHLLQREPGPLGRGRDSEEPECLSHRRHHPGG 440 450 460 470 480 490 >-- initn: 286 init1: 286 opt: 286 Z-score: 359.6 bits: 76.0 E(85289): 2.7e-13 Smith-Waterman score: 286; 100.0% identity (100.0% similar) in 41 aa overlap (1-41:1-41) 10 20 30 40 50 60 pF1KE5 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS ::::::::::::::::::::::::::::::::::::::::: XP_006 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 DRFWVRGEGPIFFYTGNEGDVWAFANNSGFVAELAAERGALLVFAEHRYYGKSLPFGAQS XP_006 DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS 70 80 90 100 110 120 >>NP_005031 (OMIM: 176785) lysosomal Pro-X carboxypeptid (496 aa) initn: 1210 init1: 425 opt: 1267 Z-score: 1607.1 bits: 306.8 E(85289): 8.9e-83 Smith-Waterman score: 1294; 42.6% identity (69.9% similar) in 488 aa overlap (4-474:15-486) 10 20 30 40 pF1KE5 MGSAPWAPVLLL----ALGLRGLQAGARRAPD--PGFQERFFQQRLDHF :::: . : ::: : .. : ... .:::..::: NP_005 MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHF 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE5 NFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSGFVAELAAERGALLV .:. ::: ::.::.:..: .. : :.::::::::. : ::.::. ..: : :.:: NP_005 GFNTV--KTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLV 70 80 90 100 110 110 120 130 140 150 160 pF1KE5 FAEHRYYGKSLPFGAQSTQRG-HTELLTVEQALADFAELLRALRRDL-GAQDAPAIAFGG ::::::::.::::: .: . . : ..:: ::::::::::.. :.: . ::.. :.::.:: NP_005 FAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGG 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE5 SYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVR ::::::.:..::::::.:.::::::::. : . :.. ::.::. ..:.:..... NP_005 SYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIH 180 190 200 210 220 230 230 240 250 260 270 pF1KE5 EAFRQIKDLFLQGAYDTVRWEFGT---CQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPT ... :. : :. ..: :. :.::... :. .: . .... :::.:::: . NP_005 RSWDAINRLSNTGS--GLQWLTGALHLCSPLTSQ-DIQHLKDWISETWVNLAMVDYPYAS 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE5 DFLGPLPANPVKVGCDRL----LSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCAD .:: :::: :.:: :. : .:.. . .. .. :: ::. .: .: . : NP_005 NFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLG 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE5 PTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRY--CLDTWGVWPRP : :.::::::. . : .:.: ::: : . .:.. :.. ::: ::: NP_005 TLG---------WSYQACTEVVMPFCTNGVDDMFE--PHSWNLKELSDDCFQQWGVRPRP 360 370 380 390 400 400 410 420 430 440 450 pF1KE5 DWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHP .:. : . : .. . .::.::::.::::.:::. .... ...::::. ::::::::... NP_005 SWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNA 410 420 430 440 450 460 460 470 480 490 pF1KE5 EDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL :: ::. ::.::. . .:.. NP_005 LDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH 470 480 490 >>NP_955450 (OMIM: 176785) lysosomal Pro-X carboxypeptid (517 aa) initn: 1164 init1: 425 opt: 1218 Z-score: 1544.5 bits: 295.3 E(85289): 2.7e-79 Smith-Waterman score: 1245; 43.7% identity (71.7% similar) in 446 aa overlap (40-474:78-507) 10 20 30 40 50 60 pF1KE5 LLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEG .:::.:. ::: ::.::.:..: .. : NP_955 YSVLYFQQKALAAGQLHICIIQLNHYKTPLVDHFGFNTV--KTFNQRYLVADKYWKKNGG 50 60 70 80 90 100 70 80 90 100 110 120 pF1KE5 PIFFYTGNEGDVWAFANNSGFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRG-HTEL :.::::::::. : ::.::. ..: : :.::::::::::.::::: .: . . : .. NP_955 SILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNF 110 120 130 140 150 160 130 140 150 160 170 180 pF1KE5 LTVEQALADFAELLRALRRDL-GAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASA :: ::::::::::.. :.: . ::.. :.::.::::::::.:..::::::.:.::::::: NP_955 LTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASA 170 180 190 200 210 220 190 200 210 220 230 240 pF1KE5 PVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGT-- :. : . :.. ::.::. ..:.:........ :. : :. ..: :. NP_955 PIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGS--GLQWLTGALH 230 240 250 260 270 280 250 260 270 280 290 300 pF1KE5 -CQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRL----LSEA :.::... :. .: . .... :::.:::: ..:: :::: :.:: :. : .:.. NP_955 LCSPLTSQ-DIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDS 290 300 310 320 330 340 310 320 330 340 350 360 pF1KE5 QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA . .. .. :: ::. .: .: . : : :.::::::. . : NP_955 LLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLG---------WSYQACTEVVMPFC 350 360 370 380 390 370 380 390 400 410 pF1KE5 SNNVTDMFPDLPFTDELRQRY--CLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLD .:.: ::: : . .:.. :.. ::: :::.:. : . : .. . .::.::::.:: NP_955 TNGVDDMFE--PHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELD 400 410 420 430 440 450 420 430 440 450 460 470 pF1KE5 PWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARR ::.:::. .... ...::::. ::::::::... :: ::. ::.::. . .:.. NP_955 PWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYD 460 470 480 490 500 510 480 490 pF1KE5 EQQPALRGGPRLSL NP_955 SAGKQH >>XP_005274150 (OMIM: 176785) PREDICTED: lysosomal Pro-X (391 aa) initn: 978 init1: 425 opt: 1020 Z-score: 1294.5 bits: 248.7 E(85289): 2.3e-65 Smith-Waterman score: 1047; 42.5% identity (71.0% similar) in 393 aa overlap (93-474:3-381) 70 80 90 100 110 120 pF1KE5 FWVRGEGPIFFYTGNEGDVWAFANNSGFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQ ..: : :.::::::::::.::::: .: . XP_005 MWDVAEELKAMLVFAEHRYYGESLPFGDNSFK 10 20 30 130 140 150 160 170 180 pF1KE5 RG-HTELLTVEQALADFAELLRALRRDL-GAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA . : ..:: ::::::::::.. :.: . ::.. :.::.::::::::.:..::::::.:. XP_005 DSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVV 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE5 GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR ::::::::. : . :.. ::.::. ..:.:........ :. : :. .. XP_005 GALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGS--GLQ 100 110 120 130 140 150 250 260 270 280 290 pF1KE5 WEFGT---CQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRL- : :. :.::... :. .: . .... :::.:::: ..:: :::: :.:: :. : XP_005 WLTGALHLCSPLTSQ-DIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLK 160 170 180 190 200 300 310 320 330 340 350 pF1KE5 ---LSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACT .:.. . .. .. :: ::. .: .: . : : :.::::: XP_005 NPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLG---------WSYQACT 210 220 230 240 250 260 360 370 380 390 400 410 pF1KE5 EINLTFASNNVTDMFPDLPFTDELRQRY--CLDTWGVWPRPDWLLTSFWGGDLRAASNII :. . : .:.: ::: : . .:.. :.. ::: :::.:. : . : .. . .::. XP_005 EVVMPFCTNGVDDMFE--PHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIV 270 280 290 300 310 420 430 440 450 460 470 pF1KE5 FSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGE ::::.::::.:::. .... ...::::. ::::::::... :: ::. ::.::. . . XP_005 FSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKN 320 330 340 350 360 370 480 490 pF1KE5 WVKAARREQQPALRGGPRLSL :.. XP_005 WIRDFYDSAGKQH 380 390 492 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 05:08:13 2016 done: Tue Nov 8 05:08:15 2016 Total Scan time: 7.920 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]