FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2157, 330 aa 1>>>pF1KE2157 330 - 330 aa - 330 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5919+/-0.000338; mu= 15.8676+/- 0.021 mean_var=92.5664+/-18.117, 0's: 0 Z-trim(118.2): 159 B-trim: 652 in 2/52 Lambda= 0.133305 statistics sampled from 30671 (30865) to 30671 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.719), E-opt: 0.2 (0.362), width: 16 Scan time: 6.830 The best scores are: opt bits E(85289) NP_002104 (OMIM: 134371,235400,603075) complement ( 330) 2371 465.7 5.9e-131 XP_011507759 (OMIM: 134371,235400,603075) PREDICTE ( 265) 1769 349.9 3.5e-96 NP_000177 (OMIM: 126700,134370,235400,609814,61069 (1231) 1468 292.6 3e-78 NP_005657 (OMIM: 600889) complement factor H-relat ( 270) 1201 240.6 2.8e-63 XP_011507760 (OMIM: 600889) PREDICTED: complement ( 266) 1169 234.5 1.9e-61 NP_110414 (OMIM: 608593,614809) complement factor ( 569) 1133 227.8 4.1e-59 XP_011507761 (OMIM: 600889) PREDICTED: complement ( 250) 1081 217.5 2.3e-56 NP_066303 (OMIM: 235400,603075,605336) complement ( 330) 1058 213.2 6.1e-55 XP_011508322 (OMIM: 608593,614809) PREDICTED: comp ( 572) 1054 212.6 1.6e-54 NP_006675 (OMIM: 605337) complement factor H-relat ( 331) 949 192.3 1.2e-48 XP_016855603 (OMIM: 605337) PREDICTED: complement ( 387) 934 189.4 1e-47 XP_006711192 (OMIM: 605337) PREDICTED: complement ( 570) 934 189.6 1.4e-47 NP_001188480 (OMIM: 605337) complement factor H-re ( 577) 934 189.6 1.4e-47 NP_001188479 (OMIM: 605337) complement factor H-re ( 578) 934 189.6 1.4e-47 XP_016855602 (OMIM: 605337) PREDICTED: complement ( 458) 799 163.5 7.7e-40 XP_016855601 (OMIM: 605337) PREDICTED: complement ( 468) 799 163.5 7.8e-40 XP_016855600 (OMIM: 605337) PREDICTED: complement ( 519) 799 163.6 8.4e-40 XP_005245170 (OMIM: 600889) PREDICTED: complement ( 205) 775 158.6 1e-38 XP_016856598 (OMIM: 600889) PREDICTED: complement ( 211) 760 155.7 7.8e-38 XP_011507762 (OMIM: 600889) PREDICTED: complement ( 201) 758 155.3 9.8e-38 NP_001299601 (OMIM: 600889) complement factor H-re ( 146) 681 140.4 2.2e-33 XP_016855599 (OMIM: 605337) PREDICTED: complement ( 519) 674 139.5 1.4e-32 XP_011507586 (OMIM: 134580,613235) PREDICTED: coag ( 675) 638 132.7 2.1e-30 XP_011507588 (OMIM: 134580,613235) PREDICTED: coag ( 628) 634 131.9 3.5e-30 NP_001985 (OMIM: 134580,613235) coagulation factor ( 661) 634 131.9 3.6e-30 XP_011507585 (OMIM: 134580,613235) PREDICTED: coag ( 676) 634 131.9 3.7e-30 NP_001160096 (OMIM: 235400,603075,605336) compleme ( 269) 598 124.7 2.2e-28 XP_016856597 (OMIM: 126700,134370,235400,609814,61 ( 446) 440 94.5 4.6e-19 NP_001014975 (OMIM: 126700,134370,235400,609814,61 ( 449) 440 94.5 4.6e-19 NP_000033 (OMIM: 138700) beta-2-glycoprotein 1 pre ( 345) 389 84.6 3.4e-16 XP_011507508 (OMIM: 120650,240500,610927,614699) P ( 969) 320 71.7 7.2e-12 NP_001006659 (OMIM: 120650,240500,610927,614699) c (1092) 320 71.7 7.9e-12 XP_011515117 (OMIM: 608399) PREDICTED: CUB and sus (2173) 316 71.2 2.2e-11 XP_016868501 (OMIM: 608399) PREDICTED: CUB and sus (3463) 316 71.4 3.2e-11 XP_016868500 (OMIM: 608399) PREDICTED: CUB and sus (3507) 316 71.4 3.2e-11 NP_443132 (OMIM: 608399) CUB and sushi domain-cont (3538) 316 71.4 3.2e-11 XP_016868499 (OMIM: 608399) PREDICTED: CUB and sus (3577) 316 71.4 3.3e-11 XP_011515118 (OMIM: 608399) PREDICTED: CUB and sus (3603) 316 71.4 3.3e-11 XP_016868498 (OMIM: 608399) PREDICTED: CUB and sus (3637) 316 71.4 3.3e-11 NP_937757 (OMIM: 608399) CUB and sushi domain-cont (3667) 316 71.4 3.3e-11 XP_016868497 (OMIM: 608399) PREDICTED: CUB and sus (3681) 316 71.4 3.3e-11 NP_937756 (OMIM: 608399) CUB and sushi domain-cont (3707) 316 71.4 3.3e-11 NP_001868 (OMIM: 120650,240500,610927,614699) comp (1033) 292 66.3 3.2e-10 XP_016857076 (OMIM: 615827) PREDICTED: sushi domai ( 490) 250 58.0 4.9e-08 NP_060452 (OMIM: 615827) sushi domain-containing p ( 490) 250 58.0 4.9e-08 XP_016857077 (OMIM: 615827) PREDICTED: sushi domai ( 490) 250 58.0 4.9e-08 XP_016857073 (OMIM: 615827) PREDICTED: sushi domai ( 562) 250 58.0 5.4e-08 XP_006711471 (OMIM: 615827) PREDICTED: sushi domai ( 492) 242 56.4 1.4e-07 XP_005273226 (OMIM: 615827) PREDICTED: sushi domai ( 492) 242 56.4 1.4e-07 XP_011507987 (OMIM: 615827) PREDICTED: sushi domai ( 492) 242 56.4 1.4e-07 >>NP_002104 (OMIM: 134371,235400,603075) complement fact (330 aa) initn: 2371 init1: 2371 opt: 2371 Z-score: 2472.1 bits: 465.7 E(85289): 5.9e-131 Smith-Waterman score: 2371; 100.0% identity (100.0% similar) in 330 aa overlap (1-330:1-330) 10 20 30 40 50 60 pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC 250 260 270 280 290 300 310 320 330 pF1KE2 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR :::::::::::::::::::::::::::::: NP_002 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 310 320 330 >>XP_011507759 (OMIM: 134371,235400,603075) PREDICTED: c (265 aa) initn: 1871 init1: 1769 opt: 1769 Z-score: 1847.7 bits: 349.9 E(85289): 3.5e-96 Smith-Waterman score: 1769; 100.0% identity (100.0% similar) in 245 aa overlap (86-330:21-265) 60 70 80 90 100 110 pF1KE2 EYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICN :::::::::::::::::::::::::::::: XP_011 MWLLVSVILISRISSVGGEGLCFFPFVENGHSESSGQTHLEGDTVQIICN 10 20 30 40 50 120 130 140 150 160 170 pF1KE2 TGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYE 60 70 80 90 100 110 180 190 200 210 220 230 pF1KE2 CRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEY 120 130 140 150 160 170 240 250 260 270 280 290 pF1KE2 QCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGES 180 190 200 210 220 230 300 310 320 330 pF1KE2 AEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR ::::::::::::::::::::::::::::::::::: XP_011 AEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 240 250 260 >>NP_000177 (OMIM: 126700,134370,235400,609814,610698) c (1231 aa) initn: 1323 init1: 1323 opt: 1468 Z-score: 1525.9 bits: 292.6 E(85289): 3e-78 Smith-Waterman score: 1469; 68.8% identity (80.1% similar) in 311 aa overlap (26-330:935-1231) 10 20 30 40 50 pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGI---LYDEEKYKPFSQVPTGEVFY :.:.::. . : .: :: NP_000 FRISEENETTCYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQY--------GEEVT 910 920 930 940 950 60 70 80 90 100 pF1KE2 YSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRL-CF-FPFVENGHSESSGQ-THLEGDT :.: .: . .. : : :: :.:.. :. .: ::. . . .. :. NP_000 YKCFEGFGIDGPAI---AKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQ 960 970 980 990 1000 1010 110 120 130 140 150 160 pF1KE2 VQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSG : : : :.. .. .:..:.. :. : :: :::::::::::::.:.:::::::::: NP_000 VTYTCATYYKM-DGASNVTCINSRWTGRPTCR--DTSCVNPPTVQNAYIVSRQMSKYPSG 1020 1030 1040 1050 1060 1070 170 180 190 200 210 220 pF1KE2 ERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAP :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ERVRYQCRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAP 1080 1090 1100 1110 1120 1130 230 240 250 260 270 280 pF1KE2 ASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLY 1140 1150 1160 1170 1180 1190 290 300 310 320 330 pF1KE2 LRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR :::::.:::::::::::::::::::::::::::::::::: NP_000 SRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 1200 1210 1220 1230 >-- initn: 828 init1: 451 opt: 590 Z-score: 613.3 bits: 123.7 E(85289): 2e-27 Smith-Waterman score: 590; 29.3% identity (58.9% similar) in 321 aa overlap (23-330:325-626) 10 20 30 40 50 pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFY ::.: :.:: :: :. .:. : .:. . NP_000 RNGFYPATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYS 300 310 320 330 340 350 60 70 80 90 100 110 pF1KE2 YSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQI : :. .: .:: :.: .: ::..::::. ::: :.::..:::.... :. ..: .... NP_000 YYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDV 360 370 380 390 400 410 120 130 140 150 160 170 pF1KE2 ICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERV :. :: : . .....:.: ::: :.: . : . ..:. : :.. : :.. NP_000 ACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYT-YALKEKA 420 430 440 450 460 470 180 190 200 210 220 pF1KE2 RYECRSPYEMFGDEE----VMCLNGNWTEPPQCKDSTGKCGPPPPID---NGDITSFPLS .:.:. : . .: : . : . .:. : : : : : .. ..:.: : :. NP_000 KYQCKLGY-VTADGETSGSITCGKDGWSAQPTCIKS---CDIPVFMNARTKNDFTWFKLN 480 490 500 510 520 230 240 250 260 270 280 pF1KE2 VYAPASSVEYQCQNLYQLEGNKR---ITCRNGQWSEPPKCLHPCVISREI-MENYNIALR ....:.:.. :. . .. :.: . ::. : : . :: . . .. : NP_000 -----DTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYE-----RECELPKIDVHLV 530 540 550 560 570 290 300 310 320 330 pF1KE2 WTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKL--EYPTCAKR :. : ..:: .: :: :. . . . . :. : . : : .. NP_000 PDRKKDQY-KVGEVLKFSCKPGFTIVGPNSV---QCYHFGLSPDLPICKEQVQSCGPPPE 580 590 600 610 620 630 NP_000 LLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVCIVEESTCGDIP 640 650 660 670 680 690 >-- initn: 391 init1: 169 opt: 273 Z-score: 283.8 bits: 62.7 E(85289): 4.5e-09 Smith-Waterman score: 275; 25.6% identity (56.4% similar) in 227 aa overlap (90-304:634-843) 60 70 80 90 100 110 pF1KE2 VSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGH-SESSGQTHLEGDTVQIICNTGY : . ::. .:.. . . ....:. :: . NP_000 VGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRF 610 620 630 640 650 660 120 130 140 150 160 170 pF1KE2 RLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPS--GERVRYEC :... :.:.::. :.: : : ...: . : .... :.:. : :. :...: NP_000 -LMKGPNKIQCVDGEWTTLPVCIVEESTCGDIPELEHGWA---QLSSPPYYYGDSVEFNC 670 680 690 700 710 180 190 200 210 220 230 pF1KE2 RSPYEMFGDEEVMCLNGNWTEPPQCK--DSTGKCGPPPPIDNGDITSFPLSV---YAPAS . :.: . . :..: ::. ::: :. :: .: : :. . : NP_000 SESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKCKS----SNLIILEEHLKNKKEFDHNS 720 730 740 750 760 770 240 250 260 270 280 pF1KE2 SVEYQCQNLYQLEGNKRITCRNGQWSEPPKC----LHPCVISREIMENYNIALRWTAKQK ...:.:.. :: . .: ::.:. .: .. : .: ...:.. NP_000 NIRYRCRGK---EGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTT------ 780 790 800 810 820 290 300 310 320 330 pF1KE2 LYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR : : ::.. .:...: NP_000 LNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRS 830 840 850 860 870 880 >-- initn: 128 init1: 112 opt: 204 Z-score: 212.1 bits: 49.5 E(85289): 4.5e-05 Smith-Waterman score: 204; 34.5% identity (60.7% similar) in 84 aa overlap (186-266:849-931) 160 170 180 190 200 210 pF1KE2 AHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPID ::. : .: : : : .. :. :: :. NP_000 NSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKI-PCSQPPQIE 820 830 840 850 860 870 220 230 240 250 260 270 pF1KE2 NGDITSFPLS--VYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLH-PCVISREI .: :.: : :: .... : :.. ... ... :: :.:: ::.: :: NP_000 HGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPPQCEGLPCKSPPEI 880 890 900 910 920 930 280 290 300 310 320 330 pF1KE2 MENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR NP_000 SHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFEN 940 950 960 970 980 990 >-- initn: 113 init1: 91 opt: 195 Z-score: 202.8 bits: 47.7 E(85289): 0.00015 Smith-Waterman score: 285; 29.5% identity (60.7% similar) in 183 aa overlap (93-265:153-324) 70 80 90 100 110 pF1KE2 SKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSG-----QTHLEGDTVQIICNTG :::. ::. . :. :..:...::.: NP_000 EINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHF-GQAVRFVCNSG 130 140 150 160 170 180 120 130 140 150 160 170 pF1KE2 YRLQNNENNISCVERG-WSTP-PKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYE :.....:. . : . : :: ::: .. :: .: ..... : .. . : .:: .:. NP_000 YKIEGDEE-MHCSDDGFWSKEKPKC--VEISCKSPDVINGSPISQKII--YKENERFQYK 190 200 210 220 230 180 190 200 210 220 230 pF1KE2 CRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSV-YAPASSVE : ::. ...: ...: :.:.... : : : ::: . :: . . .. . NP_000 CNMGYEYSERGDAVCTESGWRPLPSCEEKS--CDNPY-IPNGDYS--PLRIKHRTGDEIT 240 250 260 270 280 290 240 250 260 270 280 290 pF1KE2 YQCQN-LYQLEGNKRITCRNGQWSEPPKC-LHPCVISREIMENYNIALRWTAKQKLYLRT :::.: .: .. : . : :.: :.: NP_000 YQCRNGFYPATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGK 300 310 320 330 340 350 300 310 320 330 pF1KE2 GESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR NP_000 YYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKS 360 370 380 390 400 410 >>NP_005657 (OMIM: 600889) complement factor H-related p (270 aa) initn: 1669 init1: 1008 opt: 1201 Z-score: 1257.2 bits: 240.6 E(85289): 2.8e-63 Smith-Waterman score: 1557; 70.9% identity (77.3% similar) in 330 aa overlap (1-330:1-270) 10 20 30 40 50 60 pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: NP_005 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY ::::::::::::::::::::::: NP_005 QNNENNISCVERGWSTPPKCRSTI------------------------------------ 130 140 190 200 210 220 230 240 pF1KE2 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL :. :::::::::::::::: ::::::.:::::::::: NP_005 -----------------------SAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNL 150 160 170 180 250 260 270 280 290 300 pF1KE2 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC ::::::..::::::::::::::: :::::.::::.::: :.:: .:::: :::. .:::: NP_005 YQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVC 190 200 210 220 230 240 310 320 330 pF1KE2 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR : ::. ..::..:. : .::: ::.: .. NP_005 KSGYH-PTKSHSFRAMCQNGKLVYPSCEEK 250 260 270 >>XP_011507760 (OMIM: 600889) PREDICTED: complement fact (266 aa) initn: 1639 init1: 978 opt: 1169 Z-score: 1224.0 bits: 234.5 E(85289): 1.9e-61 Smith-Waterman score: 1523; 70.0% identity (76.4% similar) in 330 aa overlap (1-330:1-266) 10 20 30 40 50 60 pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: XP_011 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY ::::::::::::::::::: XP_011 QNNENNISCVERGWSTPPK----------------------------------------- 130 190 200 210 220 230 240 pF1KE2 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL :. : :::::::::::::::: ::::::.:::::::::: XP_011 --FSAE--------------------KCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNL 140 150 160 170 250 260 270 280 290 300 pF1KE2 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC ::::::..::::::::::::::: :::::.::::.::: :.:: .:::: :::. .:::: XP_011 YQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVC 180 190 200 210 220 230 310 320 330 pF1KE2 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR : ::. ..::..:. : .::: ::.: .. XP_011 KSGYH-PTKSHSFRAMCQNGKLVYPSCEEK 240 250 260 >>NP_110414 (OMIM: 608593,614809) complement factor H-re (569 aa) initn: 1639 init1: 1031 opt: 1133 Z-score: 1182.2 bits: 227.8 E(85289): 4.1e-59 Smith-Waterman score: 1133; 51.7% identity (68.4% similar) in 329 aa overlap (1-327:1-322) 10 20 30 40 50 60 pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV : :: :::::: .:.::::.:.::::::.::.::::: :.:::::::::::::::::::: NP_110 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL :::::::::::::::::::::::::.: ::::.:::::::: ::::::::::::::: : NP_110 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY ::::.::::::::::::: : : : : :. .. : : :. ... ::. NP_110 QNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKES-YKVGDVLKFSCRKNL 130 140 150 160 170 190 200 210 220 230 pF1KE2 EMFGDEEVMCLNGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN :.. :.: . .:. : :: .. .::::: ..::.. . :. :::.:. NP_110 IRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNP 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 LYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFV . ..: :.: : .:.:. : :.. : : . .. . . : :.: NP_110 NFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPE---LEYGYVQPSVPPYQHGVSVEVN 240 250 260 270 280 290 300 310 320 330 pF1KE2 CKRGYRLSSRSHTLRTTCWDGK-LEYPTCAKR :. : . . . :: .: : : : NP_110 CRNEYAMIGNNMI---TCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNS 300 310 320 330 340 350 >-- initn: 810 init1: 622 opt: 685 Z-score: 716.5 bits: 141.7 E(85289): 3.6e-33 Smith-Waterman score: 685; 40.2% identity (66.4% similar) in 229 aa overlap (100-327:345-568) 70 80 90 100 110 120 pF1KE2 ITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISC ::. ... .. :. .: ... : NP_110 IWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHS----VC 320 330 340 350 360 370 130 140 150 160 170 180 pF1KE2 VERGWSTPPKC-RSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEV .. :. : .. . : :: . ::. .. .. : .::.: :. : . .:. NP_110 INGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVN-YQDGEKVAVLCKENYLLPEAKEI 380 390 400 410 420 190 200 210 220 230 240 pF1KE2 MCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKR .: .: : :.: .::. ::::: :.::: :::::::: :.:.: :.::..:.:.:. NP_110 VCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVT 430 440 450 460 470 480 250 260 270 280 290 300 pF1KE2 ITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSS .:::: ::::::.:: :::.:.: :.. :: :.: ::: .::...:: :: .. NP_110 VTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMI 490 500 510 520 530 540 310 320 330 pF1KE2 RSHTLRTTCWDGKLEYPTCAKR : .:. : .::.::: : NP_110 SSPPFRAICQEGKFEYPICE 550 560 >>XP_011507761 (OMIM: 600889) PREDICTED: complement fact (250 aa) initn: 1549 init1: 888 opt: 1081 Z-score: 1132.9 bits: 217.5 E(85289): 2.3e-56 Smith-Waterman score: 1437; 69.6% identity (76.4% similar) in 309 aa overlap (22-330:2-250) 10 20 30 40 50 60 pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV ::::::::::::::::::::::::::::::::::::::: XP_011 MFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 10 20 30 40 70 80 90 100 110 120 pF1KE2 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE2 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY ::::::::::::::::::::::: :.: XP_011 QNNENNISCVERGWSTPPKCRST-----------------------ISAE---------- 110 120 190 200 210 220 230 240 pF1KE2 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL :::::::::::::::: ::::::.:::::::::: XP_011 --------------------------KCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNL 130 140 150 160 250 260 270 280 290 300 pF1KE2 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC ::::::..::::::::::::::: :::::.::::.::: :.:: .:::: :::. .:::: XP_011 YQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVC 170 180 190 200 210 220 310 320 330 pF1KE2 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR : ::. ..::..:. : .::: ::.: .. XP_011 KSGYH-PTKSHSFRAMCQNGKLVYPSCEEK 230 240 250 >>NP_066303 (OMIM: 235400,603075,605336) complement fact (330 aa) initn: 1236 init1: 561 opt: 1058 Z-score: 1107.4 bits: 213.2 E(85289): 6.1e-55 Smith-Waterman score: 1058; 40.9% identity (71.5% similar) in 330 aa overlap (1-327:1-329) 10 20 30 40 50 60 pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV : ::..::: .: ..:.. :::: :.:: :. :. .:. : .:. . : :. .: NP_066 MLLLINVILTLWVSCANGQVKPCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL .:: :.: : ::..::::. ::: :.::..:::.... :. ..:..... :. :: : NP_066 TPSGSYWDYIHCTQNGWSPAVPCLRKCYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY . .....:.:.::: :.: . : . ..:. : :.. : : .....:.:. : NP_066 PKAQTTVTCTEKGWSPTPRCIRVRTCSKSDIEIENGFI-SESSSIYILNKEIQYKCKPGY 130 140 150 160 170 190 200 210 220 230 pF1KE2 EMF-GDEE--VMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQC :. . ::...:. : : .:. ::::::::.::: ::: :.::.: : ::::: NP_066 ATADGNSSGSITCLQNGWSAQPICINSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQC 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 QNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAE : :.:.:.. .:: ::.:::::.:.:::.:..: :.. :: :. . .: : .::.. : NP_066 QPYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTIE 240 250 260 270 280 290 300 310 320 330 pF1KE2 FVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR :.:: :: .. .....: .: .::: : NP_066 FMCKLGYNANTSILSFQAVCREGIVEYPRCE 300 310 320 330 >>XP_011508322 (OMIM: 608593,614809) PREDICTED: compleme (572 aa) initn: 1560 init1: 952 opt: 1054 Z-score: 1100.0 bits: 212.6 E(85289): 1.6e-54 Smith-Waterman score: 1054; 50.5% identity (67.3% similar) in 309 aa overlap (21-327:24-325) 10 20 30 40 50 pF1KE2 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEY :.::::::.::.::::: :.::::::::::::::::: XP_011 MVKPLRQKRNQENVVFHRPCEAGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEY 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 NFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTG ::::::::::::::::::::::::::::.: ::::.:::::::: :::::::::::::: XP_011 NFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 YRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECR : :::::.::::::::::::: : : : : :. .. : : :. ... :: XP_011 YSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKES-YKVGDVLKFSCR 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 SPYEMFGDEEVMCLNGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQ . :.. :.: . .:. : :: .. .::::: ..::.. . :. :::. XP_011 KNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYD 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 CQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESA :. . ..: :.: : .:.:. : :.. : : . .. . . : :. XP_011 CNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPE---LEYGYVQPSVPPYQHGVSV 240 250 260 270 280 290 300 310 320 330 pF1KE2 EFVCKRGYRLSSRSHTLRTTCWDGK-LEYPTCAKR : :. : . . . :: .: : : : XP_011 EVNCRNEYAMIGNNMI---TCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFN 300 310 320 330 340 350 XP_011 HNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDG 360 370 380 390 400 410 >-- initn: 810 init1: 622 opt: 685 Z-score: 716.5 bits: 141.7 E(85289): 3.6e-33 Smith-Waterman score: 685; 40.2% identity (66.4% similar) in 229 aa overlap (100-327:348-571) 70 80 90 100 110 120 pF1KE2 ITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISC ::. ... .. :. .: ... : XP_011 IWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHS----VC 320 330 340 350 360 370 130 140 150 160 170 180 pF1KE2 VERGWSTPPKC-RSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEV .. :. : .. . : :: . ::. .. .. : .::.: :. : . .:. XP_011 INGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVN-YQDGEKVAVLCKENYLLPEAKEI 380 390 400 410 420 430 190 200 210 220 230 240 pF1KE2 MCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKR .: .: : :.: .::. ::::: :.::: :::::::: :.:.: :.::..:.:.:. XP_011 VCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVT 440 450 460 470 480 490 250 260 270 280 290 300 pF1KE2 ITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSS .:::: ::::::.:: :::.:.: :.. :: :.: ::: .::...:: :: .. XP_011 VTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMI 500 510 520 530 540 550 310 320 330 pF1KE2 RSHTLRTTCWDGKLEYPTCAKR : .:. : .::.::: : XP_011 SSPPFRAICQEGKFEYPICE 560 570 >>NP_006675 (OMIM: 605337) complement factor H-related p (331 aa) initn: 1085 init1: 505 opt: 949 Z-score: 994.1 bits: 192.3 E(85289): 1.2e-48 Smith-Waterman score: 949; 40.3% identity (66.9% similar) in 335 aa overlap (1-327:1-330) 10 20 30 40 50 pF1KE2 MWLLVSVILISRISSVGG-EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNF : ::..::: .: ..: :. ::::.:.:: :: . . . . .:. . : :. :: NP_006 MLLLINVILTLWVSCANGQEVKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 VSPSKSFWTRITCTEEGWSPTPKCLRLCFFP--FVENGHSESSGQTHLEGDTVQIICNTG :.:: :.: : ::..::::: ::: : .::: :.. .. . .: :. : NP_006 VTPSGSYWDYIHCTQDGWSPTVPCLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 YRLQ--NNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYE : :. ..:.:.. :::. : : . : . :. .:.. : : .. . . :: NP_006 YATADGNSSGSITCLQNGWSAQPICIKF---C-DMPVFENSRAKSNGM-RFKLHDTLDYE 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 CRSPYEM-FGDEE--VMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASS : . ::. .:. ..: . .:.. : : .:. ::::::::.::: ::: :.::.: : NP_006 CYDGYEISYGNTTGSIVCGEDGWSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 VEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRT ::::::. :.:.:.. .:: ::.:::::.:.:::.:..: :.. :: :. . : : .: NP_006 VEYQCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAKT 240 250 260 270 280 290 300 310 320 330 pF1KE2 GESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR :.. ::.:: :: .. .....: .: .::: : NP_006 GDTIEFMCKLGYNANTSVLSFQAVCREGIVEYPRCE 300 310 320 330 330 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 01:09:23 2016 done: Mon Nov 7 01:09:25 2016 Total Scan time: 6.830 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]