FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1349, 469 aa 1>>>pF1KE1349 469 - 469 aa - 469 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.3392+/-0.000348; mu= 10.8679+/- 0.022 mean_var=203.8123+/-40.747, 0's: 0 Z-trim(122.4): 241 B-trim: 0 in 0/51 Lambda= 0.089838 statistics sampled from 40158 (40436) to 40158 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.788), E-opt: 0.2 (0.474), width: 16 Scan time: 10.430 The best scores are: opt bits E(85289) NP_002612 (OMIM: 300383,312060) properdin precurso ( 469) 3644 484.7 2.3e-136 NP_001138724 (OMIM: 300383,312060) properdin precu ( 469) 3644 484.7 2.3e-136 XP_016885064 (OMIM: 300383,312060) PREDICTED: prop ( 334) 2647 355.3 1.5e-97 XP_016857926 (OMIM: 603075,608548) PREDICTED: hemi (4976) 819 119.7 1.8e-25 XP_011508340 (OMIM: 603075,608548) PREDICTED: hemi (5518) 819 119.8 2e-25 NP_114141 (OMIM: 603075,608548) hemicentin-1 precu (5635) 819 119.8 2e-25 NP_003237 (OMIM: 188060) thrombospondin-1 precurso (1170) 543 83.2 4.1e-15 NP_003238 (OMIM: 188061,603932) thrombospondin-2 p (1172) 539 82.7 5.9e-15 XP_016869182 (OMIM: 602682) PREDICTED: brain-speci (1660) 439 69.9 6e-11 XP_011515504 (OMIM: 602682) PREDICTED: brain-speci (1161) 434 69.1 7.4e-11 XP_011515501 (OMIM: 602682) PREDICTED: brain-speci (1584) 434 69.2 9.1e-11 NP_001693 (OMIM: 602682) brain-specific angiogenes (1584) 434 69.2 9.1e-11 XP_016869185 (OMIM: 602682) PREDICTED: brain-speci (1618) 434 69.3 9.2e-11 XP_016869184 (OMIM: 602682) PREDICTED: brain-speci (1623) 434 69.3 9.2e-11 XP_016869183 (OMIM: 602682) PREDICTED: brain-speci (1630) 434 69.3 9.2e-11 XP_016869181 (OMIM: 602682) PREDICTED: brain-speci (1662) 434 69.3 9.3e-11 XP_016869180 (OMIM: 602682) PREDICTED: brain-speci (1663) 434 69.3 9.3e-11 XP_016862127 (OMIM: 609298) PREDICTED: semaphorin- (1117) 431 68.7 9.4e-11 NP_001026872 (OMIM: 609298) semaphorin-5B isoform (1151) 431 68.7 9.6e-11 NP_001243275 (OMIM: 609298) semaphorin-5B isoform (1151) 431 68.7 9.6e-11 NP_001243276 (OMIM: 609298) semaphorin-5B isoform (1205) 431 68.7 9.9e-11 XP_016857396 (OMIM: 602683) PREDICTED: adhesion G (1530) 403 65.2 1.4e-09 XP_011534312 (OMIM: 602684) PREDICTED: adhesion G (1189) 401 64.8 1.5e-09 XP_016862128 (OMIM: 609298) PREDICTED: semaphorin- ( 794) 394 63.7 2.1e-09 NP_001243277 (OMIM: 609298) semaphorin-5B isoform (1057) 394 63.9 2.5e-09 XP_016866633 (OMIM: 602684) PREDICTED: adhesion G ( 813) 390 63.2 3e-09 XP_016866632 (OMIM: 602684) PREDICTED: adhesion G ( 827) 390 63.2 3.1e-09 XP_016866631 (OMIM: 602684) PREDICTED: adhesion G ( 869) 390 63.2 3.2e-09 XP_011534314 (OMIM: 602684) PREDICTED: adhesion G ( 908) 390 63.3 3.3e-09 XP_011534311 (OMIM: 602684) PREDICTED: adhesion G (1267) 390 63.4 4.1e-09 XP_016857400 (OMIM: 602683) PREDICTED: adhesion G (1478) 390 63.5 4.5e-09 XP_016866629 (OMIM: 602684) PREDICTED: adhesion G (1489) 390 63.5 4.5e-09 XP_006715597 (OMIM: 602684) PREDICTED: adhesion G (1489) 390 63.5 4.5e-09 XP_016857399 (OMIM: 602683) PREDICTED: adhesion G (1497) 390 63.5 4.5e-09 XP_016857398 (OMIM: 602683) PREDICTED: adhesion G (1511) 390 63.5 4.6e-09 XP_005248809 (OMIM: 602684) PREDICTED: adhesion G (1522) 390 63.5 4.6e-09 XP_016857397 (OMIM: 602683) PREDICTED: adhesion G (1530) 390 63.5 4.6e-09 NP_001695 (OMIM: 602684) adhesion G protein-couple (1522) 388 63.3 5.5e-09 XP_006715725 (OMIM: 612249) PREDICTED: thrombospon (1516) 381 62.4 1e-08 XP_006715723 (OMIM: 612249) PREDICTED: thrombospon (1559) 381 62.4 1e-08 XP_016865505 (OMIM: 609297) PREDICTED: semaphorin- ( 917) 377 61.6 1.1e-08 XP_011513495 (OMIM: 612249) PREDICTED: thrombospon (1588) 381 62.4 1.1e-08 XP_011513496 (OMIM: 612249) PREDICTED: thrombospon (1588) 381 62.4 1.1e-08 XP_006715722 (OMIM: 612249) PREDICTED: thrombospon (1614) 381 62.4 1.1e-08 NP_056019 (OMIM: 612249) thrombospondin type-1 dom (1657) 381 62.4 1.1e-08 XP_011512461 (OMIM: 609297) PREDICTED: semaphorin- (1027) 377 61.6 1.1e-08 XP_006714569 (OMIM: 609297) PREDICTED: semaphorin- (1074) 377 61.7 1.2e-08 XP_006714570 (OMIM: 609297) PREDICTED: semaphorin- (1074) 377 61.7 1.2e-08 XP_011512458 (OMIM: 609297) PREDICTED: semaphorin- (1074) 377 61.7 1.2e-08 XP_011512459 (OMIM: 609297) PREDICTED: semaphorin- (1074) 377 61.7 1.2e-08 >>NP_002612 (OMIM: 300383,312060) properdin precursor [H (469 aa) initn: 3644 init1: 3644 opt: 3644 Z-score: 2569.1 bits: 484.7 E(85289): 2.3e-136 Smith-Waterman score: 3644; 100.0% identity (100.0% similar) in 469 aa overlap (1-469:1-469) 10 20 30 40 50 60 pF1KE1 MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 AFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 SEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 LAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 TRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSM 370 380 390 400 410 420 430 440 450 460 pF1KE1 VEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL ::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL 430 440 450 460 >>NP_001138724 (OMIM: 300383,312060) properdin precursor (469 aa) initn: 3644 init1: 3644 opt: 3644 Z-score: 2569.1 bits: 484.7 E(85289): 2.3e-136 Smith-Waterman score: 3644; 100.0% identity (100.0% similar) in 469 aa overlap (1-469:1-469) 10 20 30 40 50 60 pF1KE1 MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 AFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 SEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 LAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 TRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSM 370 380 390 400 410 420 430 440 450 460 pF1KE1 VEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL 430 440 450 460 >>XP_016885064 (OMIM: 300383,312060) PREDICTED: properdi (334 aa) initn: 2647 init1: 2647 opt: 2647 Z-score: 1872.5 bits: 355.3 E(85289): 1.5e-97 Smith-Waterman score: 2647; 100.0% identity (100.0% similar) in 334 aa overlap (136-469:1-334) 110 120 130 140 150 160 pF1KE1 GWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNH :::::::::::::::::::::::::::::: XP_016 MGGWSGWGPWEPCSVTCSKGTRTRRRACNH 10 20 30 170 180 190 200 210 220 pF1KE1 PAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCS 40 50 60 70 80 90 230 240 250 260 270 280 pF1KE1 APEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCN 100 110 120 130 140 150 290 300 310 320 330 340 pF1KE1 HPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQS 160 170 180 190 200 210 350 360 370 380 390 400 pF1KE1 RGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQR 220 230 240 250 260 270 410 420 430 440 450 460 pF1KE1 LCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPE 280 290 300 310 320 330 pF1KE1 EEEL :::: XP_016 EEEL >>XP_016857926 (OMIM: 603075,608548) PREDICTED: hemicent (4976 aa) initn: 797 init1: 331 opt: 819 Z-score: 578.1 bits: 119.7 E(85289): 1.8e-25 Smith-Waterman score: 904; 37.5% identity (61.9% similar) in 336 aa overlap (80-412:3873-4187) 50 60 70 80 90 100 pF1KE1 GVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNG .: ::.: :::::..: : : : : XP_016 EDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLP 3850 3860 3870 3880 3890 3900 110 120 130 140 150 160 pF1KE1 QCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPK .:: :. . ... :... : : :.:: :. :: :. .:..:..:: :.::.:. . XP_016 ANGGKPCQGS-DLEMRNCQNKPC-PVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQ 3910 3920 3930 3940 3950 3960 170 180 190 200 210 220 pF1KE1 CGGH-CPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPE ::. : :.: : :. . ::.::::..: :: :: :: : .::.: :. : XP_016 HGGRPCEGNAVEIIMCNIRP-CPVHGAWSAWQPWGTCSESCGKGT----QTRARLCNNPP 3970 3980 3990 4000 4010 230 240 250 260 270 280 pF1KE1 PSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPV :. :. : : ... :. ::. : :. :. : : :.:: : .. : :. :: XP_016 PAFG--GSYCDGAETQMQVCNERN-CPIHGKWATWASWSACSVSCGGGARQRTRGCSDPV 4020 4030 4040 4050 4060 4070 290 300 310 320 330 340 pF1KE1 PQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGR ::.:: : :. ... .::. :::. :.:. :. :. : : .:. ::. : : XP_016 PQYGGRKCEGSDVQSDFCNSD-PCPTHGNWSPWSGWGTCSR------TCN--GGQMRRYR 4080 4090 4100 4110 4120 350 360 370 380 390 400 pF1KE1 TCRGRK-FDGHR-CAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRL :: . .: : :.: ...:..: . . ::. :::. : .:. : :: . ..:.:: XP_016 TCDNPPPSNGGRACGGPDSQIQRCNT-DMCPVDGSWGSWHSWSQCSASCGGGE-KTRKRL 4130 4140 4150 4160 4170 4180 410 420 430 440 450 460 pF1KE1 CTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEE : .: XP_016 CDHPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDS 4190 4200 4210 4220 4230 4240 >>XP_011508340 (OMIM: 603075,608548) PREDICTED: hemicent (5518 aa) initn: 797 init1: 331 opt: 819 Z-score: 577.6 bits: 119.8 E(85289): 2e-25 Smith-Waterman score: 904; 37.5% identity (61.9% similar) in 336 aa overlap (80-412:4532-4846) 50 60 70 80 90 100 pF1KE1 GVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNG .: ::.: :::::..: : : : : XP_011 EDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLP 4510 4520 4530 4540 4550 4560 110 120 130 140 150 160 pF1KE1 QCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPK .:: :. . ... :... : : :.:: :. :: :. .:..:..:: :.::.:. . XP_011 ANGGKPCQGS-DLEMRNCQNKPC-PVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQ 4570 4580 4590 4600 4610 170 180 190 200 210 220 pF1KE1 CGGH-CPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPE ::. : :.: : :. . ::.::::..: :: :: :: : .::.: :. : XP_011 HGGRPCEGNAVEIIMCNIRP-CPVHGAWSAWQPWGTCSESCGKGT----QTRARLCNNPP 4620 4630 4640 4650 4660 4670 230 240 250 260 270 280 pF1KE1 PSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPV :. :. : : ... :. ::. : :. :. : : :.:: : .. : :. :: XP_011 PAFG--GSYCDGAETQMQVCNERN-CPIHGKWATWASWSACSVSCGGGARQRTRGCSDPV 4680 4690 4700 4710 4720 4730 290 300 310 320 330 340 pF1KE1 PQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGR ::.:: : :. ... .::. :::. :.:. :. :. : : .:. ::. : : XP_011 PQYGGRKCEGSDVQSDFCNSD-PCPTHGNWSPWSGWGTCSR------TCN--GGQMRRYR 4740 4750 4760 4770 4780 350 360 370 380 390 400 pF1KE1 TCRGRK-FDGHR-CAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRL :: . .: : :.: ...:..: . . ::. :::. : .:. : :: . ..:.:: XP_011 TCDNPPPSNGGRACGGPDSQIQRCNT-DMCPVDGSWGSWHSWSQCSASCGGGE-KTRKRL 4790 4800 4810 4820 4830 4840 410 420 430 440 450 460 pF1KE1 CTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEE : .: XP_011 CDHPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDS 4850 4860 4870 4880 4890 4900 >>NP_114141 (OMIM: 603075,608548) hemicentin-1 precursor (5635 aa) initn: 797 init1: 331 opt: 819 Z-score: 577.5 bits: 119.8 E(85289): 2e-25 Smith-Waterman score: 904; 37.5% identity (61.9% similar) in 336 aa overlap (80-412:4532-4846) 50 60 70 80 90 100 pF1KE1 GVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNG .: ::.: :::::..: : : : : NP_114 EDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLP 4510 4520 4530 4540 4550 4560 110 120 130 140 150 160 pF1KE1 QCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPK .:: :. . ... :... : : :.:: :. :: :. .:..:..:: :.::.:. . NP_114 ANGGKPCQGS-DLEMRNCQNKPC-PVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQ 4570 4580 4590 4600 4610 170 180 190 200 210 220 pF1KE1 CGGH-CPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPE ::. : :.: : :. . ::.::::..: :: :: :: : .::.: :. : NP_114 HGGRPCEGNAVEIIMCNIRP-CPVHGAWSAWQPWGTCSESCGKGT----QTRARLCNNPP 4620 4630 4640 4650 4660 4670 230 240 250 260 270 280 pF1KE1 PSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPV :. :. : : ... :. ::. : :. :. : : :.:: : .. : :. :: NP_114 PAFG--GSYCDGAETQMQVCNERN-CPIHGKWATWASWSACSVSCGGGARQRTRGCSDPV 4680 4690 4700 4710 4720 4730 290 300 310 320 330 340 pF1KE1 PQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGR ::.:: : :. ... .::. :::. :.:. :. :. : : .:. ::. : : NP_114 PQYGGRKCEGSDVQSDFCNSD-PCPTHGNWSPWSGWGTCSR------TCN--GGQMRRYR 4740 4750 4760 4770 4780 350 360 370 380 390 400 pF1KE1 TCRGRK-FDGHR-CAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRL :: . .: : :.: ...:..: . . ::. :::. : .:. : :: . ..:.:: NP_114 TCDNPPPSNGGRACGGPDSQIQRCNT-DMCPVDGSWGSWHSWSQCSASCGGGE-KTRKRL 4790 4800 4810 4820 4830 4840 410 420 430 440 450 460 pF1KE1 CTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEE : .: NP_114 CDHPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDS 4850 4860 4870 4880 4890 4900 >>NP_003237 (OMIM: 188060) thrombospondin-1 precursor [H (1170 aa) initn: 375 init1: 283 opt: 543 Z-score: 392.2 bits: 83.2 E(85289): 4.1e-15 Smith-Waterman score: 620; 30.6% identity (53.1% similar) in 343 aa overlap (129-444:365-681) 100 110 120 130 140 150 pF1KE1 LRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEM-------GGWSGWGPWEPCSVT : .:::. ::: :. : ::.. NP_003 SCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTS 340 350 360 370 380 390 160 170 180 190 200 pF1KE1 CSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTH----GAWATWGPWTPCSA :..: . : :.:. . ...: :.. ....: :. : . :.:. :.::. ::. NP_003 CGNGIQQRGRSCD----SLNNRCEGSSVQTRTCHIQE-CDKRFKQDGGWSHWSPWSSCSV 400 410 420 430 440 210 220 230 240 250 260 pF1KE1 SCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVS .: : :: : :..: :... :::: : : : . : ::. ::::::.: . NP_003 TCGDG----VITRIRLCNSPSPQMN--GKPCEGEARETKACKK-DACPINGGWGPWSPWD 450 460 470 480 490 500 270 280 290 300 310 320 pF1KE1 PCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPC : :::: : ..: ::.:.:: :: :.::.:...::: ::.:: .. :: NP_003 ICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQ-DCPIDGCLSN-----PC 510 520 530 540 550 330 340 350 360 370 380 pF1KE1 IRRNMKSISCQEIP-GQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWS--- . ...: : :. . : : . .: .:. :. .: . .. . NP_003 F----AGVKCTSYPDGSWKCGACPPGYSGNGIQCT----DVDECKEVPDACFNHNGEHRC 560 570 580 590 600 390 400 410 420 430 pF1KE1 EWSTWGLCMPPCGPNPT------------RARQRLCTPLLPKYPPTVSMVEGQGEKNVTF : . : :: : : : ...: : : : . .. . . NP_003 ENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKNAKCNYLGH 610 620 630 640 650 660 440 450 460 pF1KE1 WGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL .. :. ::: : NP_003 YSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQED 670 680 690 700 710 720 >>NP_003238 (OMIM: 188061,603932) thrombospondin-2 precu (1172 aa) initn: 435 init1: 286 opt: 539 Z-score: 389.4 bits: 82.7 E(85289): 5.9e-15 Smith-Waterman score: 583; 32.2% identity (54.1% similar) in 351 aa overlap (131-464:369-674) 110 120 130 140 150 pF1KE1 YRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEM-----G--GWSGWGPWEPCSVTCS .::: : ::: :. : :::::. NP_003 TTCTCKKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCG 340 350 360 370 380 390 160 170 180 190 200 pF1KE1 KGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTH----GAWATWGPWTPCSASC .::. : :.:. . . : : . ...::. .. : :. :.:. :.::. ::..: NP_003 SGTQQRGRSCDVTS----NTCLGPSIQTRACSLSK-CDTRIRQDGGWSHWSPWSSCSVTC 400 410 420 430 440 450 210 220 230 240 250 260 pF1KE1 HGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPC : . :: : :..: :.. :: : : . : . : : :::. : :.::.: : : NP_003 GVG----NITRIRLCNSPVPQMG--GKNCKGSGRETKACQG-APCPIDGRWSPWSPWSAC 460 470 480 490 500 270 280 290 300 310 320 pF1KE1 PVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIR :::. : . :.:: : ::.:: :.::. . ..:: ::::: .. ::. NP_003 TVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKR-SCPVDGCLSN-----PCF- 510 520 530 540 550 330 340 350 360 370 380 pF1KE1 RNMKSISCQEIP-GQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTW . .:. .: :. : : : : :. : :: ....: : . .:: NP_003 ---PGAQCSSFPDGSWSCGSCPVG--FLGN---GT-----HCEDLDECALVPDIC-FSTS 560 570 580 590 600 390 400 410 420 430 440 pF1KE1 GLCMPPC-GPNPTRARQRLCTPLLPKY----PPTVSMVEGQGEKNVTFWGRPLPRCEELQ . : : . .: : : :.: : :.. .. ::.: .: :.. NP_003 KV--PRCVNTQPGFH----CLPCPPRYRGNQPVGVGLEAAKTEKQVC---EPENPCKD-- 610 620 630 640 650 450 460 pF1KE1 GQKLVVEEKRPCLHVPACKDPEEEEL . ... :... .:: NP_003 -KTHNCHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATY 660 670 680 690 700 710 >>XP_016869182 (OMIM: 602682) PREDICTED: brain-specific (1660 aa) initn: 389 init1: 156 opt: 439 Z-score: 317.6 bits: 69.9 E(85289): 6e-11 Smith-Waterman score: 692; 30.7% identity (51.5% similar) in 398 aa overlap (80-439:264-631) 50 60 70 80 90 100 pF1KE1 GVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNG :.::: :. :. :. : : : : :. : XP_016 VCLRDAVAGGPENCLTSLTQDRGGHGATGGWKLWSLWGECTRDCGGGLQTRTRTCLPAPG 240 250 260 270 280 290 110 120 130 pF1KE1 QCSGKVAPGTLEWQLQACEDQQCCP--------------------EMG------GW---- : :.:: : :. . : : :.: :. XP_016 -VEGGGCEGVLEEGRQ-CNREACGPAGRTSSRSQSLRSTDARRREELGDELQQFGFPAPQ 300 310 320 330 340 350 140 150 160 170 180 190 pF1KE1 SG------WGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTH .: :.:: :: ::..: .:: : : . . . .: : .:.. :... :::.: XP_016 TGDPAAEEWSPWSVCSSTCGEGWQTRTRFCV--SSSYSTQCSGPLREQRLCNNSAVCPVH 360 370 380 390 400 200 210 220 230 240 250 pF1KE1 GAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPP ::: :.::. ::..: : .. :.: : :. . :.:: : . . :. . XP_016 GAWDEWSPWSLCSSTCGRGFRD----RTRTCRPPQFG----GNPCEGPEKQTKFCN-IAL 410 420 430 440 450 460 260 270 280 290 300 310 pF1KE1 CPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCP ::: :.:. :. : : ..:. :. .. : :: : ..:: : : ..:. : :: XP_016 CPVDGNWNEWSSWSACSASCSQGRQQRTRECNGP--SYGGAECQGHWVETRDCFLQ-QCP 470 480 490 500 510 320 330 340 350 360 370 pF1KE1 VDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSI :::.:..:. :. : :..: :.: : :.: : : : : : :.. :.: . XP_016 VDGKWQAWASWGSC------SVTCG--AGSQRRERVCSGPFFGGAACQGPQDEYRQC-GT 520 530 540 550 560 380 390 400 410 420 430 pF1KE1 QHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQ-GEKNVTFW :.:: . ...: . : : : : :. . . . . :.....: XP_016 QRCPEPHEICDEDNFGAVIWKETPAGEVAAVR-C----PRNATGLILRRCELDEEGIAYW 570 580 590 600 610 620 440 450 460 pF1KE1 GRPLP-RCEELQGQKLVVEEKRPCLHVPACKDPEEEEL : :: XP_016 EPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGEGVSEVIQTLVEISQDGTSYSGDLLST 630 640 650 660 670 680 >>XP_011515504 (OMIM: 602682) PREDICTED: brain-specific (1161 aa) initn: 290 init1: 195 opt: 434 Z-score: 315.9 bits: 69.1 E(85289): 7.4e-11 Smith-Waterman score: 676; 30.4% identity (51.1% similar) in 401 aa overlap (80-439:264-634) 50 60 70 80 90 100 pF1KE1 GVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNG :.::: :. :. :. : : : : :. : XP_011 VCLRDAVAGGPENCLTSLTQDRGGHGATGGWKLWSLWGECTRDCGGGLQTRTRTCLPAPG 240 250 260 270 280 290 110 120 130 pF1KE1 QCSGKVAPGTLEWQLQACEDQQCCP--------------------EMG------GW---- : :.:: : :. . : : :.: :. XP_011 -VEGGGCEGVLEEGRQ-CNREACGPAGRTSSRSQSLRSTDARRREELGDELQQFGFPAPQ 300 310 320 330 340 350 140 150 160 170 180 190 pF1KE1 SG------WGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTH .: :.:: :: ::..: .:: : : . . . .: : .:.. :... :::.: XP_011 TGDPAAEEWSPWSVCSSTCGEGWQTRTRFCV--SSSYSTQCSGPLREQRLCNNSAVCPVH 360 370 380 390 400 200 210 220 230 240 250 pF1KE1 GAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPP ::: :.::. ::..: : .. :.: : :. . :.:: : . . :. . XP_011 GAWDEWSPWSLCSSTCGRGFRD----RTRTCRPPQFG----GNPCEGPEKQTKFCN-IAL 410 420 430 440 450 460 260 270 280 290 300 310 pF1KE1 CP---VAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAV :: : :.:. :. : : ..:. :. .. : :: : ..:: : : ..:. : XP_011 CPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNGP--SYGGAECQGHWVETRDCFLQ- 470 480 490 500 510 320 330 340 350 360 370 pF1KE1 PCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHC :::::.:..:. :. : :..: :.: : :.: : : : : : :.. :.: XP_011 QCPVDGKWQAWASWGSC------SVTCG--AGSQRRERVCSGPFFGGAACQGPQDEYRQC 520 530 540 550 560 380 390 400 410 420 pF1KE1 YSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQ-GEKNV . :.:: . ...: . : : : : :. . . . . :... XP_011 -GTQRCPEPHEICDEDNFGAVIWKETPAGEVAAVR-C----PRNATGLILRRCELDEEGI 570 580 590 600 610 620 430 440 450 460 pF1KE1 TFWGRPLP-RCEELQGQKLVVEEKRPCLHVPACKDPEEEEL ..: : :: XP_011 AYWEPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGEGVSEVIQTLVEISQDGTSYSGDL 630 640 650 660 670 680 469 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 01:18:15 2016 done: Mon Nov 7 01:18:17 2016 Total Scan time: 10.430 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]