Result of FASTA (omim) for
pFN21AE1596
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1596, 354 aa
1>>>pF1KE1596 354 - 354 aa - 354 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.2075+/-0.000358; mu= -9.8633+/- 0.023
mean_var=286.0718+/-58.598, 0's: 0 Z-trim(122.9): 13 B-trim: 11 in 1/59
Lambda= 0.075829
statistics sampled from 41789 (41803) to 41789 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.769), E-opt: 0.2 (0.49), width: 16
Scan time: 9.700
The best scores are: opt bits E(85289)
NP_001242 (OMIM: 153634) macrosialin isoform A pre ( 354) 2345 269.2 9.7e-72
NP_001035148 (OMIM: 153634) macrosialin isoform B ( 327) 2072 239.3 8.9e-63
XP_006713649 (OMIM: 605883) PREDICTED: lysosome-as ( 394) 377 53.9 6.9e-07
XP_005247417 (OMIM: 605883) PREDICTED: lysosome-as ( 418) 377 54.0 7.2e-07
XP_011535796 (OMIM: 153330) PREDICTED: lysosome-as ( 398) 356 51.7 3.4e-06
NP_005552 (OMIM: 153330) lysosome-associated membr ( 417) 356 51.7 3.5e-06
NP_054701 (OMIM: 300257,309060) lysosome-associate ( 410) 311 46.7 0.00011
>>NP_001242 (OMIM: 153634) macrosialin isoform A precurs (354 aa)
initn: 2345 init1: 2345 opt: 2345 Z-score: 1409.0 bits: 269.2 E(85289): 9.7e-72
Smith-Waterman score: 2345; 100.0% identity (100.0% similar) in 354 aa overlap (1-354:1-354)
10 20 30 40 50 60
pF1KE1 MRLAVLFSGALLGLLAAQGTGNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRLAVLFSGALLGLLAAQGTGNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 THRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 THRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNAT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 MYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 MAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCSNSSIILSPAVHLDLLSLRLQAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCSNSSIILSPAVHLDLLSLRLQAA
250 260 270 280 290 300
310 320 330 340 350
pF1KE1 QLPHTGVFGQSFSCPSDRSILLPLIIGLILLGLLALVLIAFCIIRRRPSAYQAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLPHTGVFGQSFSCPSDRSILLPLIIGLILLGLLALVLIAFCIIRRRPSAYQAL
310 320 330 340 350
>>NP_001035148 (OMIM: 153634) macrosialin isoform B prec (327 aa)
initn: 2072 init1: 2072 opt: 2072 Z-score: 1248.1 bits: 239.3 E(85289): 8.9e-63
Smith-Waterman score: 2100; 92.4% identity (92.4% similar) in 354 aa overlap (1-354:1-327)
10 20 30 40 50 60
pF1KE1 MRLAVLFSGALLGLLAAQGTGNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTT
:::::::::::::::: :::::::::::::::::
NP_001 MRLAVLFSGALLGLLA---------------------------ESTGTTSHRTTKSHKTT
10 20 30
70 80 90 100 110 120
pF1KE1 THRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 THRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNAT
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 VHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRV
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 MYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSY
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 MAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCSNSSIILSPAVHLDLLSLRLQAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCSNSSIILSPAVHLDLLSLRLQAA
220 230 240 250 260 270
310 320 330 340 350
pF1KE1 QLPHTGVFGQSFSCPSDRSILLPLIIGLILLGLLALVLIAFCIIRRRPSAYQAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLPHTGVFGQSFSCPSDRSILLPLIIGLILLGLLALVLIAFCIIRRRPSAYQAL
280 290 300 310 320
>>XP_006713649 (OMIM: 605883) PREDICTED: lysosome-associ (394 aa)
initn: 188 init1: 86 opt: 377 Z-score: 244.7 bits: 53.9 E(85289): 6.9e-07
Smith-Waterman score: 395; 29.8% identity (60.7% similar) in 359 aa overlap (15-349:40-388)
10 20 30 40
pF1KE1 MRLAVLFSGALLGLLAAQGTGNDCPHKKSATL-LPSFTVTPTVT
:::. . . .::. .: :.::..:
XP_006 RDYSQPTAAATVQDIKKPVQQPAKQAPHQTLAARFMDGHITFQTAATVKIP--TTTPATT
10 20 30 40 50 60
50 60 70 80 90
pF1KE1 ESTGTTSH-----RTTKSHKTTTHRTTTTGTTSHGPTTATHN--PTTT--SHGNVTVHPT
..:.::: ::.. ...: . . .. ::. : .. :: : .: . : :
XP_006 KNTATTSPITYTLVTTQATPNNSHTAPPVTEVTVGPSLAPYSLPPTITPPAHTTGTSSST
70 80 90 100 110 120
100 110 120 130 140
pF1KE1 -SNSTATSQGPSTATHSPATTS---H----GNATVHPTS--NSTATSPGFTSSAHPEPPP
:..:... ::. : ::: : : :. :.:: ..::.. . : .: :
XP_006 VSHTTGNTTQPSNQTTLPATLSIALHKSTTGQKPVQPTHAPGTTAAAHNTTRTAAPASTV
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE1 PSPS--PSPTSKETIGDYTWTNGSQPCVHLQAQIQIRVMYTTQGGGEAWGISVLNPNKTK
:.:. :.:.: .: : : :::. :.. . ::. :. . . ... .:: :.
XP_006 PGPTLAPQPSSVKT-GIYQVLNGSRLCIKAEMGIQLIVQDKESVFSPRRYFNI-DPNATQ
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE1 VQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSYMAVEYNVSFPHAAQWTFSAQNA
..:.: . .:::.: : ... : .: .. :.: ... .:: :.. ... .
XP_006 ASGNCGTRKSNLLLNFQGGFVNLTFTKD--EESYYISEVGAYLTVSDPETI---YQGIKH
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE1 SLRDLQAPLGQSFSC-SNSSIILSPAVHLDLLSLRLQAAQLPHTGVFGQSFSCPSDRSIL
.. .:. .:.::.: :..:. :: ... ...::: .. ::.. : :::.
XP_006 AVVMFQTAVGHSFKCVSEQSLQLSAHLQVKTTDVQLQAFDFEDDH-FGNADECFSDRNRR
310 320 330 340 350
330 340 350
pF1KE1 -LPLIIGLILLGLLALVLIAFCIIRRRPSAYQAL
.:. .:: . :::...: : . :.:::
XP_006 EIPVAMGLSITGLLVILLTACLVARKRPSRGYERM
360 370 380 390
>>XP_005247417 (OMIM: 605883) PREDICTED: lysosome-associ (418 aa)
initn: 188 init1: 86 opt: 377 Z-score: 244.3 bits: 54.0 E(85289): 7.2e-07
Smith-Waterman score: 395; 29.8% identity (60.7% similar) in 359 aa overlap (15-349:64-412)
10 20 30 40
pF1KE1 MRLAVLFSGALLGLLAAQGTGNDCPHKKSATL-LPSFTVTPTVT
:::. . . .::. .: :.::..:
XP_005 RDYSQPTAAATVQDIKKPVQQPAKQAPHQTLAARFMDGHITFQTAATVKIP--TTTPATT
40 50 60 70 80 90
50 60 70 80 90
pF1KE1 ESTGTTSH-----RTTKSHKTTTHRTTTTGTTSHGPTTATHN--PTTT--SHGNVTVHPT
..:.::: ::.. ...: . . .. ::. : .. :: : .: . : :
XP_005 KNTATTSPITYTLVTTQATPNNSHTAPPVTEVTVGPSLAPYSLPPTITPPAHTTGTSSST
100 110 120 130 140 150
100 110 120 130 140
pF1KE1 -SNSTATSQGPSTATHSPATTS---H----GNATVHPTS--NSTATSPGFTSSAHPEPPP
:..:... ::. : ::: : : :. :.:: ..::.. . : .: :
XP_005 VSHTTGNTTQPSNQTTLPATLSIALHKSTTGQKPVQPTHAPGTTAAAHNTTRTAAPASTV
160 170 180 190 200 210
150 160 170 180 190 200
pF1KE1 PSPS--PSPTSKETIGDYTWTNGSQPCVHLQAQIQIRVMYTTQGGGEAWGISVLNPNKTK
:.:. :.:.: .: : : :::. :.. . ::. :. . . ... .:: :.
XP_005 PGPTLAPQPSSVKT-GIYQVLNGSRLCIKAEMGIQLIVQDKESVFSPRRYFNI-DPNATQ
220 230 240 250 260
210 220 230 240 250 260
pF1KE1 VQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSYMAVEYNVSFPHAAQWTFSAQNA
..:.: . .:::.: : ... : .: .. :.: ... .:: :.. ... .
XP_005 ASGNCGTRKSNLLLNFQGGFVNLTFTKD--EESYYISEVGAYLTVSDPETI---YQGIKH
270 280 290 300 310 320
270 280 290 300 310 320
pF1KE1 SLRDLQAPLGQSFSC-SNSSIILSPAVHLDLLSLRLQAAQLPHTGVFGQSFSCPSDRSIL
.. .:. .:.::.: :..:. :: ... ...::: .. ::.. : :::.
XP_005 AVVMFQTAVGHSFKCVSEQSLQLSAHLQVKTTDVQLQAFDFEDDH-FGNADECFSDRNRR
330 340 350 360 370 380
330 340 350
pF1KE1 -LPLIIGLILLGLLALVLIAFCIIRRRPSAYQAL
.:. .:: . :::...: : . :.:::
XP_005 EIPVAMGLSITGLLVILLTACLVARKRPSRGYERM
390 400 410
>>XP_011535796 (OMIM: 153330) PREDICTED: lysosome-associ (398 aa)
initn: 212 init1: 134 opt: 356 Z-score: 232.2 bits: 51.7 E(85289): 3.4e-06
Smith-Waterman score: 359; 28.5% identity (59.2% similar) in 267 aa overlap (91-354:142-398)
70 80 90 100 110 120
pF1KE1 THRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNAT
:: .. ... .. : : .. :.:..
XP_011 ASSKEIKTVESITDIRADIDKKYRCVSGTQVHMNNVTVTLHDATIQAYLSNSSFSRGETR
120 130 140 150 160 170
130 140 150 160 170 180
pF1KE1 VHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRV
. : .:.: : :: ::::: : : .. :. .. . :. . .:. .
XP_011 CEQDRPSPTTAP-------PAPPSPSPSPVPKSP-SVDKYNVSGTNGTCLLASMGLQLNL
180 190 200 210 220
190 200 210 220 230 240
pF1KE1 MYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSY
: . . . . .:::::...::: ::: : : . :. .. . .
XP_011 TYERKDNTTVTRLLNINPNKTSASGSC-GAHLVTLELHSEGTTVLLFQFGMNASSSRFFL
230 240 250 260 270 280
250 260 270 280 290
pF1KE1 MAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCS-NSSIILSPAVHLDLLSLRLQA
.... :. .: : . .:.: :.::: ::: .:.:..:. . . .. : ...... .::
XP_011 QGIQLNTILPDARDPAFKAANGSLRALQATVGNSYKCNAEEHVRVTKAFSVNIFKVWVQA
290 300 310 320 330 340
300 310 320 330 340 350
pF1KE1 AQLPHTGVFGQSFSCPSDR-SILLPLIIGLILLGLLALVLIAFCIIRRRPSA-YQAL
.. . : ::. : :. :.:.:. .: : ::. .::::. . :.: : ::..
XP_011 FKV-EGGQFGSVEECLLDENSMLIPIAVGGALAGLVLIVLIAYLVGRKRSHAGYQTI
350 360 370 380 390
>>NP_005552 (OMIM: 153330) lysosome-associated membrane (417 aa)
initn: 212 init1: 134 opt: 356 Z-score: 231.9 bits: 51.7 E(85289): 3.5e-06
Smith-Waterman score: 359; 28.5% identity (59.2% similar) in 267 aa overlap (91-354:161-417)
70 80 90 100 110 120
pF1KE1 THRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNAT
:: .. ... .. : : .. :.:..
NP_005 ASSKEIKTVESITDIRADIDKKYRCVSGTQVHMNNVTVTLHDATIQAYLSNSSFSRGETR
140 150 160 170 180 190
130 140 150 160 170 180
pF1KE1 VHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRV
. : .:.: : :: ::::: : : .. :. .. . :. . .:. .
NP_005 CEQDRPSPTTAP-------PAPPSPSPSPVPKSP-SVDKYNVSGTNGTCLLASMGLQLNL
200 210 220 230 240
190 200 210 220 230 240
pF1KE1 MYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSY
: . . . . .:::::...::: ::: : : . :. .. . .
NP_005 TYERKDNTTVTRLLNINPNKTSASGSC-GAHLVTLELHSEGTTVLLFQFGMNASSSRFFL
250 260 270 280 290 300
250 260 270 280 290
pF1KE1 MAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCS-NSSIILSPAVHLDLLSLRLQA
.... :. .: : . .:.: :.::: ::: .:.:..:. . . .. : ...... .::
NP_005 QGIQLNTILPDARDPAFKAANGSLRALQATVGNSYKCNAEEHVRVTKAFSVNIFKVWVQA
310 320 330 340 350 360
300 310 320 330 340 350
pF1KE1 AQLPHTGVFGQSFSCPSDR-SILLPLIIGLILLGLLALVLIAFCIIRRRPSA-YQAL
.. . : ::. : :. :.:.:. .: : ::. .::::. . :.: : ::..
NP_005 FKV-EGGQFGSVEECLLDENSMLIPIAVGGALAGLVLIVLIAYLVGRKRSHAGYQTI
370 380 390 400 410
>>NP_054701 (OMIM: 300257,309060) lysosome-associated me (410 aa)
initn: 231 init1: 98 opt: 311 Z-score: 205.4 bits: 46.7 E(85289): 0.00011
Smith-Waterman score: 311; 25.6% identity (55.2% similar) in 355 aa overlap (13-354:70-410)
10 20 30
pF1KE1 MRLAVLFSGALLGLLAAQGT--GNDCPHKKSATLL-PSFTVT
: .. .:. :.: : :. . :.:.
NP_054 TCLYAKWQMNFTVRYETTNKTYKTVTISDHGTVTYNGSICGDDQNGPKIAVQFGPGFSWI
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE1 PTVTESTGTTSHRTTKSHKTTTHRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTA
. :....: : ... .: :: . ..: :. . . : . :: .
NP_054 ANFTKAASTYSIDSVSFSYNTGDNTTFPDAEDKGILTVDELLAIRIPLNDLFR--CNSLS
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE1 TSQGPSTATHS-----PATTSHGNATVHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSK
: . ... : : ...:..... . . . . : : :. .:.: :
NP_054 TLEKNDVVQHYWDVLVQAFVQNGTVSTNEFLCDKDKTSTVAPTIHTTVPSPTTTPTPKEK
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE1 ETIGDYTWTNGSQPCVHLQAQIQIRVMYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHL
: :. .::.. :. .:. . :: .. .. .::: :. :::. .: :
NP_054 PEAGTYSVNNGNDTCLLATMGLQLNI---TQD--KVASVININPNTTHSTGSCR-SHTAL
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE1 LL--SFPYGHLSFGFMQDLQQKVVYLSYMAVEYNVSFPHAAQWTFSAQNASLRDLQAPLG
: : .:.: : ... ::. : :.:. . .:: : .: .::::
NP_054 LRLNSSTIKYLDFVFAVKNENRF-YLK----EVNISMYLVNGSVFSIANNNLSYWDAPLG
280 290 300 310 320
280 290 300 310 320 330
pF1KE1 QSFSCSN-SSIILSPAVHLDLLSLRLQAAQLPHTGVFGQSFSCP-SDRSILLPLIIGLIL
.:. :.. ... .: : ... ..::.: .. . : .. . : .: .::.:.:.: :
NP_054 SSYMCNKEQTVSVSGAFQINTFDLRVQPFNVTQ-GKYSTAQECSLDDDTILIPIIVGAGL
330 340 350 360 370 380
340 350
pF1KE1 LGLLALVLIAFCIIRRRPSA-YQAL
::. ...::. : ::. : ::.:
NP_054 SGLIIVIVIAYVIGRRKSYAGYQTL
390 400 410
354 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 19:22:12 2016 done: Sat Nov 5 19:22:13 2016
Total Scan time: 9.700 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]