Result of FASTA (omim) for
pFN21AE1556
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1556, 460 aa
1>>>pF1KE1556 460 - 460 aa - 460 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2717+/-0.000399; mu= 18.6961+/- 0.025
mean_var=84.0791+/-16.683, 0's: 0 Z-trim(113.8): 25 B-trim: 452 in 1/53
Lambda= 0.139872
statistics sampled from 23352 (23372) to 23352 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.645), E-opt: 0.2 (0.274), width: 16
Scan time: 9.510
The best scores are: opt bits E(85289)
NP_665736 (OMIM: 601496) GDNF family receptor alph ( 460) 3134 642.5 6.9e-184
NP_001138925 (OMIM: 601496) GDNF family receptor a ( 460) 3134 642.5 6.9e-184
NP_005255 (OMIM: 601496) GDNF family receptor alph ( 465) 3114 638.5 1.1e-182
XP_005269753 (OMIM: 601496) PREDICTED: GDNF family ( 465) 3114 638.5 1.1e-182
XP_011537936 (OMIM: 601496) PREDICTED: GDNF family ( 465) 3114 638.5 1.1e-182
XP_011542786 (OMIM: 601956) PREDICTED: GDNF family ( 464) 1436 299.9 9.8e-81
XP_006716390 (OMIM: 601956) PREDICTED: GDNF family ( 464) 1436 299.9 9.8e-81
NP_001486 (OMIM: 601956) GDNF family receptor alph ( 464) 1436 299.9 9.8e-81
NP_001158510 (OMIM: 601956) GDNF family receptor a ( 359) 1114 234.8 2.9e-61
NP_001158511 (OMIM: 601956) GDNF family receptor a ( 331) 1033 218.4 2.3e-56
NP_001487 (OMIM: 605710) GDNF family receptor alph ( 400) 705 152.3 2.2e-36
>>NP_665736 (OMIM: 601496) GDNF family receptor alpha-1 (460 aa)
initn: 3134 init1: 3134 opt: 3134 Z-score: 3422.3 bits: 642.5 E(85289): 6.9e-184
Smith-Waterman score: 3134; 100.0% identity (100.0% similar) in 460 aa overlap (1-460:1-460)
10 20 30 40 50 60
pF1KE1 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 SLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 YEPVNSRLSDIFRVVPFISVEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTTSVSND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 YEPVNSRLSDIFRVVPFISVEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTTSVSND
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREKPNCLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 VCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREKPNCLN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPNYIDSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 LQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPNYIDSS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPVQTTTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPVQTTTA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 TTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNYEKEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 TTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNYEKEGL
370 380 390 400 410 420
430 440 450 460
pF1KE1 GASSHITTKSMAAPPSCGLSPLLVLVVTALSTLLSLTETS
::::::::::::::::::::::::::::::::::::::::
NP_665 GASSHITTKSMAAPPSCGLSPLLVLVVTALSTLLSLTETS
430 440 450 460
>>NP_001138925 (OMIM: 601496) GDNF family receptor alpha (460 aa)
initn: 3134 init1: 3134 opt: 3134 Z-score: 3422.3 bits: 642.5 E(85289): 6.9e-184
Smith-Waterman score: 3134; 100.0% identity (100.0% similar) in 460 aa overlap (1-460:1-460)
10 20 30 40 50 60
pF1KE1 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 YEPVNSRLSDIFRVVPFISVEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTTSVSND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YEPVNSRLSDIFRVVPFISVEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTTSVSND
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREKPNCLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREKPNCLN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPNYIDSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPNYIDSS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPVQTTTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPVQTTTA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 TTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNYEKEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNYEKEGL
370 380 390 400 410 420
430 440 450 460
pF1KE1 GASSHITTKSMAAPPSCGLSPLLVLVVTALSTLLSLTETS
::::::::::::::::::::::::::::::::::::::::
NP_001 GASSHITTKSMAAPPSCGLSPLLVLVVTALSTLLSLTETS
430 440 450 460
>>NP_005255 (OMIM: 601496) GDNF family receptor alpha-1 (465 aa)
initn: 2207 init1: 2207 opt: 3114 Z-score: 3400.4 bits: 638.5 E(85289): 1.1e-182
Smith-Waterman score: 3114; 98.9% identity (98.9% similar) in 465 aa overlap (1-460:1-465)
10 20 30 40 50 60
pF1KE1 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSP
70 80 90 100 110 120
130 140 150 160 170
pF1KE1 YEPVNSRLSDIFRVVPFIS-----VEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTT
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
NP_005 YEPVNSRLSDIFRVVPFISDVFQQVEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTT
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 SVSNDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SVSNDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREK
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE1 PNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPN
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE1 YIDSSSLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YIDSSSLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPV
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE1 QTTTATTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QTTTATTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNY
370 380 390 400 410 420
420 430 440 450 460
pF1KE1 EKEGLGASSHITTKSMAAPPSCGLSPLLVLVVTALSTLLSLTETS
:::::::::::::::::::::::::::::::::::::::::::::
NP_005 EKEGLGASSHITTKSMAAPPSCGLSPLLVLVVTALSTLLSLTETS
430 440 450 460
>>XP_005269753 (OMIM: 601496) PREDICTED: GDNF family rec (465 aa)
initn: 2207 init1: 2207 opt: 3114 Z-score: 3400.4 bits: 638.5 E(85289): 1.1e-182
Smith-Waterman score: 3114; 98.9% identity (98.9% similar) in 465 aa overlap (1-460:1-465)
10 20 30 40 50 60
pF1KE1 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSP
70 80 90 100 110 120
130 140 150 160 170
pF1KE1 YEPVNSRLSDIFRVVPFIS-----VEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTT
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
XP_005 YEPVNSRLSDIFRVVPFISDVFQQVEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTT
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 SVSNDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVSNDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREK
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE1 PNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPN
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE1 YIDSSSLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YIDSSSLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPV
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE1 QTTTATTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QTTTATTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNY
370 380 390 400 410 420
420 430 440 450 460
pF1KE1 EKEGLGASSHITTKSMAAPPSCGLSPLLVLVVTALSTLLSLTETS
:::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKEGLGASSHITTKSMAAPPSCGLSPLLVLVVTALSTLLSLTETS
430 440 450 460
>>XP_011537936 (OMIM: 601496) PREDICTED: GDNF family rec (465 aa)
initn: 2207 init1: 2207 opt: 3114 Z-score: 3400.4 bits: 638.5 E(85289): 1.1e-182
Smith-Waterman score: 3114; 98.9% identity (98.9% similar) in 465 aa overlap (1-460:1-465)
10 20 30 40 50 60
pF1KE1 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSP
70 80 90 100 110 120
130 140 150 160 170
pF1KE1 YEPVNSRLSDIFRVVPFIS-----VEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTT
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
XP_011 YEPVNSRLSDIFRVVPFISDVFQQVEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTT
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 SVSNDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVSNDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREK
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE1 PNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPN
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE1 YIDSSSLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YIDSSSLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPV
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE1 QTTTATTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTTTATTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNY
370 380 390 400 410 420
420 430 440 450 460
pF1KE1 EKEGLGASSHITTKSMAAPPSCGLSPLLVLVVTALSTLLSLTETS
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKEGLGASSHITTKSMAAPPSCGLSPLLVLVVTALSTLLSLTETS
430 440 450 460
>>XP_011542786 (OMIM: 601956) PREDICTED: GDNF family rec (464 aa)
initn: 1385 init1: 612 opt: 1436 Z-score: 1570.5 bits: 299.9 E(85289): 9.8e-81
Smith-Waterman score: 1436; 49.8% identity (75.5% similar) in 436 aa overlap (27-447:38-460)
10 20 30 40 50
pF1KE1 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGK
.:::.:.. : :..::..:::::::.::.
XP_011 CLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 ETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSL-QGNDL
. : ::. ::..:.:.:... ::.:::::::::: .::.::::.. .: .:...
XP_011 DRNTMLAN-----KECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEF
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 LEDSPYEPVNSRLSDIFRVVPFIS---VEHI--PKGNNCLDAAKACNLDDICKKYRSAYI
: ::::::.::::::::.. ..: .. . :.:.::::::::::.: ::: ::.::
XP_011 YEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYI
130 140 150 160 170 180
180 190 200 210 220
pF1KE1 TPCTTSVS-NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCS
. :. .: .. :::::::::::::::.::....: ::::::.: ::.:::::::.: ::
XP_011 SICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCS
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE1 YEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIG
::..::::::.:. :.:...:::::::: .::. ..:.:: .:: :: .:.:.::
XP_011 YEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIG
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE1 TVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVT
:::::.::: .. :.:::.: .::: ::: ::: : .: ::.:::::::::.::.
XP_011 FDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVN
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE1 VWQPAFPVQTTTATTTTALRVKNKPLGPA--GSENEIPTHVLPPCANLQAQKLKSNVSGN
: .: : . .: : ::.. : : .. . . : :. :...: : ::.: : .
XP_011 V-SPKGP----SFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKE
370 380 390 400 410
410 420 430 440 450 460
pF1KE1 THLCISNGNYEKEGLGASSHITTKSMAAP----PSCGLSPLLVLVVTALSTLLSLTETS
.:... . .. .:. . : ..: :: .:. : ::..
XP_011 LSMCFTELT---TNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
420 430 440 450 460
>>XP_006716390 (OMIM: 601956) PREDICTED: GDNF family rec (464 aa)
initn: 1385 init1: 612 opt: 1436 Z-score: 1570.5 bits: 299.9 E(85289): 9.8e-81
Smith-Waterman score: 1436; 49.8% identity (75.5% similar) in 436 aa overlap (27-447:38-460)
10 20 30 40 50
pF1KE1 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGK
.:::.:.. : :..::..:::::::.::.
XP_006 CLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 ETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSL-QGNDL
. : ::. ::..:.:.:... ::.:::::::::: .::.::::.. .: .:...
XP_006 DRNTMLAN-----KECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEF
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 LEDSPYEPVNSRLSDIFRVVPFIS---VEHI--PKGNNCLDAAKACNLDDICKKYRSAYI
: ::::::.::::::::.. ..: .. . :.:.::::::::::.: ::: ::.::
XP_006 YEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYI
130 140 150 160 170 180
180 190 200 210 220
pF1KE1 TPCTTSVS-NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCS
. :. .: .. :::::::::::::::.::....: ::::::.: ::.:::::::.: ::
XP_006 SICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCS
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE1 YEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIG
::..::::::.:. :.:...:::::::: .::. ..:.:: .:: :: .:.:.::
XP_006 YEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIG
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE1 TVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVT
:::::.::: .. :.:::.: .::: ::: ::: : .: ::.:::::::::.::.
XP_006 FDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVN
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE1 VWQPAFPVQTTTATTTTALRVKNKPLGPA--GSENEIPTHVLPPCANLQAQKLKSNVSGN
: .: : . .: : ::.. : : .. . . : :. :...: : ::.: : .
XP_006 V-SPKGP----SFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKE
370 380 390 400 410
410 420 430 440 450 460
pF1KE1 THLCISNGNYEKEGLGASSHITTKSMAAP----PSCGLSPLLVLVVTALSTLLSLTETS
.:... . .. .:. . : ..: :: .:. : ::..
XP_006 LSMCFTELT---TNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
420 430 440 450 460
>>NP_001486 (OMIM: 601956) GDNF family receptor alpha-2 (464 aa)
initn: 1385 init1: 612 opt: 1436 Z-score: 1570.5 bits: 299.9 E(85289): 9.8e-81
Smith-Waterman score: 1436; 49.8% identity (75.5% similar) in 436 aa overlap (27-447:38-460)
10 20 30 40 50
pF1KE1 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGK
.:::.:.. : :..::..:::::::.::.
NP_001 CLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 ETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSL-QGNDL
. : ::. ::..:.:.:... ::.:::::::::: .::.::::.. .: .:...
NP_001 DRNTMLAN-----KECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEF
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 LEDSPYEPVNSRLSDIFRVVPFIS---VEHI--PKGNNCLDAAKACNLDDICKKYRSAYI
: ::::::.::::::::.. ..: .. . :.:.::::::::::.: ::: ::.::
NP_001 YEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYI
130 140 150 160 170 180
180 190 200 210 220
pF1KE1 TPCTTSVS-NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCS
. :. .: .. :::::::::::::::.::....: ::::::.: ::.:::::::.: ::
NP_001 SICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCS
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE1 YEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIG
::..::::::.:. :.:...:::::::: .::. ..:.:: .:: :: .:.:.::
NP_001 YEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIG
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE1 TVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVT
:::::.::: .. :.:::.: .::: ::: ::: : .: ::.:::::::::.::.
NP_001 FDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVN
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE1 VWQPAFPVQTTTATTTTALRVKNKPLGPA--GSENEIPTHVLPPCANLQAQKLKSNVSGN
: .: : . .: : ::.. : : .. . . : :. :...: : ::.: : .
NP_001 V-SPKGP----SFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKE
370 380 390 400 410
410 420 430 440 450 460
pF1KE1 THLCISNGNYEKEGLGASSHITTKSMAAP----PSCGLSPLLVLVVTALSTLLSLTETS
.:... . .. .:. . : ..: :: .:. : ::..
NP_001 LSMCFTELT---TNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
420 430 440 450 460
>>NP_001158510 (OMIM: 601956) GDNF family receptor alpha (359 aa)
initn: 1059 init1: 612 opt: 1114 Z-score: 1220.8 bits: 234.8 E(85289): 2.9e-61
Smith-Waterman score: 1114; 49.4% identity (73.7% similar) in 350 aa overlap (112-447:14-355)
90 100 110 120 130
pF1KE1 KSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRVVPFIS--
:... : ::::::.::::::::.. ..:
NP_001 MILANVFCLFFFLGEEFYEASPYEPVTSRLSDIFRLASIFSGT
10 20 30 40
140 150 160 170 180 190
pF1KE1 -VEHI--PKGNNCLDAAKACNLDDICKKYRSAYITPCTTSVS-NDVCNRRKCHKALRQFF
.. . :.:.::::::::::.: ::: ::.::. :. .: .. ::::::::::::::
NP_001 GADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFF
50 60 70 80 90 100
200 210 220 230 240 250
pF1KE1 DKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREKPNCLNLQDSCKTNYICRSRL
:.::....: ::::::.: ::.:::::::.: ::::..::::::.:. :.:...:::::
NP_001 DRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRL
110 120 130 140 150 160
260 270 280 290 300 310
pF1KE1 ADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPNYIDSS--SLSVAPWCDCSNS
::: .::. ..:.:: .:: :: .:.:.:: :::::.::: .. :.:::.: .:
NP_001 ADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGS
170 180 190 200 210 220
320 330 340 350 360 370
pF1KE1 GNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPVQTTTATTTTALRVKNKPL
:: ::: ::: : .: ::.:::::::::.::.: .: : . .: : ::.. :
NP_001 GNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNV-SPKGP----SFQATQAPRVEKTPS
230 240 250 260 270
380 390 400 410 420 430
pF1KE1 GPA--GSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNYEKEGLGASSHITTKSM
: .. . . : :. :...: : ::.: : . .:... .. .:. . :
NP_001 LPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTE---LTTNIIPGSNKVIKPN
280 290 300 310 320 330
440 450 460
pF1KE1 AAP----PSCGLSPLLVLVVTALSTLLSLTETS
..: :: .:. : ::..
NP_001 SGPSRARPSAALTVLSVLMLKLAL
340 350
>>NP_001158511 (OMIM: 601956) GDNF family receptor alpha (331 aa)
initn: 960 init1: 612 opt: 1033 Z-score: 1132.9 bits: 218.4 E(85289): 2.3e-56
Smith-Waterman score: 1033; 48.0% identity (72.7% similar) in 333 aa overlap (128-447:3-327)
100 110 120 130 140 150
pF1KE1 NCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRVVPFISVEHIP----KGNNCLDAA
:...: . :... : :.:.:::::
NP_001 MILANVFCLFFFLGTGADPVVSAKSNHCLDAA
10 20 30
160 170 180 190 200 210
pF1KE1 KACNLDDICKKYRSAYITPCTTSVS-NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCR
:::::.: ::: ::.::. :. .: .. :::::::::::::::.::....: ::::::.
NP_001 KACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQ
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE1 DIACTERRRQTIVPVCSYEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSC
: ::.:::::::.: ::::..::::::.:. :.:...:::::::: .::. ..:.::
NP_001 DQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSC
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE1 LKENYADCLLAYSGLIGTVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDN
.:: :: .:.:.:: :::::.::: .. :.:::.: .::: ::: ::: : .:
NP_001 PADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTEN
160 170 180 190 200 210
340 350 360 370 380
pF1KE1 TCLKNAIQAFGNGSDVTVWQPAFPVQTTTATTTTALRVKNKPLGPA--GSENEIPTHVLP
::.:::::::::.::.: .: : . .: : ::.. : : .. . . : :.
NP_001 PCLRNAIQAFGNGTDVNV-SPKGP----SFQATQAPRVEKTPSLPDDLSDSTSLGTSVIT
220 230 240 250 260
390 400 410 420 430 440
pF1KE1 PCANLQAQKLKSNVSGNTHLCISNGNYEKEGLGASSHITTKSMAAP----PSCGLSPLLV
:...: : ::.: : . .:... . .. .:. . : ..: :: .:. : :
NP_001 TCTSVQEQGLKANNSKELSMCFTELT---TNIIPGSNKVIKPNSGPSRARPSAALTVLSV
270 280 290 300 310 320
450 460
pF1KE1 LVVTALSTLLSLTETS
:..
NP_001 LMLKLAL
330
460 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 01:22:27 2016 done: Mon Nov 7 01:22:29 2016
Total Scan time: 9.510 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]