FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1381, 783 aa 1>>>pF1KE1381 783 - 783 aa - 783 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.6566+/-0.00035; mu= -4.3114+/- 0.022 mean_var=262.0619+/-53.127, 0's: 0 Z-trim(122.6): 35 B-trim: 0 in 0/59 Lambda= 0.079227 statistics sampled from 40951 (40986) to 40951 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.782), E-opt: 0.2 (0.481), width: 16 Scan time: 15.990 The best scores are: opt bits E(85289) NP_004283 (OMIM: 605965) ras and Rab interactor 1 ( 783) 5234 611.7 3.7e-174 XP_011543701 (OMIM: 605965) PREDICTED: ras and Rab ( 755) 5038 589.3 2e-167 XP_011543703 (OMIM: 605965) PREDICTED: ras and Rab ( 702) 4684 548.8 2.8e-155 XP_011543702 (OMIM: 605965) PREDICTED: ras and Rab ( 721) 2926 347.9 8.9e-95 XP_016874076 (OMIM: 605965) PREDICTED: ras and Rab ( 722) 2924 347.7 1e-94 XP_005260790 (OMIM: 610222,613075) PREDICTED: ras ( 689) 715 95.2 1e-18 XP_011527561 (OMIM: 610222,613075) PREDICTED: ras ( 842) 715 95.2 1.2e-18 XP_016883381 (OMIM: 610222,613075) PREDICTED: ras ( 842) 715 95.2 1.2e-18 XP_016883380 (OMIM: 610222,613075) PREDICTED: ras ( 850) 715 95.2 1.2e-18 NP_061866 (OMIM: 610222,613075) ras and Rab intera ( 895) 715 95.2 1.3e-18 XP_011527559 (OMIM: 610222,613075) PREDICTED: ras ( 895) 715 95.2 1.3e-18 XP_006723640 (OMIM: 610222,613075) PREDICTED: ras ( 895) 715 95.2 1.3e-18 XP_011527560 (OMIM: 610222,613075) PREDICTED: ras ( 895) 715 95.2 1.3e-18 XP_006723638 (OMIM: 610222,613075) PREDICTED: ras ( 895) 715 95.2 1.3e-18 XP_006723637 (OMIM: 610222,613075) PREDICTED: ras ( 895) 715 95.2 1.3e-18 XP_005260788 (OMIM: 610222,613075) PREDICTED: ras ( 895) 715 95.2 1.3e-18 XP_016883379 (OMIM: 610222,613075) PREDICTED: ras ( 895) 715 95.2 1.3e-18 XP_016883378 (OMIM: 610222,613075) PREDICTED: ras ( 925) 715 95.3 1.3e-18 NP_001229510 (OMIM: 610222,613075) ras and Rab int ( 944) 715 95.3 1.3e-18 XP_016883377 (OMIM: 610222,613075) PREDICTED: ras ( 944) 715 95.3 1.3e-18 XP_016883376 (OMIM: 610222,613075) PREDICTED: ras ( 944) 715 95.3 1.3e-18 XP_011527557 (OMIM: 610222,613075) PREDICTED: ras ( 962) 715 95.3 1.4e-18 XP_011535467 (OMIM: 610223) PREDICTED: ras and Rab ( 648) 500 70.6 2.4e-11 XP_016877143 (OMIM: 610223) PREDICTED: ras and Rab ( 883) 392 58.3 1.6e-07 XP_016877142 (OMIM: 610223) PREDICTED: ras and Rab ( 888) 392 58.3 1.6e-07 XP_016877141 (OMIM: 610223) PREDICTED: ras and Rab ( 941) 392 58.3 1.7e-07 NP_079108 (OMIM: 610223) ras and Rab interactor 3 ( 985) 392 58.3 1.8e-07 XP_016877140 (OMIM: 610223) PREDICTED: ras and Rab ( 954) 384 57.4 3.3e-07 XP_016883382 (OMIM: 610222,613075) PREDICTED: ras ( 692) 359 54.5 1.8e-06 NP_001306916 (OMIM: 610223) ras and Rab interactor ( 910) 304 48.3 0.00018 XP_011535466 (OMIM: 610223) PREDICTED: ras and Rab ( 909) 301 47.9 0.00023 >>NP_004283 (OMIM: 605965) ras and Rab interactor 1 [Hom (783 aa) initn: 5234 init1: 5234 opt: 5234 Z-score: 3247.7 bits: 611.7 E(85289): 3.7e-174 Smith-Waterman score: 5234; 100.0% identity (100.0% similar) in 783 aa overlap (1-783:1-783) 10 20 30 40 50 60 pF1KE1 MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA 730 740 750 760 770 780 pF1KE1 AEE ::: NP_004 AEE >>XP_011543701 (OMIM: 605965) PREDICTED: ras and Rab int (755 aa) initn: 5038 init1: 5038 opt: 5038 Z-score: 3126.9 bits: 589.3 E(85289): 2e-167 Smith-Waterman score: 5038; 100.0% identity (100.0% similar) in 754 aa overlap (30-783:2-755) 10 20 30 40 50 60 pF1KE1 MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE ::::::::::::::::::::::::::::::: XP_011 MPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE 10 20 30 70 80 90 100 110 120 pF1KE1 RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE1 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE1 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE1 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE1 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE1 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE1 KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE1 GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE1 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL 520 530 540 550 560 570 610 620 630 640 650 660 pF1KE1 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA 580 590 600 610 620 630 670 680 690 700 710 720 pF1KE1 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG 640 650 660 670 680 690 730 740 750 760 770 780 pF1KE1 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA 700 710 720 730 740 750 pF1KE1 AEE ::: XP_011 AEE >>XP_011543703 (OMIM: 605965) PREDICTED: ras and Rab int (702 aa) initn: 4684 init1: 4684 opt: 4684 Z-score: 2908.7 bits: 548.8 E(85289): 2.8e-155 Smith-Waterman score: 4684; 100.0% identity (100.0% similar) in 702 aa overlap (82-783:1-702) 60 70 80 90 100 110 pF1KE1 PGRVVSLRERLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEA :::::::::::::::::::::::::::::: XP_011 MLRTEPPGTFLVRKSNTRQCQALCMRLPEA 10 20 30 120 130 140 150 160 170 pF1KE1 SGPSFVSSHYILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGPSFVSSHYILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATH 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE1 KELEAISHLGIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KELEAISHLGIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPG 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE1 DLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRES 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE1 SVGYRVPAGSGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVGYRVPAGSGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMS 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE1 AAFCSLLAPERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAFCSLLAPERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARA 280 290 300 310 320 330 420 430 440 450 460 470 pF1KE1 MLSAELGPEKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLSAELGPEKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRL 340 350 360 370 380 390 480 490 500 510 520 530 pF1KE1 ARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEG 400 410 420 430 440 450 540 550 560 570 580 590 pF1KE1 EGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSG 460 470 480 490 500 510 600 610 620 630 640 650 pF1KE1 LGQAHTLPLSPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGQAHTLPLSPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEAS 520 530 540 550 560 570 660 670 680 690 700 710 pF1KE1 IATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQG 580 590 600 610 620 630 720 730 740 750 760 770 pF1KE1 AVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPG 640 650 660 670 680 690 780 pF1KE1 EPEAEGSRAAEE :::::::::::: XP_011 EPEAEGSRAAEE 700 >>XP_011543702 (OMIM: 605965) PREDICTED: ras and Rab int (721 aa) initn: 2902 init1: 2902 opt: 2926 Z-score: 1822.5 bits: 347.9 E(85289): 8.9e-95 Smith-Waterman score: 4695; 92.1% identity (92.1% similar) in 783 aa overlap (1-783:1-721) 10 20 30 40 50 60 pF1KE1 MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF ::::::::: XP_011 KLLSPKRLE--------------------------------------------------- 490 500 510 520 530 540 pF1KE1 GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 -----------LEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL 430 440 450 460 470 550 560 570 580 590 600 pF1KE1 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL 480 490 500 510 520 530 610 620 630 640 650 660 pF1KE1 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA 540 550 560 570 580 590 670 680 690 700 710 720 pF1KE1 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG 600 610 620 630 640 650 730 740 750 760 770 780 pF1KE1 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA 660 670 680 690 700 710 pF1KE1 AEE ::: XP_011 AEE 720 >>XP_016874076 (OMIM: 605965) PREDICTED: ras and Rab int (722 aa) initn: 2896 init1: 2896 opt: 2924 Z-score: 1821.3 bits: 347.7 E(85289): 1e-94 Smith-Waterman score: 4702; 92.2% identity (92.2% similar) in 783 aa overlap (1-783:1-722) 10 20 30 40 50 60 pF1KE1 MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF :::::::: XP_016 KLLSPKRL---------------------------------------------------- 490 500 510 520 530 540 pF1KE1 GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ---------VELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL 430 440 450 460 470 550 560 570 580 590 600 pF1KE1 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL 480 490 500 510 520 530 610 620 630 640 650 660 pF1KE1 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA 540 550 560 570 580 590 670 680 690 700 710 720 pF1KE1 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG 600 610 620 630 640 650 730 740 750 760 770 780 pF1KE1 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA 660 670 680 690 700 710 pF1KE1 AEE ::: XP_016 AEE 720 >>XP_005260790 (OMIM: 610222,613075) PREDICTED: ras and (689 aa) initn: 766 init1: 460 opt: 715 Z-score: 457.0 bits: 95.2 E(85289): 1e-18 Smith-Waterman score: 847; 34.4% identity (63.1% similar) in 491 aa overlap (252-703:183-669) 230 240 250 260 270 280 pF1KE1 LCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPV-LPGAVPSQTER : .. :: ..:: .: : : ..: XP_005 PRLKKQASFLEAEGGAKTLSGGRPGAGPELELGTAGSPGGAPPEAAPGDCTRAPPPSSES 160 170 180 190 200 210 290 300 310 320 pF1KE1 LPPCQLLRRESSVGYRVPAGSGPSLP---PMPSL-QEVDCGSP------SSSEEEGVPG- :::. :.. : . . ..:. :: :: . :.: .: :..: .: XP_005 RPPCHGGRQRLS-DMSISTSSSDSLEFDRSMPLFGYEADTNSSLEDYEGESDQETMAPPI 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE1 ----SRGSPATSPHLGRRRPLLRSMSAAFCSLLAPERQVGRAAAALMQDRHTAAGQLVQD .:.: . :.: . . :...:..: :...::... : : : .:. : : :::: XP_005 KSKKKRSSSFVLPKLVKSQ--LQKVSGVFSSFMTPEKRMVRRIAELSRDKCTYFGCLVQD 280 290 300 310 320 390 400 410 420 430 pF1KE1 LLTQVRAGPE-----PQELQGIRQALSRARAMLS--AELGP--EKLLSPKRLEHVLEKSL .. .. . : . :: ::: ..... .:: .:: : :.:. ... ::::.. XP_005 YVSFLQENKECHVSSTDMLQTIRQFMTQVKNYLSQSSELDPPIESLIPEDQIDVVLEKAM 330 340 350 360 370 380 440 450 460 470 480 490 pF1KE1 HCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAFGSHLSLPSPVELEQVR : .::::. . : :. :::: .: :.:.:.: ..: .: :. :..:... XP_005 HKCILKPLKGHVEAMLKDFHMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIK 390 400 410 420 430 440 500 510 520 530 540 550 pF1KE1 QKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFLPLLSLVLAHCDLPELL :.. . . ::: .: ::..:::.: ..... :. :::.:::.:. :.:.::. :: XP_005 VKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELD 450 460 470 480 490 500 560 570 580 590 600 610 pF1KE1 LEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPLSPVQELRRSLSLWEQR : ::: :::.:::: ::::::::: ..:.:.... . .. : .: : .: :..: XP_005 TEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLS-SETRDTLRQWHKR 510 520 530 540 550 560 620 630 640 650 660 670 pF1KE1 R-----LPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCATKFRVTQPNTF : .:.. ::. ::::.:. .::::.::: : : . . :.:: ::.: .:. . XP_005 RTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEY 570 580 590 600 610 620 680 690 700 710 720 pF1KE1 GLFLYKEQGYHRLPPGALAHRL---------PTTGYLVYRRAEWPETQGAVTEEEGSGQS .:::. .. ...: . ... : ..::.: XP_005 SLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTT 630 640 650 660 670 680 730 740 750 760 770 780 pF1KE1 EARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRAAE XP_005 S >>XP_011527561 (OMIM: 610222,613075) PREDICTED: ras and (842 aa) initn: 1094 init1: 460 opt: 715 Z-score: 455.7 bits: 95.2 E(85289): 1.2e-18 Smith-Waterman score: 985; 31.8% identity (54.9% similar) in 758 aa overlap (100-703:75-822) 70 80 90 100 110 120 pF1KE1 LQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSHYILESPGGV : ..: .::: : . . : :: XP_011 LQLSLSEEEAAEVLQAQPPGIFLVHKSTKMQKKVLSLRLPCEFGAPL-KEFAIKESTYTF 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE1 SLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHLGIEFWSSSL ::::: . : :: .:: :: .::.: . :.:: :: : .. .:: ....:..:::: XP_011 SLEGSGISFADLFRLIAFYCISRDVLPFTLKLPYAISTAKSEAQLEELAQMGLNFWSSPA 110 120 130 140 150 160 190 200 210 220 pF1KE1 NIKAQRGP------AGGPVLP----QL---------KARSPQELD-QGTGAALCFFNPLF . : : .. : : :: :.:.:.::. . :..::::.:::: XP_011 DSKPPNLPPPHRPLSSDGVCPASLRQLCLINGVHSIKTRTPSELECSQTNGALCFINPLF 170 180 190 200 210 220 230 240 250 260 pF1KE1 ----PGDL-GPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPV------P---------- :: : :: . :. .. . .: :: :: ::: . : XP_011 LKVHSQDLSGGLKRPS-TRTPNANGTERTRSP--PPRPPPPAINSLHTSPRLARTETQTS 230 240 250 260 270 280 270 280 290 300 310 pF1KE1 -------------VLPGAVPSQTERLPPCQLLRRESSV----GYRVPAGSGPSLPPMPSL .:::. :. .:: .: .. : . : .. .:. :. : : XP_011 MPETVNHNKHGNVALPGTKPTP---IPPPRLKKQASFLEAEGGAKTLSGGRPGAG--PEL 290 300 310 320 330 320 330 340 pF1KE1 QEVDCGSPSSSEEEGVPG--SRGSPATS---P--HLGRRR-------------------- . :::... :..:: .:. : .: : : ::.: XP_011 ELGTAGSPGGAPPEAAPGDCTRAPPPSSESRPPCHGGRQRLSDMSISTSSSDSLEFDRSM 340 350 360 370 380 390 350 pF1KE1 PL----------------------------------------------LRSMSAAFCSLL :: :...:..: :.. XP_011 PLFGYEADTNSSLEDYEGESDQETMAPPIKSKKKRSSSFVLPKLVKSQLQKVSGVFSSFM 400 410 420 430 440 450 360 370 380 390 400 410 pF1KE1 APERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPE-----PQELQGIRQALSRARAML .::... : : : .:. : : :::: .. .. . : . :: ::: ..... .: XP_011 TPEKRMVRRIAELSRDKCTYFGCLVQDYVSFLQENKECHVSSTDMLQTIRQFMTQVKNYL 460 470 480 490 500 510 420 430 440 450 460 pF1KE1 S--AELGP--EKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGL : .:: : :.:. ... ::::..: .::::. . : :. :::: .: :.: XP_011 SQSSELDPPIESLIPEDQIDVVLEKAMHKCILKPLKGHVEAMLKDFHMADGSWKQLKENL 520 530 540 550 560 570 470 480 490 500 510 520 pF1KE1 RLARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQ .:.: ..: .: :. :..:... :.. . . ::: .: ::..:::.: ..... XP_011 QLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENN 580 590 600 610 620 630 530 540 550 560 570 580 pF1KE1 EGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALL :. :::.:::.:. :.:.::. :: : ::: :::.:::: ::::::::: ..:.:. XP_011 SGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLI 640 650 660 670 680 690 590 600 610 620 630 640 pF1KE1 SGLGQAHTLPLSPVQELRRSLSLWEQRR-----LPATHCFQHLLRVAYQDPSSGCTSKTL ... . .. : .: : .: :..:: .:.. ::. ::::.:. .::::.::: XP_011 KNFQEEQAARLLS-SETRDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTL 700 710 720 730 740 750 650 660 670 680 690 pF1KE1 AVPPEASIATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRL---------PT : : . . :.:: ::.: .:. ..:::. .. ...: . ... : XP_011 LVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPH 760 770 780 790 800 810 700 710 720 730 740 750 pF1KE1 TGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETT ..::.: XP_011 IFHFVYKRIKNDPYGIIFQNGEEDLTTS 820 830 840 >>XP_016883381 (OMIM: 610222,613075) PREDICTED: ras and (842 aa) initn: 1094 init1: 460 opt: 715 Z-score: 455.7 bits: 95.2 E(85289): 1.2e-18 Smith-Waterman score: 985; 31.8% identity (54.9% similar) in 758 aa overlap (100-703:75-822) 70 80 90 100 110 120 pF1KE1 LQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSHYILESPGGV : ..: .::: : . . : :: XP_016 LQLSLSEEEAAEVLQAQPPGIFLVHKSTKMQKKVLSLRLPCEFGAPL-KEFAIKESTYTF 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE1 SLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHLGIEFWSSSL ::::: . : :: .:: :: .::.: . :.:: :: : .. .:: ....:..:::: XP_016 SLEGSGISFADLFRLIAFYCISRDVLPFTLKLPYAISTAKSEAQLEELAQMGLNFWSSPA 110 120 130 140 150 160 190 200 210 220 pF1KE1 NIKAQRGP------AGGPVLP----QL---------KARSPQELD-QGTGAALCFFNPLF . : : .. : : :: :.:.:.::. . :..::::.:::: XP_016 DSKPPNLPPPHRPLSSDGVCPASLRQLCLINGVHSIKTRTPSELECSQTNGALCFINPLF 170 180 190 200 210 220 230 240 250 260 pF1KE1 ----PGDL-GPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPV------P---------- :: : :: . :. .. . .: :: :: ::: . : XP_016 LKVHSQDLSGGLKRPS-TRTPNANGTERTRSP--PPRPPPPAINSLHTSPRLARTETQTS 230 240 250 260 270 280 270 280 290 300 310 pF1KE1 -------------VLPGAVPSQTERLPPCQLLRRESSV----GYRVPAGSGPSLPPMPSL .:::. :. .:: .: .. : . : .. .:. :. : : XP_016 MPETVNHNKHGNVALPGTKPTP---IPPPRLKKQASFLEAEGGAKTLSGGRPGAG--PEL 290 300 310 320 330 320 330 340 pF1KE1 QEVDCGSPSSSEEEGVPG--SRGSPATS---P--HLGRRR-------------------- . :::... :..:: .:. : .: : : ::.: XP_016 ELGTAGSPGGAPPEAAPGDCTRAPPPSSESRPPCHGGRQRLSDMSISTSSSDSLEFDRSM 340 350 360 370 380 390 350 pF1KE1 PL----------------------------------------------LRSMSAAFCSLL :: :...:..: :.. XP_016 PLFGYEADTNSSLEDYEGESDQETMAPPIKSKKKRSSSFVLPKLVKSQLQKVSGVFSSFM 400 410 420 430 440 450 360 370 380 390 400 410 pF1KE1 APERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPE-----PQELQGIRQALSRARAML .::... : : : .:. : : :::: .. .. . : . :: ::: ..... .: XP_016 TPEKRMVRRIAELSRDKCTYFGCLVQDYVSFLQENKECHVSSTDMLQTIRQFMTQVKNYL 460 470 480 490 500 510 420 430 440 450 460 pF1KE1 S--AELGP--EKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGL : .:: : :.:. ... ::::..: .::::. . : :. :::: .: :.: XP_016 SQSSELDPPIESLIPEDQIDVVLEKAMHKCILKPLKGHVEAMLKDFHMADGSWKQLKENL 520 530 540 550 560 570 470 480 490 500 510 520 pF1KE1 RLARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQ .:.: ..: .: :. :..:... :.. . . ::: .: ::..:::.: ..... XP_016 QLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENN 580 590 600 610 620 630 530 540 550 560 570 580 pF1KE1 EGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALL :. :::.:::.:. :.:.::. :: : ::: :::.:::: ::::::::: ..:.:. XP_016 SGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLI 640 650 660 670 680 690 590 600 610 620 630 640 pF1KE1 SGLGQAHTLPLSPVQELRRSLSLWEQRR-----LPATHCFQHLLRVAYQDPSSGCTSKTL ... . .. : .: : .: :..:: .:.. ::. ::::.:. .::::.::: XP_016 KNFQEEQAARLLS-SETRDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTL 700 710 720 730 740 750 650 660 670 680 690 pF1KE1 AVPPEASIATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRL---------PT : : . . :.:: ::.: .:. ..:::. .. ...: . ... : XP_016 LVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPH 760 770 780 790 800 810 700 710 720 730 740 750 pF1KE1 TGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETT ..::.: XP_016 IFHFVYKRIKNDPYGIIFQNGEEDLTTS 820 830 840 >>XP_016883380 (OMIM: 610222,613075) PREDICTED: ras and (850 aa) initn: 1094 init1: 460 opt: 715 Z-score: 455.7 bits: 95.2 E(85289): 1.2e-18 Smith-Waterman score: 985; 31.8% identity (54.9% similar) in 758 aa overlap (100-703:83-830) 70 80 90 100 110 120 pF1KE1 LQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSHYILESPGGV : ..: .::: : . . : :: XP_016 LQLSLSEEEAAEVLQAQPPGIFLVHKSTKMQKKVLSLRLPCEFGAPL-KEFAIKESTYTF 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 SLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHLGIEFWSSSL ::::: . : :: .:: :: .::.: . :.:: :: : .. .:: ....:..:::: XP_016 SLEGSGISFADLFRLIAFYCISRDVLPFTLKLPYAISTAKSEAQLEELAQMGLNFWSSPA 120 130 140 150 160 170 190 200 210 220 pF1KE1 NIKAQRGP------AGGPVLP----QL---------KARSPQELD-QGTGAALCFFNPLF . : : .. : : :: :.:.:.::. . :..::::.:::: XP_016 DSKPPNLPPPHRPLSSDGVCPASLRQLCLINGVHSIKTRTPSELECSQTNGALCFINPLF 180 190 200 210 220 230 230 240 250 260 pF1KE1 ----PGDL-GPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPV------P---------- :: : :: . :. .. . .: :: :: ::: . : XP_016 LKVHSQDLSGGLKRPS-TRTPNANGTERTRSP--PPRPPPPAINSLHTSPRLARTETQTS 240 250 260 270 280 270 280 290 300 310 pF1KE1 -------------VLPGAVPSQTERLPPCQLLRRESSV----GYRVPAGSGPSLPPMPSL .:::. :. .:: .: .. : . : .. .:. :. : : XP_016 MPETVNHNKHGNVALPGTKPTP---IPPPRLKKQASFLEAEGGAKTLSGGRPGAG--PEL 290 300 310 320 330 340 320 330 340 pF1KE1 QEVDCGSPSSSEEEGVPG--SRGSPATS---P--HLGRRR-------------------- . :::... :..:: .:. : .: : : ::.: XP_016 ELGTAGSPGGAPPEAAPGDCTRAPPPSSESRPPCHGGRQRLSDMSISTSSSDSLEFDRSM 350 360 370 380 390 400 350 pF1KE1 PL----------------------------------------------LRSMSAAFCSLL :: :...:..: :.. XP_016 PLFGYEADTNSSLEDYEGESDQETMAPPIKSKKKRSSSFVLPKLVKSQLQKVSGVFSSFM 410 420 430 440 450 460 360 370 380 390 400 410 pF1KE1 APERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPE-----PQELQGIRQALSRARAML .::... : : : .:. : : :::: .. .. . : . :: ::: ..... .: XP_016 TPEKRMVRRIAELSRDKCTYFGCLVQDYVSFLQENKECHVSSTDMLQTIRQFMTQVKNYL 470 480 490 500 510 520 420 430 440 450 460 pF1KE1 S--AELGP--EKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGL : .:: : :.:. ... ::::..: .::::. . : :. :::: .: :.: XP_016 SQSSELDPPIESLIPEDQIDVVLEKAMHKCILKPLKGHVEAMLKDFHMADGSWKQLKENL 530 540 550 560 570 580 470 480 490 500 510 520 pF1KE1 RLARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQ .:.: ..: .: :. :..:... :.. . . ::: .: ::..:::.: ..... XP_016 QLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENN 590 600 610 620 630 640 530 540 550 560 570 580 pF1KE1 EGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALL :. :::.:::.:. :.:.::. :: : ::: :::.:::: ::::::::: ..:.:. XP_016 SGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLI 650 660 670 680 690 700 590 600 610 620 630 640 pF1KE1 SGLGQAHTLPLSPVQELRRSLSLWEQRR-----LPATHCFQHLLRVAYQDPSSGCTSKTL ... . .. : .: : .: :..:: .:.. ::. ::::.:. .::::.::: XP_016 KNFQEEQAARLLS-SETRDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTL 710 720 730 740 750 760 650 660 670 680 690 pF1KE1 AVPPEASIATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRL---------PT : : . . :.:: ::.: .:. ..:::. .. ...: . ... : XP_016 LVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPH 770 780 790 800 810 820 700 710 720 730 740 750 pF1KE1 TGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETT ..::.: XP_016 IFHFVYKRIKNDPYGIIFQNGEEDLTTS 830 840 850 >>NP_061866 (OMIM: 610222,613075) ras and Rab interactor (895 aa) initn: 1094 init1: 460 opt: 715 Z-score: 455.3 bits: 95.2 E(85289): 1.3e-18 Smith-Waterman score: 985; 31.8% identity (54.9% similar) in 758 aa overlap (100-703:128-875) 70 80 90 100 110 120 pF1KE1 LQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSHYILESPGGV : ..: .::: : . . : :: NP_061 LQLSLSEEEAAEVLQAQPPGIFLVHKSTKMQKKVLSLRLPCEFGAPL-KEFAIKESTYTF 100 110 120 130 140 150 130 140 150 160 170 180 pF1KE1 SLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHLGIEFWSSSL ::::: . : :: .:: :: .::.: . :.:: :: : .. .:: ....:..:::: NP_061 SLEGSGISFADLFRLIAFYCISRDVLPFTLKLPYAISTAKSEAQLEELAQMGLNFWSSPA 160 170 180 190 200 210 190 200 210 220 pF1KE1 NIKAQRGP------AGGPVLP----QL---------KARSPQELD-QGTGAALCFFNPLF . : : .. : : :: :.:.:.::. . :..::::.:::: NP_061 DSKPPNLPPPHRPLSSDGVCPASLRQLCLINGVHSIKTRTPSELECSQTNGALCFINPLF 220 230 240 250 260 270 230 240 250 260 pF1KE1 ----PGDL-GPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPV------P---------- :: : :: . :. .. . .: :: :: ::: . : NP_061 LKVHSQDLSGGLKRPS-TRTPNANGTERTRSP--PPRPPPPAINSLHTSPRLARTETQTS 280 290 300 310 320 330 270 280 290 300 310 pF1KE1 -------------VLPGAVPSQTERLPPCQLLRRESSV----GYRVPAGSGPSLPPMPSL .:::. :. .:: .: .. : . : .. .:. :. : : NP_061 MPETVNHNKHGNVALPGTKPTP---IPPPRLKKQASFLEAEGGAKTLSGGRPGAG--PEL 340 350 360 370 380 320 330 340 pF1KE1 QEVDCGSPSSSEEEGVPG--SRGSPATS---P--HLGRRR-------------------- . :::... :..:: .:. : .: : : ::.: NP_061 ELGTAGSPGGAPPEAAPGDCTRAPPPSSESRPPCHGGRQRLSDMSISTSSSDSLEFDRSM 390 400 410 420 430 440 350 pF1KE1 PL----------------------------------------------LRSMSAAFCSLL :: :...:..: :.. NP_061 PLFGYEADTNSSLEDYEGESDQETMAPPIKSKKKRSSSFVLPKLVKSQLQKVSGVFSSFM 450 460 470 480 490 500 360 370 380 390 400 410 pF1KE1 APERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPE-----PQELQGIRQALSRARAML .::... : : : .:. : : :::: .. .. . : . :: ::: ..... .: NP_061 TPEKRMVRRIAELSRDKCTYFGCLVQDYVSFLQENKECHVSSTDMLQTIRQFMTQVKNYL 510 520 530 540 550 560 420 430 440 450 460 pF1KE1 S--AELGP--EKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGL : .:: : :.:. ... ::::..: .::::. . : :. :::: .: :.: NP_061 SQSSELDPPIESLIPEDQIDVVLEKAMHKCILKPLKGHVEAMLKDFHMADGSWKQLKENL 570 580 590 600 610 620 470 480 490 500 510 520 pF1KE1 RLARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQ .:.: ..: .: :. :..:... :.. . . ::: .: ::..:::.: ..... NP_061 QLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENN 630 640 650 660 670 680 530 540 550 560 570 580 pF1KE1 EGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALL :. :::.:::.:. :.:.::. :: : ::: :::.:::: ::::::::: ..:.:. NP_061 SGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLI 690 700 710 720 730 740 590 600 610 620 630 640 pF1KE1 SGLGQAHTLPLSPVQELRRSLSLWEQRR-----LPATHCFQHLLRVAYQDPSSGCTSKTL ... . .. : .: : .: :..:: .:.. ::. ::::.:. .::::.::: NP_061 KNFQEEQAARLLS-SETRDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTL 750 760 770 780 790 800 650 660 670 680 690 pF1KE1 AVPPEASIATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRL---------PT : : . . :.:: ::.: .:. ..:::. .. ...: . ... : NP_061 LVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPH 810 820 830 840 850 860 700 710 720 730 740 750 pF1KE1 TGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETT ..::.: NP_061 IFHFVYKRIKNDPYGIIFQNGEEDLTTS 870 880 890 783 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 01:25:40 2016 done: Mon Nov 7 01:25:43 2016 Total Scan time: 15.990 Total Display time: 0.210 Function used was FASTA [36.3.4 Apr, 2011]