FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6416, 549 aa 1>>>pF1KE6416 549 - 549 aa - 549 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4747+/-0.000396; mu= 17.1559+/- 0.024 mean_var=61.0697+/-12.575, 0's: 0 Z-trim(111.1): 34 B-trim: 0 in 0/51 Lambda= 0.164120 statistics sampled from 19629 (19656) to 19629 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.586), E-opt: 0.2 (0.23), width: 16 Scan time: 8.410 The best scores are: opt bits E(85289) NP_001177921 (OMIM: 603690,612539,614482) acetyl-c ( 549) 3662 876.0 0 NP_004724 (OMIM: 603690,612539,614482) acetyl-coen ( 549) 3662 876.0 0 XP_011511613 (OMIM: 603690,612539,614482) PREDICTE ( 448) 2113 509.2 1.1e-143 XP_016862952 (OMIM: 603690,612539,614482) PREDICTE ( 379) 1940 468.2 2e-131 XP_016862951 (OMIM: 603690,612539,614482) PREDICTE ( 447) 1740 420.9 4.2e-117 XP_016862953 (OMIM: 603690,612539,614482) PREDICTE ( 278) 1556 377.2 3.6e-104 >>NP_001177921 (OMIM: 603690,612539,614482) acetyl-coenz (549 aa) initn: 3662 init1: 3662 opt: 3662 Z-score: 4681.3 bits: 876.0 E(85289): 0 Smith-Waterman score: 3662; 100.0% identity (100.0% similar) in 549 aa overlap (1-549:1-549) 10 20 30 40 50 60 pF1KE6 MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 FLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 LKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 CNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 LFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYAL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 HQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGS 490 500 510 520 530 540 pF1KE6 SSWKCKRNN ::::::::: NP_001 SSWKCKRNN >>NP_004724 (OMIM: 603690,612539,614482) acetyl-coenzyme (549 aa) initn: 3662 init1: 3662 opt: 3662 Z-score: 4681.3 bits: 876.0 E(85289): 0 Smith-Waterman score: 3662; 100.0% identity (100.0% similar) in 549 aa overlap (1-549:1-549) 10 20 30 40 50 60 pF1KE6 MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 FLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 LKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 CNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 LFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYAL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 HQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGS 490 500 510 520 530 540 pF1KE6 SSWKCKRNN ::::::::: NP_004 SSWKCKRNN >>XP_011511613 (OMIM: 603690,612539,614482) PREDICTED: a (448 aa) initn: 2113 init1: 2113 opt: 2113 Z-score: 2700.6 bits: 509.2 E(85289): 1.1e-143 Smith-Waterman score: 2782; 81.6% identity (81.6% similar) in 549 aa overlap (1-549:1-448) 10 20 30 40 50 60 pF1KE6 MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 FLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 LKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 CNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 LFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILP ::::::::::::::::::::: XP_011 LFAIIKMPAVLTFCLLILTAK--------------------------------------- 310 320 370 380 390 400 410 420 pF1KE6 LIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYAL XP_011 ------------------------------------------------------------ 430 440 450 460 470 480 pF1KE6 HQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 --VTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV 330 340 350 360 370 490 500 510 520 530 540 pF1KE6 GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGS 380 390 400 410 420 430 pF1KE6 SSWKCKRNN ::::::::: XP_011 SSWKCKRNN 440 >>XP_016862952 (OMIM: 603690,612539,614482) PREDICTED: a (379 aa) initn: 1966 init1: 1940 opt: 1940 Z-score: 2480.4 bits: 468.2 E(85289): 2e-131 Smith-Waterman score: 1940; 100.0% identity (100.0% similar) in 291 aa overlap (259-549:89-379) 230 240 250 260 270 280 pF1KE6 NVLFLALESADFCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVK :::::::::::::::::::::::::::::: XP_016 VRFIYPFERVCDVGGKLINLLEIIVWEITQDFLFFWGTVFLITTTLVALLKKENEVSVVK 60 70 80 90 100 110 290 300 310 320 330 340 pF1KE6 EETQGITDTYKLLFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EETQGITDTYKLLFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALL 120 130 140 150 160 170 350 360 370 380 390 400 pF1KE6 AVPMVPLQIILPLIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVPMVPLQIILPLIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPI 180 190 200 210 220 230 410 420 430 440 450 460 pF1KE6 YYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVAL 240 250 260 270 280 290 470 480 490 500 510 520 pF1KE6 WLVDPLTVKECVGASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WLVDPLTVKECVGASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFL 300 310 320 330 340 350 530 540 pF1KE6 GPKFKKLQDEGSSSWKCKRNN ::::::::::::::::::::: XP_016 GPKFKKLQDEGSSSWKCKRNN 360 370 >>XP_016862951 (OMIM: 603690,612539,614482) PREDICTED: a (447 aa) initn: 2618 init1: 1740 opt: 1740 Z-score: 2223.3 bits: 420.9 E(85289): 4.2e-117 Smith-Waterman score: 2449; 74.1% identity (78.1% similar) in 549 aa overlap (1-549:1-447) 10 20 30 40 50 60 pF1KE6 MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 FLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 LKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 CNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKL :::::::::::::::::::..: . ...:.. .: :. XP_016 CNKYLRFQPQPRGIVTLSDWFF------------SSRCCNRTEIG-----RRGSTQR--- 250 260 270 280 310 320 330 340 350 360 pF1KE6 LFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILP :: : :: : .. XP_016 -----------TFSL------IGSSNGS-------------------------------- 290 370 380 390 400 410 420 pF1KE6 LIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYAL .. ::. :. . : .: ..: .: :.:: XP_016 --FADNTASD------YQQIHCR-------------SPAIKH-----------ILQSHAL 300 310 430 440 450 460 470 480 pF1KE6 HQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 -QVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV 320 330 340 350 360 370 490 500 510 520 530 540 pF1KE6 GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGS 380 390 400 410 420 430 pF1KE6 SSWKCKRNN ::::::::: XP_016 SSWKCKRNN 440 >>XP_016862953 (OMIM: 603690,612539,614482) PREDICTED: a (278 aa) initn: 1582 init1: 1556 opt: 1556 Z-score: 1991.2 bits: 377.2 E(85289): 3.6e-104 Smith-Waterman score: 1556; 98.7% identity (99.1% similar) in 232 aa overlap (318-549:47-278) 290 300 310 320 330 340 pF1KE6 KEETQGITDTYKLLFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLAL : .:::::::::::::::::::::::::: XP_016 TFWAMFCFWPLNLPTFVTNICGFSLNPEESLLFQIGFSAADAVTGLKLVEEGVPKEHLAL 20 30 40 50 60 70 350 360 370 380 390 400 pF1KE6 LAVPMVPLQIILPLIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAVPMVPLQIILPLIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFP 80 90 100 110 120 130 410 420 430 440 450 460 pF1KE6 IYYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVA 140 150 160 170 180 190 470 480 490 500 510 520 pF1KE6 LWLVDPLTVKECVGASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LWLVDPLTVKECVGASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFF 200 210 220 230 240 250 530 540 pF1KE6 LGPKFKKLQDEGSSSWKCKRNN :::::::::::::::::::::: XP_016 LGPKFKKLQDEGSSSWKCKRNN 260 270 549 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:04:16 2016 done: Tue Nov 8 13:04:18 2016 Total Scan time: 8.410 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]