FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2270, 146 aa 1>>>pF1KE2270 146 - 146 aa - 146 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9748+/-0.000259; mu= 14.7737+/- 0.016 mean_var=66.1457+/-13.134, 0's: 0 Z-trim(120.7): 24 B-trim: 0 in 0/51 Lambda= 0.157697 statistics sampled from 36303 (36327) to 36303 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.791), E-opt: 0.2 (0.426), width: 16 Scan time: 5.550 The best scores are: opt bits E(85289) NP_001275543 (OMIM: 105150,604312,611953) cystatin ( 146) 982 230.9 5.8e-61 NP_000090 (OMIM: 105150,604312,611953) cystatin-C ( 146) 982 230.9 5.8e-61 NP_001313 (OMIM: 123856) cystatin-SA precursor [Ho ( 141) 542 130.7 7.7e-31 NP_001890 (OMIM: 123857) cystatin-S precursor [Hom ( 141) 529 127.8 6e-30 NP_001889 (OMIM: 123855) cystatin-SN precursor [Ho ( 141) 523 126.4 1.5e-29 NP_001891 (OMIM: 123858) cystatin-D precursor [Hom ( 142) 488 118.5 3.9e-27 NP_001314 (OMIM: 601891) cystatin-M precursor [Hom ( 149) 282 71.6 5.2e-13 NP_001268659 (OMIM: 608683) cystatin-8 precursor [ ( 142) 260 66.6 1.6e-11 NP_005483 (OMIM: 608683) cystatin-8 precursor [Hom ( 142) 260 66.6 1.6e-11 NP_003641 (OMIM: 603253) cystatin-F precursor [Hom ( 145) 254 65.2 4.2e-11 NP_570612 (OMIM: 609731) cystatin-11 isoform 1 pre ( 138) 228 59.3 2.4e-09 NP_542177 (OMIM: 616536) cystatin-9-like precursor ( 147) 194 51.6 5.4e-07 NP_001159923 (OMIM: 228960,612358) kininogen-1 iso ( 391) 172 46.9 3.8e-05 NP_000884 (OMIM: 228960,612358) kininogen-1 isofor ( 427) 172 46.9 4e-05 NP_001095886 (OMIM: 228960,612358) kininogen-1 iso ( 644) 172 47.0 5.6e-05 >>NP_001275543 (OMIM: 105150,604312,611953) cystatin-C p (146 aa) initn: 982 init1: 982 opt: 982 Z-score: 1215.4 bits: 230.9 E(85289): 5.8e-61 Smith-Waterman score: 982; 100.0% identity (100.0% similar) in 146 aa overlap (1-146:1-146) 10 20 30 40 50 60 pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRK 70 80 90 100 110 120 130 140 pF1KE2 AFCSFQIYAVPWQGTMTLSKSTCQDA :::::::::::::::::::::::::: NP_001 AFCSFQIYAVPWQGTMTLSKSTCQDA 130 140 >>NP_000090 (OMIM: 105150,604312,611953) cystatin-C prec (146 aa) initn: 982 init1: 982 opt: 982 Z-score: 1215.4 bits: 230.9 E(85289): 5.8e-61 Smith-Waterman score: 982; 100.0% identity (100.0% similar) in 146 aa overlap (1-146:1-146) 10 20 30 40 50 60 pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRK 70 80 90 100 110 120 130 140 pF1KE2 AFCSFQIYAVPWQGTMTLSKSTCQDA :::::::::::::::::::::::::: NP_000 AFCSFQIYAVPWQGTMTLSKSTCQDA 130 140 >>NP_001313 (OMIM: 123856) cystatin-SA precursor [Homo s (141 aa) initn: 584 init1: 490 opt: 542 Z-score: 674.6 bits: 130.7 E(85289): 7.7e-31 Smith-Waterman score: 542; 56.5% identity (79.6% similar) in 147 aa overlap (1-146:1-141) 10 20 30 40 50 pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLV-GGPMDASVEEEGVRRALDFAVGE :: :: . ::::: ::::: :: . :.. :: .::....: :.::: :...: NP_001 MAWPLCTLLLLLATQAVALAWSPQ------EEDRIIEGGIYDADLNDERVQRALHFVISE 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 YNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKR ::::..: :. : :.:.:::.:::.:::::.:.:.::: :::.:::::.: ::.::.:.. NP_001 YNKATEDEYYRRLLRVLRAREQIVGGVNYFFDIEVGRTICTKSQPNLDTCAFHEQPELQK 60 70 80 90 100 110 120 130 140 pF1KE2 KAFCSFQIYAVPWQGTMTLSKSTCQDA : .:::::: :::. :.: .: ::.: NP_001 KQLCSFQIYEVPWEDRMSLVNSRCQEA 120 130 140 >>NP_001890 (OMIM: 123857) cystatin-S precursor [Homo sa (141 aa) initn: 583 init1: 486 opt: 529 Z-score: 658.7 bits: 127.8 E(85289): 6e-30 Smith-Waterman score: 529; 55.8% identity (78.2% similar) in 147 aa overlap (1-146:1-141) 10 20 30 40 50 pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLV-GGPMDASVEEEGVRRALDFAVGE :: :: . :::.: :: ::: :: . :.. :: .::....: :.::: ::..: NP_001 MARPLCTLLLLMATLAGALA------SSSKEENRIIPGGIYDADLNDEWVQRALHFAISE 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 YNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKR ::::..: :. : :::.:::.: .:::::.:::.::: :::.:::::.: ::.::.:.. NP_001 YNKATEDEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQK 60 70 80 90 100 110 120 130 140 pF1KE2 KAFCSFQIYAVPWQGTMTLSKSTCQDA : .:::.:: :::. :.: .: ::.: NP_001 KQLCSFEIYEVPWEDRMSLVNSRCQEA 120 130 140 >>NP_001889 (OMIM: 123855) cystatin-SN precursor [Homo s (141 aa) initn: 573 init1: 473 opt: 523 Z-score: 651.3 bits: 126.4 E(85289): 1.5e-29 Smith-Waterman score: 523; 55.1% identity (78.9% similar) in 147 aa overlap (1-146:1-141) 10 20 30 40 50 pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLV-GGPMDASVEEEGVRRALDFAVGE :: : . ::::: :::::: :: . :.. :: ..:....: :.::: ::..: NP_001 MAQYLSTLLLLLATLAVALAWSPK------EEDRIIPGGIYNADLNDEWVQRALHFAISE 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 YNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKR ::::..: :. : :.:.:::.: :.:::::.:::.::: :::.:::::.: ::.::.:.. NP_001 YNKATKDDYYRRPLRVLRARQQTVGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQK 60 70 80 90 100 110 120 130 140 pF1KE2 KAFCSFQIYAVPWQGTMTLSKSTCQDA : .:::.:: :::.. .: :: ::.. NP_001 KQLCSFEIYEVPWENRRSLVKSRCQES 120 130 140 >>NP_001891 (OMIM: 123858) cystatin-D precursor [Homo sa (142 aa) initn: 482 init1: 334 opt: 488 Z-score: 608.2 bits: 118.5 E(85289): 3.9e-27 Smith-Waterman score: 488; 51.0% identity (78.6% similar) in 145 aa overlap (1-144:1-140) 10 20 30 40 50 60 pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEY : :...:::::. : ::.: ::. .. :.:: .......:. :::::..:: NP_001 MMWPMHTPLLLLTALMVAVA-----GSASAQSRTLAGGIHATDLNDKSVQCALDFAISEY 10 20 30 40 50 70 80 90 100 110 pF1KE2 NKASN-DMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKR ::. : : :.:: :::. : .:::.::::...:..:::::::.:::::::::.:::.::. NP_001 NKVINKDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFNDQPKLKE 60 70 80 90 100 110 120 130 140 pF1KE2 KAFCSFQIYAVPWQGTMTLSKSTCQDA . :::::: :::. ... . :. NP_001 EEFCSFQINEVPWEDKISILNYKCRKV 120 130 140 >>NP_001314 (OMIM: 601891) cystatin-M precursor [Homo sa (149 aa) initn: 251 init1: 193 opt: 282 Z-score: 354.6 bits: 71.6 E(85289): 5.2e-13 Smith-Waterman score: 282; 36.4% identity (65.0% similar) in 143 aa overlap (8-143:7-146) 10 20 30 40 50 pF1KE2 MAGPLRAPLLL-LAILAVALAVSPA-AGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVG :: : ::..: : . : : . : . :.:: : : .. :..: . ::. NP_001 MARSNLPLALGLALVAFCLLALPRDARARPQE--RMVGELRDLSPDDPQVQKAAQAAVA 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 EYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQP-----NLDNCPFHD :: .::..:. : ....:..:.:::..::: .:.: : : ::. .: .::. NP_001 SYNMGSNSIYYFRDTHIIKAQSQLVAGIKYFLTMEMGSTDCRKTRVTGDHVDLTTCPLAA 60 70 80 90 100 110 120 130 140 pF1KE2 QPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA . ..: :.:.. .::::.. : : .: NP_001 GAQ-QEKLRCDFEVLVVPWQNSSQLLKHNCVQM 120 130 140 >>NP_001268659 (OMIM: 608683) cystatin-8 precursor [Homo (142 aa) initn: 239 init1: 239 opt: 260 Z-score: 327.9 bits: 66.6 E(85289): 1.6e-11 Smith-Waterman score: 260; 34.0% identity (66.0% similar) in 144 aa overlap (6-146:3-142) 10 20 30 40 50 pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVG---GPMDASVEEEGVRRALDFAV : : : .:.. ::. .: ..: : : :..:: . .:.. : ::. NP_001 MPRCRWLSLILLTIPLAL--VARKDPKKNETGVLRKLKPVNAS--NANVKQCLWFAM 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 GEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHL :::: :.: : ......:. :.. ..:..:::..:. : : . . : .... .: NP_001 QEYNKESEDKYVFLVVKTLQAQLQVTNLLEYLIDVEIARSDCRKPLSTNEICAIQENSKL 60 70 80 90 100 110 120 130 140 pF1KE2 KRKAFCSFQIYAVPWQGTMTLSKSTCQDA ::: ::: . :.::.: .:. .. :.:: NP_001 KRKLSCSFLVGALPWNGEFTVMEKKCEDA 120 130 140 >>NP_005483 (OMIM: 608683) cystatin-8 precursor [Homo sa (142 aa) initn: 239 init1: 239 opt: 260 Z-score: 327.9 bits: 66.6 E(85289): 1.6e-11 Smith-Waterman score: 260; 34.0% identity (66.0% similar) in 144 aa overlap (6-146:3-142) 10 20 30 40 50 pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVG---GPMDASVEEEGVRRALDFAV : : : .:.. ::. .: ..: : : :..:: . .:.. : ::. NP_005 MPRCRWLSLILLTIPLAL--VARKDPKKNETGVLRKLKPVNAS--NANVKQCLWFAM 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 GEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHL :::: :.: : ......:. :.. ..:..:::..:. : : . . : .... .: NP_005 QEYNKESEDKYVFLVVKTLQAQLQVTNLLEYLIDVEIARSDCRKPLSTNEICAIQENSKL 60 70 80 90 100 110 120 130 140 pF1KE2 KRKAFCSFQIYAVPWQGTMTLSKSTCQDA ::: ::: . :.::.: .:. .. :.:: NP_005 KRKLSCSFLVGALPWNGEFTVMEKKCEDA 120 130 140 >>NP_003641 (OMIM: 603253) cystatin-F precursor [Homo sa (145 aa) initn: 270 init1: 176 opt: 254 Z-score: 320.4 bits: 65.2 E(85289): 4.2e-11 Smith-Waterman score: 254; 35.6% identity (63.0% similar) in 135 aa overlap (5-132:1-133) 10 20 30 40 50 pF1KE2 MAGPLRAPLLLLAILAVALAVSPAAGSSPGK-----PPRLVGG-PMDASVEEEGVRRALD .:: :::. :..: ..: :: :. : : .... :: .: NP_003 MRAAGTLLAF--CCLVLSTTGGPSPDTCSQDLNSRVKPGFPKTIKTNDPGVLQAAR 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 FAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQP-NLDNCPFHD ..: ..:. .:::. . ...:: ::: :..:.:.::.::::: :.: ::.: :. NP_003 YSVEKFNNCTNDMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQT 60 70 80 90 100 110 120 130 140 pF1KE2 QPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA . ::. : ....::: NP_003 NHTLKQTLSCYSEVWVVPWLQHFEVPVLRCH 120 130 140 146 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 01:36:59 2016 done: Mon Nov 7 01:37:00 2016 Total Scan time: 5.550 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]