FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4521, 557 aa 1>>>pF1KE4521 557 - 557 aa - 557 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5111+/-0.000462; mu= 23.4089+/- 0.028 mean_var=75.2646+/-15.608, 0's: 0 Z-trim(109.3): 230 B-trim: 0 in 0/54 Lambda= 0.147836 statistics sampled from 17182 (17429) to 17182 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.551), E-opt: 0.2 (0.204), width: 16 Scan time: 9.850 The best scores are: opt bits E(85289) NP_003051 (OMIM: 212140,603377) solute carrier fam ( 557) 3686 796.4 0 NP_003050 (OMIM: 180300,604190) solute carrier fam ( 551) 2864 621.1 2.8e-177 NP_001295051 (OMIM: 212140,603377) solute carrier ( 581) 2805 608.6 1.8e-173 XP_016865267 (OMIM: 212140,603377) PREDICTED: solu ( 381) 2494 542.0 1.2e-153 XP_011541892 (OMIM: 212140,603377) PREDICTED: solu ( 351) 2233 486.3 6.7e-137 XP_016865265 (OMIM: 180300,604190) PREDICTED: solu ( 375) 1747 382.7 1.1e-105 XP_006714738 (OMIM: 180300,604190) PREDICTED: solu ( 375) 1747 382.7 1.1e-105 XP_011541891 (OMIM: 180300,604190) PREDICTED: solu ( 459) 1175 260.8 6.7e-69 NP_003049 (OMIM: 602608) solute carrier family 22 ( 555) 995 222.5 2.8e-57 NP_003048 (OMIM: 602607) solute carrier family 22 ( 554) 994 222.3 3.2e-57 NP_068812 (OMIM: 604842) solute carrier family 22 ( 556) 972 217.6 8.3e-56 NP_006663 (OMIM: 604995) solute carrier family 22 ( 546) 942 211.2 6.9e-54 XP_011534506 (OMIM: 608276) PREDICTED: solute carr ( 534) 937 210.1 1.4e-53 XP_006715034 (OMIM: 604995) PREDICTED: solute carr ( 549) 937 210.1 1.4e-53 NP_149116 (OMIM: 608276) solute carrier family 22 ( 577) 937 210.2 1.5e-53 XP_005267159 (OMIM: 602607) PREDICTED: solute carr ( 610) 936 210.0 1.8e-53 XP_005267160 (OMIM: 602607) PREDICTED: solute carr ( 573) 935 209.7 2e-53 NP_696961 (OMIM: 604995) solute carrier family 22 ( 548) 928 208.2 5.5e-53 XP_006715033 (OMIM: 604995) PREDICTED: solute carr ( 551) 911 204.6 6.8e-52 NP_653186 (OMIM: 220150,607096) solute carrier fam ( 553) 894 201.0 8.4e-51 NP_695008 (OMIM: 607582) solute carrier family 22 ( 550) 890 200.1 1.5e-50 NP_004247 (OMIM: 604047) solute carrier family 22 ( 551) 886 199.3 2.7e-50 XP_016874051 (OMIM: 607582) PREDICTED: solute carr ( 551) 886 199.3 2.7e-50 NP_004781 (OMIM: 607582) solute carrier family 22 ( 563) 871 196.1 2.5e-49 XP_011534507 (OMIM: 608276) PREDICTED: solute carr ( 515) 859 193.5 1.4e-48 NP_694857 (OMIM: 602607) solute carrier family 22 ( 506) 855 192.6 2.5e-48 XP_006715615 (OMIM: 602607) PREDICTED: solute carr ( 483) 848 191.1 6.9e-48 NP_004245 (OMIM: 607581) solute carrier family 22 ( 542) 841 189.6 2.1e-47 NP_001171661 (OMIM: 607581) solute carrier family ( 542) 841 189.6 2.1e-47 NP_060890 (OMIM: 608275) solute carrier family 22 ( 547) 841 189.7 2.1e-47 NP_001171662 (OMIM: 607581) solute carrier family ( 451) 838 188.9 2.9e-47 NP_060954 (OMIM: 607097) solute carrier family 22 ( 550) 808 182.6 2.8e-45 XP_005267163 (OMIM: 604842) PREDICTED: solute carr ( 425) 792 179.1 2.5e-44 XP_016865687 (OMIM: 604995) PREDICTED: solute carr ( 602) 776 175.8 3.3e-43 XP_011512559 (OMIM: 604995) PREDICTED: solute carr ( 607) 773 175.2 5.2e-43 XP_016865689 (OMIM: 604995) PREDICTED: solute carr ( 543) 767 173.9 1.2e-42 XP_011512558 (OMIM: 604995) PREDICTED: solute carr ( 610) 767 173.9 1.3e-42 XP_016866692 (OMIM: 604842) PREDICTED: solute carr ( 404) 759 172.0 3.2e-42 XP_011534378 (OMIM: 604842) PREDICTED: solute carr ( 404) 759 172.0 3.2e-42 XP_011534377 (OMIM: 604842) PREDICTED: solute carr ( 404) 759 172.0 3.2e-42 XP_011543666 (OMIM: 607581) PREDICTED: solute carr ( 419) 752 170.5 9.1e-42 NP_001171665 (OMIM: 607581) solute carrier family ( 419) 752 170.5 9.1e-42 XP_016865690 (OMIM: 604995) PREDICTED: solute carr ( 420) 751 170.3 1.1e-41 XP_011512563 (OMIM: 604995) PREDICTED: solute carr ( 420) 751 170.3 1.1e-41 XP_011534508 (OMIM: 608276) PREDICTED: solute carr ( 483) 732 166.3 1.9e-40 XP_005267241 (OMIM: 608276) PREDICTED: solute carr ( 407) 728 165.4 3.1e-40 XP_011534511 (OMIM: 608276) PREDICTED: solute carr ( 442) 728 165.4 3.3e-40 XP_011534510 (OMIM: 608276) PREDICTED: solute carr ( 447) 728 165.5 3.3e-40 XP_011534509 (OMIM: 608276) PREDICTED: solute carr ( 459) 728 165.5 3.4e-40 XP_011543318 (OMIM: 607580) PREDICTED: solute carr ( 541) 720 163.8 1.2e-39 >>NP_003051 (OMIM: 212140,603377) solute carrier family (557 aa) initn: 3686 init1: 3686 opt: 3686 Z-score: 4251.3 bits: 796.4 E(85289): 0 Smith-Waterman score: 3686; 99.8% identity (99.8% similar) in 557 aa overlap (1-557:1-557) 10 20 30 40 50 60 pF1KE4 MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCPDGWEFS ::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::: NP_003 AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 TGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 AKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 PPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 VYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTR 490 500 510 520 530 540 550 pF1KE4 MLKDGQERPTILKSTAF ::::::::::::::::: NP_003 MLKDGQERPTILKSTAF 550 >>NP_003050 (OMIM: 180300,604190) solute carrier family (551 aa) initn: 2845 init1: 1888 opt: 2864 Z-score: 3303.8 bits: 621.1 E(85289): 2.8e-177 Smith-Waterman score: 2864; 76.3% identity (90.7% similar) in 557 aa overlap (1-557:1-551) 10 20 30 40 50 60 pF1KE4 MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS ::::::: ::::::::::::::::::::::::::.:.: ::: .:::::::::::::::: NP_003 MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCPDGWEFS ::::..::::::::::::::: ::::::::::::::::::::::::::::::: :::::: NP_003 AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQ :::::::.::::::::::.::.::: ::::::::::::.:::::::::::::::.::..: NP_003 QDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 TGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYA :::::::::: ..:::.::::.::::::::::.::.:::::::::::::::::::: :.: NP_003 TGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKA :::.:::::::::::::::.:::.:::::: ::::::::::::::: ::.::: ::.:: NP_003 VGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 AKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFG :: :.:.::..::: : .:. :::. ::::.:: :: ..::::..::: :::::. NP_003 AKMNNIAVPAVIFDSVE--ELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFA 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV ::::.:::::: ..::::::..:.:::. :::::. ::::: .:..:: ::.::::.::: NP_003 LSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLV 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE4 PPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF : : :.:. :::.::::.:.::::.::.:::::::.::::.:::.:::::.:::..::: NP_003 PVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYF 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE4 VYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTR ::::::.:.::::.:::::.: .:::::.:::.: ::.:..:: .:: .. : .:: NP_003 VYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGK---KTR 480 490 500 510 520 530 550 pF1KE4 MLKDGQERPTILKSTAF . .: : .: ::: NP_003 DSMETEENPKVLI-TAF 540 550 >>NP_001295051 (OMIM: 212140,603377) solute carrier fami (581 aa) initn: 2803 init1: 2803 opt: 2805 Z-score: 3235.5 bits: 608.6 E(85289): 1.8e-173 Smith-Waterman score: 3628; 95.7% identity (95.7% similar) in 581 aa overlap (1-557:1-581) 10 20 30 40 50 60 pF1KE4 MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCPDGWEFS ::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::: NP_001 AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS 70 80 90 100 110 120 130 140 150 pF1KE4 QDVYLSTIVTE------------------------WNLVCEDDWKAPLTISLFFVGVLLG ::::::::::: ::::::::::::::::::::::::: NP_001 QDVYLSTIVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLG 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE4 SFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFV 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE4 LGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWF 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE4 IPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLR 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE4 TWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQY 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE4 LPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPT 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE4 VVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTP 490 500 510 520 530 540 520 530 540 550 pF1KE4 LPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF ::::::::::::::::::::::::::::::::::::::::: NP_001 LPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF 550 560 570 580 >>XP_016865267 (OMIM: 212140,603377) PREDICTED: solute c (381 aa) initn: 2494 init1: 2494 opt: 2494 Z-score: 2879.3 bits: 542.0 E(85289): 1.2e-153 Smith-Waterman score: 2494; 100.0% identity (100.0% similar) in 381 aa overlap (177-557:1-381) 150 160 170 180 190 200 pF1KE4 SLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMG :::::::::::::::::::::::::::::: XP_016 MGMQTGFSFLQIFSKNFEMFVVLFVLVGMG 10 20 30 210 220 230 240 250 260 pF1KE4 QISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMP 40 50 60 70 80 90 270 280 290 300 310 320 pF1KE4 GVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQ 100 110 120 130 140 150 330 340 350 360 370 380 pF1KE4 QSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPA 160 170 180 190 200 210 390 400 410 420 430 440 pF1KE4 YVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMV 220 230 240 250 260 270 450 460 470 480 490 500 pF1KE4 YVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILT 280 290 300 310 320 330 510 520 530 540 550 pF1KE4 LFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF 340 350 360 370 380 >>XP_011541892 (OMIM: 212140,603377) PREDICTED: solute c (351 aa) initn: 2233 init1: 2233 opt: 2233 Z-score: 2578.8 bits: 486.3 E(85289): 6.7e-137 Smith-Waterman score: 2233; 100.0% identity (100.0% similar) in 340 aa overlap (218-557:12-351) 190 200 210 220 230 240 pF1KE4 IFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLP :::::::::::::::::::::::::::::: XP_011 MWQHLSWVWPSGTEILGKSVRIIFSTLGVCIFYAFGYMVLP 10 20 30 40 250 260 270 280 290 300 pF1KE4 LFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIV 50 60 70 80 90 100 310 320 330 340 350 360 pF1KE4 VPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPN 110 120 130 140 150 160 370 380 390 400 410 420 pF1KE4 LHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYL 170 180 190 200 210 220 430 440 450 460 470 480 pF1KE4 ATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYD 230 240 250 260 270 280 490 500 510 520 530 540 pF1KE4 RFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQE 290 300 310 320 330 340 550 pF1KE4 RPTILKSTAF :::::::::: XP_011 RPTILKSTAF 350 >>XP_016865265 (OMIM: 180300,604190) PREDICTED: solute c (375 aa) initn: 1728 init1: 971 opt: 1747 Z-score: 2018.3 bits: 382.7 E(85289): 1.1e-105 Smith-Waterman score: 1747; 69.6% identity (87.9% similar) in 381 aa overlap (177-557:1-375) 150 160 170 180 190 200 pF1KE4 SLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMG :..::::::::::: ..:::.::::.:::: XP_016 MAVQTGFSFLQIFSISWEMFTVLFVIVGMG 10 20 30 210 220 230 240 250 260 pF1KE4 QISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMP ::::::.::.:::::::::::::::::::: :.: :::.:::::::::::::::.:::.: XP_016 QISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVP 40 50 60 70 80 90 270 280 290 300 310 320 pF1KE4 GVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQ ::::: ::::::::::::::: ::.::: ::.:::: :.:.::..::: : .:. :: XP_016 GVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVE--ELNPLKQ 100 110 120 130 140 330 340 350 360 370 380 pF1KE4 QSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPA :. ::::.:: :: ..::::..::: :::::.::::.:::::: ..::::::..:.:: XP_016 QKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPA 150 160 170 180 190 200 390 400 410 420 430 440 pF1KE4 YVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMV :. :::::. ::::: .:..:: ::.::::.:::: : :.:. :::.::::.:.::::. XP_016 YITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSML 210 220 230 240 250 260 450 460 470 480 490 500 pF1KE4 YVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILT ::.:::::::.::::.:::.:::::.:::..:::::::::.:.::::.:::::.: .::: XP_016 YVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILT 270 280 290 300 310 320 510 520 530 540 550 pF1KE4 LFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF ::.:::.: ::.:..:: .:: .. : .:: . .: : .: ::: XP_016 LFFPESLGMTLPETLEQMQKVKWFRSGK---KTRDSMETEENPKVLI-TAF 330 340 350 360 370 >>XP_006714738 (OMIM: 180300,604190) PREDICTED: solute c (375 aa) initn: 1728 init1: 971 opt: 1747 Z-score: 2018.3 bits: 382.7 E(85289): 1.1e-105 Smith-Waterman score: 1747; 69.6% identity (87.9% similar) in 381 aa overlap (177-557:1-375) 150 160 170 180 190 200 pF1KE4 SLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMG :..::::::::::: ..:::.::::.:::: XP_006 MAVQTGFSFLQIFSISWEMFTVLFVIVGMG 10 20 30 210 220 230 240 250 260 pF1KE4 QISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMP ::::::.::.:::::::::::::::::::: :.: :::.:::::::::::::::.:::.: XP_006 QISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVP 40 50 60 70 80 90 270 280 290 300 310 320 pF1KE4 GVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQ ::::: ::::::::::::::: ::.::: ::.:::: :.:.::..::: : .:. :: XP_006 GVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVE--ELNPLKQ 100 110 120 130 140 330 340 350 360 370 380 pF1KE4 QSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPA :. ::::.:: :: ..::::..::: :::::.::::.:::::: ..::::::..:.:: XP_006 QKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPA 150 160 170 180 190 200 390 400 410 420 430 440 pF1KE4 YVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMV :. :::::. ::::: .:..:: ::.::::.:::: : :.:. :::.::::.:.::::. XP_006 YITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSML 210 220 230 240 250 260 450 460 470 480 490 500 pF1KE4 YVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILT ::.:::::::.::::.:::.:::::.:::..:::::::::.:.::::.:::::.: .::: XP_006 YVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILT 270 280 290 300 310 320 510 520 530 540 550 pF1KE4 LFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF ::.:::.: ::.:..:: .:: .. : .:: . .: : .: ::: XP_006 LFFPESLGMTLPETLEQMQKVKWFRSGK---KTRDSMETEENPKVLI-TAF 330 340 350 360 370 >>XP_011541891 (OMIM: 180300,604190) PREDICTED: solute c (459 aa) initn: 1973 init1: 971 opt: 1175 Z-score: 1357.9 bits: 260.8 E(85289): 6.7e-69 Smith-Waterman score: 1821; 56.8% identity (71.0% similar) in 558 aa overlap (1-557:1-459) 10 20 30 40 50 60 pF1KE4 MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS ::::::: ::::::::::::::::::::::::::.:.: ::: .:::::::::::::::: XP_011 MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCPDGWEFS ::::..::::::::::::::: ::::::::::::::::::::::::::::::: :::::: XP_011 AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQ :::::::.::: :. .: :.. : .: XP_011 QDVYLSTVVTEV-------WQE----------------------ERSLRNH--GCTDWLQ 130 140 190 200 210 220 230 240 pF1KE4 TGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYA .::. .:.. :.. XP_011 LPADFLH----------------QLGDVH--------------------------CVICH 150 160 250 260 270 280 290 pF1KE4 FGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWW-FIPESPRWLISQGRFEEAEVIIRK :. : : . :: .: :::::::::::: ::.::: ::.: XP_011 RGHG--P-------DLQ-----------LCGSLHTRFIPESPRWLISQRRFREAEDIIQK 170 180 190 200 300 310 320 330 340 350 pF1KE4 AAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYF ::: :.:.::..::: : .:. :::. ::::.:: :: ..::::..::: ::::: XP_011 AAKMNNIAVPAVIFDSVE--ELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYF 210 220 230 240 250 260 360 370 380 390 400 410 pF1KE4 GLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQL .::::.:::::: ..::::::..:.:::. :::::. ::::: .:..:: ::.::::.:: XP_011 ALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQL 270 280 290 300 310 320 420 430 440 450 460 470 pF1KE4 VPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPY :: : :.:. :::.::::.:.::::.::.:::::::.::::.:::.:::::.:::..:: XP_011 VPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPY 330 340 350 360 370 380 480 490 500 510 520 530 pF1KE4 FVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHT :::::::.:.::::.:::::.: .:::::.:::.: ::.:..:: .:: .. : .: XP_011 FVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGK---KT 390 400 410 420 430 440 540 550 pF1KE4 RMLKDGQERPTILKSTAF : . .: : .: ::: XP_011 RDSMETEENPKVLI-TAF 450 >>NP_003049 (OMIM: 602608) solute carrier family 22 memb (555 aa) initn: 939 init1: 350 opt: 995 Z-score: 1149.4 bits: 222.5 E(85289): 2.8e-57 Smith-Waterman score: 995; 34.7% identity (64.9% similar) in 547 aa overlap (5-533:6-541) 10 20 30 40 50 pF1KE4 MRDYDEVTAFLGEWGPFQRLIFFLL---SASIIPNGFTGLSSVFLIATPEHRCRVPDAA :.: ::. ::. .:::: ::.. : ..:. ::: ::.:::: : .: NP_003 MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPI-YVGI--VFLGFTPDHRCRSPGVA 10 20 30 40 50 60 70 80 90 100 pF1KE4 NLS--SAWR-----NHTVPLRLRDGREVPHSCRRYRLA-TIANFSALGLEPGRDVDLGQL .:: .: :.::: :. :..::::.. . ..:. . . :.. ..: NP_003 ELSLRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRL 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 EQESCPDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFG : ::: . .. :.::::.:::: ..: : : :: ..::. : ..:::: NP_003 PLGPCRDGWVY--ETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFG 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 RKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRI :: :..:. .... . :. .: .. .... .. :. . .... ...: ::..:. : NP_003 RKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYR- 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 IFSTLGVC--IFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLIS :.:. . :. : .:: :: . :: : ....:. . . .: :::::::::: NP_003 --RTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLIS 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 QGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIM :.. :: ::.. :: :: .:... . .:.. ..:: . ..:::.:: .:: :.. NP_003 QNKNAEAMRIIKHIAKKNGKSLPASL-QRLRLEEETGKKL-NPSFLDLVRTPQIRKHTMI 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE4 SIMLWMTISVGYFGLSLDTPNLHGD-IFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMAT .. :.: :: : :: . .: :: :... : ::.:: :: . : .. . ::: :. NP_003 LMYNWFTSSVLYQGLIMHM-GLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAA 360 370 380 390 400 410 420 430 440 450 460 pF1KE4 ALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGV . ...:.. : ..: :: .: .. .:..:.: :. .: . .:::::: .::.:: . NP_003 SNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHI 410 420 430 440 450 460 470 480 490 500 510 520 pF1KE4 SSTASRLGSILSPYFVY-LGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQ- :. .:.:..:..:: : :: ...: : .... :.:.:::. : ::.::.. NP_003 CSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEA 470 480 490 500 510 520 530 540 550 pF1KE4 --MLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF : : . :.. NP_003 ENMQRPRKNKEKMIYLQVQKLDIPLN 530 540 550 >>NP_003048 (OMIM: 602607) solute carrier family 22 memb (554 aa) initn: 883 init1: 332 opt: 994 Z-score: 1148.3 bits: 222.3 E(85289): 3.2e-57 Smith-Waterman score: 994; 35.6% identity (64.4% similar) in 567 aa overlap (1-550:1-552) 10 20 30 40 50 pF1KE4 MRDYDEVTAFLGEWGPFQR---LIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAAN : :.. .:: : ::. ::. ::::.. : .:. ::: ::.:.:. : .:. NP_003 MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPI-CVGI--VFLGFTPDHHCQSPGVAE 10 20 30 40 50 60 70 80 90 100 pF1KE4 LSS--AWR-----NHTVPLRLRDGREVPHSCRRYRLATIANFSALG-LEPGRDV--DLGQ ::. .: :.::: :. .::::.. : :::. ..: .. . .. NP_003 LSQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVD--WNQSALSCVDPLASLATNRSH 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 LEQESCPDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRF : : ::: . :. :.::::.:::: :.:: : : . .: :.::. : ..::: NP_003 LPLGPCQDGWVY--DTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRF 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 GRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVR ::: :. :. ... . :. :: :. .... .: :. . .:..:...: ::..:.. : NP_003 GRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSR 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 IIFSTLGVCIFYAF--GYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLI :... .:: : ..: .:: . :: : .:...: : . .: .:::::::. NP_003 ---RTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 SQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTI :: : :: :. . :. :: . :. . : .:.. : : .. ::.:: .: :. NP_003 SQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEK--LSPSFADLFRTPRLRKRTF 300 310 320 330 340 350 360 370 380 390 400 pF1KE4 MSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMAT . ..::.: :: : :: : :..... . ::.::.:. .: . .. . : : :: NP_003 ILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAM 350 360 370 380 390 400 410 420 430 440 450 460 pF1KE4 ALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGV . .:.:.. : : .. :::..: ... ::..:.: :..:. . .:::::: :::.:: : NP_003 SNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMV 410 420 430 440 450 460 470 480 490 500 510 520 pF1KE4 SSTASRLGSILSPYFVY-LGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQM :. .:.:..:..:. : . :: ::.. : .:.: .::.:::. :. ::.: : NP_003 CSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPET---M 470 480 490 500 510 520 530 540 550 pF1KE4 LRVKGMKHRKTPS-HTRMLKDGQERPTILKSTAF .... .. :. .: .:: .:. NP_003 KDAENLGRKAKPKENTIYLKVQTSEPSGT 530 540 550 557 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:16:49 2016 done: Sun Nov 6 00:16:51 2016 Total Scan time: 9.850 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]