FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3906, 459 aa 1>>>pF1KE3906 459 - 459 aa - 459 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8642+/-0.000587; mu= 10.8873+/- 0.036 mean_var=206.6908+/-48.646, 0's: 0 Z-trim(111.9): 555 B-trim: 1306 in 2/52 Lambda= 0.089210 statistics sampled from 19992 (20685) to 19992 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.593), E-opt: 0.2 (0.243), width: 16 Scan time: 8.240 The best scores are: opt bits E(85289) NP_001813 (OMIM: 118423,604356) N-chimaerin isofor ( 459) 3090 411.4 2.5e-114 XP_016867211 (OMIM: 602857) PREDICTED: beta-chimae ( 500) 2321 312.5 1.6e-84 XP_016867210 (OMIM: 602857) PREDICTED: beta-chimae ( 575) 2321 312.6 1.8e-84 NP_001280001 (OMIM: 602857) beta-chimaerin isoform ( 453) 2319 312.2 1.9e-84 NP_004058 (OMIM: 602857) beta-chimaerin isoform 2 ( 468) 2319 312.2 1.9e-84 XP_011513409 (OMIM: 602857) PREDICTED: beta-chimae ( 494) 2319 312.2 2e-84 NP_001279998 (OMIM: 602857) beta-chimaerin isoform ( 543) 2319 312.3 2.1e-84 XP_011513407 (OMIM: 602857) PREDICTED: beta-chimae ( 569) 2319 312.3 2.1e-84 NP_001279999 (OMIM: 602857) beta-chimaerin isoform ( 481) 2311 311.2 3.9e-84 XP_011513408 (OMIM: 602857) PREDICTED: beta-chimae ( 556) 2311 311.3 4.3e-84 NP_001280000 (OMIM: 602857) beta-chimaerin isoform ( 433) 2138 288.9 1.9e-77 NP_001193531 (OMIM: 118423,604356) N-chimaerin iso ( 334) 1861 253.1 8.5e-67 NP_001020372 (OMIM: 118423,604356) N-chimaerin iso ( 433) 1700 232.5 1.7e-60 NP_001035025 (OMIM: 602857) beta-chimaerin isoform ( 332) 1499 206.5 9e-53 NP_001280002 (OMIM: 602857) beta-chimaerin isoform ( 287) 1413 195.3 1.8e-49 NP_001280010 (OMIM: 602857) beta-chimaerin isoform ( 261) 1405 194.3 3.4e-49 NP_001280005 (OMIM: 602857) beta-chimaerin isoform ( 274) 847 122.5 1.5e-27 NP_001280009 (OMIM: 602857) beta-chimaerin isoform ( 286) 835 120.9 4.4e-27 NP_001280008 (OMIM: 602857) beta-chimaerin isoform ( 197) 820 118.8 1.3e-26 NP_001280004 (OMIM: 602857) beta-chimaerin isoform ( 241) 749 109.8 8.4e-24 NP_001280006 (OMIM: 602857) beta-chimaerin isoform ( 260) 677 100.6 5.4e-21 XP_011519925 (OMIM: 604875) PREDICTED: unconventio (1737) 480 76.3 7.5e-13 XP_016877719 (OMIM: 604875) PREDICTED: unconventio (2547) 480 76.5 9.5e-13 NP_008832 (OMIM: 604875) unconventional myosin-IXa (2548) 480 76.5 9.5e-13 XP_011519924 (OMIM: 604875) PREDICTED: unconventio (2566) 480 76.5 9.5e-13 XP_016877718 (OMIM: 604875) PREDICTED: unconventio (2566) 480 76.5 9.5e-13 XP_011519923 (OMIM: 604875) PREDICTED: unconventio (2598) 480 76.5 9.6e-13 XP_011519922 (OMIM: 604875) PREDICTED: unconventio (2618) 480 76.5 9.6e-13 XP_016877717 (OMIM: 604875) PREDICTED: unconventio (2619) 480 76.5 9.6e-13 XP_011519921 (OMIM: 604875) PREDICTED: unconventio (2619) 480 76.5 9.6e-13 XP_006720602 (OMIM: 604875) PREDICTED: unconventio (2619) 480 76.5 9.6e-13 XP_011519920 (OMIM: 604875) PREDICTED: unconventio (2620) 480 76.5 9.6e-13 XP_011519919 (OMIM: 604875) PREDICTED: unconventio (2637) 480 76.5 9.7e-13 XP_011519916 (OMIM: 604875) PREDICTED: unconventio (2638) 480 76.5 9.7e-13 XP_011519918 (OMIM: 604875) PREDICTED: unconventio (2638) 480 76.5 9.7e-13 XP_011519917 (OMIM: 604875) PREDICTED: unconventio (2638) 480 76.5 9.7e-13 XP_011519915 (OMIM: 604875) PREDICTED: unconventio (2638) 480 76.5 9.7e-13 NP_954976 (OMIM: 610591) rho GTPase-activating pro ( 548) 465 73.7 1.4e-12 XP_011522776 (OMIM: 610591) PREDICTED: rho GTPase- ( 581) 465 73.7 1.5e-12 XP_005257185 (OMIM: 610591) PREDICTED: rho GTPase- ( 667) 465 73.8 1.6e-12 XP_016879801 (OMIM: 610591) PREDICTED: rho GTPase- ( 689) 465 73.8 1.6e-12 XP_011522774 (OMIM: 610591) PREDICTED: rho GTPase- ( 722) 465 73.8 1.7e-12 XP_011522773 (OMIM: 610591) PREDICTED: rho GTPase- ( 865) 465 73.9 1.9e-12 XP_006721810 (OMIM: 610591) PREDICTED: rho GTPase- ( 867) 465 73.9 1.9e-12 NP_001269219 (OMIM: 610591) rho GTPase-activating ( 889) 465 74.0 1.9e-12 XP_006721808 (OMIM: 610591) PREDICTED: rho GTPase- ( 889) 465 74.0 1.9e-12 XP_011522771 (OMIM: 610591) PREDICTED: rho GTPase- ( 900) 465 74.0 1.9e-12 XP_016879800 (OMIM: 610591) PREDICTED: rho GTPase- ( 922) 465 74.0 1.9e-12 XP_011522770 (OMIM: 610591) PREDICTED: rho GTPase- ( 922) 465 74.0 1.9e-12 XP_011517909 (OMIM: 609870) PREDICTED: rho GTPase- (1491) 453 72.7 7.6e-12 >>NP_001813 (OMIM: 118423,604356) N-chimaerin isoform 1 (459 aa) initn: 3090 init1: 3090 opt: 3090 Z-score: 2173.5 bits: 411.4 E(85289): 2.5e-114 Smith-Waterman score: 3090; 100.0% identity (100.0% similar) in 459 aa overlap (1-459:1-459) 10 20 30 40 50 60 pF1KE3 MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 QLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 EKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 GLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 PKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGI 370 380 390 400 410 420 430 440 450 pF1KE3 VFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF ::::::::::::::::::::::::::::::::::::::: NP_001 VFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 430 440 450 >>XP_016867211 (OMIM: 602857) PREDICTED: beta-chimaerin (500 aa) initn: 2322 init1: 1505 opt: 2321 Z-score: 1638.2 bits: 312.5 E(85289): 1.6e-84 Smith-Waterman score: 2321; 73.4% identity (91.0% similar) in 455 aa overlap (5-459:47-500) 10 20 30 pF1KE3 MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRIT : :..::.::.:::::::::::::.:.:: XP_016 VYSEPRSPRELPKSPDTQASLQFPQTDYKLLEDAEEYQPPIWKSYLYQLQQEAPRPKRII 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE3 CTCEVENRPKYYGREFHGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRN : :::::::::::::::.:::: ::.:: .::.:..:::::::: ::::::::.:: : XP_016 CPREVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLN 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE3 FRLYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLNRE .::..:::::::::::::::::::::::::::::::::::.::: ::::::.::.:: :: XP_016 YRLFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLRE 140 150 160 170 180 190 160 170 180 190 200 210 pF1KE3 PAYKKHMPVLKETHDERDSTGQDGVSEKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFR . .. . :. . . : .. .. ....::::::.: .:.. .::: ::::::::: XP_016 KVSRR-LSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFR 200 210 220 230 240 250 220 230 240 250 260 270 pF1KE3 GPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLV ::::::::::::::::::::.:.:::::::::::: :::::.::::..:::: ::::::: XP_016 GPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLV 260 270 280 290 300 310 280 290 300 310 320 330 pF1KE3 KAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYE :::.:.::::::.::::::.:::.::::::::::.. ::::::::::::::::::.:.: XP_016 KAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYP 320 330 340 350 360 370 340 350 360 370 380 390 pF1KE3 DINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETL :::::::::::::::::::.::::.: :::..::: . ::.::..::.: :::::: ::: XP_016 DINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETL 380 390 400 410 420 430 400 410 420 430 440 450 pF1KE3 RYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKN :::: :::.::..::.:.:::::::::::::::: :: .....:.:.:::.:.:..::.: XP_016 RYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIEN 440 450 460 470 480 490 pF1KE3 EDILF ::.:: XP_016 EDVLF 500 >>XP_016867210 (OMIM: 602857) PREDICTED: beta-chimaerin (575 aa) initn: 2322 init1: 1505 opt: 2321 Z-score: 1637.5 bits: 312.6 E(85289): 1.8e-84 Smith-Waterman score: 2321; 73.4% identity (91.0% similar) in 455 aa overlap (5-459:122-575) 10 20 30 pF1KE3 MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRIT : :..::.::.:::::::::::::.:.:: XP_016 IYSEPRSPRELPKSPDTQASLQFPQTDYKLLEDAEEYQPPIWKSYLYQLQQEAPRPKRII 100 110 120 130 140 150 40 50 60 70 80 90 pF1KE3 CTCEVENRPKYYGREFHGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRN : :::::::::::::::.:::: ::.:: .::.:..:::::::: ::::::::.:: : XP_016 CPREVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLN 160 170 180 190 200 210 100 110 120 130 140 150 pF1KE3 FRLYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLNRE .::..:::::::::::::::::::::::::::::::::::.::: ::::::.::.:: :: XP_016 YRLFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLRE 220 230 240 250 260 270 160 170 180 190 200 210 pF1KE3 PAYKKHMPVLKETHDERDSTGQDGVSEKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFR . .. . :. . . : .. .. ....::::::.: .:.. .::: ::::::::: XP_016 KVSRR-LSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFR 280 290 300 310 320 330 220 230 240 250 260 270 pF1KE3 GPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLV ::::::::::::::::::::.:.:::::::::::: :::::.::::..:::: ::::::: XP_016 GPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLV 340 350 360 370 380 390 280 290 300 310 320 330 pF1KE3 KAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYE :::.:.::::::.::::::.:::.::::::::::.. ::::::::::::::::::.:.: XP_016 KAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYP 400 410 420 430 440 450 340 350 360 370 380 390 pF1KE3 DINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETL :::::::::::::::::::.::::.: :::..::: . ::.::..::.: :::::: ::: XP_016 DINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETL 460 470 480 490 500 510 400 410 420 430 440 450 pF1KE3 RYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKN :::: :::.::..::.:.:::::::::::::::: :: .....:.:.:::.:.:..::.: XP_016 RYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIEN 520 530 540 550 560 570 pF1KE3 EDILF ::.:: XP_016 EDVLF >>NP_001280001 (OMIM: 602857) beta-chimaerin isoform 6 [ (453 aa) initn: 2320 init1: 1505 opt: 2319 Z-score: 1637.3 bits: 312.2 E(85289): 1.9e-84 Smith-Waterman score: 2319; 73.5% identity (91.2% similar) in 453 aa overlap (7-459:2-453) 10 20 30 40 50 60 pF1KE3 MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAAD :..::.::.:::::::::::::.:.:: : :::::::::::::::.:::: :: NP_001 MDAEEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKYYGREFHGIISREQAD 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 QLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDG .:: .::.:..:::::::: ::::::::.:: :.::..::::::::::::::::::::: NP_001 ELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRFESIHDLVTDG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 LITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVS ::::::::::::::.::: ::::::.::.:: :: . .. . :. . . : .. .. NP_001 LITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVSRR-LSRSKNEPRKTNVTHEEHTA 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 EKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCG ....::::::.: .:.. .::: :::::::::::::::::::::::::::::.:.::: NP_001 VEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCG 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 LNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSE ::::::::: :::::.::::..:::: ::::::::::.:.::::::.::::::.:::.:: NP_001 LNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSE 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE3 GLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAY ::::::::.. ::::::::::::::::::.:.: :::::::::::::::::::.::::.: NP_001 GLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTY 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 PKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGI :::..::: . ::.::..::.: :::::: ::::::: :::.::..::.:.:::::::: NP_001 SKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGI 360 370 380 390 400 410 430 440 450 pF1KE3 VFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF :::::::: :: .....:.:.:::.:.:..::.:::.:: NP_001 VFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF 420 430 440 450 >>NP_004058 (OMIM: 602857) beta-chimaerin isoform 2 [Hom (468 aa) initn: 2320 init1: 1505 opt: 2319 Z-score: 1637.1 bits: 312.2 E(85289): 1.9e-84 Smith-Waterman score: 2319; 73.5% identity (91.2% similar) in 453 aa overlap (7-459:17-468) 10 20 30 40 50 pF1KE3 MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREF :..::.::.:::::::::::::.:.:: : ::::::::::::: NP_004 MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKYYGREF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 HGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRF ::.:::: ::.:: .::.:..:::::::: ::::::::.:: :.::..::::::::::: NP_004 HGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 ESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDE ::::::::::::::::::::::::.::: ::::::.::.:: :: . .. . :. . NP_004 ESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVSRR-LSRSKNEPRK 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 RDSTGQDGVSEKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHWCEYCANFMWGLI . : .. .. ....::::::.: .:.. .::: ::::::::::::::::::::::::: NP_004 TNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLI 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 AQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIR ::::.:.:::::::::::: :::::.::::..:::: ::::::::::.:.::::::.::: NP_004 AQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIR 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 EIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDL :::.:::.::::::::::.. ::::::::::::::::::.:.: :::::::::::::::: NP_004 EIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDL 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 PIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKE :::.::::.: :::..::: . ::.::..::.: :::::: ::::::: :::.::..::. NP_004 PIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKD 360 370 380 390 400 410 420 430 440 450 pF1KE3 NLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF :.:::::::::::::::: :: .....:.:.:::.:.:..::.:::.:: NP_004 NFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF 420 430 440 450 460 >>XP_011513409 (OMIM: 602857) PREDICTED: beta-chimaerin (494 aa) initn: 2320 init1: 1505 opt: 2319 Z-score: 1636.9 bits: 312.2 E(85289): 2e-84 Smith-Waterman score: 2319; 73.5% identity (91.2% similar) in 453 aa overlap (7-459:43-494) 10 20 30 pF1KE3 MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCT :..::.::.:::::::::::::.:.:: : XP_011 SVSSVYSEPRSPRELPKSPDTQASLQFPQTDAEEYQPPIWKSYLYQLQQEAPRPKRIICP 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE3 CEVENRPKYYGREFHGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFR :::::::::::::::.:::: ::.:: .::.:..:::::::: ::::::::.:: :.: XP_011 REVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYR 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE3 LYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPA :..:::::::::::::::::::::::::::::::::::.::: ::::::.::.:: :: . XP_011 LFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKV 140 150 160 170 180 190 160 170 180 190 200 210 pF1KE3 YKKHMPVLKETHDERDSTGQDGVSEKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGP .. . :. . . : .. .. ....::::::.: .:.. .::: ::::::::::: XP_011 SRR-LSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGP 200 210 220 230 240 250 220 230 240 250 260 270 pF1KE3 HWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKA ::::::::::::::::::.:.:::::::::::: :::::.::::..:::: ::::::::: XP_011 HWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKA 260 270 280 290 300 310 280 290 300 310 320 330 pF1KE3 HTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDI :.:.::::::.::::::.:::.::::::::::.. ::::::::::::::::::.:.: :: XP_011 HNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDI 320 330 340 350 360 370 340 350 360 370 380 390 pF1KE3 NIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRY :::::::::::::::::.::::.: :::..::: . ::.::..::.: :::::: ::::: XP_011 NIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRY 380 390 400 410 420 430 400 410 420 430 440 450 pF1KE3 LMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNED :: :::.::..::.:.:::::::::::::::: :: .....:.:.:::.:.:..::.::: XP_011 LMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENED 440 450 460 470 480 490 pF1KE3 ILF .:: XP_011 VLF >>NP_001279998 (OMIM: 602857) beta-chimaerin isoform 3 [ (543 aa) initn: 2320 init1: 1505 opt: 2319 Z-score: 1636.4 bits: 312.3 E(85289): 2.1e-84 Smith-Waterman score: 2319; 73.5% identity (91.2% similar) in 453 aa overlap (7-459:92-543) 10 20 30 pF1KE3 MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCT :..::.::.:::::::::::::.:.:: : NP_001 FTFGKRVVFDSHCLKRQHTFADGLHSSCTSDAEEYQPPIWKSYLYQLQQEAPRPKRIICP 70 80 90 100 110 120 40 50 60 70 80 90 pF1KE3 CEVENRPKYYGREFHGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFR :::::::::::::::.:::: ::.:: .::.:..:::::::: ::::::::.:: :.: NP_001 REVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYR 130 140 150 160 170 180 100 110 120 130 140 150 pF1KE3 LYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPA :..:::::::::::::::::::::::::::::::::::.::: ::::::.::.:: :: . NP_001 LFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKV 190 200 210 220 230 240 160 170 180 190 200 210 pF1KE3 YKKHMPVLKETHDERDSTGQDGVSEKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGP .. . :. . . : .. .. ....::::::.: .:.. .::: ::::::::::: NP_001 SRR-LSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGP 250 260 270 280 290 300 220 230 240 250 260 270 pF1KE3 HWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKA ::::::::::::::::::.:.:::::::::::: :::::.::::..:::: ::::::::: NP_001 HWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKA 310 320 330 340 350 360 280 290 300 310 320 330 pF1KE3 HTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDI :.:.::::::.::::::.:::.::::::::::.. ::::::::::::::::::.:.: :: NP_001 HNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDI 370 380 390 400 410 420 340 350 360 370 380 390 pF1KE3 NIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRY :::::::::::::::::.::::.: :::..::: . ::.::..::.: :::::: ::::: NP_001 NIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRY 430 440 450 460 470 480 400 410 420 430 440 450 pF1KE3 LMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNED :: :::.::..::.:.:::::::::::::::: :: .....:.:.:::.:.:..::.::: NP_001 LMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENED 490 500 510 520 530 540 pF1KE3 ILF .:: NP_001 VLF >>XP_011513407 (OMIM: 602857) PREDICTED: beta-chimaerin (569 aa) initn: 2320 init1: 1505 opt: 2319 Z-score: 1636.2 bits: 312.3 E(85289): 2.1e-84 Smith-Waterman score: 2319; 73.5% identity (91.2% similar) in 453 aa overlap (7-459:118-569) 10 20 30 pF1KE3 MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCT :..::.::.:::::::::::::.:.:: : XP_011 SCTSIYSEPRSPRELPKSPDTQASLQFPQTDAEEYQPPIWKSYLYQLQQEAPRPKRIICP 90 100 110 120 130 140 40 50 60 70 80 90 pF1KE3 CEVENRPKYYGREFHGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFR :::::::::::::::.:::: ::.:: .::.:..:::::::: ::::::::.:: :.: XP_011 REVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYR 150 160 170 180 190 200 100 110 120 130 140 150 pF1KE3 LYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPA :..:::::::::::::::::::::::::::::::::::.::: ::::::.::.:: :: . XP_011 LFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKV 210 220 230 240 250 260 160 170 180 190 200 210 pF1KE3 YKKHMPVLKETHDERDSTGQDGVSEKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGP .. . :. . . : .. .. ....::::::.: .:.. .::: ::::::::::: XP_011 SRR-LSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGP 270 280 290 300 310 320 220 230 240 250 260 270 pF1KE3 HWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKA ::::::::::::::::::.:.:::::::::::: :::::.::::..:::: ::::::::: XP_011 HWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKA 330 340 350 360 370 380 280 290 300 310 320 330 pF1KE3 HTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDI :.:.::::::.::::::.:::.::::::::::.. ::::::::::::::::::.:.: :: XP_011 HNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDI 390 400 410 420 430 440 340 350 360 370 380 390 pF1KE3 NIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRY :::::::::::::::::.::::.: :::..::: . ::.::..::.: :::::: ::::: XP_011 NIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRY 450 460 470 480 490 500 400 410 420 430 440 450 pF1KE3 LMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNED :: :::.::..::.:.:::::::::::::::: :: .....:.:.:::.:.:..::.::: XP_011 LMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENED 510 520 530 540 550 560 pF1KE3 ILF .:: XP_011 VLF >>NP_001279999 (OMIM: 602857) beta-chimaerin isoform 4 [ (481 aa) initn: 2312 init1: 1505 opt: 2311 Z-score: 1631.4 bits: 311.2 E(85289): 3.9e-84 Smith-Waterman score: 2311; 73.6% identity (91.1% similar) in 451 aa overlap (9-459:32-481) 10 20 30 pF1KE3 MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCE .::.::.:::::::::::::.:.:: : : NP_001 AASSNSSLSGSSVSSVYSEPRSPRELPKYAEEYQPPIWKSYLYQLQQEAPRPKRIICPRE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 VENRPKYYGREFHGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLY ::::::::::::::.:::: ::.:: .::.:..:::::::: ::::::::.:: :.::. NP_001 VENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLF 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 YDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYK .:::::::::::::::::::::::::::::::::::.::: ::::::.::.:: :: . . NP_001 HDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVSR 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 KHMPVLKETHDERDSTGQDGVSEKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHW . . :. . . : .. .. ....::::::.: .:.. .::: ::::::::::::: NP_001 R-LSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHW 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 CEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHT ::::::::::::::::.:.:::::::::::: :::::.::::..:::: ::::::::::. NP_001 CEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHN 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 TKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINI :.::::::.::::::.:::.::::::::::.. ::::::::::::::::::.:.: :::: NP_001 TQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINI 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 ITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLM :::::::::::::::.::::.: :::..::: . ::.::..::.: :::::: ::::::: NP_001 ITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLM 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE3 AHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDIL :::.::..::.:.:::::::::::::::: :: .....:.:.:::.:.:..::.:::.: NP_001 IHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVL 430 440 450 460 470 480 pF1KE3 F : NP_001 F >>XP_011513408 (OMIM: 602857) PREDICTED: beta-chimaerin (556 aa) initn: 2312 init1: 1505 opt: 2311 Z-score: 1630.8 bits: 311.3 E(85289): 4.3e-84 Smith-Waterman score: 2311; 73.6% identity (91.1% similar) in 451 aa overlap (9-459:107-556) 10 20 30 pF1KE3 MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCE .::.::.:::::::::::::.:.:: : : XP_011 RQHTFADGLHSSCTSIYSEPRSPRELPKYAEEYQPPIWKSYLYQLQQEAPRPKRIICPRE 80 90 100 110 120 130 40 50 60 70 80 90 pF1KE3 VENRPKYYGREFHGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLY ::::::::::::::.:::: ::.:: .::.:..:::::::: ::::::::.:: :.::. XP_011 VENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLF 140 150 160 170 180 190 100 110 120 130 140 150 pF1KE3 YDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYK .:::::::::::::::::::::::::::::::::::.::: ::::::.::.:: :: . . XP_011 HDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVSR 200 210 220 230 240 250 160 170 180 190 200 210 pF1KE3 KHMPVLKETHDERDSTGQDGVSEKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHW . . :. . . : .. .. ....::::::.: .:.. .::: ::::::::::::: XP_011 R-LSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHW 260 270 280 290 300 310 220 230 240 250 260 270 pF1KE3 CEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHT ::::::::::::::::.:.:::::::::::: :::::.::::..:::: ::::::::::. XP_011 CEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHN 320 330 340 350 360 370 280 290 300 310 320 330 pF1KE3 TKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINI :.::::::.::::::.:::.::::::::::.. ::::::::::::::::::.:.: :::: XP_011 TQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINI 380 390 400 410 420 430 340 350 360 370 380 390 pF1KE3 ITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLM :::::::::::::::.::::.: :::..::: . ::.::..::.: :::::: ::::::: XP_011 ITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLM 440 450 460 470 480 490 400 410 420 430 440 450 pF1KE3 AHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDIL :::.::..::.:.:::::::::::::::: :: .....:.:.:::.:.:..::.:::.: XP_011 IHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVL 500 510 520 530 540 550 pF1KE3 F : XP_011 F 459 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 09:04:51 2016 done: Sun Nov 6 09:04:53 2016 Total Scan time: 8.240 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]