FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6303, 347 aa 1>>>pF1KE6303 347 - 347 aa - 347 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7513+/-0.000353; mu= 19.1504+/- 0.022 mean_var=59.5744+/-11.943, 0's: 0 Z-trim(114.1): 17 B-trim: 284 in 2/48 Lambda= 0.166167 statistics sampled from 23800 (23808) to 23800 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.279), width: 16 Scan time: 7.240 The best scores are: opt bits E(85289) NP_839952 (OMIM: 601385,611093) tumor suppressor c ( 347) 2342 569.7 3.2e-162 NP_006756 (OMIM: 601385,611093) tumor suppressor c ( 348) 2318 564.0 1.7e-160 XP_011542954 (OMIM: 601385,611093) PREDICTED: tumo ( 292) 1952 476.2 3.9e-134 XP_016869350 (OMIM: 601385,611093) PREDICTED: tumo ( 292) 1952 476.2 3.9e-134 XP_011542953 (OMIM: 601385,611093) PREDICTED: tumo ( 303) 1947 475.0 9.1e-134 XP_016869349 (OMIM: 601385,611093) PREDICTED: tumo ( 305) 1947 475.0 9.2e-134 XP_011542956 (OMIM: 601385,611093) PREDICTED: tumo ( 258) 1743 426.1 4.2e-119 NP_115497 (OMIM: 300715,300853) magnesium transpor ( 367) 1643 402.2 9.2e-112 >>NP_839952 (OMIM: 601385,611093) tumor suppressor candi (347 aa) initn: 2342 init1: 2342 opt: 2342 Z-score: 3033.4 bits: 569.7 E(85289): 3.2e-162 Smith-Waterman score: 2342; 100.0% identity (100.0% similar) in 347 aa overlap (1-347:1-347) 10 20 30 40 50 60 pF1KE6 MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_839 MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 SRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_839 SRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 AFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_839 AFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 WIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_839 WIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 AMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_839 AMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNE 250 260 270 280 290 300 310 320 330 340 pF1KE6 AATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSFLIK ::::::::::::::::::::::::::::::::::::::::::::::: NP_839 AATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSFLIK 310 320 330 340 >>NP_006756 (OMIM: 601385,611093) tumor suppressor candi (348 aa) initn: 2318 init1: 2318 opt: 2318 Z-score: 3002.3 bits: 564.0 E(85289): 1.7e-160 Smith-Waterman score: 2318; 100.0% identity (100.0% similar) in 343 aa overlap (1-343:1-343) 10 20 30 40 50 60 pF1KE6 MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 SRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 AFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 WIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 WIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 AMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNE 250 260 270 280 290 300 310 320 330 340 pF1KE6 AATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSFLIK ::::::::::::::::::::::::::::::::::::::::::: NP_006 AATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSDLDFE 310 320 330 340 >>XP_011542954 (OMIM: 601385,611093) PREDICTED: tumor su (292 aa) initn: 1952 init1: 1952 opt: 1952 Z-score: 2529.2 bits: 476.2 E(85289): 3.9e-134 Smith-Waterman score: 1952; 100.0% identity (100.0% similar) in 287 aa overlap (57-343:1-287) 30 40 50 60 70 80 pF1KE6 FLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSM :::::::::::::::::::::::::::::: XP_011 MEWSSRRSIFRMNGDKFRKFIKAPPRNYSM 10 20 30 90 100 110 120 130 140 pF1KE6 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE6 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE6 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE6 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF 220 230 240 250 260 270 330 340 pF1KE6 SFLLSIFRSKYHGYPYSFLIK ::::::::::::::::: XP_011 SFLLSIFRSKYHGYPYSDLDFE 280 290 >>XP_016869350 (OMIM: 601385,611093) PREDICTED: tumor su (292 aa) initn: 1952 init1: 1952 opt: 1952 Z-score: 2529.2 bits: 476.2 E(85289): 3.9e-134 Smith-Waterman score: 1952; 100.0% identity (100.0% similar) in 287 aa overlap (57-343:1-287) 30 40 50 60 70 80 pF1KE6 FLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSM :::::::::::::::::::::::::::::: XP_016 MEWSSRRSIFRMNGDKFRKFIKAPPRNYSM 10 20 30 90 100 110 120 130 140 pF1KE6 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE6 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE6 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE6 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF 220 230 240 250 260 270 330 340 pF1KE6 SFLLSIFRSKYHGYPYSFLIK ::::::::::::::::: XP_016 SFLLSIFRSKYHGYPYSDLDFE 280 290 >>XP_011542953 (OMIM: 601385,611093) PREDICTED: tumor su (303 aa) initn: 1947 init1: 1947 opt: 1947 Z-score: 2522.5 bits: 475.0 E(85289): 9.1e-134 Smith-Waterman score: 1947; 100.0% identity (100.0% similar) in 286 aa overlap (57-342:1-286) 30 40 50 60 70 80 pF1KE6 FLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSM :::::::::::::::::::::::::::::: XP_011 MEWSSRRSIFRMNGDKFRKFIKAPPRNYSM 10 20 30 90 100 110 120 130 140 pF1KE6 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE6 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE6 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE6 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF 220 230 240 250 260 270 330 340 pF1KE6 SFLLSIFRSKYHGYPYSFLIK :::::::::::::::: XP_011 SFLLSIFRSKYHGYPYREKSSDKNVYQKTDTWS 280 290 300 >>XP_016869349 (OMIM: 601385,611093) PREDICTED: tumor su (305 aa) initn: 1947 init1: 1947 opt: 1947 Z-score: 2522.5 bits: 475.0 E(85289): 9.2e-134 Smith-Waterman score: 1947; 100.0% identity (100.0% similar) in 286 aa overlap (57-342:1-286) 30 40 50 60 70 80 pF1KE6 FLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSM :::::::::::::::::::::::::::::: XP_016 MEWSSRRSIFRMNGDKFRKFIKAPPRNYSM 10 20 30 90 100 110 120 130 140 pF1KE6 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE6 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE6 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE6 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF 220 230 240 250 260 270 330 340 pF1KE6 SFLLSIFRSKYHGYPYSFLIK :::::::::::::::: XP_016 SFLLSIFRSKYHGYPYRHAVVLTVKSSVWRKYIHP 280 290 300 >>XP_011542956 (OMIM: 601385,611093) PREDICTED: tumor su (258 aa) initn: 1743 init1: 1743 opt: 1743 Z-score: 2259.2 bits: 426.1 E(85289): 4.2e-119 Smith-Waterman score: 1743; 100.0% identity (100.0% similar) in 256 aa overlap (57-312:1-256) 30 40 50 60 70 80 pF1KE6 FLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSM :::::::::::::::::::::::::::::: XP_011 MEWSSRRSIFRMNGDKFRKFIKAPPRNYSM 10 20 30 90 100 110 120 130 140 pF1KE6 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE6 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE6 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE6 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF :::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRTF 220 230 240 250 330 340 pF1KE6 SFLLSIFRSKYHGYPYSFLIK >>NP_115497 (OMIM: 300715,300853) magnesium transporter (367 aa) initn: 1633 init1: 1633 opt: 1643 Z-score: 2127.5 bits: 402.2 E(85289): 9.2e-112 Smith-Waterman score: 1643; 69.1% identity (93.8% similar) in 324 aa overlap (24-346:43-366) 10 20 30 40 50 pF1KE6 MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLC-IQLGGGQKKKENLLAEK : ... ::..: . ...:.::: .:.:: NP_115 RPTLRPSRSKVSLIEGRGANMAARWRFWCVSVTMVVALLIVCDVPSASAQRKKEMVLSEK 20 30 40 50 60 70 60 70 80 90 100 110 pF1KE6 VEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQIL : :::::...: ..::::::::...::::::::.:::::::: .::: ::.::.::.::: NP_115 VSQLMEWTNKRPVIRMNGDKFRRLVKAPPRNYSVIVMFTALQLHRQCVVCKQADEEFQIL 80 90 100 110 120 130 120 130 140 150 160 170 pF1KE6 ANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIG :::::::::: :..::.:::.:::.::::.:::::::::..:: ::.:::.::..:: : NP_115 ANSWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFINFPAKGKPKRGDTYELQVRG 140 150 160 170 180 190 180 190 200 210 220 230 pF1KE6 FAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWA :.:::.:.::::::::.:::.:::::.: . :.::....:::.::::.:.::..:::::: NP_115 FSAEQIARWIADRTDVNIRVIRPPNYAGPLMLGLLLAVIGGLVYLRRSNMEFLFNKTGWA 200 210 220 230 240 250 240 250 260 270 280 290 pF1KE6 MVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAIT ...::.:.::::::::::::::::::::::.:.:.:::::::::::::.::.:..:...: NP_115 FAALCFVLAMTSGQMWNHIRGPPYAHKNPHTGHVNYIHGSSQAQFVAETHIVLLFNGGVT 260 270 280 290 300 310 300 310 320 330 340 pF1KE6 MGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSFLIK .::::: ::::: :.:::.:.:..:.::::.:::..::::::::::::::::. NP_115 LGMVLLCEAATSDMDIGKRKIMCVAGIGLVVLFFSWMLSIFRSKYHGYPYSFLMS 320 330 340 350 360 347 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:54:39 2016 done: Tue Nov 8 11:54:40 2016 Total Scan time: 7.240 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]