FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0897, 255 aa 1>>>pF1KE0897 255 - 255 aa - 255 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8244+/-0.000412; mu= 7.8591+/- 0.026 mean_var=115.9732+/-23.076, 0's: 0 Z-trim(114.2): 80 B-trim: 543 in 2/52 Lambda= 0.119096 statistics sampled from 23832 (23907) to 23832 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.28), width: 16 Scan time: 5.720 The best scores are: opt bits E(85289) NP_005810 (OMIM: 603944) syntaxin-6 isoform 1 [Hom ( 255) 1622 289.5 3.9e-78 XP_011507360 (OMIM: 603944) PREDICTED: syntaxin-6 ( 271) 1464 262.4 6.2e-70 NP_003756 (OMIM: 603765) syntaxin-10 isoform 1 [Ho ( 249) 1000 182.6 5.7e-46 XP_016855496 (OMIM: 603944) PREDICTED: syntaxin-6 ( 154) 970 177.3 1.4e-44 NP_001273139 (OMIM: 603944) syntaxin-6 isoform 2 [ ( 154) 970 177.3 1.4e-44 NP_001258539 (OMIM: 603765) syntaxin-10 isoform 3 ( 246) 879 161.8 1e-39 XP_016855495 (OMIM: 603944) PREDICTED: syntaxin-6 ( 170) 812 150.2 2.2e-36 XP_011507361 (OMIM: 603944) PREDICTED: syntaxin-6 ( 170) 812 150.2 2.2e-36 NP_001258538 (OMIM: 603765) syntaxin-10 isoform 2 ( 220) 744 138.6 9e-33 XP_011526699 (OMIM: 603765) PREDICTED: syntaxin-10 ( 131) 533 102.2 4.9e-22 NP_001258540 (OMIM: 603765) syntaxin-10 isoform 4 ( 200) 477 92.7 5.4e-19 NP_004844 (OMIM: 604203) syntaxin-8 [Homo sapiens] ( 236) 181 41.9 0.0013 XP_011522381 (OMIM: 604203) PREDICTED: syntaxin-8 ( 181) 179 41.5 0.0013 >>NP_005810 (OMIM: 603944) syntaxin-6 isoform 1 [Homo sa (255 aa) initn: 1622 init1: 1622 opt: 1622 Z-score: 1523.7 bits: 289.5 E(85289): 3.9e-78 Smith-Waterman score: 1622; 100.0% identity (100.0% similar) in 255 aa overlap (1-255:1-255) 10 20 30 40 50 60 pF1KE0 MSMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MSMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 QALLGDSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QALLGDSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GVLKNMSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GVLKNMSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAI 190 200 210 220 230 240 250 pF1KE0 LFAVLLVVLILFLVL ::::::::::::::: NP_005 LFAVLLVVLILFLVL 250 >>XP_011507360 (OMIM: 603944) PREDICTED: syntaxin-6 isof (271 aa) initn: 1464 init1: 1464 opt: 1464 Z-score: 1376.6 bits: 262.4 E(85289): 6.2e-70 Smith-Waterman score: 1464; 100.0% identity (100.0% similar) in 230 aa overlap (1-230:1-230) 10 20 30 40 50 60 pF1KE0 MSMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 QALLGDSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QALLGDSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GVLKNMSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAI :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVLKNMSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSVLEAVAFDQA 190 200 210 220 230 240 250 pF1KE0 LFAVLLVVLILFLVL XP_011 WDQEVRPALRHQPKDPLNLPSPPANKGTSRC 250 260 270 >>NP_003756 (OMIM: 603765) syntaxin-10 isoform 1 [Homo s (249 aa) initn: 1042 init1: 551 opt: 1000 Z-score: 946.2 bits: 182.6 E(85289): 5.7e-46 Smith-Waterman score: 1000; 61.2% identity (84.7% similar) in 255 aa overlap (1-255:1-249) 10 20 30 40 50 60 pF1KE0 MSMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWD ::.:::::::.::::::::::.::.::: ::::. ... :::.:::::::::.::::::: NP_003 MSLEDPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNR ::::.:::.:::::: ::.: : .:. ::.:. :..:..:::.: . .. :. ::.:: NP_003 LEDLEETIGIVEANPGKFKLPAGDLQERKVFVERMREAVQEMKDHMVSPTAVAFLERNNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 QALLGDSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSI . : : ..:. . .: :: :.:..:::::: ::::...::.:::.::::: NP_003 EILAGKPAAQK---SPSDL---LDASAVSATSRYIEEQQATQQLIMDEQDQQLEMVSGSI 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 GVLKNMSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAI :::.:: :.: ::.::..::. :..:.. ::::.:.:..:::::::::::::::::::. NP_003 QVLKHMSGRVGEELDEQGIMLDAFAQEMDHTQSRMDGVLRKLAKVSHMTSDRRQWCAIAV 180 190 200 210 220 230 250 pF1KE0 LFAVLLVVLILFLVL : .:::.::::.. : NP_003 LVGVLLLVLILLFSL 240 >>XP_016855496 (OMIM: 603944) PREDICTED: syntaxin-6 isof (154 aa) initn: 970 init1: 970 opt: 970 Z-score: 921.4 bits: 177.3 E(85289): 1.4e-44 Smith-Waterman score: 970; 100.0% identity (100.0% similar) in 154 aa overlap (102-255:1-154) 80 90 100 110 120 130 pF1KE0 EANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNRQALLGDSGSQN :::::::::::::::::::::::::::::: XP_016 MKDQMSTSSVQALAERKNRQALLGDSGSQN 10 20 30 140 150 160 170 180 190 pF1KE0 WSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIG 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE0 GELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAILFAVLLVVLIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAILFAVLLVVLIL 100 110 120 130 140 150 pF1KE0 FLVL :::: XP_016 FLVL >>NP_001273139 (OMIM: 603944) syntaxin-6 isoform 2 [Homo (154 aa) initn: 970 init1: 970 opt: 970 Z-score: 921.4 bits: 177.3 E(85289): 1.4e-44 Smith-Waterman score: 970; 100.0% identity (100.0% similar) in 154 aa overlap (102-255:1-154) 80 90 100 110 120 130 pF1KE0 EANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNRQALLGDSGSQN :::::::::::::::::::::::::::::: NP_001 MKDQMSTSSVQALAERKNRQALLGDSGSQN 10 20 30 140 150 160 170 180 190 pF1KE0 WSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIG 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE0 GELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAILFAVLLVVLIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAILFAVLLVVLIL 100 110 120 130 140 150 pF1KE0 FLVL :::: NP_001 FLVL >>NP_001258539 (OMIM: 603765) syntaxin-10 isoform 3 [Hom (246 aa) initn: 891 init1: 549 opt: 879 Z-score: 834.0 bits: 161.8 E(85289): 1e-39 Smith-Waterman score: 879; 60.0% identity (83.9% similar) in 230 aa overlap (1-230:1-224) 10 20 30 40 50 60 pF1KE0 MSMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWD ::.:::::::.::::::::::.::.::: ::::. ... :::.:::::::::.::::::: NP_001 MSLEDPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNR ::::.:::.:::::: ::.: : .:. ::.:. :..:..:::.: . .. :. ::.:: NP_001 LEDLEETIGIVEANPGKFKLPAGDLQERKVFVERMREAVQEMKDHMVSPTAVAFLERNNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 QALLGDSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSI . : : ..:. . .: :: :.:..:::::: ::::...::.:::.::::: NP_001 EILAGKPAAQK---SPSDL---LDASAVSATSRYIEEQQATQQLIMDEQDQQLEMVSGSI 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 GVLKNMSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAI :::.:: :.: ::.::..::. :..:.. ::::.:.:..:::::::::: NP_001 QVLKHMSGRVGEELDEQGIMLDAFAQEMDHTQSRMDGVLRKLAKVSHMTSGESPQGRGQS 180 190 200 210 220 230 250 pF1KE0 LFAVLLVVLILFLVL NP_001 WWGQVVGGTLSP 240 >>XP_016855495 (OMIM: 603944) PREDICTED: syntaxin-6 isof (170 aa) initn: 812 init1: 812 opt: 812 Z-score: 774.1 bits: 150.2 E(85289): 2.2e-36 Smith-Waterman score: 812; 100.0% identity (100.0% similar) in 129 aa overlap (102-230:1-129) 80 90 100 110 120 130 pF1KE0 EANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNRQALLGDSGSQN :::::::::::::::::::::::::::::: XP_016 MKDQMSTSSVQALAERKNRQALLGDSGSQN 10 20 30 140 150 160 170 180 190 pF1KE0 WSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIG 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE0 GELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAILFAVLLVVLIL ::::::::::::::::::::::::::::::::::::::: XP_016 GELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSVLEAVAFDQAWDQEVRPALRH 100 110 120 130 140 150 pF1KE0 FLVL XP_016 QPKDPLNLPSPPANKGTSRC 160 170 >>XP_011507361 (OMIM: 603944) PREDICTED: syntaxin-6 isof (170 aa) initn: 812 init1: 812 opt: 812 Z-score: 774.1 bits: 150.2 E(85289): 2.2e-36 Smith-Waterman score: 812; 100.0% identity (100.0% similar) in 129 aa overlap (102-230:1-129) 80 90 100 110 120 130 pF1KE0 EANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNRQALLGDSGSQN :::::::::::::::::::::::::::::: XP_011 MKDQMSTSSVQALAERKNRQALLGDSGSQN 10 20 30 140 150 160 170 180 190 pF1KE0 WSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIG 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE0 GELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAILFAVLLVVLIL ::::::::::::::::::::::::::::::::::::::: XP_011 GELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSVLEAVAFDQAWDQEVRPALRH 100 110 120 130 140 150 pF1KE0 FLVL XP_011 QPKDPLNLPSPPANKGTSRC 160 170 >>NP_001258538 (OMIM: 603765) syntaxin-10 isoform 2 [Hom (220 aa) initn: 756 init1: 549 opt: 744 Z-score: 709.3 bits: 138.6 E(85289): 9e-33 Smith-Waterman score: 744; 59.2% identity (81.6% similar) in 201 aa overlap (1-201:1-195) 10 20 30 40 50 60 pF1KE0 MSMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWD ::.:::::::.::::::::::.::.::: ::::. ... :::.:::::::::.::::::: NP_001 MSLEDPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNR ::::.:::.:::::: ::.: : .:. ::.:. :..:..:::.: . .. :. ::.:: NP_001 LEDLEETIGIVEANPGKFKLPAGDLQERKVFVERMREAVQEMKDHMVSPTAVAFLERNNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 QALLGDSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSI . : : ..:. . .: :: :.:..:::::: ::::...::.:::.::::: NP_001 EILAGKPAAQK---SPSDL---LDASAVSATSRYIEEQQATQQLIMDEQDQQLEMVSGSI 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 GVLKNMSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAI :::.:: :.: ::.::: . NP_001 QVLKHMSGRVGEELDEQACWMPSPKRWTTPSPAWTGSSGSWPKYPT 180 190 200 210 220 >>XP_011526699 (OMIM: 603765) PREDICTED: syntaxin-10 iso (131 aa) initn: 533 init1: 533 opt: 533 Z-score: 516.7 bits: 102.2 E(85289): 4.9e-22 Smith-Waterman score: 533; 65.3% identity (88.4% similar) in 121 aa overlap (1-121:1-121) 10 20 30 40 50 60 pF1KE0 MSMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWD ::.:::::::.::::::::::.::.::: ::::. ... :::.:::::::::.::::::: XP_011 MSLEDPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNR ::::.:::.:::::: ::.: : .:. ::.:. :..:..:::.: . .. :. ::.:: XP_011 LEDLEETIGIVEANPGKFKLPAGDLQERKVFVERMREAVQEMKDHMVSPTAVAFLERNNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 QALLGDSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSI . XP_011 EMRKLRHKEAK 130 255 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 02:00:19 2016 done: Mon Nov 7 02:00:20 2016 Total Scan time: 5.720 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]