FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6709, 713 aa 1>>>pF1KE6709 713 - 713 aa - 713 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2506+/-0.000397; mu= 20.0010+/- 0.025 mean_var=72.6971+/-14.727, 0's: 0 Z-trim(111.7): 21 B-trim: 1012 in 1/53 Lambda= 0.150423 statistics sampled from 20307 (20322) to 20307 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.238), width: 16 Scan time: 6.080 The best scores are: opt bits E(85289) NP_005923 (OMIM: 602241) mitochondrial intermediat ( 713) 4791 1049.8 0 XP_011533399 (OMIM: 602241) PREDICTED: mitochondri ( 651) 4360 956.2 0 XP_011533400 (OMIM: 602241) PREDICTED: mitochondri ( 621) 4124 905.0 0 XP_011526530 (OMIM: 601117) PREDICTED: thimet olig ( 480) 644 149.7 2.6e-35 NP_003240 (OMIM: 601117) thimet oligopeptidase [Ho ( 689) 644 149.8 3.4e-35 XP_006714724 (OMIM: 611530) PREDICTED: neurolysin, ( 681) 631 147.0 2.4e-34 NP_065777 (OMIM: 611530) neurolysin, mitochondrial ( 704) 631 147.0 2.5e-34 XP_016865162 (OMIM: 611530) PREDICTED: neurolysin, ( 663) 288 72.5 6e-12 XP_005248616 (OMIM: 611530) PREDICTED: neurolysin, ( 686) 288 72.5 6.2e-12 >>NP_005923 (OMIM: 602241) mitochondrial intermediate pe (713 aa) initn: 4791 init1: 4791 opt: 4791 Z-score: 5616.4 bits: 1049.8 E(85289): 0 Smith-Waterman score: 4791; 100.0% identity (100.0% similar) in 713 aa overlap (1-713:1-713) 10 20 30 40 50 60 pF1KE6 MLCVGRLGGLGARAAALPPRRAGRGSLEAGIRARRVSTSWSPVGAAFNVKPQGSRLDLFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MLCVGRLGGLGARAAALPPRRAGRGSLEAGIRARRVSTSWSPVGAAFNVKPQGSRLDLFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ERRGLFGVPELSAPEGFHIAQEKALRKTELLVDRACSTPPGPQTVLIFDELSDSLCRVAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ERRGLFGVPELSAPEGFHIAQEKALRKTELLVDRACSTPPGPQTVLIFDELSDSLCRVAD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 LADFVKIAHPEPAFREAAEEACRSIGTMVEKLNTNVDLYQSLQKLLADKKLVDSLDPETR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LADFVKIAHPEPAFREAAEEACRSIGTMVEKLNTNVDLYQSLQKLLADKKLVDSLDPETR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 RVAELFMFDFEISGIHLDKEKRKRAVDLNVKILDLSSTFLMGTNFPNKIEKHLLPEHIRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RVAELFMFDFEISGIHLDKEKRKRAVDLNVKILDLSSTFLMGTNFPNKIEKHLLPEHIRR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 NFTSAGDHIIIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NFTSAGDHIIIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 FSHRALQGTIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQNSEVMPWDPPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FSHRALQGTIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQNSEVMPWDPPY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 YSGVIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YSGVIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 AVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 SPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 NQFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NQFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDIL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 KETQEKFYGLPYVPNTAWQLRFSHLVGYGARYYSYLMSRAVASMVWKECFLQDPFNRAAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KETQEKFYGLPYVPNTAWQLRFSHLVGYGARYYSYLMSRAVASMVWKECFLQDPFNRAAG 610 620 630 640 650 660 670 680 690 700 710 pF1KE6 ERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE 670 680 690 700 710 >>XP_011533399 (OMIM: 602241) PREDICTED: mitochondrial i (651 aa) initn: 4360 init1: 4360 opt: 4360 Z-score: 5111.4 bits: 956.2 E(85289): 0 Smith-Waterman score: 4360; 99.8% identity (100.0% similar) in 650 aa overlap (64-713:2-651) 40 50 60 70 80 90 pF1KE6 RRVSTSWSPVGAAFNVKPQGSRLDLFGERRGLFGVPELSAPEGFHIAQEKALRKTELLVD :::::::::::::::::::::::::::::: XP_011 MGLFGVPELSAPEGFHIAQEKALRKTELLVD 10 20 30 100 110 120 130 140 150 pF1KE6 RACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVEKLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVEKLN 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE6 TNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLDKEKRKRAVDLNVKIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLDKEKRKRAVDLNVKIL 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE6 DLSSTFLMGTNFPNKIEKHLLPEHIRRNFTSAGDHIIIDGLHAESPDDLVREAAYKIFLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLSSTFLMGTNFPNKIEKHLLPEHIRRNFTSAGDHIIIDGLHAESPDDLVREAAYKIFLY 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE6 PNAGQLKCLEELLSSRDLLAKLVGYSTFSHRALQGTIAKNPETVMQFLEKLSDKLSERTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PNAGQLKCLEELLSSRDLLAKLVGYSTFSHRALQGTIAKNPETVMQFLEKLSDKLSERTL 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE6 KDFEMIRGMKMKLNPQNSEVMPWDPPYYSGVIRAERYNIEPSLYCPFFSLGACMEGLNIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDFEMIRGMKMKLNPQNSEVMPWDPPYYSGVIRAERYNIEPSLYCPFFSLGACMEGLNIL 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE6 LNRLLGISLYAEQPAKGEVWSEDVRKLAVVHESEGLLGYIYCDFFQRADKPHQDCHFTIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNRLLGISLYAEQPAKGEVWSEDVRKLAVVHESEGLLGYIYCDFFQRADKPHQDCHFTIR 340 350 360 370 380 390 460 470 480 490 500 510 pF1KE6 GGRLKEDGDYQLPVVVLMLNLPRSSRSSPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHV ::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::: XP_011 GGRLKEDGDYQLPVVVLMLNLPRSSRSSPTLLTPSMMENLFHEMGHAMHSMLGRTRYQHV 400 410 420 430 440 450 520 530 540 550 560 570 pF1KE6 TGTRCPTDFAEVPSILMEYFANDYRVVNQFARHYQTGQPLPKNMVSRLCESKKVCAAADM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGTRCPTDFAEVPSILMEYFANDYRVVNQFARHYQTGQPLPKNMVSRLCESKKVCAAADM 460 470 480 490 500 510 580 590 600 610 620 630 pF1KE6 QLQVFYATLDQIYHGKHPLRNSTTDILKETQEKFYGLPYVPNTAWQLRFSHLVGYGARYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLQVFYATLDQIYHGKHPLRNSTTDILKETQEKFYGLPYVPNTAWQLRFSHLVGYGARYY 520 530 540 550 560 570 640 650 660 670 680 690 pF1KE6 SYLMSRAVASMVWKECFLQDPFNRAAGERYRREMLAHGGGREPMLMVEGMLQKCPSVDDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYLMSRAVASMVWKECFLQDPFNRAAGERYRREMLAHGGGREPMLMVEGMLQKCPSVDDF 580 590 600 610 620 630 700 710 pF1KE6 VSALVSDLDLDFETFLMDSE :::::::::::::::::::: XP_011 VSALVSDLDLDFETFLMDSE 640 650 >>XP_011533400 (OMIM: 602241) PREDICTED: mitochondrial i (621 aa) initn: 4124 init1: 4124 opt: 4124 Z-score: 4834.9 bits: 905.0 E(85289): 0 Smith-Waterman score: 4124; 99.7% identity (99.8% similar) in 619 aa overlap (1-619:1-619) 10 20 30 40 50 60 pF1KE6 MLCVGRLGGLGARAAALPPRRAGRGSLEAGIRARRVSTSWSPVGAAFNVKPQGSRLDLFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLCVGRLGGLGARAAALPPRRAGRGSLEAGIRARRVSTSWSPVGAAFNVKPQGSRLDLFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ERRGLFGVPELSAPEGFHIAQEKALRKTELLVDRACSTPPGPQTVLIFDELSDSLCRVAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERRGLFGVPELSAPEGFHIAQEKALRKTELLVDRACSTPPGPQTVLIFDELSDSLCRVAD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 LADFVKIAHPEPAFREAAEEACRSIGTMVEKLNTNVDLYQSLQKLLADKKLVDSLDPETR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LADFVKIAHPEPAFREAAEEACRSIGTMVEKLNTNVDLYQSLQKLLADKKLVDSLDPETR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 RVAELFMFDFEISGIHLDKEKRKRAVDLNVKILDLSSTFLMGTNFPNKIEKHLLPEHIRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVAELFMFDFEISGIHLDKEKRKRAVDLNVKILDLSSTFLMGTNFPNKIEKHLLPEHIRR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 NFTSAGDHIIIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NFTSAGDHIIIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 FSHRALQGTIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQNSEVMPWDPPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSHRALQGTIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQNSEVMPWDPPY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 YSGVIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YSGVIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 AVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 SPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVV :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPTLLTPSMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 NQFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NQFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDIL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 KETQEKFYGLPYVPNTAWQLRFSHLVGYGARYYSYLMSRAVASMVWKECFLQDPFNRAAG ::::::::::::::::: : XP_011 KETQEKFYGLPYVPNTAVQEA 610 620 >>XP_011526530 (OMIM: 601117) PREDICTED: thimet oligopep (480 aa) initn: 497 init1: 292 opt: 644 Z-score: 755.0 bits: 149.7 E(85289): 2.6e-35 Smith-Waterman score: 644; 28.6% identity (63.4% similar) in 423 aa overlap (282-694:47-463) 260 270 280 290 300 310 pF1KE6 DGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYSTFSHRALQGTIA :.::.. : ..:.:. : . .:. ..: XP_011 PLLKKCHVPETRRKVEEAFNCRCKEENCAILKELVTLRAQKSRLLGFHTHADYVLEMNMA 20 30 40 50 60 70 320 330 340 350 360 pF1KE6 KNPETVMQFLEKLSDKLS-----ERTLKDFEMIRGMKMKLN-PQNSEVMPWDPPYYSGVI :. .:: ::..:..::. ::.. .:. :. . . : .... :: :: . . XP_011 KTSQTVATFLDELAQKLKPLGEQERAVI-LELKRAECERRGLPFDGRIRAWDMRYYMNQV 80 90 100 110 120 130 370 380 390 400 410 420 pF1KE6 RAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKLAVVHE . :: .. .: .: . . .:: . ..:::.... :. :.. : :::: .. XP_011 EETRYCVDQNLLKEYFPVQVVTHGLLGIYQELLGLAFHHEEGASA--WHEDVRLYTARDA 140 150 160 170 180 190 430 440 450 460 470 480 pF1KE6 SEG-LLGYIYCDFFQRADK-PHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRSSPT . : ..: .: :.. : : : : : .. : :..::. :. ..... :. . . ..:. XP_011 ASGEVVGKFYLDLYPREGKYGHAAC-FGLQPGCLRQDGSRQIAIAAMVANFTKPTADAPS 200 210 220 230 240 250 490 500 510 520 530 540 pF1KE6 LLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVVNQF :: .:. :::.::.::.. ..... .::. ::.:.:: ..: .. . . . .. XP_011 LLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQEPLLRM 260 270 280 290 300 310 550 560 570 580 590 600 pF1KE6 ARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDILKET .:::.::. .:.... .: ::... .. :. : .:: : . . . . . XP_011 SRHYRTGSAVPRELLEKLIESRQANTGLFNLRQIVLAKVDQALHTQTDA-DPAEEYARLC 320 330 340 350 360 370 610 620 630 640 650 660 pF1KE6 QEKFYGLPYVPNTAWQLRFSHLVG-YGARYYSYLMSRAVASMVWKECFLQDP-FNRAAGE :: . :.: .:.: :.::.: : :.::.:: :.. . ... : :. .: .: XP_011 QE-ILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNSKVGM 380 390 400 410 420 430 670 680 690 700 710 pF1KE6 RYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE :: .: ::... :.. .: . :. : :. XP_011 DYRSCILRPGGSEDASAMLRRFLGRDPKQDAFLLSKGLQVGGCEPEPQVC 440 450 460 470 480 >>NP_003240 (OMIM: 601117) thimet oligopeptidase [Homo s (689 aa) initn: 542 init1: 292 opt: 644 Z-score: 752.8 bits: 149.8 E(85289): 3.4e-35 Smith-Waterman score: 714; 27.5% identity (58.5% similar) in 607 aa overlap (120-694:80-672) 90 100 110 120 130 140 pF1KE6 LLVDRACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMV .. :: . . : .: :. :: .... . NP_003 QVGTQEFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFD 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE6 EKLNTNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLDKE--------K ... :.:: . : .: ::: ::. : : .. . .:.:: .: : NP_003 VEMSMREDVYQRIV-WLQEKVQKDSLRPEAARYLERLIKLGRRNGLHLPRETQENIKRIK 110 120 130 140 150 160 210 220 230 240 pF1KE6 RKRA---VDLNVKILDLSSTFL------MG---TNFPNKIEKHLLPEHIRRNFTSAGDHI .: . .:.: : :. ..::: .: .: :..:: : . . : : NP_003 KKLSLLCIDFN-KNLNEDTTFLPFTLQELGGLPEDFLNSLEKM---EDGKLKVTLKYPHY 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE6 --IIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYSTFSHRALQ .. :. :.:: : . :: ::.. : ..:.:. : . .:. NP_003 FPLLKKCHVPETRRKVEEAFNCRCKEENCAILK---ELVTLRAQKSRLLGFHTHADYVLE 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE6 GTIAKNPETVMQFLEKLSDKLS-----ERTLKDFEMIRGMKMKLN-PQNSEVMPWDPPYY ..::. .:: ::..:..::. ::.. .:. :. . . : .... :: :: NP_003 MNMAKTSQTVATFLDELAQKLKPLGEQERAVI-LELKRAECERRGLPFDGRIRAWDMRYY 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE6 SGVIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKLA . .. :: .. .: .: . . .:: . ..:::.... :. :.. : :::: . NP_003 MNQVEETRYCVDQNLLKEYFPVQVVTHGLLGIYQELLGLAFHHEEGASA--WHEDVRLYT 350 360 370 380 390 430 440 450 460 470 pF1KE6 VVHESEG-LLGYIYCDFFQRADK-PHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSR . . : ..: .: :.. : : : : : .. : :..::. :. ..... :. . . NP_003 ARDAASGEVVGKFYLDLYPREGKYGHAAC-FGLQPGCLRQDGSRQIAIAAMVANFTKPTA 400 410 420 430 440 450 480 490 500 510 520 530 pF1KE6 SSPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRV ..:.:: .:. :::.::.::.. ..... .::. ::.:.:: ..: .. . . NP_003 DAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQEP 460 470 480 490 500 510 540 550 560 570 580 590 pF1KE6 VNQFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDI . ...:::.::. .:.... .: ::... .. :. : .:: : . . . . NP_003 LLRMSRHYRTGSAVPRELLEKLIESRQANTGLFNLRQIVLAKVDQALHTQTDA-DPAEEY 520 530 540 550 560 570 600 610 620 630 640 650 pF1KE6 LKETQEKFYGLPYVPNTAWQLRFSHLVG-YGARYYSYLMSRAVASMVWKECFLQDP-FNR . :: . :.: .:.: :.::.: : :.::.:: :.. . ... : :. .: NP_003 ARLCQE-ILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNS 580 590 600 610 620 630 660 670 680 690 700 710 pF1KE6 AAGERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE .: :: .: ::... :.. .: . :. : :. NP_003 KVGMDYRSCILRPGGSEDASAMLRRFLGRDPKQDAFLLSKGLQVGGCEPEPQVC 640 650 660 670 680 >>XP_006714724 (OMIM: 611530) PREDICTED: neurolysin, mit (681 aa) initn: 515 init1: 271 opt: 631 Z-score: 737.6 bits: 147.0 E(85289): 2.4e-34 Smith-Waterman score: 659; 26.9% identity (56.0% similar) in 605 aa overlap (121-694:82-673) 100 110 120 130 140 150 pF1KE6 LVDRACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVE . :: . . . : :. :: . .. . XP_006 VGMLGIEEVTYENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDI 60 70 80 90 100 110 160 170 180 190 200 pF1KE6 KLNTNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLD-------KEKRK ... :... . .: : .. ::.:: : . . .:.:: : .: XP_006 EMSMRGDIFERIVHLQETCDL-GKIKPEARRYLEKSIKMGKRNGLHLPEQVQNEIKSMKK 120 130 140 150 160 170 210 220 230 240 250 pF1KE6 RAVDLNV---KILDLSSTFLMGTNFPNKIEKHLLPEHIRRNFTSAGD---HIIIDGLHAE : .: . : :. ..:::. : .: : ::. . .. .. : .: . : XP_006 RMSELCIDFNKNLNEDDTFLV---F-SKAELGALPDDFIDSLEKTDDDKYKITLKYPHYF 180 190 200 210 220 260 270 280 290 300 pF1KE6 S--PDDLVREAAYKIFLYPNAGQLKCLEE-------LLSSRDLLAKLVGYSTFSHRALQG . :. .. . :. .: :: :: : .:::.:::: . .:. XP_006 PVMKKCCIPETRRRMEMAFNT---RCKEENTIILQQLLPLRTKVAKLLGYSTHADFVLEM 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE6 TIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQ-----NSEVMPWDPPYYSG . ::. : ::. ::.::. . :.: ..: : . .... :: :: XP_006 NTAKSTSRVTAFLDDLSQKLKPLGEAEREFILNLKKKECKDRGFEYDGKINAWDLYYYMT 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE6 VIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKLAVV . .:.:. . .: . . ::: ..:::.:. :: . ..::...: .: XP_006 QTEELKYSIDQEFLKEYFPIEVVTEGLLNTYQELLGLSF--EQMTDAHVWNKSVTLYTVK 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE6 HESEG-LLGYIYCDFFQRADK-PHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRSS .. : .:: .: :.. : : : : : .. : : ::. .. :..:..:. . . XP_006 DKATGEVLGQFYLDLYPREGKYNHAAC-FGLQPGCLLPDGSRMMAVAALVVNFSQPVAGR 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE6 PTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVVN :.:: ... :::.::.::.. ..: . . .:: :::.:::: ..: .. : . XP_006 PSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVDSLR 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE6 QFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDILK ....::. :.:. ... .: :. : .. :. . .:: : . : ..... : XP_006 RLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSL-DAASEYAK 530 540 550 560 570 610 620 630 640 650 pF1KE6 ETQEKFYGLPYVPNTAWQLRFSHLVG-YGARYYSYLMSRAVASMVWKECFLQDPF-NRAA .: . :. .:.: :.::.: : ..::.:: :.. . .. :: .. . : . XP_006 YCSE-ILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMNPEV 580 590 600 610 620 630 660 670 680 690 700 710 pF1KE6 GERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE : .:: .: ::. . : :....:.. :. :. XP_006 GMKYRNLILKPGGSLDGMDMLHNFLKREPNQKAFLMSRGLHAP 640 650 660 670 680 >>NP_065777 (OMIM: 611530) neurolysin, mitochondrial [Ho (704 aa) initn: 515 init1: 271 opt: 631 Z-score: 737.4 bits: 147.0 E(85289): 2.5e-34 Smith-Waterman score: 659; 26.9% identity (56.0% similar) in 605 aa overlap (121-694:105-696) 100 110 120 130 140 150 pF1KE6 LVDRACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVE . :: . . . : :. :: . .. . NP_065 VGMLGIEEVTYENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDI 80 90 100 110 120 130 160 170 180 190 200 pF1KE6 KLNTNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLD-------KEKRK ... :... . .: : .. ::.:: : . . .:.:: : .: NP_065 EMSMRGDIFERIVHLQETCDL-GKIKPEARRYLEKSIKMGKRNGLHLPEQVQNEIKSMKK 140 150 160 170 180 190 210 220 230 240 250 pF1KE6 RAVDLNV---KILDLSSTFLMGTNFPNKIEKHLLPEHIRRNFTSAGD---HIIIDGLHAE : .: . : :. ..:::. : .: : ::. . .. .. : .: . : NP_065 RMSELCIDFNKNLNEDDTFLV---F-SKAELGALPDDFIDSLEKTDDDKYKITLKYPHYF 200 210 220 230 240 260 270 280 290 300 pF1KE6 S--PDDLVREAAYKIFLYPNAGQLKCLEE-------LLSSRDLLAKLVGYSTFSHRALQG . :. .. . :. .: :: :: : .:::.:::: . .:. NP_065 PVMKKCCIPETRRRMEMAFNT---RCKEENTIILQQLLPLRTKVAKLLGYSTHADFVLEM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 TIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQ-----NSEVMPWDPPYYSG . ::. : ::. ::.::. . :.: ..: : . .... :: :: NP_065 NTAKSTSRVTAFLDDLSQKLKPLGEAEREFILNLKKKECKDRGFEYDGKINAWDLYYYMT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 VIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKLAVV . .:.:. . .: . . ::: ..:::.:. :: . ..::...: .: NP_065 QTEELKYSIDQEFLKEYFPIEVVTEGLLNTYQELLGLSF--EQMTDAHVWNKSVTLYTVK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 HESEG-LLGYIYCDFFQRADK-PHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRSS .. : .:: .: :.. : : : : : .. : : ::. .. :..:..:. . . NP_065 DKATGEVLGQFYLDLYPREGKYNHAAC-FGLQPGCLLPDGSRMMAVAALVVNFSQPVAGR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 PTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVVN :.:: ... :::.::.::.. ..: . . .:: :::.:::: ..: .. : . NP_065 PSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVDSLR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 QFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDILK ....::. :.:. ... .: :. : .. :. . .:: : . : ..... : NP_065 RLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSL-DAASEYAK 550 560 570 580 590 600 610 620 630 640 650 pF1KE6 ETQEKFYGLPYVPNTAWQLRFSHLVG-YGARYYSYLMSRAVASMVWKECFLQDPF-NRAA .: . :. .:.: :.::.: : ..::.:: :.. . .. :: .. . : . NP_065 YCSE-ILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMNPEV 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE6 GERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE : .:: .: ::. . : :....:.. :. :. NP_065 GMKYRNLILKPGGSLDGMDMLHNFLKREPNQKAFLMSRGLHAP 670 680 690 700 >>XP_016865162 (OMIM: 611530) PREDICTED: neurolysin, mit (663 aa) initn: 396 init1: 152 opt: 288 Z-score: 335.5 bits: 72.5 E(85289): 6e-12 Smith-Waterman score: 560; 26.0% identity (53.9% similar) in 605 aa overlap (121-694:82-655) 100 110 120 130 140 150 pF1KE6 LVDRACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVE . :: . . . : :. :: . .. . XP_016 VGMLGIEEVTYENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDI 60 70 80 90 100 110 160 170 180 190 200 pF1KE6 KLNTNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLD-------KEKRK ... :... . .: : .. ::.:: : . . .:.:: : .: XP_016 EMSMRGDIFERIVHLQETCDL-GKIKPEARRYLEKSIKMGKRNGLHLPEQVQNEIKSMKK 120 130 140 150 160 170 210 220 230 240 250 pF1KE6 RAVDLNV---KILDLSSTFLMGTNFPNKIEKHLLPEHIRRNFTSAGD---HIIIDGLHAE : .: . : :. ..:::. : .: : ::. . .. .. : .: . : XP_016 RMSELCIDFNKNLNEDDTFLV---F-SKAELGALPDDFIDSLEKTDDDKYKITLKYPHYF 180 190 200 210 220 260 270 280 290 300 pF1KE6 S--PDDLVREAAYKIFLYPNAGQLKCLEE-------LLSSRDLLAKLVGYSTFSHRALQG . :. .. . :. .: :: :: : .:::.:::: . .:. XP_016 PVMKKCCIPETRRRMEMAFNT---RCKEENTIILQQLLPLRTKVAKLLGYSTHADFVLEM 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE6 TIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQ-----NSEVMPWDPPYYSG . ::. : ::. ::.::. . :.: ..: : . .... :: :: XP_016 NTAKSTSRVTAFLDDLSQKLKPLGEAEREFILNLKKKECKDRGFEYDGKINAWDLYYYMT 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE6 VIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKLAVV . .:.:. . .: . . ::: ..:::.:. :: . ..::...: .: XP_016 QTEELKYSIDQEFLKEYFPIEVVTEGLLNTYQELLGLSF--EQMTDAHVWNKSVTLYTVK 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE6 HESEG-LLGYIYCDFFQRADK-PHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRSS .. : .:: .: :.. : : : : : .. : : ::. .. :..:..:. . . XP_016 DKATGEVLGQFYLDLYPREGKYNHAAC-FGLQPGCLLPDGSRMMAVAALVVNFSQPVAGR 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE6 PTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVVN :.:: :. .: . . .:: :::.:::: ..: .. : . XP_016 PSLLR--------HD----------ETDFARFSGTNVETDFVEVPSQMLENWVWDVDSLR 470 480 490 500 550 560 570 580 590 600 pF1KE6 QFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDILK ....::. :.:. ... .: :. : .. :. . .:: : . : ..... : XP_016 RLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSL-DAASEYAK 510 520 530 540 550 560 610 620 630 640 650 pF1KE6 ETQEKFYGLPYVPNTAWQLRFSHLVG-YGARYYSYLMSRAVASMVWKECFLQDPF-NRAA .: . :. .:.: :.::.: : ..::.:: :.. . .. :: .. . : . XP_016 YCSE-ILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMNPEV 570 580 590 600 610 620 660 670 680 690 700 710 pF1KE6 GERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE : .:: .: ::. . : :....:.. :. :. XP_016 GMKYRNLILKPGGSLDGMDMLHNFLKREPNQKAFLMSRGLHAP 630 640 650 660 >>XP_005248616 (OMIM: 611530) PREDICTED: neurolysin, mit (686 aa) initn: 396 init1: 152 opt: 288 Z-score: 335.3 bits: 72.5 E(85289): 6.2e-12 Smith-Waterman score: 560; 26.0% identity (53.9% similar) in 605 aa overlap (121-694:105-678) 100 110 120 130 140 150 pF1KE6 LVDRACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVE . :: . . . : :. :: . .. . XP_005 VGMLGIEEVTYENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDI 80 90 100 110 120 130 160 170 180 190 200 pF1KE6 KLNTNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLD-------KEKRK ... :... . .: : .. ::.:: : . . .:.:: : .: XP_005 EMSMRGDIFERIVHLQETCDL-GKIKPEARRYLEKSIKMGKRNGLHLPEQVQNEIKSMKK 140 150 160 170 180 190 210 220 230 240 250 pF1KE6 RAVDLNV---KILDLSSTFLMGTNFPNKIEKHLLPEHIRRNFTSAGD---HIIIDGLHAE : .: . : :. ..:::. : .: : ::. . .. .. : .: . : XP_005 RMSELCIDFNKNLNEDDTFLV---F-SKAELGALPDDFIDSLEKTDDDKYKITLKYPHYF 200 210 220 230 240 260 270 280 290 300 pF1KE6 S--PDDLVREAAYKIFLYPNAGQLKCLEE-------LLSSRDLLAKLVGYSTFSHRALQG . :. .. . :. .: :: :: : .:::.:::: . .:. XP_005 PVMKKCCIPETRRRMEMAFNT---RCKEENTIILQQLLPLRTKVAKLLGYSTHADFVLEM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 TIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQ-----NSEVMPWDPPYYSG . ::. : ::. ::.::. . :.: ..: : . .... :: :: XP_005 NTAKSTSRVTAFLDDLSQKLKPLGEAEREFILNLKKKECKDRGFEYDGKINAWDLYYYMT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 VIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKLAVV . .:.:. . .: . . ::: ..:::.:. :: . ..::...: .: XP_005 QTEELKYSIDQEFLKEYFPIEVVTEGLLNTYQELLGLSF--EQMTDAHVWNKSVTLYTVK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 HESEG-LLGYIYCDFFQRADK-PHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRSS .. : .:: .: :.. : : : : : .. : : ::. .. :..:..:. . . XP_005 DKATGEVLGQFYLDLYPREGKYNHAAC-FGLQPGCLLPDGSRMMAVAALVVNFSQPVAGR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 PTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVVN :.:: :. .: . . .:: :::.:::: ..: .. : . XP_005 PSLLR--------HD----------ETDFARFSGTNVETDFVEVPSQMLENWVWDVDSLR 490 500 510 520 550 560 570 580 590 600 pF1KE6 QFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDILK ....::. :.:. ... .: :. : .. :. . .:: : . : ..... : XP_005 RLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSL-DAASEYAK 530 540 550 560 570 580 610 620 630 640 650 pF1KE6 ETQEKFYGLPYVPNTAWQLRFSHLVG-YGARYYSYLMSRAVASMVWKECFLQDPF-NRAA .: . :. .:.: :.::.: : ..::.:: :.. . .. :: .. . : . XP_005 YCSE-ILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMNPEV 590 600 610 620 630 640 660 670 680 690 700 710 pF1KE6 GERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE : .:: .: ::. . : :....:.. :. :. XP_005 GMKYRNLILKPGGSLDGMDMLHNFLKREPNQKAFLMSRGLHAP 650 660 670 680 713 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 15:35:17 2016 done: Tue Nov 8 15:35:18 2016 Total Scan time: 6.080 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]