Result of FASTA (omim) for
pFN21AE1462
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1462, 236 aa
1>>>pF1KE1462 236 - 236 aa - 236 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3325+/-0.000382; mu= 10.2345+/- 0.024
mean_var=110.4554+/-21.494, 0's: 0 Z-trim(115.2): 33 B-trim: 452 in 2/51
Lambda= 0.122034
statistics sampled from 25507 (25532) to 25507 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.669), E-opt: 0.2 (0.299), width: 16
Scan time: 6.580
The best scores are: opt bits E(85289)
NP_004844 (OMIM: 604203) syntaxin-8 [Homo sapiens] ( 236) 1509 276.1 3.6e-74
XP_011522381 (OMIM: 604203) PREDICTED: syntaxin-8 ( 181) 841 158.4 7.4e-39
NP_001273139 (OMIM: 603944) syntaxin-6 isoform 2 [ ( 154) 178 41.6 0.0009
XP_016855496 (OMIM: 603944) PREDICTED: syntaxin-6 ( 154) 178 41.6 0.0009
NP_005810 (OMIM: 603944) syntaxin-6 isoform 1 [Hom ( 255) 181 42.3 0.00092
NP_003756 (OMIM: 603765) syntaxin-10 isoform 1 [Ho ( 249) 174 41.1 0.0021
>>NP_004844 (OMIM: 604203) syntaxin-8 [Homo sapiens] (236 aa)
initn: 1509 init1: 1509 opt: 1509 Z-score: 1452.6 bits: 276.1 E(85289): 3.6e-74
Smith-Waterman score: 1509; 100.0% identity (100.0% similar) in 236 aa overlap (1-236:1-236)
10 20 30 40 50 60
pF1KE1 MAPDPWFSTYDSTCQIAQEIAEKIQQRNQYERKGEKAPKLTVTIRALLQNLKEKIALLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MAPDPWFSTYDSTCQIAQEIAEKIQQRNQYERKGEKAPKLTVTIRALLQNLKEKIALLKD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LLLRAVSTHQITQLEGDRRQNLLDDLVTRERLLLASFKNEGAEPDLIRSSLMSEEAKRGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LLLRAVSTHQITQLEGDRRQNLLDDLVTRERLLLASFKNEGAEPDLIRSSLMSEEAKRGA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 PNPWLFEEPEETRGLGFDEIRQQQQKIIQEQDAGLDALSSIISRQKQMGQEIGNELDEQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PNPWLFEEPEETRGLGFDEIRQQQQKIIQEQDAGLDALSSIISRQKQMGQEIGNELDEQN
130 140 150 160 170 180
190 200 210 220 230
pF1KE1 EIIDDLANLVENTDEKLRNETRRVNMVDRKSASCGMIMVILLLLVAIVVVAVWPTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EIIDDLANLVENTDEKLRNETRRVNMVDRKSASCGMIMVILLLLVAIVVVAVWPTN
190 200 210 220 230
>>XP_011522381 (OMIM: 604203) PREDICTED: syntaxin-8 isof (181 aa)
initn: 848 init1: 828 opt: 841 Z-score: 818.6 bits: 158.4 E(85289): 7.4e-39
Smith-Waterman score: 841; 78.8% identity (84.9% similar) in 179 aa overlap (62-236:6-181)
40 50 60 70 80 90
pF1KE1 RKGEKAPKLTVTIRALLQNLKEKIALLKDLLLRAVSTHQITQLEGDRRQNLLDDLVTRER
:: .. .:. :. . :: : .
XP_011 MTTRSLLNVLREFWQAQMSGSPHTILL---VKLPK
10 20 30
100 110 120 130 140
pF1KE1 LLLASFKNEGAEPDLI----RSSLMSEEAKRGAPNPWLFEEPEETRGLGFDEIRQQQQKI
:: .:.:: . . ::::::::::::::::::::::::::::::::::::::::
XP_011 KLLRKFNNEINMKEKVKRHQRSSLMSEEAKRGAPNPWLFEEPEETRGLGFDEIRQQQQKI
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE1 IQEQDAGLDALSSIISRQKQMGQEIGNELDEQNEIIDDLANLVENTDEKLRNETRRVNMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQEQDAGLDALSSIISRQKQMGQEIGNELDEQNEIIDDLANLVENTDEKLRNETRRVNMV
100 110 120 130 140 150
210 220 230
pF1KE1 DRKSASCGMIMVILLLLVAIVVVAVWPTN
:::::::::::::::::::::::::::::
XP_011 DRKSASCGMIMVILLLLVAIVVVAVWPTN
160 170 180
>>NP_001273139 (OMIM: 603944) syntaxin-6 isoform 2 [Homo (154 aa)
initn: 230 init1: 165 opt: 178 Z-score: 188.7 bits: 41.6 E(85289): 0.0009
Smith-Waterman score: 178; 30.3% identity (72.7% similar) in 99 aa overlap (138-232:55-153)
110 120 130 140 150 160
pF1KE1 RSSLMSEEAKRGAPNPWLFEEPEETRGLGFDEIRQQQQKIIQEQDAGLDALSSIISRQKQ
.: . ::: :...:: :. .:. :. :.
NP_001 DSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKN
30 40 50 60 70 80
170 180 190 200 210 220
pF1KE1 MGQEIGNELDEQNEIIDDLANLVENTDEKLRNETRRVNMVDRKSAS----CGMIMVILLL
:.:.::.::.:: ...:... .:.:. .: : ... :.. ... :.. ... .:
NP_001 MSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAILFAVL
90 100 110 120 130 140
230
pF1KE1 LVAIVVVAVWPTN
::.... :
NP_001 LVVLILFLVL
150
>>XP_016855496 (OMIM: 603944) PREDICTED: syntaxin-6 isof (154 aa)
initn: 230 init1: 165 opt: 178 Z-score: 188.7 bits: 41.6 E(85289): 0.0009
Smith-Waterman score: 178; 30.3% identity (72.7% similar) in 99 aa overlap (138-232:55-153)
110 120 130 140 150 160
pF1KE1 RSSLMSEEAKRGAPNPWLFEEPEETRGLGFDEIRQQQQKIIQEQDAGLDALSSIISRQKQ
.: . ::: :...:: :. .:. :. :.
XP_016 DSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKN
30 40 50 60 70 80
170 180 190 200 210 220
pF1KE1 MGQEIGNELDEQNEIIDDLANLVENTDEKLRNETRRVNMVDRKSAS----CGMIMVILLL
:.:.::.::.:: ...:... .:.:. .: : ... :.. ... :.. ... .:
XP_016 MSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAILFAVL
90 100 110 120 130 140
230
pF1KE1 LVAIVVVAVWPTN
::.... :
XP_016 LVVLILFLVL
150
>>NP_005810 (OMIM: 603944) syntaxin-6 isoform 1 [Homo sa (255 aa)
initn: 214 init1: 165 opt: 181 Z-score: 188.5 bits: 42.3 E(85289): 0.00092
Smith-Waterman score: 181; 28.1% identity (65.0% similar) in 160 aa overlap (80-232:100-254)
50 60 70 80 90 100
pF1KE1 NLKEKIALLKDLLLRAVSTHQITQLEGDRRQNLLDDLVTRERLLLASFKNEGAEPDLIRS
... :.. : :: ::. : :. .
NP_005 IVEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNRQA---LLGD
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 SLMSEEAKRGAPNPW--LFEEPEETRGLGFDEIRQQQQKIIQEQDAGLDALSSIISRQKQ
: :.. . :. . . : .: ... . ..: . ::: :...:: :. .:. :. :.
NP_005 S-GSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKN
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE1 MGQEIGNELDEQNEIIDDLANLVENTDEKLRNETRRVNMV-----DRKSASCGMIMVILL
:.:.::.::.:: ...:... .:.:. .: : ... : ::.. :.. ... .
NP_005 MSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQW-CAIAILFAV
190 200 210 220 230 240
230
pF1KE1 LLVAIVVVAVWPTN
:::.... :
NP_005 LLVVLILFLVL
250
>>NP_003756 (OMIM: 603765) syntaxin-10 isoform 1 [Homo s (249 aa)
initn: 181 init1: 124 opt: 174 Z-score: 182.0 bits: 41.1 E(85289): 0.0021
Smith-Waterman score: 174; 23.4% identity (55.6% similar) in 239 aa overlap (10-232:25-249)
10 20 30 40
pF1KE1 MAPDPWFSTYDSTCQIAQEIA----EKIQQRNQYERKGEKAPKLT
:. :.. :: : :... .. :.: .
NP_003 MSLEDPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLR-----
10 20 30 40 50
50 60 70 80 90 100
pF1KE1 VTIRALLQNLKEKIALLKDLLLRAVSTHQITQLEGDRRQNLLDDLVTRERLLLASFKNEG
.:. :..:.: :.... .. .. :: .. . .: : : . .:..
NP_003 -SIEWDLEDLEETIGIVE------ANPGKFKLPAGDLQERKV--FVERMREAVQEMKDHM
60 70 80 90 100
110 120 130 140 150
pF1KE1 AEPDLI-------RSSLMSEEAKRGAPNPWLFEEPEETRGLGFDEIRQQQQKIIQEQDAG
. : . : : .. : . .:. : . . ..: . :: :..:::
NP_003 VSPTAVAFLERNNREILAGKPAAQKSPSDLLDASAVSATSRYIEEQQATQQLIMDEQDQQ
110 120 130 140 150 160
160 170 180 190 200
pF1KE1 LDALSSIISRQKQMGQEIGNELDEQNEIIDDLANLVENTDEKLRNETRRVNMV-----DR
:. .:. :. :.:. ..:.:::::. ..: .:. ...:. .. . :.. : ::
NP_003 LEMVSGSIQVLKHMSGRVGEELDEQGIMLDAFAQEMDHTQSRMDGVLRKLAKVSHMTSDR
170 180 190 200 210 220
210 220 230
pF1KE1 KSASCGMIMVILLLLVAIVVVAVWPTN
.. ..: .:::: :.. ..
NP_003 RQWCAIAVLVGVLLLVLILLFSL
230 240
236 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 02:02:01 2016 done: Mon Nov 7 02:02:02 2016
Total Scan time: 6.580 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]