FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4435, 452 aa 1>>>pF1KE4435 452 - 452 aa - 452 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2792+/-0.000414; mu= 17.4974+/- 0.026 mean_var=63.7943+/-12.988, 0's: 0 Z-trim(110.6): 39 B-trim: 69 in 1/49 Lambda= 0.160577 statistics sampled from 18981 (19013) to 18981 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.59), E-opt: 0.2 (0.223), width: 16 Scan time: 6.430 The best scores are: opt bits E(85289) NP_002159 (OMIM: 147650,613657) isocitrate dehydro ( 452) 3074 721.2 1.3e-207 NP_001276839 (OMIM: 147650,613657) isocitrate dehy ( 400) 2726 640.6 2.2e-183 NP_001277043 (OMIM: 147650,613657) isocitrate dehy ( 322) 2215 522.2 8e-148 NP_001269315 (OMIM: 137800,147700) isocitrate dehy ( 414) 1934 457.1 3.9e-128 NP_001269316 (OMIM: 137800,147700) isocitrate dehy ( 414) 1934 457.1 3.9e-128 NP_005887 (OMIM: 137800,147700) isocitrate dehydro ( 414) 1934 457.1 3.9e-128 >>NP_002159 (OMIM: 147650,613657) isocitrate dehydrogena (452 aa) initn: 3074 init1: 3074 opt: 3074 Z-score: 3848.1 bits: 721.2 E(85289): 1.3e-207 Smith-Waterman score: 3074; 100.0% identity (100.0% similar) in 452 aa overlap (1-452:1-452) 10 20 30 40 50 60 pF1KE4 MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH 370 380 390 400 410 420 430 440 450 pF1KE4 GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ :::::::::::::::::::::::::::::::: NP_002 GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ 430 440 450 >>NP_001276839 (OMIM: 147650,613657) isocitrate dehydrog (400 aa) initn: 2726 init1: 2726 opt: 2726 Z-score: 3413.2 bits: 640.6 E(85289): 2.2e-183 Smith-Waterman score: 2726; 100.0% identity (100.0% similar) in 400 aa overlap (53-452:1-400) 30 40 50 60 70 80 pF1KE4 PAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYF :::::::::::::::::::::::::::::: NP_001 MDGDEMTRIIWQFIKEKLILPHVDIQLKYF 10 20 30 90 100 110 120 130 140 pF1KE4 DLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNI 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE4 LGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGS 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE4 GVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRF 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE4 KDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQ 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE4 GFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHR 280 290 300 310 320 330 390 400 410 420 430 440 pF1KE4 GKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIK 340 350 360 370 380 390 450 pF1KE4 SNLDRALGRQ :::::::::: NP_001 SNLDRALGRQ 400 >>NP_001277043 (OMIM: 147650,613657) isocitrate dehydrog (322 aa) initn: 2215 init1: 2215 opt: 2215 Z-score: 2774.8 bits: 522.2 E(85289): 8e-148 Smith-Waterman score: 2215; 100.0% identity (100.0% similar) in 322 aa overlap (131-452:1-322) 110 120 130 140 150 160 pF1KE4 ALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRL :::::::::::::::::::::::::::::: NP_001 MWKSPNGTIRNILGGTVFREPIICKNIPRL 10 20 30 170 180 190 200 210 220 pF1KE4 VPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMG 40 50 60 70 80 90 230 240 250 260 270 280 pF1KE4 MYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDK 100 110 120 130 140 150 290 300 310 320 330 340 pF1KE4 NKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGK 160 170 180 190 200 210 350 360 370 380 390 400 pF1KE4 TIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEK 220 230 240 250 260 270 410 420 430 440 450 pF1KE4 VCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ 280 290 300 310 320 >>NP_001269315 (OMIM: 137800,147700) isocitrate dehydrog (414 aa) initn: 1912 init1: 1134 opt: 1934 Z-score: 2421.4 bits: 457.1 E(85289): 3.9e-128 Smith-Waterman score: 1934; 70.8% identity (88.4% similar) in 397 aa overlap (50-445:10-405) 20 30 40 50 60 70 pF1KE4 AWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQL ::::.:::::::::..::::::.:.:...: NP_001 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDL 10 20 30 80 90 100 110 120 130 pF1KE4 KYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTI . .:::. ::: :.:::: :.: : .:..:.:::::::::: ::::::::.::::::::: NP_001 HSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTI 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE4 RNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPK ::::::::::: :::::::::: ::.::: :::::.::::.:::::. : ....::. NP_001 RNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPS 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE4 DGSGVKEWEVYNFP-AGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAY ::. . :.:: .:::.::::: :.:: :::: ::.:..: ::::.:::::::: : NP_001 DGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKY 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE4 DGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSD :::::::::::.::.::..:. .:::::::::::::::..:: :::.::::::::::::: NP_001 DGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSD 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE4 ILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRG .:::.::::.::::::::::::.:::::::::::::: .:::. ::::::::::::::: NP_001 SVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRG 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE4 LEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFL : ::.:::.:..: ::. ::.: .::.:.: ::::::.::.:: ::. .. .::: .:. NP_001 LAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD-YLNTFEFM 340 350 360 370 380 390 440 450 pF1KE4 DTIKSNLDRALGRQ : . :: NP_001 DKLGENLKIKLAQAKL 400 410 >>NP_001269316 (OMIM: 137800,147700) isocitrate dehydrog (414 aa) initn: 1912 init1: 1134 opt: 1934 Z-score: 2421.4 bits: 457.1 E(85289): 3.9e-128 Smith-Waterman score: 1934; 70.8% identity (88.4% similar) in 397 aa overlap (50-445:10-405) 20 30 40 50 60 70 pF1KE4 AWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQL ::::.:::::::::..::::::.:.:...: NP_001 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDL 10 20 30 80 90 100 110 120 130 pF1KE4 KYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTI . .:::. ::: :.:::: :.: : .:..:.:::::::::: ::::::::.::::::::: NP_001 HSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTI 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE4 RNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPK ::::::::::: :::::::::: ::.::: :::::.::::.:::::. : ....::. NP_001 RNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPS 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE4 DGSGVKEWEVYNFP-AGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAY ::. . :.:: .:::.::::: :.:: :::: ::.:..: ::::.:::::::: : NP_001 DGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKY 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE4 DGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSD :::::::::::.::.::..:. .:::::::::::::::..:: :::.::::::::::::: NP_001 DGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSD 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE4 ILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRG .:::.::::.::::::::::::.:::::::::::::: .:::. ::::::::::::::: NP_001 SVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRG 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE4 LEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFL : ::.:::.:..: ::. ::.: .::.:.: ::::::.::.:: ::. .. .::: .:. NP_001 LAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD-YLNTFEFM 340 350 360 370 380 390 440 450 pF1KE4 DTIKSNLDRALGRQ : . :: NP_001 DKLGENLKIKLAQAKL 400 410 >>NP_005887 (OMIM: 137800,147700) isocitrate dehydrogena (414 aa) initn: 1912 init1: 1134 opt: 1934 Z-score: 2421.4 bits: 457.1 E(85289): 3.9e-128 Smith-Waterman score: 1934; 70.8% identity (88.4% similar) in 397 aa overlap (50-445:10-405) 20 30 40 50 60 70 pF1KE4 AWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQL ::::.:::::::::..::::::.:.:...: NP_005 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDL 10 20 30 80 90 100 110 120 130 pF1KE4 KYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTI . .:::. ::: :.:::: :.: : .:..:.:::::::::: ::::::::.::::::::: NP_005 HSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTI 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE4 RNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPK ::::::::::: :::::::::: ::.::: :::::.::::.:::::. : ....::. NP_005 RNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPS 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE4 DGSGVKEWEVYNFP-AGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAY ::. . :.:: .:::.::::: :.:: :::: ::.:..: ::::.:::::::: : NP_005 DGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKY 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE4 DGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSD :::::::::::.::.::..:. .:::::::::::::::..:: :::.::::::::::::: NP_005 DGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSD 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE4 ILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRG .:::.::::.::::::::::::.:::::::::::::: .:::. ::::::::::::::: NP_005 SVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRG 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE4 LEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFL : ::.:::.:..: ::. ::.: .::.:.: ::::::.::.:: ::. .. .::: .:. NP_005 LAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD-YLNTFEFM 340 350 360 370 380 390 440 450 pF1KE4 DTIKSNLDRALGRQ : . :: NP_005 DKLGENLKIKLAQAKL 400 410 452 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:09:12 2016 done: Sun Nov 6 01:09:13 2016 Total Scan time: 6.430 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]