FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3629, 822 aa 1>>>pF1KE3629 822 - 822 aa - 822 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1128+/-0.000425; mu= 12.5100+/- 0.026 mean_var=135.9105+/-30.491, 0's: 0 Z-trim(114.9): 218 B-trim: 1336 in 1/52 Lambda= 0.110014 statistics sampled from 24716 (24954) to 24716 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.293), width: 16 Scan time: 12.220 The best scores are: opt bits E(85289) NP_149106 (OMIM: 616899,616900) TBC domain-contain ( 830) 5557 894.4 0 NP_001156908 (OMIM: 616899,616900) TBC domain-cont ( 893) 5020 809.2 0 NP_001156907 (OMIM: 616899,616900) TBC domain-cont ( 893) 5020 809.2 0 XP_016864337 (OMIM: 616899,616900) PREDICTED: TBC ( 787) 5016 808.5 0 XP_016864335 (OMIM: 616899,616900) PREDICTED: TBC ( 893) 5016 808.6 0 XP_011530719 (OMIM: 616899,616900) PREDICTED: TBC ( 893) 5016 808.6 0 NP_001277697 (OMIM: 616899,616900) TBC domain-cont ( 721) 4875 786.1 0 XP_016864338 (OMIM: 616899,616900) PREDICTED: TBC ( 721) 4871 785.5 0 XP_016864336 (OMIM: 616899,616900) PREDICTED: TBC ( 857) 4773 770.0 0 NP_001156909 (OMIM: 616899,616900) TBC domain-cont ( 854) 4684 755.8 1.8e-217 XP_011516744 (OMIM: 615882) PREDICTED: rab GTPase- ( 900) 301 60.2 4.7e-08 XP_016870059 (OMIM: 615882) PREDICTED: rab GTPase- ( 900) 301 60.2 4.7e-08 XP_016870056 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 301 60.3 5.4e-08 XP_016870057 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 301 60.3 5.4e-08 XP_011516743 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 301 60.3 5.4e-08 NP_036329 (OMIM: 615882) rab GTPase-activating pro (1069) 301 60.3 5.4e-08 XP_011516742 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 301 60.3 5.4e-08 XP_016870058 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 301 60.3 5.4e-08 NP_114143 (OMIM: 610020) TBC1 domain family member ( 508) 268 54.8 1.1e-06 XP_016858483 (OMIM: 609238) PREDICTED: rab GTPase- ( 778) 270 55.2 1.3e-06 NP_055672 (OMIM: 609238) rab GTPase-activating pro ( 815) 270 55.3 1.3e-06 XP_006711756 (OMIM: 609238) PREDICTED: rab GTPase- ( 985) 270 55.3 1.5e-06 XP_005245738 (OMIM: 609238) PREDICTED: rab GTPase- (1014) 270 55.3 1.6e-06 NP_001191169 (OMIM: 610020) TBC1 domain family mem ( 515) 265 54.3 1.6e-06 XP_005245737 (OMIM: 609238) PREDICTED: rab GTPase- (1051) 270 55.3 1.6e-06 XP_011508525 (OMIM: 609238) PREDICTED: rab GTPase- (1051) 270 55.3 1.6e-06 NP_001161694 (OMIM: 616659) TBC1 domain family mem ( 615) 251 52.2 8.6e-06 NP_078958 (OMIM: 616659) TBC1 domain family member ( 648) 251 52.2 9e-06 NP_940919 (OMIM: 610831) carabin isoform 1 [Homo s ( 446) 247 51.4 1e-05 XP_006718601 (OMIM: 610831) PREDICTED: carabin iso ( 446) 247 51.4 1e-05 XP_006718603 (OMIM: 610831) PREDICTED: carabin iso ( 446) 247 51.4 1e-05 XP_006718602 (OMIM: 610831) PREDICTED: carabin iso ( 446) 247 51.4 1e-05 NP_056342 (OMIM: 613620) TBC1 domain family member ( 808) 250 52.1 1.2e-05 NP_001273734 (OMIM: 614855) TBC1 domain family mem ( 353) 241 50.4 1.7e-05 NP_001106834 (OMIM: 614855) TBC1 domain family mem ( 413) 241 50.4 1.9e-05 NP_001317567 (OMIM: 614855) TBC1 domain family mem ( 465) 241 50.5 2.1e-05 XP_011543304 (OMIM: 610831) PREDICTED: carabin iso ( 313) 237 49.7 2.4e-05 XP_006713958 (OMIM: 614855) PREDICTED: TBC1 domain ( 693) 241 50.6 2.8e-05 NP_065824 (OMIM: 614855) TBC1 domain family member ( 693) 241 50.6 2.8e-05 NP_001106832 (OMIM: 614855) TBC1 domain family mem ( 693) 241 50.6 2.8e-05 XP_016863968 (OMIM: 614855) PREDICTED: TBC1 domain ( 389) 234 49.3 3.9e-05 XP_016857774 (OMIM: 602942) PREDICTED: ecotropic v ( 741) 237 50.0 4.6e-05 XP_016857773 (OMIM: 602942) PREDICTED: ecotropic v ( 777) 237 50.0 4.8e-05 XP_016857772 (OMIM: 602942) PREDICTED: ecotropic v ( 785) 237 50.0 4.9e-05 NP_005656 (OMIM: 602942) ecotropic viral integrati ( 810) 237 50.0 5e-05 XP_016857770 (OMIM: 602942) PREDICTED: ecotropic v ( 818) 237 50.0 5e-05 NP_001295177 (OMIM: 602942) ecotropic viral integr ( 821) 237 50.0 5e-05 XP_016857769 (OMIM: 602942) PREDICTED: ecotropic v ( 826) 237 50.0 5e-05 XP_016857766 (OMIM: 602942) PREDICTED: ecotropic v ( 854) 237 50.0 5.2e-05 XP_016857765 (OMIM: 602942) PREDICTED: ecotropic v ( 859) 237 50.0 5.2e-05 >>NP_149106 (OMIM: 616899,616900) TBC domain-containing (830 aa) initn: 5557 init1: 5557 opt: 5557 Z-score: 4774.5 bits: 894.4 E(85289): 0 Smith-Waterman score: 5557; 100.0% identity (100.0% similar) in 822 aa overlap (1-822:9-830) 10 20 30 40 50 pF1KE3 MGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDIS :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDIS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 RGKHERLVVVAEHCERSLEDLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 RGKHERLVVVAEHCERSLEDLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 KSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 KSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 ETVIDLLNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 ETVIDLLNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPE 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 DISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 DISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 ESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 ESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAA 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 ATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 ATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVE 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE3 GAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 GAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLV 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE3 YWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 YWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAF 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE3 HDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 HDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAIL 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE3 QQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 QQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDS 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE3 SGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 SGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTP 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE3 SKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 SKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGK 730 740 750 760 770 780 780 790 800 810 820 pF1KE3 VIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI :::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 VIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI 790 800 810 820 830 >>NP_001156908 (OMIM: 616899,616900) TBC domain-containi (893 aa) initn: 5020 init1: 5020 opt: 5020 Z-score: 4313.4 bits: 809.2 E(85289): 0 Smith-Waterman score: 5202; 92.5% identity (92.5% similar) in 854 aa overlap (32-822:40-893) 10 20 30 40 50 60 pF1KE3 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV :::::::::::::::::::::::::::::: NP_001 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV 10 20 30 40 50 60 70 80 pF1KE3 VAEHCERSLEDLLRERKPVR---------------------------------------- ::::::::::::::::::: NP_001 VAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGH 70 80 90 100 110 120 90 100 110 pF1KE3 -----------------------YPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS ::::::::::::::::::::::::::::::::::::: NP_001 IKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS 130 140 150 160 170 180 120 130 140 150 160 170 pF1KE3 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL 190 200 210 220 230 240 180 190 200 210 220 230 pF1KE3 LNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC 250 260 270 280 290 300 240 250 260 270 280 290 pF1KE3 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG 310 320 330 340 350 360 300 310 320 330 340 350 pF1KE3 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI 370 380 390 400 410 420 360 370 380 390 400 410 pF1KE3 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK 430 440 450 460 470 480 420 430 440 450 460 470 pF1KE3 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD 490 500 510 520 530 540 480 490 500 510 520 530 pF1KE3 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS 550 560 570 580 590 600 540 550 560 570 580 590 pF1KE3 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR 610 620 630 640 650 660 600 610 620 630 640 650 pF1KE3 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS 670 680 690 700 710 720 660 670 680 690 700 710 pF1KE3 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS 730 740 750 760 770 780 720 730 740 750 760 770 pF1KE3 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG 790 800 810 820 830 840 780 790 800 810 820 pF1KE3 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI :::::::::::::::::::::::::::::::::::::::::::: NP_001 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI 850 860 870 880 890 >>NP_001156907 (OMIM: 616899,616900) TBC domain-containi (893 aa) initn: 5020 init1: 5020 opt: 5020 Z-score: 4313.4 bits: 809.2 E(85289): 0 Smith-Waterman score: 5202; 92.5% identity (92.5% similar) in 854 aa overlap (32-822:40-893) 10 20 30 40 50 60 pF1KE3 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV :::::::::::::::::::::::::::::: NP_001 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV 10 20 30 40 50 60 70 80 pF1KE3 VAEHCERSLEDLLRERKPVR---------------------------------------- ::::::::::::::::::: NP_001 VAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGH 70 80 90 100 110 120 90 100 110 pF1KE3 -----------------------YPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS ::::::::::::::::::::::::::::::::::::: NP_001 IKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS 130 140 150 160 170 180 120 130 140 150 160 170 pF1KE3 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL 190 200 210 220 230 240 180 190 200 210 220 230 pF1KE3 LNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC 250 260 270 280 290 300 240 250 260 270 280 290 pF1KE3 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG 310 320 330 340 350 360 300 310 320 330 340 350 pF1KE3 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI 370 380 390 400 410 420 360 370 380 390 400 410 pF1KE3 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK 430 440 450 460 470 480 420 430 440 450 460 470 pF1KE3 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD 490 500 510 520 530 540 480 490 500 510 520 530 pF1KE3 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS 550 560 570 580 590 600 540 550 560 570 580 590 pF1KE3 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR 610 620 630 640 650 660 600 610 620 630 640 650 pF1KE3 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS 670 680 690 700 710 720 660 670 680 690 700 710 pF1KE3 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS 730 740 750 760 770 780 720 730 740 750 760 770 pF1KE3 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG 790 800 810 820 830 840 780 790 800 810 820 pF1KE3 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI :::::::::::::::::::::::::::::::::::::::::::: NP_001 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI 850 860 870 880 890 >>XP_016864337 (OMIM: 616899,616900) PREDICTED: TBC doma (787 aa) initn: 5016 init1: 5016 opt: 5016 Z-score: 4310.8 bits: 808.5 E(85289): 0 Smith-Waterman score: 5016; 99.6% identity (99.9% similar) in 744 aa overlap (79-822:44-787) 50 60 70 80 90 100 pF1KE3 VDISRGKHERLVVVAEHCERSLEDLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPL :. ::::::::::::::::::::::::::: XP_016 HNILLDRKGHIKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPL 20 30 40 50 60 70 110 120 130 140 150 160 pF1KE3 PSGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDII 80 90 100 110 120 130 170 180 190 200 210 220 pF1KE3 KELPETVIDLLNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADL ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: XP_016 KELPETVIDLLNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADL 140 150 160 170 180 190 230 240 250 260 270 280 pF1KE3 TLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFL 200 210 220 230 240 250 290 300 310 320 330 340 pF1KE3 FEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNE 260 270 280 290 300 310 350 360 370 380 390 400 pF1KE3 LSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAAL 320 330 340 350 360 370 410 420 430 440 450 460 pF1KE3 LGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSH 380 390 400 410 420 430 470 480 490 500 510 520 pF1KE3 PDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQ 440 450 460 470 480 490 530 540 550 560 570 580 pF1KE3 MIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIG 500 510 520 530 540 550 590 600 610 620 630 640 pF1KE3 VAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKP 560 570 580 590 600 610 650 660 670 680 690 700 pF1KE3 SSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGH 620 630 640 650 660 670 710 720 730 740 750 760 pF1KE3 FKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQN 680 690 700 710 720 730 770 780 790 800 810 820 pF1KE3 FKGKVIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKGKVIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI 740 750 760 770 780 >>XP_016864335 (OMIM: 616899,616900) PREDICTED: TBC doma (893 aa) initn: 5016 init1: 5016 opt: 5016 Z-score: 4310.0 bits: 808.6 E(85289): 0 Smith-Waterman score: 5198; 92.4% identity (92.5% similar) in 854 aa overlap (32-822:40-893) 10 20 30 40 50 60 pF1KE3 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV :::::::::::::::::::::::::::::: XP_016 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV 10 20 30 40 50 60 70 80 pF1KE3 VAEHCERSLEDLLRERKPVR---------------------------------------- ::::::::::::::::::: XP_016 VAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGH 70 80 90 100 110 120 90 100 110 pF1KE3 -----------------------YPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS ::::::::::::::::::::::::::::::::::::: XP_016 IKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS 130 140 150 160 170 180 120 130 140 150 160 170 pF1KE3 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL 190 200 210 220 230 240 180 190 200 210 220 230 pF1KE3 LNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: XP_016 LNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC 250 260 270 280 290 300 240 250 260 270 280 290 pF1KE3 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG 310 320 330 340 350 360 300 310 320 330 340 350 pF1KE3 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI 370 380 390 400 410 420 360 370 380 390 400 410 pF1KE3 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK 430 440 450 460 470 480 420 430 440 450 460 470 pF1KE3 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD 490 500 510 520 530 540 480 490 500 510 520 530 pF1KE3 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS 550 560 570 580 590 600 540 550 560 570 580 590 pF1KE3 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR 610 620 630 640 650 660 600 610 620 630 640 650 pF1KE3 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS 670 680 690 700 710 720 660 670 680 690 700 710 pF1KE3 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS 730 740 750 760 770 780 720 730 740 750 760 770 pF1KE3 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG 790 800 810 820 830 840 780 790 800 810 820 pF1KE3 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI :::::::::::::::::::::::::::::::::::::::::::: XP_016 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI 850 860 870 880 890 >>XP_011530719 (OMIM: 616899,616900) PREDICTED: TBC doma (893 aa) initn: 5016 init1: 5016 opt: 5016 Z-score: 4310.0 bits: 808.6 E(85289): 0 Smith-Waterman score: 5198; 92.4% identity (92.5% similar) in 854 aa overlap (32-822:40-893) 10 20 30 40 50 60 pF1KE3 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV :::::::::::::::::::::::::::::: XP_011 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV 10 20 30 40 50 60 70 80 pF1KE3 VAEHCERSLEDLLRERKPVR---------------------------------------- ::::::::::::::::::: XP_011 VAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGH 70 80 90 100 110 120 90 100 110 pF1KE3 -----------------------YPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS ::::::::::::::::::::::::::::::::::::: XP_011 IKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS 130 140 150 160 170 180 120 130 140 150 160 170 pF1KE3 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL 190 200 210 220 230 240 180 190 200 210 220 230 pF1KE3 LNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: XP_011 LNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC 250 260 270 280 290 300 240 250 260 270 280 290 pF1KE3 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG 310 320 330 340 350 360 300 310 320 330 340 350 pF1KE3 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI 370 380 390 400 410 420 360 370 380 390 400 410 pF1KE3 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK 430 440 450 460 470 480 420 430 440 450 460 470 pF1KE3 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD 490 500 510 520 530 540 480 490 500 510 520 530 pF1KE3 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS 550 560 570 580 590 600 540 550 560 570 580 590 pF1KE3 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR 610 620 630 640 650 660 600 610 620 630 640 650 pF1KE3 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS 670 680 690 700 710 720 660 670 680 690 700 710 pF1KE3 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS 730 740 750 760 770 780 720 730 740 750 760 770 pF1KE3 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG 790 800 810 820 830 840 780 790 800 810 820 pF1KE3 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI :::::::::::::::::::::::::::::::::::::::::::: XP_011 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI 850 860 870 880 890 >>NP_001277697 (OMIM: 616899,616900) TBC domain-containi (721 aa) initn: 4875 init1: 4875 opt: 4875 Z-score: 4190.4 bits: 786.1 E(85289): 0 Smith-Waterman score: 4875; 100.0% identity (100.0% similar) in 721 aa overlap (102-822:1-721) 80 90 100 110 120 130 pF1KE3 DLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWSLGIILFELCVGRK :::::::::::::::::::::::::::::: NP_001 MPSKKPLPSGPKSDVWSLGIILFELCVGRK 10 20 30 140 150 160 170 180 190 pF1KE3 LFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRP 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE3 TPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSI 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE3 EEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVT 160 170 180 190 200 210 320 330 340 350 360 370 pF1KE3 LSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRI 220 230 240 250 260 270 380 390 400 410 420 430 pF1KE3 ILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTD 280 290 300 310 320 330 440 450 460 470 480 490 pF1KE3 RQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNN 340 350 360 370 380 390 500 510 520 530 540 550 pF1KE3 EALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY 400 410 420 430 440 450 560 570 580 590 600 610 pF1KE3 AIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLF 460 470 480 490 500 510 620 630 640 650 660 670 pF1KE3 SDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPK 520 530 540 550 560 570 680 690 700 710 720 730 pF1KE3 TDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNS 580 590 600 610 620 630 740 750 760 770 780 790 pF1KE3 EDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVGHVAKHTAEFAAHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVGHVAKHTAEFAAHL 640 650 660 670 680 690 800 810 820 pF1KE3 VKMKYPRICILDGGINKIKPTGLLTIPSPQI ::::::::::::::::::::::::::::::: NP_001 VKMKYPRICILDGGINKIKPTGLLTIPSPQI 700 710 720 >>XP_016864338 (OMIM: 616899,616900) PREDICTED: TBC doma (721 aa) initn: 4871 init1: 4871 opt: 4871 Z-score: 4186.9 bits: 785.5 E(85289): 0 Smith-Waterman score: 4871; 99.9% identity (100.0% similar) in 721 aa overlap (102-822:1-721) 80 90 100 110 120 130 pF1KE3 DLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWSLGIILFELCVGRK :::::::::::::::::::::::::::::: XP_016 MPSKKPLPSGPKSDVWSLGIILFELCVGRK 10 20 30 140 150 160 170 180 190 pF1KE3 LFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRP 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE3 TPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSI :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSI 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE3 EEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVT 160 170 180 190 200 210 320 330 340 350 360 370 pF1KE3 LSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRI 220 230 240 250 260 270 380 390 400 410 420 430 pF1KE3 ILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTD 280 290 300 310 320 330 440 450 460 470 480 490 pF1KE3 RQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNN 340 350 360 370 380 390 500 510 520 530 540 550 pF1KE3 EALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY 400 410 420 430 440 450 560 570 580 590 600 610 pF1KE3 AIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLF 460 470 480 490 500 510 620 630 640 650 660 670 pF1KE3 SDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPK 520 530 540 550 560 570 680 690 700 710 720 730 pF1KE3 TDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNS 580 590 600 610 620 630 740 750 760 770 780 790 pF1KE3 EDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVGHVAKHTAEFAAHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVGHVAKHTAEFAAHL 640 650 660 670 680 690 800 810 820 pF1KE3 VKMKYPRICILDGGINKIKPTGLLTIPSPQI ::::::::::::::::::::::::::::::: XP_016 VKMKYPRICILDGGINKIKPTGLLTIPSPQI 700 710 720 >>XP_016864336 (OMIM: 616899,616900) PREDICTED: TBC doma (857 aa) initn: 4773 init1: 4773 opt: 4773 Z-score: 4101.8 bits: 770.0 E(85289): 0 Smith-Waterman score: 4955; 92.1% identity (92.2% similar) in 818 aa overlap (32-786:40-857) 10 20 30 40 50 60 pF1KE3 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV :::::::::::::::::::::::::::::: XP_016 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV 10 20 30 40 50 60 70 80 pF1KE3 VAEHCERSLEDLLRERKPVR---------------------------------------- ::::::::::::::::::: XP_016 VAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGH 70 80 90 100 110 120 90 100 110 pF1KE3 -----------------------YPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS ::::::::::::::::::::::::::::::::::::: XP_016 IKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS 130 140 150 160 170 180 120 130 140 150 160 170 pF1KE3 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL 190 200 210 220 230 240 180 190 200 210 220 230 pF1KE3 LNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: XP_016 LNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC 250 260 270 280 290 300 240 250 260 270 280 290 pF1KE3 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG 310 320 330 340 350 360 300 310 320 330 340 350 pF1KE3 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI 370 380 390 400 410 420 360 370 380 390 400 410 pF1KE3 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK 430 440 450 460 470 480 420 430 440 450 460 470 pF1KE3 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD 490 500 510 520 530 540 480 490 500 510 520 530 pF1KE3 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS 550 560 570 580 590 600 540 550 560 570 580 590 pF1KE3 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR 610 620 630 640 650 660 600 610 620 630 640 650 pF1KE3 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS 670 680 690 700 710 720 660 670 680 690 700 710 pF1KE3 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS 730 740 750 760 770 780 720 730 740 750 760 770 pF1KE3 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG 790 800 810 820 830 840 780 790 800 810 820 pF1KE3 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI :::::::: XP_016 HVAKHTAE 850 >>NP_001156909 (OMIM: 616899,616900) TBC domain-containi (854 aa) initn: 5212 init1: 4684 opt: 4684 Z-score: 4025.5 bits: 755.8 E(85289): 1.8e-217 Smith-Waterman score: 5172; 92.8% identity (94.2% similar) in 847 aa overlap (1-822:9-854) 10 20 30 40 50 pF1KE3 MGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDIS :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDIS 10 20 30 40 50 60 60 70 80 90 100 pF1KE3 RGKHERLVVVAEHCERSLEDLLRERKPVRYPSYL--APEVIAQGIFKTTDHMPSKKPL-P :::::::::::::::::::::::::::: . : : ::. ::. . : .. : : NP_001 RGKHERLVVVAEHCERSLEDLLRERKPVSCSTVLCIAFEVL-QGLQYMNKHGIVHRALSP 70 80 90 100 110 110 120 130 140 pF1KE3 ---------------------SGPKSDV-WSLGIILFELCVGRKLFQSLDISERLKFLLT .. .:: . .: . ::::::::::::::::::: NP_001 HNILLDRKGHIKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEGRKLFQSLDISERLKFLLT 120 130 140 150 160 170 150 160 170 180 190 200 pF1KE3 LDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDELMKDKVFSEVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDELMKDKVFSEVSP 180 190 200 210 220 230 210 220 230 240 250 260 pF1KE3 LYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEK 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE3 ELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGE 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE3 AFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQ 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE3 IWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDEL 420 430 440 450 460 470 450 460 470 480 490 500 pF1KE3 LSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYL 480 490 500 510 520 530 510 520 530 540 550 560 pF1KE3 YNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLH 540 550 560 570 580 590 570 580 590 600 610 620 pF1KE3 KIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESI 600 610 620 630 640 650 630 640 650 660 670 680 pF1KE3 NLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSE 660 670 680 690 700 710 690 700 710 720 730 740 pF1KE3 VSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPF 720 730 740 750 760 770 750 760 770 780 790 800 pF1KE3 SAAFTAEGELTQGPYTAMLQNFKGKVIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAAFTAEGELTQGPYTAMLQNFKGKVIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGIN 780 790 800 810 820 830 810 820 pF1KE3 KIKPTGLLTIPSPQI ::::::::::::::: NP_001 KIKPTGLLTIPSPQI 840 850 822 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 02:04:04 2016 done: Mon Nov 7 02:04:06 2016 Total Scan time: 12.220 Total Display time: 0.270 Function used was FASTA [36.3.4 Apr, 2011]