FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4591, 1107 aa 1>>>pF1KE4591 1107 - 1107 aa - 1107 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2378+/-0.000377; mu= 13.3274+/- 0.024 mean_var=138.1361+/-28.385, 0's: 0 Z-trim(117.1): 37 B-trim: 555 in 1/55 Lambda= 0.109124 statistics sampled from 28784 (28823) to 28784 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.682), E-opt: 0.2 (0.338), width: 16 Scan time: 13.460 The best scores are: opt bits E(85289) NP_001243778 (OMIM: 174761,612591,615381) DNA poly (1107) 7467 1188.1 0 NP_002682 (OMIM: 174761,612591,615381) DNA polymer (1107) 7467 1188.1 0 XP_011525340 (OMIM: 174761,612591,615381) PREDICTE (1107) 7467 1188.1 0 XP_016882370 (OMIM: 174761,612591,615381) PREDICTE (1107) 7467 1188.1 0 XP_016882371 (OMIM: 174761,612591,615381) PREDICTE (1083) 4703 752.9 2.3e-216 XP_005259065 (OMIM: 174761,612591,615381) PREDICTE (1083) 4703 752.9 2.3e-216 NP_001295561 (OMIM: 174761,612591,615381) DNA poly (1133) 4043 649.0 4.4e-185 NP_001273361 (OMIM: 602776) DNA polymerase zeta ca (3052) 779 135.5 4.7e-30 NP_001273360 (OMIM: 602776) DNA polymerase zeta ca (3052) 779 135.5 4.7e-30 XP_016866643 (OMIM: 602776) PREDICTED: DNA polymer (3078) 779 135.5 4.8e-30 XP_016866642 (OMIM: 602776) PREDICTED: DNA polymer (3078) 779 135.5 4.8e-30 XP_016866641 (OMIM: 602776) PREDICTED: DNA polymer (3078) 779 135.5 4.8e-30 XP_011534333 (OMIM: 602776) PREDICTED: DNA polymer (3079) 779 135.5 4.8e-30 XP_011534334 (OMIM: 602776) PREDICTED: DNA polymer (3079) 779 135.5 4.8e-30 NP_002903 (OMIM: 602776) DNA polymerase zeta catal (3130) 779 135.5 4.8e-30 XP_011534332 (OMIM: 602776) PREDICTED: DNA polymer (3131) 779 135.5 4.8e-30 XP_011534331 (OMIM: 602776) PREDICTED: DNA polymer (3156) 779 135.5 4.9e-30 XP_011534330 (OMIM: 602776) PREDICTED: DNA polymer (3157) 779 135.5 4.9e-30 XP_006724562 (OMIM: 301220,310465,312040) PREDICTE (1326) 448 83.1 1.2e-14 XP_011543842 (OMIM: 301220,310465,312040) PREDICTE (1350) 448 83.1 1.2e-14 XP_016885085 (OMIM: 301220,310465,312040) PREDICTE (1353) 448 83.1 1.2e-14 XP_016885084 (OMIM: 301220,310465,312040) PREDICTE (1432) 448 83.1 1.3e-14 XP_016885083 (OMIM: 301220,310465,312040) PREDICTE (1443) 448 83.1 1.3e-14 NP_058633 (OMIM: 301220,310465,312040) DNA polymer (1462) 448 83.2 1.3e-14 NP_001317289 (OMIM: 301220,310465,312040) DNA poly (1468) 448 83.2 1.3e-14 XP_016866644 (OMIM: 602776) PREDICTED: DNA polymer (2254) 240 50.5 0.00013 XP_011534338 (OMIM: 602776) PREDICTED: DNA polymer (2328) 240 50.5 0.00013 >>NP_001243778 (OMIM: 174761,612591,615381) DNA polymera (1107 aa) initn: 7467 init1: 7467 opt: 7467 Z-score: 6357.2 bits: 1188.1 E(85289): 0 Smith-Waterman score: 7467; 99.9% identity (100.0% similar) in 1107 aa overlap (1-1107:1-1107) 10 20 30 40 50 60 pF1KE4 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSHG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.: NP_001 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE4 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE4 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE4 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE4 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE4 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY 1030 1040 1050 1060 1070 1080 1090 1100 pF1KE4 MRKKVRKDLEDQEQLLRRFGPPGPEAW ::::::::::::::::::::::::::: NP_001 MRKKVRKDLEDQEQLLRRFGPPGPEAW 1090 1100 >>NP_002682 (OMIM: 174761,612591,615381) DNA polymerase (1107 aa) initn: 7467 init1: 7467 opt: 7467 Z-score: 6357.2 bits: 1188.1 E(85289): 0 Smith-Waterman score: 7467; 99.9% identity (100.0% similar) in 1107 aa overlap (1-1107:1-1107) 10 20 30 40 50 60 pF1KE4 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSHG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.: NP_002 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE4 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE4 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE4 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE4 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE4 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY 1030 1040 1050 1060 1070 1080 1090 1100 pF1KE4 MRKKVRKDLEDQEQLLRRFGPPGPEAW ::::::::::::::::::::::::::: NP_002 MRKKVRKDLEDQEQLLRRFGPPGPEAW 1090 1100 >>XP_011525340 (OMIM: 174761,612591,615381) PREDICTED: D (1107 aa) initn: 7467 init1: 7467 opt: 7467 Z-score: 6357.2 bits: 1188.1 E(85289): 0 Smith-Waterman score: 7467; 99.9% identity (100.0% similar) in 1107 aa overlap (1-1107:1-1107) 10 20 30 40 50 60 pF1KE4 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSHG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.: XP_011 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE4 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE4 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE4 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE4 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE4 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY 1030 1040 1050 1060 1070 1080 1090 1100 pF1KE4 MRKKVRKDLEDQEQLLRRFGPPGPEAW ::::::::::::::::::::::::::: XP_011 MRKKVRKDLEDQEQLLRRFGPPGPEAW 1090 1100 >>XP_016882370 (OMIM: 174761,612591,615381) PREDICTED: D (1107 aa) initn: 7467 init1: 7467 opt: 7467 Z-score: 6357.2 bits: 1188.1 E(85289): 0 Smith-Waterman score: 7467; 99.9% identity (100.0% similar) in 1107 aa overlap (1-1107:1-1107) 10 20 30 40 50 60 pF1KE4 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSHG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.: XP_016 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE4 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE4 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE4 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE4 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE4 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY 1030 1040 1050 1060 1070 1080 1090 1100 pF1KE4 MRKKVRKDLEDQEQLLRRFGPPGPEAW ::::::::::::::::::::::::::: XP_016 MRKKVRKDLEDQEQLLRRFGPPGPEAW 1090 1100 >>XP_016882371 (OMIM: 174761,612591,615381) PREDICTED: D (1083 aa) initn: 4695 init1: 4695 opt: 4703 Z-score: 4005.6 bits: 752.9 E(85289): 2.3e-216 Smith-Waterman score: 7253; 97.7% identity (97.8% similar) in 1107 aa overlap (1-1107:1-1083) 10 20 30 40 50 60 pF1KE4 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSHG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.: XP_016 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV :::::::::::::::::::::::::::::::::: :: XP_016 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALK------------------------SV 670 680 690 730 740 750 760 770 780 pF1KE4 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD 700 710 720 730 740 750 790 800 810 820 830 840 pF1KE4 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV 760 770 780 790 800 810 850 860 870 880 890 900 pF1KE4 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH 820 830 840 850 860 870 910 920 930 940 950 960 pF1KE4 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ 880 890 900 910 920 930 970 980 990 1000 1010 1020 pF1KE4 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS 940 950 960 970 980 990 1030 1040 1050 1060 1070 1080 pF1KE4 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY 1000 1010 1020 1030 1040 1050 1090 1100 pF1KE4 MRKKVRKDLEDQEQLLRRFGPPGPEAW ::::::::::::::::::::::::::: XP_016 MRKKVRKDLEDQEQLLRRFGPPGPEAW 1060 1070 1080 >>XP_005259065 (OMIM: 174761,612591,615381) PREDICTED: D (1083 aa) initn: 4695 init1: 4695 opt: 4703 Z-score: 4005.6 bits: 752.9 E(85289): 2.3e-216 Smith-Waterman score: 7253; 97.7% identity (97.8% similar) in 1107 aa overlap (1-1107:1-1083) 10 20 30 40 50 60 pF1KE4 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSHG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.: XP_005 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV :::::::::::::::::::::::::::::::::: :: XP_005 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALK------------------------SV 670 680 690 730 740 750 760 770 780 pF1KE4 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD 700 710 720 730 740 750 790 800 810 820 830 840 pF1KE4 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV 760 770 780 790 800 810 850 860 870 880 890 900 pF1KE4 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH 820 830 840 850 860 870 910 920 930 940 950 960 pF1KE4 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ 880 890 900 910 920 930 970 980 990 1000 1010 1020 pF1KE4 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS 940 950 960 970 980 990 1030 1040 1050 1060 1070 1080 pF1KE4 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY 1000 1010 1020 1030 1040 1050 1090 1100 pF1KE4 MRKKVRKDLEDQEQLLRRFGPPGPEAW ::::::::::::::::::::::::::: XP_005 MRKKVRKDLEDQEQLLRRFGPPGPEAW 1060 1070 1080 >>NP_001295561 (OMIM: 174761,612591,615381) DNA polymera (1133 aa) initn: 7453 init1: 4042 opt: 4043 Z-score: 3443.7 bits: 649.0 E(85289): 4.4e-185 Smith-Waterman score: 7405; 97.6% identity (97.7% similar) in 1133 aa overlap (1-1107:1-1133) 10 20 30 40 50 60 pF1KE4 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSHG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.: NP_001 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG 490 500 510 520 530 540 550 560 570 580 590 pF1KE4 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKG-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGVRPQDRAG 550 560 570 580 590 600 600 610 620 630 pF1KE4 ------------------YYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTE :::::::::::::::::::::::::::::::::::::::::: NP_001 AAWELLALTPGRGCSPPRYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTE 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE4 DQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAKAELAKETDPLRRQVLDGRQLALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAKAELAKETDPLRRQVLDGRQLALK 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE4 VSANSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSANSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYG 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE4 DTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLF 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE4 SSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCN 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE4 RIDISQLVITKELTRAASDYAGKQAHVELAERMRKRDPGSAPSLGDRVPYVIISAAKGVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RIDISQLVITKELTRAASDYAGKQAHVELAERMRKRDPGSAPSLGDRVPYVIISAAKGVA 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE4 AYMKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AYMKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTV 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KE4 LTGKVGGLLAFAKRRNCCIGCRTVLSHQGAVCEFCQPRESELYQKEVSHLNALEERFSRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTGKVGGLLAFAKRRNCCIGCRTVLSHQGAVCEFCQPRESELYQKEVSHLNALEERFSRL 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 pF1KE4 WTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQEQLLRRFGPPGPEAW ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQEQLLRRFGPPGPEAW 1090 1100 1110 1120 1130 >>NP_001273361 (OMIM: 602776) DNA polymerase zeta cataly (3052 aa) initn: 889 init1: 312 opt: 779 Z-score: 660.5 bits: 135.5 E(85289): 4.7e-30 Smith-Waterman score: 1161; 26.5% identity (56.6% similar) in 1121 aa overlap (52-1099:1989-3052) 30 40 50 60 70 80 pF1KE4 LWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQSVLEGVADGQVPPSAIDPRWLR ... .. : .:.. . : .: . . : NP_001 FSSSVNPDDKPVVPPKMDVSPCILPTTAHTKEDVDNSQIALQAPTTG-CSQTASESQMLP 1960 1970 1980 1990 2000 2010 90 100 110 120 130 140 pF1KE4 PTPPALDPQTEPLIFQQLEIDHYVGPAQP-VPGGPPPSHGSVPVLRAFGVTDEGFSVCCH :. : ::. . .. . ..:.. ..: : :: .. : .:.. :. : . NP_001 PVASASDPEKD----EDDDDNYYISYSSPDSPVIPPWQQPISPDSKALNGDDRPSSPVEE 2020 2030 2040 2050 2060 2070 150 160 170 180 190 pF1KE4 IHGFA-PYFYTPAPPGFGPEHMGDLQRELNLA-ISRDSRGGRELTGPAVLAVELCSRESM . ..: : : :. .. :. : .. :. .: :. : ::. NP_001 LPSLAFENFLKPIKDGIQKSPCSEPQEPLVISPINTRARTGK------------C--ESL 2080 2090 2100 2110 200 210 220 230 240 250 pF1KE4 FGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPSFAPYEANVDFEIRFMVDT .:. .:... :.:::. .. ::. : : ... . .: NP_001 C-FHS---TPIIQ------------RKLLERLPEAPGLSPLSTEPKTQKLS--NKKGSNT 2120 2130 2140 2150 2160 260 270 280 290 300 310 pF1KE4 DIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDV-----VSHPPEGP-WQRIAPLRV : . : ...: . :... : . ... :. ..: : . NP_001 DTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGFKVSIQNLQEAKALHEIQNLTL 2170 2180 2190 2200 2210 2220 320 330 340 350 pF1KE4 LSFDIECAGRKGIFPEPERDPVIQICSL--GLRWGEPEP-FLRLALT------------- .: ... :. . :.:: :: ::.: . : : . :: NP_001 ISVELHARTRRDLEPDPEFDP---ICALFYCISSDTPLPDTEKTELTGVIVIDKDKTVFS 2230 2240 2250 2260 2270 360 370 380 390 400 pF1KE4 --LRPCAPIL------GAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLIS .: .:.: : .: :. :.. ...:. .:::.. ::.:: . ::.. NP_001 QDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDPDILLGYEIQMHSWGYLLQ 2280 2290 2300 2310 2320 2330 410 420 430 440 450 460 pF1KE4 RAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYK :: .:... ...:: . : .. . . : . ...:::. ... ... : NP_001 RAAALSIDLCRMISRVPDDKIENRFAA-ERDEYGSYTMSEINIVGRITLNLWRIMRNEVA 2340 2350 2360 2370 2380 2390 470 480 490 500 510 520 pF1KE4 LRSYTLNAVSFHFLGEQKEDVQHSIITD-LQNGNDQTRRRLAVYCLKDAYLPLRLLERLM : .::.. :::: : .. ...: ..: .: : ... . .. . :..::.: NP_001 LTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLD 2400 2410 2420 2430 2440 2450 530 540 550 560 570 580 pF1KE4 VLVNAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQA--MHEGLLMPVV--KSEGGEDYTG .. .. ::::. :. . ..:.::.: .: :..:: : :. . : : .:. NP_001 LIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCV 2460 2470 2480 2490 2500 2510 590 600 610 620 630 pF1KE4 ATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQF------ ..:: . .:. . .:::.::::::..:.: :..: : : ...:: :.: NP_001 PLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCL--GHVENLG-KYDEFKFGCTS 2520 2530 2540 2550 2560 2570 640 650 660 670 680 pF1KE4 ----------IR-----TPTGDEFVKTSVRKGLLPQILENLLSARKRAKAEL-AKETDPL .: .:.: ::: :::::.::..::..:..: .: . : . : NP_001 LRVPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRA 2580 2590 2600 2610 2620 2630 690 700 710 720 730 740 pF1KE4 RRQVLDGRQLALKVSANSVYGFTGAQV-GKLPCLEISQSVTGFGRQMIEKTKQLVESKYT ..::.:::.::. :: ..:.:.:. :..::.:...:.. .:. .:.. .::.. : NP_001 LSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVND--T 2640 2650 2660 2670 2680 2690 750 760 770 780 790 800 pF1KE4 VENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFP . : :.::::::::.. . .. ... .:.: :. :.. :.:..:.:::::.: NP_001 KKWG----ARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLP 2700 2710 2720 2730 2740 810 820 830 840 850 860 pF1KE4 YLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGA .: .::::.: .. . . .: ::.:.::::.:: :.... ::. :. :: NP_001 CVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISLI 2750 2760 2770 2780 2790 2800 870 880 890 900 910 pF1KE4 VAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH-VELAERMRKRDPGSAPSLG ..: :: .. .:......:: . : : . .::...: : : :..: NP_001 KQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVG 2810 2820 2830 2840 2850 2860 920 930 940 950 960 970 pF1KE4 DRVPYVIISAAKGVAAYMKSEDPLFVLEH-SLPIDTQYYLEQQLAKPLLRIFEPILG--- .::::::: .. :: . . :. ::. .: ... ::. .:. :: ::: ..: NP_001 ERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFS-LIGIDV 2870 2880 2890 2900 2910 2920 980 990 1000 1010 1020 1030 pF1KE4 -EGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLSHQGAVCEFC--QPR : .. . .. :. : . . .: . : . .: ..: : ::. NP_001 FSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPV-CDDLTQH--GICSKCRSQPQ 2930 2940 2950 2960 2970 2980 1040 1050 1060 1070 1080 1090 pF1KE4 E-SELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLED . . . ..:. .:. .:.. .. :. : : . . . :.: .::... ..: ..: NP_001 HVAVILNQEIRELERQQEQLVKI---CKNCTGCFDRHIPCVSLNCPVLFKLSRVNRELSK 2990 3000 3010 3020 3030 3040 1100 pF1KE4 Q---EQLLRRFGPPGPEAW .::: .: NP_001 APYLRQLLDQF 3050 >>NP_001273360 (OMIM: 602776) DNA polymerase zeta cataly (3052 aa) initn: 889 init1: 312 opt: 779 Z-score: 660.5 bits: 135.5 E(85289): 4.7e-30 Smith-Waterman score: 1161; 26.5% identity (56.6% similar) in 1121 aa overlap (52-1099:1989-3052) 30 40 50 60 70 80 pF1KE4 LWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQSVLEGVADGQVPPSAIDPRWLR ... .. : .:.. . : .: . . : NP_001 FSSSVNPDDKPVVPPKMDVSPCILPTTAHTKEDVDNSQIALQAPTTG-CSQTASESQMLP 1960 1970 1980 1990 2000 2010 90 100 110 120 130 140 pF1KE4 PTPPALDPQTEPLIFQQLEIDHYVGPAQP-VPGGPPPSHGSVPVLRAFGVTDEGFSVCCH :. : ::. . .. . ..:.. ..: : :: .. : .:.. :. : . NP_001 PVASASDPEKD----EDDDDNYYISYSSPDSPVIPPWQQPISPDSKALNGDDRPSSPVEE 2020 2030 2040 2050 2060 2070 150 160 170 180 190 pF1KE4 IHGFA-PYFYTPAPPGFGPEHMGDLQRELNLA-ISRDSRGGRELTGPAVLAVELCSRESM . ..: : : :. .. :. : .. :. .: :. : ::. NP_001 LPSLAFENFLKPIKDGIQKSPCSEPQEPLVISPINTRARTGK------------C--ESL 2080 2090 2100 2110 200 210 220 230 240 250 pF1KE4 FGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPSFAPYEANVDFEIRFMVDT .:. .:... :.:::. .. ::. : : ... . .: NP_001 C-FHS---TPIIQ------------RKLLERLPEAPGLSPLSTEPKTQKLS--NKKGSNT 2120 2130 2140 2150 2160 260 270 280 290 300 310 pF1KE4 DIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDV-----VSHPPEGP-WQRIAPLRV : . : ...: . :... : . ... :. ..: : . NP_001 DTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGFKVSIQNLQEAKALHEIQNLTL 2170 2180 2190 2200 2210 2220 320 330 340 350 pF1KE4 LSFDIECAGRKGIFPEPERDPVIQICSL--GLRWGEPEP-FLRLALT------------- .: ... :. . :.:: :: ::.: . : : . :: NP_001 ISVELHARTRRDLEPDPEFDP---ICALFYCISSDTPLPDTEKTELTGVIVIDKDKTVFS 2230 2240 2250 2260 2270 360 370 380 390 400 pF1KE4 --LRPCAPIL------GAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLIS .: .:.: : .: :. :.. ...:. .:::.. ::.:: . ::.. NP_001 QDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDPDILLGYEIQMHSWGYLLQ 2280 2290 2300 2310 2320 2330 410 420 430 440 450 460 pF1KE4 RAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYK :: .:... ...:: . : .. . . : . ...:::. ... ... : NP_001 RAAALSIDLCRMISRVPDDKIENRFAA-ERDEYGSYTMSEINIVGRITLNLWRIMRNEVA 2340 2350 2360 2370 2380 2390 470 480 490 500 510 520 pF1KE4 LRSYTLNAVSFHFLGEQKEDVQHSIITD-LQNGNDQTRRRLAVYCLKDAYLPLRLLERLM : .::.. :::: : .. ...: ..: .: : ... . .. . :..::.: NP_001 LTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLD 2400 2410 2420 2430 2440 2450 530 540 550 560 570 580 pF1KE4 VLVNAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQA--MHEGLLMPVV--KSEGGEDYTG .. .. ::::. :. . ..:.::.: .: :..:: : :. . : : .:. NP_001 LIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCV 2460 2470 2480 2490 2500 2510 590 600 610 620 630 pF1KE4 ATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQF------ ..:: . .:. . .:::.::::::..:.: :..: : : ...:: :.: NP_001 PLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCL--GHVENLG-KYDEFKFGCTS 2520 2530 2540 2550 2560 2570 640 650 660 670 680 pF1KE4 ----------IR-----TPTGDEFVKTSVRKGLLPQILENLLSARKRAKAEL-AKETDPL .: .:.: ::: :::::.::..::..:..: .: . : . : NP_001 LRVPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRA 2580 2590 2600 2610 2620 2630 690 700 710 720 730 740 pF1KE4 RRQVLDGRQLALKVSANSVYGFTGAQV-GKLPCLEISQSVTGFGRQMIEKTKQLVESKYT ..::.:::.::. :: ..:.:.:. :..::.:...:.. .:. .:.. .::.. : NP_001 LSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVND--T 2640 2650 2660 2670 2680 2690 750 760 770 780 790 800 pF1KE4 VENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFP . : :.::::::::.. . .. ... .:.: :. :.. :.:..:.:::::.: NP_001 KKWG----ARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLP 2700 2710 2720 2730 2740 810 820 830 840 850 860 pF1KE4 YLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGA .: .::::.: .. . . .: ::.:.::::.:: :.... ::. :. :: NP_001 CVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISLI 2750 2760 2770 2780 2790 2800 870 880 890 900 910 pF1KE4 VAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH-VELAERMRKRDPGSAPSLG ..: :: .. .:......:: . : : . .::...: : : :..: NP_001 KQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVG 2810 2820 2830 2840 2850 2860 920 930 940 950 960 970 pF1KE4 DRVPYVIISAAKGVAAYMKSEDPLFVLEH-SLPIDTQYYLEQQLAKPLLRIFEPILG--- .::::::: .. :: . . :. ::. .: ... ::. .:. :: ::: ..: NP_001 ERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFS-LIGIDV 2870 2880 2890 2900 2910 2920 980 990 1000 1010 1020 1030 pF1KE4 -EGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLSHQGAVCEFC--QPR : .. . .. :. : . . .: . : . .: ..: : ::. NP_001 FSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPV-CDDLTQH--GICSKCRSQPQ 2930 2940 2950 2960 2970 2980 1040 1050 1060 1070 1080 1090 pF1KE4 E-SELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLED . . . ..:. .:. .:.. .. :. : : . . . :.: .::... ..: ..: NP_001 HVAVILNQEIRELERQQEQLVKI---CKNCTGCFDRHIPCVSLNCPVLFKLSRVNRELSK 2990 3000 3010 3020 3030 3040 1100 pF1KE4 Q---EQLLRRFGPPGPEAW .::: .: NP_001 APYLRQLLDQF 3050 >>XP_016866643 (OMIM: 602776) PREDICTED: DNA polymerase (3078 aa) initn: 889 init1: 312 opt: 779 Z-score: 660.5 bits: 135.5 E(85289): 4.8e-30 Smith-Waterman score: 1121; 30.0% identity (62.0% similar) in 753 aa overlap (387-1099:2343-3078) 360 370 380 390 400 410 pF1KE4 LRPCAPILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQ ..:::.. ::.:: . ::..:: .:... XP_016 NIIKRGCHQHVRCFQYPHFFYFCKQLRERNMYDPDILLGYEIQMHSWGYLLQRAAALSID 2320 2330 2340 2350 2360 2370 420 430 440 450 460 470 pF1KE4 TFPFLGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNA ...:: . : .. . . : . ...:::. ... ... : : .::.. XP_016 LCRMISRVPDDKIENRFAA-ERDEYGSYTMSEINIVGRITLNLWRIMRNEVALTNYTFEN 2380 2390 2400 2410 2420 2430 480 490 500 510 520 530 pF1KE4 VSFHFLGEQKEDVQHSIITD-LQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEM :::: : .. ...: ..: .: : ... . .. . :..::.: .. .. :: XP_016 VSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEM 2440 2450 2460 2470 2480 2490 540 550 560 570 580 590 pF1KE4 ARVTGVPLSYLLSRGQQVKVVSQLLRQA--MHEGLLMPVV--KSEGGEDYTGATVIEPLK ::. :. . ..:.::.: .: :..:: : :. . : : .:. ..:: . XP_016 ARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCVPLIMEPES 2500 2510 2520 2530 2540 2550 600 610 620 630 pF1KE4 GYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQF-------------- .:. . .:::.::::::..:.: :..: : : ...:: :.: XP_016 RFYSNSVLVLDFQSLYPSIVIAYNYCFSTCL--GHVENLG-KYDEFKFGCTSLRVPPDLL 2560 2570 2580 2590 2600 640 650 660 670 680 pF1KE4 --IR-----TPTGDEFVKTSVRKGLLPQILENLLSARKRAKAEL-AKETDPLRRQVLDGR .: .:.: ::: :::::.::..::..:..: .: . : . : ..::.: XP_016 YQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRALSRMLDAR 2610 2620 2630 2640 2650 2660 690 700 710 720 730 740 pF1KE4 QLALKVSANSVYGFTGAQV-GKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYSTS ::.::. :: ..:.:.:. :..::.:...:.. .:. .:.. .::.. : . : XP_016 QLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVND--TKKWG---- 2670 2680 2690 2700 2710 2720 750 760 770 780 790 800 pF1KE4 AKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYLLISKKR :.::::::::.. . .. ... .:.: :. :.. :.:..:.:::::.: .: .::: XP_016 ARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLPCVLQTKKR 2730 2740 2750 2760 2770 2780 810 820 830 840 850 860 pF1KE4 YAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAVAHAQDVI :.: .. . . .: ::.:.::::.:: :.... ::. :. :: ..: XP_016 YVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISLIKQYVQRQC 2790 2800 2810 2820 2830 2840 870 880 890 900 910 920 pF1KE4 SDLLCNRIDISQLVITKELTRAASDYAGKQAH-VELAERMRKRDPGSAPSLGDRVPYVII :: .. .:......:: . : : . .::...: : : :..:.::::::: XP_016 MKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVPYVII 2850 2860 2870 2880 2890 2900 930 940 950 960 970 980 pF1KE4 SAAKGVAAYMKSEDPLFVLEH-SLPIDTQYYLEQQLAKPLLRIFEPILG----EGRAEAV .. :: . . :. ::. .: ... ::. .:. :: ::: ..: : XP_016 YGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFS-LIGIDVFSWYHELP 2910 2920 2930 2940 2950 2960 990 1000 1010 1020 1030 pF1KE4 LLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLSHQGAVCEFC--QPRE-SELYQK .. . .. :. : . . .: . : . .: ..: : ::.. . . .. XP_016 RIHKATSSSRSEPEGRKGTISQYFTTLHCPV-CDDLTQH--GICSKCRSQPQHVAVILNQ 2970 2980 2990 3000 3010 1040 1050 1060 1070 1080 1090 pF1KE4 EVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQ---EQLL :. .:. .:.. .. :. : : . . . :.: .::... ..: ..: .::: XP_016 EIRELERQQEQLVKI---CKNCTGCFDRHIPCVSLNCPVLFKLSRVNRELSKAPYLRQLL 3020 3030 3040 3050 3060 3070 1100 pF1KE4 RRFGPPGPEAW .: XP_016 DQF 1107 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 23:44:36 2016 done: Sat Nov 5 23:44:38 2016 Total Scan time: 13.460 Total Display time: 0.450 Function used was FASTA [36.3.4 Apr, 2011]