FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3939, 518 aa 1>>>pF1KE3939 518 - 518 aa - 518 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.9266+/-0.000792; mu= 9.2105+/- 0.047 mean_var=193.1664+/-43.172, 0's: 0 Z-trim(108.6): 780 B-trim: 1142 in 2/47 Lambda= 0.092280 statistics sampled from 15789 (16730) to 15789 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.555), E-opt: 0.2 (0.196), width: 16 Scan time: 7.280 The best scores are: opt bits E(85289) NP_057199 (OMIM: 605760) ankyrin repeat and SOCS b ( 518) 3478 477.3 4.9e-134 NP_665862 (OMIM: 605760) ankyrin repeat and SOCS b ( 445) 2997 413.1 8.4e-115 NP_001188894 (OMIM: 605760) ankyrin repeat and SOC ( 445) 2997 413.1 8.4e-115 XP_011535137 (OMIM: 605759) PREDICTED: ankyrin rep ( 533) 638 99.2 3.3e-20 NP_057234 (OMIM: 605759) ankyrin repeat and SOCS b ( 587) 638 99.2 3.5e-20 XP_016876858 (OMIM: 605759) PREDICTED: ankyrin rep ( 600) 638 99.2 3.5e-20 XP_005267815 (OMIM: 605759) PREDICTED: ankyrin rep ( 635) 638 99.3 3.7e-20 NP_001189358 (OMIM: 605759) ankyrin repeat and SOC ( 635) 638 99.3 3.7e-20 NP_065210 (OMIM: 182900,612641) ankyrin-1 isoform (1719) 548 87.8 2.8e-16 XP_011542807 (OMIM: 182900,612641) PREDICTED: anky (1751) 548 87.8 2.8e-16 XP_011542806 (OMIM: 182900,612641) PREDICTED: anky (1752) 548 87.8 2.8e-16 XP_016868818 (OMIM: 182900,612641) PREDICTED: anky (1759) 548 87.8 2.8e-16 NP_065208 (OMIM: 182900,612641) ankyrin-1 isoform (1856) 548 87.8 2.9e-16 NP_000028 (OMIM: 182900,612641) ankyrin-1 isoform (1880) 548 87.9 3e-16 NP_065209 (OMIM: 182900,612641) ankyrin-1 isoform (1881) 548 87.9 3e-16 XP_011542804 (OMIM: 182900,612641) PREDICTED: anky (1889) 548 87.9 3e-16 NP_001135918 (OMIM: 182900,612641) ankyrin-1 isofo (1897) 548 87.9 3e-16 XP_011542803 (OMIM: 182900,612641) PREDICTED: anky (1913) 548 87.9 3e-16 XP_011542802 (OMIM: 182900,612641) PREDICTED: anky (1914) 548 87.9 3e-16 XP_005273533 (OMIM: 182900,612641) PREDICTED: anky (1921) 548 87.9 3e-16 XP_016868813 (OMIM: 182900,612641) PREDICTED: anky (1922) 548 87.9 3e-16 XP_016868812 (OMIM: 182900,612641) PREDICTED: anky (1936) 548 87.9 3e-16 XP_016868811 (OMIM: 182900,612641) PREDICTED: anky (1937) 548 87.9 3e-16 XP_016868810 (OMIM: 182900,612641) PREDICTED: anky (1940) 548 87.9 3e-16 XP_011542805 (OMIM: 182900,612641) PREDICTED: anky (1791) 506 82.2 1.4e-14 XP_016868817 (OMIM: 182900,612641) PREDICTED: anky (1792) 506 82.2 1.4e-14 XP_016868816 (OMIM: 182900,612641) PREDICTED: anky (1807) 506 82.2 1.4e-14 XP_016868815 (OMIM: 182900,612641) PREDICTED: anky (1892) 506 82.3 1.4e-14 XP_016868814 (OMIM: 182900,612641) PREDICTED: anky (1908) 506 82.3 1.4e-14 XP_011542798 (OMIM: 182900,612641) PREDICTED: anky (1944) 506 82.3 1.5e-14 XP_016868809 (OMIM: 182900,612641) PREDICTED: anky (1946) 506 82.3 1.5e-14 XP_011542797 (OMIM: 182900,612641) PREDICTED: anky (1953) 506 82.3 1.5e-14 XP_011542796 (OMIM: 182900,612641) PREDICTED: anky (1954) 506 82.3 1.5e-14 XP_016868808 (OMIM: 182900,612641) PREDICTED: anky (1961) 506 82.3 1.5e-14 XP_011542793 (OMIM: 182900,612641) PREDICTED: anky (1968) 506 82.3 1.5e-14 XP_011542792 (OMIM: 182900,612641) PREDICTED: anky (1969) 506 82.3 1.5e-14 XP_016863596 (OMIM: 106410,600919) PREDICTED: anky (1797) 502 81.7 2e-14 XP_016863595 (OMIM: 106410,600919) PREDICTED: anky (1806) 502 81.7 2e-14 XP_016863591 (OMIM: 106410,600919) PREDICTED: anky (1838) 502 81.7 2e-14 XP_016863589 (OMIM: 106410,600919) PREDICTED: anky (1846) 502 81.7 2e-14 XP_016863586 (OMIM: 106410,600919) PREDICTED: anky (1858) 502 81.7 2.1e-14 XP_016863580 (OMIM: 106410,600919) PREDICTED: anky (1879) 502 81.7 2.1e-14 XP_016863601 (OMIM: 106410,600919) PREDICTED: anky (1689) 484 79.3 1e-13 XP_016863600 (OMIM: 106410,600919) PREDICTED: anky (1755) 484 79.3 1e-13 XP_016863599 (OMIM: 106410,600919) PREDICTED: anky (1763) 484 79.3 1e-13 XP_016863598 (OMIM: 106410,600919) PREDICTED: anky (1770) 484 79.3 1e-13 XP_016863597 (OMIM: 106410,600919) PREDICTED: anky (1772) 484 79.3 1e-13 XP_016863594 (OMIM: 106410,600919) PREDICTED: anky (1810) 484 79.3 1.1e-13 XP_016863592 (OMIM: 106410,600919) PREDICTED: anky (1816) 484 79.3 1.1e-13 XP_016863593 (OMIM: 106410,600919) PREDICTED: anky (1818) 484 79.3 1.1e-13 >>NP_057199 (OMIM: 605760) ankyrin repeat and SOCS box p (518 aa) initn: 3478 init1: 3478 opt: 3478 Z-score: 2527.4 bits: 477.3 E(85289): 4.9e-134 Smith-Waterman score: 3478; 100.0% identity (100.0% similar) in 518 aa overlap (1-518:1-518) 10 20 30 40 50 60 pF1KE3 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 ENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 ENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 FRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 FRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSID 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 TLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 TLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLR 430 440 450 460 470 480 490 500 510 pF1KE3 SDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG :::::::::::::::::::::::::::::::::::::: NP_057 SDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG 490 500 510 >>NP_665862 (OMIM: 605760) ankyrin repeat and SOCS box p (445 aa) initn: 2997 init1: 2997 opt: 2997 Z-score: 2182.0 bits: 413.1 E(85289): 8.4e-115 Smith-Waterman score: 2997; 100.0% identity (100.0% similar) in 445 aa overlap (74-518:1-445) 50 60 70 80 90 100 pF1KE3 WMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGA :::::::::::::::::::::::::::::: NP_665 MKTFEGFCALHLAASQGHWKIVQILLEAGA 10 20 30 110 120 130 140 150 160 pF1KE3 DPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 DPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIK 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE3 LLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 LLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEG 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE3 HTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 HTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSP 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE3 VYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 VYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQ 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE3 INELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 INELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGF 280 290 300 310 320 330 410 420 430 440 450 460 pF1KE3 DPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 DPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLT 340 350 360 370 380 390 470 480 490 500 510 pF1KE3 HLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 HLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG 400 410 420 430 440 >>NP_001188894 (OMIM: 605760) ankyrin repeat and SOCS bo (445 aa) initn: 2997 init1: 2997 opt: 2997 Z-score: 2182.0 bits: 413.1 E(85289): 8.4e-115 Smith-Waterman score: 2997; 100.0% identity (100.0% similar) in 445 aa overlap (74-518:1-445) 50 60 70 80 90 100 pF1KE3 WMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGA :::::::::::::::::::::::::::::: NP_001 MKTFEGFCALHLAASQGHWKIVQILLEAGA 10 20 30 110 120 130 140 150 160 pF1KE3 DPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIK 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE3 LLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEG 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE3 HTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSP 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE3 VYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQ 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE3 INELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGF 280 290 300 310 320 330 410 420 430 440 450 460 pF1KE3 DPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLT 340 350 360 370 380 390 470 480 490 500 510 pF1KE3 HLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG 400 410 420 430 440 >>XP_011535137 (OMIM: 605759) PREDICTED: ankyrin repeat (533 aa) initn: 525 init1: 281 opt: 638 Z-score: 483.8 bits: 99.2 E(85289): 3.3e-20 Smith-Waterman score: 684; 28.9% identity (60.2% similar) in 543 aa overlap (17-502:10-531) 10 20 30 40 50 60 pF1KE3 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ : ..:. ..:. ..:.:... ...::.:.:::::...: ::. XP_011 MRPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLK 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV .: : . : ..:.. :..::. .:: . ::.:::.:. .. . :::. : XP_011 VLQRA--YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKAC 60 70 80 90 100 110 130 140 150 160 170 pF1KE3 ENGQIDVLRLLLQHGANVNGSHSMC--GWNSLHQASFQENAEIIKLLLRKGANKECQDDF : . .....:.::.:..: : : ::..::.. ... :....:. ::. : .. . XP_011 ERKNAEAVKILVQHNADTN--HR-CNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAY 120 130 140 150 160 180 190 200 210 220 230 pF1KE3 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP :::::::::: :.::.: .: . ::..: :: :.:. :. : .. : . ::.:::.::: XP_011 GITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE3 DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEI . :.:. ::.: :.. :. .:...:.:.:.:. . :::.. :. .:.. :: XP_011 N-KTNKDGL-LPLHIASKKGNYRIVQMLLPVTSRT-RIRRSGVSPLHLAAERNHDEVLEA 230 240 250 260 270 280 300 310 320 pF1KE3 LLRNGY---SPDA-----------QACLVFGFS----------------------SPVCM :: . .: : .. : :. ::. . XP_011 LLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLV 290 300 310 320 330 340 330 340 350 360 370 pF1KE3 AFQKDCEFFGIVNILLKYGAQINEL---H-LAY----CLKYEKFSIFRYFLRKGCSLGP- :... : . ...:: .::.:. : :. . .. .:...... ::. : XP_011 AIRHGC--LRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPC 350 360 370 380 390 400 380 390 400 410 420 pF1KE3 WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDP-LILLC--------NSWIDSVSIDTLIF .. .: : : . . . .: .: .. .: . : . ::.: XP_011 FSCLYGNGPHPPAPQPSSR--FNDAPAADKEPSVVQFCEFVSAPEVSRWAGPI-IDVL-- 410 420 430 440 450 430 440 450 460 470 480 pF1KE3 TLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPS-LTHLCRLEIRSSLKSERLRSDS :.... : ... ... . : . .. : : :.:::::..:... . :.. XP_011 -LDYVGNVQLCSRLKEHIDSFED--WAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIK--- 460 470 480 490 500 510 490 500 510 pF1KE3 YISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG .. :::: : :: ::. XP_011 LLDTLPLPGRLIRYLKYENTQ 520 530 >>NP_057234 (OMIM: 605759) ankyrin repeat and SOCS box p (587 aa) initn: 525 init1: 281 opt: 638 Z-score: 483.3 bits: 99.2 E(85289): 3.5e-20 Smith-Waterman score: 684; 28.9% identity (60.2% similar) in 543 aa overlap (17-502:64-585) 10 20 30 40 pF1KE3 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMP : ..:. ..:. ..:.:... ...::.: NP_057 PMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLP 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE3 IHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPN .:::::...: ::..: : . : ..:.. :..::. .:: . ::.:::.:. NP_057 LHEAAYYGQVGCLKVLQRA--YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPD 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE3 ATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC--GWNSLHQASFQENAEIIKL .. . :::. : : . .....:.::.:..: : : ::..::.. ... :.... NP_057 ISNKSRETPLYKACERKNAEAVKILVQHNADTN--HR-CNRGWTALHESVSRNDLEVMQI 160 170 180 190 200 170 180 190 200 210 220 pF1KE3 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH :. ::. : .. .:::::::::: :.::.: .: . ::..: :: :.:. :. : .. : NP_057 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEH 210 220 230 240 250 260 230 240 250 260 270 280 pF1KE3 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV . ::.:::.::: . :.:. ::.: :.. :. .:...:.:.:.:. . :::. NP_057 EEVVEFLLSQGADAN-KTNKDGL-LPLHIASKKGNYRIVQMLLPVTSRT-RIRRSGVSPL 270 280 290 300 310 320 290 300 310 pF1KE3 YSAVFGGHEDCLEILLRNGY---SPDA-----------QACLVFGFS------------- . :. .:.. :: :: . .: : .. : :. NP_057 HLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQH 330 340 350 360 370 380 320 330 340 350 360 pF1KE3 ---------SPVCMAFQKDCEFFGIVNILLKYGAQINEL---H-LAY----CLKYEKFSI ::. .:... : . ...:: .::.:. : :. . .. .:. NP_057 GADPNRDVISPLLVAIRHGC--LRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSL 390 400 410 420 430 440 370 380 390 400 410 pF1KE3 FRYFLRKGCSLGP-WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDP-LILLC-------- ..... ::. : .. .: : : . . . .: .: .. .: NP_057 LKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSR--FNDAPAADKEPSVVQFCEFVSAPEV 450 460 470 480 490 500 420 430 440 450 460 pF1KE3 NSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPS-LTHLCRLE . : . ::.: :.... : ... ... . : . .. : : :.:::::. NP_057 SRWAGPI-IDVL---LDYVGNVQLCSRLKEHIDSFED--WAVIKEKAEPPRPLAHLCRLR 510 520 530 540 550 470 480 490 500 510 pF1KE3 IRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG .:... . :.. .. :::: : :: ::. NP_057 VRKAIGKYRIK---LLDTLPLPGRLIRYLKYENTQ 560 570 580 >>XP_016876858 (OMIM: 605759) PREDICTED: ankyrin repeat (600 aa) initn: 525 init1: 281 opt: 638 Z-score: 483.2 bits: 99.2 E(85289): 3.5e-20 Smith-Waterman score: 684; 28.9% identity (60.2% similar) in 543 aa overlap (17-502:77-598) 10 20 30 40 pF1KE3 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMP : ..:. ..:. ..:.:... ...::.: XP_016 TTAEATASACTNRQPAHFYPWTRPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLP 50 60 70 80 90 100 50 60 70 80 90 100 pF1KE3 IHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPN .:::::...: ::..: : . : ..:.. :..::. .:: . ::.:::.:. XP_016 LHEAAYYGQVGCLKVLQRA--YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPD 110 120 130 140 150 160 110 120 130 140 150 160 pF1KE3 ATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC--GWNSLHQASFQENAEIIKL .. . :::. : : . .....:.::.:..: : : ::..::.. ... :.... XP_016 ISNKSRETPLYKACERKNAEAVKILVQHNADTN--HR-CNRGWTALHESVSRNDLEVMQI 170 180 190 200 210 220 170 180 190 200 210 220 pF1KE3 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH :. ::. : .. .:::::::::: :.::.: .: . ::..: :: :.:. :. : .. : XP_016 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEH 230 240 250 260 270 280 230 240 250 260 270 280 pF1KE3 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV . ::.:::.::: . :.:. ::.: :.. :. .:...:.:.:.:. . :::. XP_016 EEVVEFLLSQGADAN-KTNKDGL-LPLHIASKKGNYRIVQMLLPVTSRT-RIRRSGVSPL 290 300 310 320 330 290 300 310 pF1KE3 YSAVFGGHEDCLEILLRNGY---SPDA-----------QACLVFGFS------------- . :. .:.. :: :: . .: : .. : :. XP_016 HLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQH 340 350 360 370 380 390 320 330 340 350 360 pF1KE3 ---------SPVCMAFQKDCEFFGIVNILLKYGAQINEL---H-LAY----CLKYEKFSI ::. .:... : . ...:: .::.:. : :. . .. .:. XP_016 GADPNRDVISPLLVAIRHGC--LRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSL 400 410 420 430 440 450 370 380 390 400 410 pF1KE3 FRYFLRKGCSLGP-WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDP-LILLC-------- ..... ::. : .. .: : : . . . .: .: .. .: XP_016 LKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSR--FNDAPAADKEPSVVQFCEFVSAPEV 460 470 480 490 500 510 420 430 440 450 460 pF1KE3 NSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPS-LTHLCRLE . : . ::.: :.... : ... ... . : . .. : : :.:::::. XP_016 SRWAGPI-IDVL---LDYVGNVQLCSRLKEHIDSFED--WAVIKEKAEPPRPLAHLCRLR 520 530 540 550 560 470 480 490 500 510 pF1KE3 IRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG .:... . :.. .. :::: : :: ::. XP_016 VRKAIGKYRIK---LLDTLPLPGRLIRYLKYENTQ 570 580 590 600 >>XP_005267815 (OMIM: 605759) PREDICTED: ankyrin repeat (635 aa) initn: 525 init1: 281 opt: 638 Z-score: 483.0 bits: 99.3 E(85289): 3.7e-20 Smith-Waterman score: 684; 28.9% identity (60.2% similar) in 543 aa overlap (17-502:112-633) 10 20 30 40 pF1KE3 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMP : ..:. ..:. ..:.:... ...::.: XP_005 PMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLP 90 100 110 120 130 140 50 60 70 80 90 100 pF1KE3 IHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPN .:::::...: ::..: : . : ..:.. :..::. .:: . ::.:::.:. XP_005 LHEAAYYGQVGCLKVLQRA--YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPD 150 160 170 180 190 110 120 130 140 150 160 pF1KE3 ATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC--GWNSLHQASFQENAEIIKL .. . :::. : : . .....:.::.:..: : : ::..::.. ... :.... XP_005 ISNKSRETPLYKACERKNAEAVKILVQHNADTN--HR-CNRGWTALHESVSRNDLEVMQI 200 210 220 230 240 250 170 180 190 200 210 220 pF1KE3 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH :. ::. : .. .:::::::::: :.::.: .: . ::..: :: :.:. :. : .. : XP_005 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEH 260 270 280 290 300 310 230 240 250 260 270 280 pF1KE3 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV . ::.:::.::: . :.:. ::.: :.. :. .:...:.:.:.:. . :::. XP_005 EEVVEFLLSQGADAN-KTNKDGL-LPLHIASKKGNYRIVQMLLPVTSRT-RIRRSGVSPL 320 330 340 350 360 370 290 300 310 pF1KE3 YSAVFGGHEDCLEILLRNGY---SPDA-----------QACLVFGFS------------- . :. .:.. :: :: . .: : .. : :. XP_005 HLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQH 380 390 400 410 420 430 320 330 340 350 360 pF1KE3 ---------SPVCMAFQKDCEFFGIVNILLKYGAQINEL---H-LAY----CLKYEKFSI ::. .:... : . ...:: .::.:. : :. . .. .:. XP_005 GADPNRDVISPLLVAIRHGC--LRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSL 440 450 460 470 480 490 370 380 390 400 410 pF1KE3 FRYFLRKGCSLGP-WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDP-LILLC-------- ..... ::. : .. .: : : . . . .: .: .. .: XP_005 LKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSR--FNDAPAADKEPSVVQFCEFVSAPEV 500 510 520 530 540 420 430 440 450 460 pF1KE3 NSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPS-LTHLCRLE . : . ::.: :.... : ... ... . : . .. : : :.:::::. XP_005 SRWAGPI-IDVL---LDYVGNVQLCSRLKEHIDSFED--WAVIKEKAEPPRPLAHLCRLR 550 560 570 580 590 600 470 480 490 500 510 pF1KE3 IRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG .:... . :.. .. :::: : :: ::. XP_005 VRKAIGKYRIK---LLDTLPLPGRLIRYLKYENTQ 610 620 630 >>NP_001189358 (OMIM: 605759) ankyrin repeat and SOCS bo (635 aa) initn: 525 init1: 281 opt: 638 Z-score: 483.0 bits: 99.3 E(85289): 3.7e-20 Smith-Waterman score: 684; 28.9% identity (60.2% similar) in 543 aa overlap (17-502:112-633) 10 20 30 40 pF1KE3 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMP : ..:. ..:. ..:.:... ...::.: NP_001 PMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLP 90 100 110 120 130 140 50 60 70 80 90 100 pF1KE3 IHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPN .:::::...: ::..: : . : ..:.. :..::. .:: . ::.:::.:. NP_001 LHEAAYYGQVGCLKVLQRA--YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPD 150 160 170 180 190 110 120 130 140 150 160 pF1KE3 ATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC--GWNSLHQASFQENAEIIKL .. . :::. : : . .....:.::.:..: : : ::..::.. ... :.... NP_001 ISNKSRETPLYKACERKNAEAVKILVQHNADTN--HR-CNRGWTALHESVSRNDLEVMQI 200 210 220 230 240 250 170 180 190 200 210 220 pF1KE3 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH :. ::. : .. .:::::::::: :.::.: .: . ::..: :: :.:. :. : .. : NP_001 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEH 260 270 280 290 300 310 230 240 250 260 270 280 pF1KE3 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV . ::.:::.::: . :.:. ::.: :.. :. .:...:.:.:.:. . :::. NP_001 EEVVEFLLSQGADAN-KTNKDGL-LPLHIASKKGNYRIVQMLLPVTSRT-RIRRSGVSPL 320 330 340 350 360 370 290 300 310 pF1KE3 YSAVFGGHEDCLEILLRNGY---SPDA-----------QACLVFGFS------------- . :. .:.. :: :: . .: : .. : :. NP_001 HLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQH 380 390 400 410 420 430 320 330 340 350 360 pF1KE3 ---------SPVCMAFQKDCEFFGIVNILLKYGAQINEL---H-LAY----CLKYEKFSI ::. .:... : . ...:: .::.:. : :. . .. .:. NP_001 GADPNRDVISPLLVAIRHGC--LRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSL 440 450 460 470 480 490 370 380 390 400 410 pF1KE3 FRYFLRKGCSLGP-WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDP-LILLC-------- ..... ::. : .. .: : : . . . .: .: .. .: NP_001 LKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSR--FNDAPAADKEPSVVQFCEFVSAPEV 500 510 520 530 540 420 430 440 450 460 pF1KE3 NSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPS-LTHLCRLE . : . ::.: :.... : ... ... . : . .. : : :.:::::. NP_001 SRWAGPI-IDVL---LDYVGNVQLCSRLKEHIDSFED--WAVIKEKAEPPRPLAHLCRLR 550 560 570 580 590 600 470 480 490 500 510 pF1KE3 IRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG .:... . :.. .. :::: : :: ::. NP_001 VRKAIGKYRIK---LLDTLPLPGRLIRYLKYENTQ 610 620 630 >>NP_065210 (OMIM: 182900,612641) ankyrin-1 isoform 2 [H (1719 aa) initn: 1119 init1: 212 opt: 548 Z-score: 413.2 bits: 87.8 E(85289): 2.8e-16 Smith-Waterman score: 548; 32.1% identity (62.8% similar) in 371 aa overlap (9-370:271-627) 10 20 30 pF1KE3 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDV : . . :::.:.:.. . :: .: ... NP_065 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 250 260 270 280 290 300 40 50 60 70 80 90 pF1KE3 ADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQIL . : ::: :: . ..:...:.. :. . : :.. . ::.:: :: .....: NP_065 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI---TLDHLTPLHVAAHCGHHRVAKVL 310 320 330 340 350 100 110 120 130 140 150 pF1KE3 LEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQEN :. :: ::. .:. ::: .: ..... :..:::. ::.... . : . :: :::. . NP_065 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV-TESGLTPLHVASFMGH 360 370 380 390 400 410 160 170 180 190 200 210 pF1KE3 AEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFI :.: ::..::. . .. ::: .::. :. : . :... :.:: .: : ::: NP_065 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 420 430 440 450 460 470 220 230 240 250 260 270 pF1KE3 AAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTK-ILDLLIPLTNRACDTG ::. :::. :.::: ..:.:.: . . :.: ::. ::.. .: :: ...:: : NP_065 AARIGHTNMVKLLLENNANPNLATTAG--HTPLHIAAREGHVETVLALLEKEASQACMTK 480 490 500 510 520 530 280 290 300 310 320 330 pF1KE3 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNIL . .:.. :. :. :.::. :.: . :.. :. .: ... . ::..: NP_065 -KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN--GLT-PLHVAVHHNN--LDIVKLL 540 550 560 570 580 340 350 360 370 380 pF1KE3 LKYGAQ--------INELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQA : :.. . ::.: : .. . : .:. : : NP_065 LPRGGSPHSPAWNGYTPLHIA--AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG 590 600 610 620 630 640 390 400 410 420 430 440 pF1KE3 KYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNA NP_065 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 650 660 670 680 690 700 >-- initn: 434 init1: 192 opt: 291 Z-score: 228.3 bits: 53.6 E(85289): 5.6e-06 Smith-Waterman score: 307; 33.8% identity (67.5% similar) in 157 aa overlap (75-231:631-786) 50 60 70 80 90 100 pF1KE3 MPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGAD .. .: :::::..:: ..: .:: :. NP_065 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 610 620 630 640 650 660 110 120 130 140 150 160 pF1KE3 PNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKL : . ::: :....:.. : .:..::. :... : :.. :: :: : ...:. NP_065 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRM-GYTPLHVASHYGNIKLVKF 670 680 690 700 710 170 180 190 200 210 220 pF1KE3 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH ::.. :. . . .: .:: ::: :. . ...:...::. : . : .::: :: . :. NP_065 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 720 730 740 750 760 770 230 240 250 260 270 280 pF1KE3 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV . ...: NP_065 ISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDE 780 790 800 810 820 830 >-- initn: 383 init1: 200 opt: 266 Z-score: 210.3 bits: 50.3 E(85289): 5.6e-05 Smith-Waterman score: 366; 32.2% identity (67.4% similar) in 233 aa overlap (9-236:39-263) 10 20 30 pF1KE3 MDFTEAYADTCSTVGL-----AAREGNVKVLRKLLKKG .::. :: :..::.::.. .::.: NP_065 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 RSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWK .... ..: .: :: .. : .. :.: .. : ..: :: :..::...: . NP_065 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK---GFTPLYMAAQENHLE 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 IVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQA .:..::: ::. :..: . ::: .:...:. .:. :...:.. :. . .:: : NP_065 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK--GKVRL---PALHIA 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 SFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKA . ..... .::.. : . . :.::: .::.: .:. ..:.. ::.:: . NP_065 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 TPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRA ::: ::...:.. :.:::. :: NP_065 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 250 260 270 280 290 300 >>XP_011542807 (OMIM: 182900,612641) PREDICTED: ankyrin- (1751 aa) initn: 1119 init1: 212 opt: 548 Z-score: 413.1 bits: 87.8 E(85289): 2.8e-16 Smith-Waterman score: 548; 32.1% identity (62.8% similar) in 371 aa overlap (9-370:304-660) 10 20 30 pF1KE3 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDV : . . :::.:.:.. . :: .: ... XP_011 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 280 290 300 310 320 330 40 50 60 70 80 90 pF1KE3 ADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQIL . : ::: :: . ..:...:.. :. . : :.. . ::.:: :: .....: XP_011 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI---TLDHLTPLHVAAHCGHHRVAKVL 340 350 360 370 380 390 100 110 120 130 140 150 pF1KE3 LEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQEN :. :: ::. .:. ::: .: ..... :..:::. ::.... . : . :: :::. . XP_011 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV-TESGLTPLHVASFMGH 400 410 420 430 440 160 170 180 190 200 210 pF1KE3 AEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFI :.: ::..::. . .. ::: .::. :. : . :... :.:: .: : ::: XP_011 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 450 460 470 480 490 500 220 230 240 250 260 270 pF1KE3 AAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTK-ILDLLIPLTNRACDTG ::. :::. :.::: ..:.:.: . . :.: ::. ::.. .: :: ...:: : XP_011 AARIGHTNMVKLLLENNANPNLATTAG--HTPLHIAAREGHVETVLALLEKEASQACMTK 510 520 530 540 550 560 280 290 300 310 320 330 pF1KE3 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNIL . .:.. :. :. :.::. :.: . :.. :. .: ... . ::..: XP_011 -KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN--GLT-PLHVAVHHNN--LDIVKLL 570 580 590 600 610 620 340 350 360 370 380 pF1KE3 LKYGAQ--------INELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQA : :.. . ::.: : .. . : .:. : : XP_011 LPRGGSPHSPAWNGYTPLHIA--AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG 630 640 650 660 670 390 400 410 420 430 440 pF1KE3 KYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNA XP_011 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 680 690 700 710 720 730 >-- initn: 434 init1: 192 opt: 291 Z-score: 228.2 bits: 53.6 E(85289): 5.7e-06 Smith-Waterman score: 307; 33.8% identity (67.5% similar) in 157 aa overlap (75-231:664-819) 50 60 70 80 90 100 pF1KE3 MPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGAD .. .: :::::..:: ..: .:: :. XP_011 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 640 650 660 670 680 690 110 120 130 140 150 160 pF1KE3 PNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKL : . ::: :....:.. : .:..::. :... : :.. :: :: : ...:. XP_011 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRM-GYTPLHVASHYGNIKLVKF 700 710 720 730 740 750 170 180 190 200 210 220 pF1KE3 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH ::.. :. . . .: .:: ::: :. . ...:...::. : . : .::: :: . :. XP_011 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 760 770 780 790 800 810 230 240 250 260 270 280 pF1KE3 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV . ...: XP_011 ISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDE 820 830 840 850 860 870 >-- initn: 403 init1: 200 opt: 266 Z-score: 210.2 bits: 50.3 E(85289): 5.7e-05 Smith-Waterman score: 366; 32.2% identity (67.4% similar) in 233 aa overlap (9-236:72-296) 10 20 30 pF1KE3 MDFTEAYADTCSTVGL-----AAREGNVKVLRKLLKKG .::. :: :..::.::.. .::.: XP_011 KADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 50 60 70 80 90 100 40 50 60 70 80 90 pF1KE3 RSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWK .... ..: .: :: .. : .. :.: .. : ..: :: :..::...: . XP_011 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK---GFTPLYMAAQENHLE 110 120 130 140 150 100 110 120 130 140 150 pF1KE3 IVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQA .:..::: ::. :..: . ::: .:...:. .:. :...:.. :. . .:: : XP_011 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK--GKVRL---PALHIA 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE3 SFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKA . ..... .::.. : . . :.::: .::.: .:. ..:.. ::.:: . XP_011 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE3 TPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRA ::: ::...:.. :.:::. :: XP_011 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 280 290 300 310 320 330 518 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 08:46:16 2016 done: Sun Nov 6 08:46:17 2016 Total Scan time: 7.280 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]