FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6302, 311 aa 1>>>pF1KE6302 311 - 311 aa - 311 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0061+/-0.000363; mu= 17.7208+/- 0.023 mean_var=70.9616+/-14.806, 0's: 0 Z-trim(114.9): 251 B-trim: 2075 in 2/48 Lambda= 0.152252 statistics sampled from 24693 (24978) to 24693 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.662), E-opt: 0.2 (0.293), width: 16 Scan time: 5.520 The best scores are: opt bits E(85289) NP_005975 (OMIM: 190315,615182) tricarboxylate tra ( 311) 2088 467.6 1.4e-131 NP_001243463 (OMIM: 190315,615182) tricarboxylate ( 318) 1911 428.7 7.4e-120 NP_001274316 (OMIM: 190315,615182) tricarboxylate ( 208) 1400 316.3 3.3e-86 NP_085134 (OMIM: 607571) mitochondrial 2-oxodicarb ( 299) 424 102.1 1.5e-21 NP_001164641 (OMIM: 607571) mitochondrial 2-oxodic ( 298) 412 99.4 9.2e-21 XP_011535589 (OMIM: 607571) PREDICTED: mitochondri ( 303) 400 96.8 5.8e-20 NP_000378 (OMIM: 212138,613698) mitochondrial carn ( 301) 385 93.5 5.6e-19 XP_005263263 (OMIM: 113730,601665) PREDICTED: mito ( 306) 375 91.3 2.6e-18 NP_068605 (OMIM: 113730,601665) mitochondrial brow ( 307) 372 90.7 4.1e-18 NP_003346 (OMIM: 601693,607447) mitochondrial unco ( 309) 370 90.2 5.6e-18 NP_060345 (OMIM: 205950,610819) solute carrier fam ( 304) 367 89.6 8.8e-18 XP_011532171 (OMIM: 205950,610819) PREDICTED: solu ( 298) 365 89.1 1.2e-17 XP_006713277 (OMIM: 205950,610819) PREDICTED: solu ( 300) 365 89.1 1.2e-17 XP_011510372 (OMIM: 603667,612949) PREDICTED: calc ( 587) 365 89.4 2e-17 XP_011535590 (OMIM: 607571) PREDICTED: mitochondri ( 269) 361 88.2 2e-17 NP_003696 (OMIM: 603667,612949) calcium-binding mi ( 678) 365 89.4 2.2e-17 XP_011530530 (OMIM: 113730,601665) PREDICTED: mito ( 277) 357 87.3 3.8e-17 NP_003347 (OMIM: 601665,602044) mitochondrial unco ( 312) 320 79.3 1.1e-14 NP_036272 (OMIM: 606794) mitochondrial dicarboxyla ( 287) 311 77.2 4.2e-14 XP_011535591 (OMIM: 607571) PREDICTED: mitochondri ( 267) 303 75.5 1.4e-13 NP_848621 (OMIM: 610823) mitochondrial coenzyme A ( 318) 299 74.6 2.9e-13 XP_005259918 (OMIM: 610823) PREDICTED: mitochondri ( 318) 299 74.6 2.9e-13 XP_011526239 (OMIM: 610823) PREDICTED: mitochondri ( 318) 299 74.6 2.9e-13 NP_001308473 (OMIM: 610823) mitochondrial coenzyme ( 318) 299 74.6 2.9e-13 XP_016882159 (OMIM: 610823) PREDICTED: mitochondri ( 382) 299 74.7 3.3e-13 NP_997000 (OMIM: 609911) solute carrier family 25 ( 308) 292 73.1 8.1e-13 NP_005879 (OMIM: 600370,610773) phosphate carrier ( 362) 292 73.2 9.1e-13 NP_112489 (OMIM: 609767) mitoferrin-2 [Homo sapien ( 364) 285 71.6 2.7e-12 NP_073714 (OMIM: 601665,602044) mitochondrial unco ( 275) 280 70.4 4.6e-12 NP_002626 (OMIM: 600370,610773) phosphate carrier ( 361) 281 70.7 4.9e-12 NP_998776 (OMIM: 600370,610773) phosphate carrier ( 361) 281 70.7 4.9e-12 XP_016876476 (OMIM: 615064) PREDICTED: mitochondri ( 237) 278 69.9 5.6e-12 XP_016876469 (OMIM: 615064) PREDICTED: mitochondri ( 237) 278 69.9 5.6e-12 NP_689546 (OMIM: 615064) mitochondrial basic amino ( 237) 278 69.9 5.6e-12 XP_011534748 (OMIM: 615064) PREDICTED: mitochondri ( 237) 278 69.9 5.6e-12 XP_016876470 (OMIM: 615064) PREDICTED: mitochondri ( 237) 278 69.9 5.6e-12 XP_016876472 (OMIM: 615064) PREDICTED: mitochondri ( 237) 278 69.9 5.6e-12 XP_016876471 (OMIM: 615064) PREDICTED: mitochondri ( 237) 278 69.9 5.6e-12 XP_016876474 (OMIM: 615064) PREDICTED: mitochondri ( 237) 278 69.9 5.6e-12 XP_011534750 (OMIM: 615064) PREDICTED: mitochondri ( 237) 278 69.9 5.6e-12 NP_001278742 (OMIM: 615064) mitochondrial basic am ( 237) 278 69.9 5.6e-12 NP_001278743 (OMIM: 615064) mitochondrial basic am ( 237) 278 69.9 5.6e-12 XP_016876475 (OMIM: 615064) PREDICTED: mitochondri ( 237) 278 69.9 5.6e-12 XP_011534749 (OMIM: 615064) PREDICTED: mitochondri ( 237) 278 69.9 5.6e-12 XP_016876473 (OMIM: 615064) PREDICTED: mitochondri ( 237) 278 69.9 5.6e-12 XP_011534746 (OMIM: 615064) PREDICTED: mitochondri ( 297) 278 70.0 6.6e-12 NP_001034444 (OMIM: 615064) mitochondrial basic am ( 303) 278 70.0 6.7e-12 NP_057696 (OMIM: 610387) mitoferrin-1 isoform 1 [H ( 338) 278 70.1 7.3e-12 XP_006720102 (OMIM: 615064) PREDICTED: mitochondri ( 342) 278 70.1 7.4e-12 XP_011534745 (OMIM: 615064) PREDICTED: mitochondri ( 348) 278 70.1 7.5e-12 >>NP_005975 (OMIM: 190315,615182) tricarboxylate transpo (311 aa) initn: 2088 init1: 2088 opt: 2088 Z-score: 2483.1 bits: 467.6 E(85289): 1.4e-131 Smith-Waterman score: 2088; 100.0% identity (100.0% similar) in 311 aa overlap (1-311:1-311) 10 20 30 40 50 60 pF1KE6 MPAPRAPRALAAAAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MPAPRAPRALAAAAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 PPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 STRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 STRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 YQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 LDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEV 250 260 270 280 290 300 310 pF1KE6 VKLLNKVWKTD ::::::::::: NP_005 VKLLNKVWKTD 310 >>NP_001243463 (OMIM: 190315,615182) tricarboxylate tran (318 aa) initn: 1893 init1: 1893 opt: 1911 Z-score: 2272.8 bits: 428.7 E(85289): 7.4e-120 Smith-Waterman score: 1911; 92.6% identity (95.5% similar) in 309 aa overlap (4-311:10-318) 10 20 30 40 50 pF1KE6 MPAPRAPRALAAAAPASGKAKLT-HPGKAILAGGLAGGIEICITFPTEYVKTQL :: :.. .. .: . . . : . ::::::::::::::::::::::: NP_001 MFPAALARRPRRPKSGTGEGPERQRPGGSLRSGFPVPAGGLAGGIEICITFPTEYVKTQL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 QLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE6 DAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVR 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE6 EQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE6 SVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIV 250 260 270 280 290 300 300 310 pF1KE6 FVIYDEVVKLLNKVWKTD :::::::::::::::::: NP_001 FVIYDEVVKLLNKVWKTD 310 >>NP_001274316 (OMIM: 190315,615182) tricarboxylate tran (208 aa) initn: 1400 init1: 1400 opt: 1400 Z-score: 1668.8 bits: 316.3 E(85289): 3.3e-86 Smith-Waterman score: 1400; 100.0% identity (100.0% similar) in 208 aa overlap (104-311:1-208) 80 90 100 110 120 130 pF1KE6 TVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGV :::::::::::::::::::::::::::::: NP_001 MFEFLSNHMRDAQGRLDSTRGLLCGLGAGV 10 20 30 140 150 160 170 180 190 pF1KE6 AEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGS 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE6 NQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEA 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE6 HKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNKVWKTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNKVWKTD 160 170 180 190 200 >>NP_085134 (OMIM: 607571) mitochondrial 2-oxodicarboxyl (299 aa) initn: 231 init1: 104 opt: 424 Z-score: 508.0 bits: 102.1 E(85289): 1.5e-21 Smith-Waterman score: 424; 29.3% identity (62.0% similar) in 300 aa overlap (27-308:15-299) 10 20 30 40 50 pF1KE6 MPAPRAPRALAAAAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDE-RS . :.::: :: .:::. : . :::..:... . NP_085 MSAKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCAT 10 20 30 40 60 70 80 90 100 110 pF1KE6 HPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRL : :... : :. . .:..:.:.:. . . :: ::.: :: ... : . NP_085 DPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFE----QYKKLLGYV 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 DSTRGL---LCGLGAGVAEAVVVVCPMETIKVKFIHDQTS--PNPKYRGFFHGVREIVRE . . .: . :::.:..::.:: :.:..:: . .... .:. :. .:.:... NP_085 SLSPALTFAIAGLGSGLTEAIVV-NPFEVVKVGLQANRNTFAEQPSTVGY---ARQIIKK 110 120 130 140 150 160 180 190 200 210 220 pF1KE6 QG--LKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNP-NKPMNPLIT-----GVF .: :.: .:::::. ..: . . : . ...: : :: .:.. :. NP_085 EGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMI----PVNK--DPILEFWRKFGI- 170 180 190 200 210 230 240 250 260 270 280 pF1KE6 GAIAGAASVFGNTPLDVIKTRMQGLEAH----KYRNTWDCGLQILKKEGLKAFYKGTVPR : ..:. . : :.:: :.:.:: . :::. . . ..::. :.::: .:. NP_085 GLLSGTIASVINIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPK 220 230 240 250 260 270 290 300 310 pF1KE6 LGRVCLDVAIVFVIYDEVVKLLNKVWKTD . :. :.....:. . . :.. : NP_085 IMRLGPGGAVMLLVYEYTYSWLQENW 280 290 >>NP_001164641 (OMIM: 607571) mitochondrial 2-oxodicarbo (298 aa) initn: 231 init1: 104 opt: 412 Z-score: 493.8 bits: 99.4 E(85289): 9.2e-21 Smith-Waterman score: 412; 29.2% identity (62.1% similar) in 298 aa overlap (27-306:15-297) 10 20 30 40 50 pF1KE6 MPAPRAPRALAAAAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDE-RS . :.::: :: .:::. : . :::..:... . NP_001 MSAKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCAT 10 20 30 40 60 70 80 90 100 110 pF1KE6 HPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRL : :... : :. . .:..:.:.:. . . :: ::.: :: ... : . NP_001 DPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFE----QYKKLLGYV 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 DSTRGL---LCGLGAGVAEAVVVVCPMETIKVKFIHDQTS--PNPKYRGFFHGVREIVRE . . .: . :::.:..::.:: :.:..:: . .... .:. :. .:.:... NP_001 SLSPALTFAIAGLGSGLTEAIVV-NPFEVVKVGLQANRNTFAEQPSTVGY---ARQIIKK 110 120 130 140 150 160 180 190 200 210 220 pF1KE6 QG--LKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNP-NKPMNPLIT-----GVF .: :.: .:::::. ..: . . : . ...: : :: .:.. :. NP_001 EGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMI----PVNK--DPILEFWRKFGI- 170 180 190 200 210 230 240 250 260 270 280 pF1KE6 GAIAGAASVFGNTPLDVIKTRMQGLEAH----KYRNTWDCGLQILKKEGLKAFYKGTVPR : ..:. . : :.:: :.:.:: . :::. . . ..::. :.::: .:. NP_001 GLLSGTIASVINIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPK 220 230 240 250 260 270 290 300 310 pF1KE6 LGRVCLDVAIVFVIYDEVVKLLNKVWKTD . :. :.....:. . . :.. NP_001 IMRLGPGGAVMLLVYEYTYSWLQEN 280 290 >>XP_011535589 (OMIM: 607571) PREDICTED: mitochondrial 2 (303 aa) initn: 207 init1: 80 opt: 400 Z-score: 479.4 bits: 96.8 E(85289): 5.8e-20 Smith-Waterman score: 400; 28.6% identity (61.6% similar) in 297 aa overlap (30-308:22-303) 10 20 30 40 50 pF1KE6 MPAPRAPRALAAAAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDE-RS : .:: . .:::. : . :::..:... . XP_011 MCSGPSGPLFTPLQAALCARRLPSGLLSLVEICLMHPLDVVKTRFQIQRCAT 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 HPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRL : :... : :. . .:..:.:.:. . . :: ::.: :: ... : . XP_011 DPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFE----QYKKLLGYV 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 DSTRGL---LCGLGAGVAEAVVVVCPMETIKVKFIHDQTS--PNPKYRGFFHGVREIVRE . . .: . :::.:..::.:: :.:..:: . .... .:. :. .:.:... XP_011 SLSPALTFAIAGLGSGLTEAIVV-NPFEVVKVGLQANRNTFAEQPSTVGY---ARQIIKK 110 120 130 140 150 160 180 190 200 210 220 pF1KE6 QG--LKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNP-NKPMNPLIT-----GVF .: :.: .:::::. ..: . . : . ...: : :: .:.. :. XP_011 EGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMI----PVNK--DPILEFWRKFGI- 170 180 190 200 210 230 240 250 260 270 280 pF1KE6 GAIAGAASVFGNTPLDVIKTRMQGLEAH----KYRNTWDCGLQILKKEGLKAFYKGTVPR : ..:. . : :.:: :.:.:: . :::. . . ..::. :.::: .:. XP_011 GLLSGTIASVINIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPK 220 230 240 250 260 270 290 300 310 pF1KE6 LGRVCLDVAIVFVIYDEVVKLLNKVWKTD . :. :.....:. . . :.. : XP_011 IMRLGPGGAVMLLVYEYTYSWLQENW 280 290 300 >>NP_000378 (OMIM: 212138,613698) mitochondrial carnitin (301 aa) initn: 286 init1: 134 opt: 385 Z-score: 461.7 bits: 93.5 E(85289): 5.6e-19 Smith-Waterman score: 385; 29.1% identity (57.6% similar) in 302 aa overlap (19-310:4-298) 10 20 30 40 50 pF1KE6 MPAPRAPRALAAAAPASGKAKLTHPGKAILAGGLAGGIEICITF---PTEYVKTQLQLDE . : : : .::::..: .:..: : . ::..:: . NP_000 MADQPKPISPLKNLLAGGFGG---VCLVFVGHPLDTVKVRLQTQP 10 20 30 40 60 70 80 90 100 110 pF1KE6 RS---HPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSN-HMR : .:: : : :: :.:. .:. :::::... . : : :: : : . .. ... NP_000 PSLPGQPPMYSGTFDCFRKTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQK 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 DAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVR . :. . . :. .:: .. .. : : :: . . .: . :: : . .... . NP_000 HPEDVLSYPQLFAAGMLSGVF-TTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQ 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 EQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWY--RGDNPNKPMNPLITGVFGAIAG : :..: :.: . :.... ... :... :.: . .: .. : : : :.::: NP_000 EFGIRGIYKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRIL-VAGGIAG 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 AASVFGNTPLDVIKTRMQGLEAHKYRNTW-DCGLQILKKEGLKAFYKGTVPRLGRVCLDV . : ::.:.:.: :: : . : .... ::. ..::: . :. NP_000 IFNWAVAIPPDVLKSRFQTAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPAN 230 240 250 260 270 280 300 310 pF1KE6 AIVFVIYDEVVKLLNKVWKTD : :. .. ..:.:: : : NP_000 AACFLGFEVAMKFLN--WATPNL 290 300 >>XP_005263263 (OMIM: 113730,601665) PREDICTED: mitochon (306 aa) initn: 361 init1: 161 opt: 375 Z-score: 449.7 bits: 91.3 E(85289): 2.6e-18 Smith-Waterman score: 375; 26.4% identity (62.4% similar) in 303 aa overlap (20-310:6-301) 10 20 30 40 50 pF1KE6 MPAPRAPRALAAAAPASGKAKLTHP--GKAILAGGLAGGIEICITFPTEYVKTQLQLD-- :. .:: : ....:.:. . :::: . .:..::.. XP_005 MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGE 10 20 30 40 60 70 80 90 100 110 pF1KE6 -ERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDA : ::.:. . .:...: . :: :: . : .: .:..:.:... ... . . XP_005 CPTSSVIRYKGVLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFL--T 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 QGRLDSTRG--LLCGLGAGVAEAVVVVCPMETIKVKFIHDQT---SPNPKYRGFFHGVRE :. . : .: :: .: . :: . : :..::. .. :. . .:.: : ... : XP_005 AGKETPSLGSKILAGLTTG-GVAVFIGQPTEVVKVR-LQAQSHLHGIKPRYTGTYNAYRI 110 120 130 140 150 160 180 190 200 210 220 pF1KE6 IVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNP--LITGVFGA :. .:: : ..: : ..... . .. .. ... . .: : :.... XP_005 IATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSAL--- 170 180 190 200 210 230 240 250 260 270 280 pF1KE6 IAGAASVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCL ::: .. ..:.::.:::. . .:... .:..... .:: ::.:: :: . :. XP_005 IAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGS 220 230 240 250 260 270 290 300 310 pF1KE6 DVAIVFVIYDEVVKLLNKVWKTD .:.:: .... . :.: .: XP_005 WNVIMFVCFEQLKRELSKSRQTMDCAT 280 290 300 >>NP_068605 (OMIM: 113730,601665) mitochondrial brown fa (307 aa) initn: 333 init1: 161 opt: 372 Z-score: 446.1 bits: 90.7 E(85289): 4.1e-18 Smith-Waterman score: 372; 26.2% identity (62.3% similar) in 302 aa overlap (20-310:6-302) 10 20 30 40 50 pF1KE6 MPAPRAPRALAAAAPASGKAKLTHP--GKAILAGGLAGGIEICITFPTEYVKTQLQLD-- :. .:: : ....:.:. . :::: . .:..::.. NP_068 MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGE 10 20 30 40 60 70 80 90 100 110 pF1KE6 -ERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDA : ::.:. . .:...: . :: :: . : .: .:..:.:... ... . . NP_068 CPTSSVIRYKGVLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAG 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 QGRLDSTRG-LLCGLGAGVAEAVVVVCPMETIKVKFIHDQT---SPNPKYRGFFHGVREI . : . .: :: .: . :: . : :..::. .. :. . .:.: : ... : : NP_068 KETAPSLGSKILAGLTTG-GVAVFIGQPTEVVKVR-LQAQSHLHGIKPRYTGTYNAYRII 110 120 130 140 150 160 180 190 200 210 220 pF1KE6 VREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNP--LITGVFGAI . .:: : ..: : ..... . .. .. ... . .: : :.... : NP_068 ATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSAL---I 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE6 AGAASVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLD :: .. ..:.::.:::. . .:... .:..... .:: ::.:: :: . :. NP_068 AGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSW 230 240 250 260 270 280 290 300 310 pF1KE6 VAIVFVIYDEVVKLLNKVWKTD .:.:: .... . :.: .: NP_068 NVIMFVCFEQLKRELSKSRQTMDCAT 290 300 >>NP_003346 (OMIM: 601693,607447) mitochondrial uncoupli (309 aa) initn: 337 init1: 163 opt: 370 Z-score: 443.7 bits: 90.2 E(85289): 5.6e-18 Smith-Waterman score: 370; 28.1% identity (61.9% similar) in 299 aa overlap (19-304:5-298) 10 20 30 40 50 pF1KE6 MPAPRAPRALAAAAPASGKAKLTHPGKAI--LAGGLAGGIEICITFPTEYVKTQLQLDER :: . : .. :..: :. : :::: . .:..::.. . NP_003 MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGE 10 20 30 40 60 70 80 90 100 110 pF1KE6 SHPP-------RYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNH :. : .:::. . ::..: .:: :: . : .. :.::.:... ... NP_003 SQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQF 50 60 70 80 90 100 120 130 140 150 160 pF1KE6 MRDAQGRLDSTRG--LLCGLGAGVAEAVVVVCPMETIKVKF-IHDQTSPNPKYRGFFHGV . ..: .. : :: : .: : ::.:. : ...::.: . ... . .:.. .. NP_003 Y--TKGSEHASIGSRLLAGSTTG-ALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAY 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE6 REIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPL-ITGVFG . :.::.:..: ..: . .: ... . .. .. ... : : .:..:: NP_003 KTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFG 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE6 AIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVC :: .. .:.::.:::... .: .. :.: .:.::: .::::: .: . :. NP_003 --AGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLG 230 240 250 260 270 280 290 300 310 pF1KE6 LDVAIVFVIYDEVVKLLNKVWKTD ...:: :... . : NP_003 SWNVVMFVTYEQLKRALMAACTSREAPF 290 300 311 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:54:05 2016 done: Tue Nov 8 11:54:06 2016 Total Scan time: 5.520 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]