FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6402, 535 aa 1>>>pF1KE6402 535 - 535 aa - 535 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9226+/-0.000442; mu= 14.6229+/- 0.028 mean_var=64.8295+/-13.030, 0's: 0 Z-trim(109.5): 71 B-trim: 138 in 1/50 Lambda= 0.159290 statistics sampled from 17577 (17648) to 17577 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.567), E-opt: 0.2 (0.207), width: 16 Scan time: 9.520 The best scores are: opt bits E(85289) NP_005580 (OMIM: 603178,614105) methylmalonate-sem ( 535) 3520 818.2 0 NP_001265522 (OMIM: 603178,614105) methylmalonate- ( 522) 2791 650.7 3.1e-186 NP_001265523 (OMIM: 603178,614105) methylmalonate- ( 381) 2552 595.8 7.9e-170 XP_016876820 (OMIM: 603178,614105) PREDICTED: meth ( 381) 2552 595.8 7.9e-170 NP_000687 (OMIM: 602733) 4-trimethylaminobutyralde ( 518) 800 193.2 1.7e-48 NP_072090 (OMIM: 606467) aldehyde dehydrogenase fa ( 487) 780 188.6 3.8e-47 NP_000680 (OMIM: 100640) retinal dehydrogenase 1 [ ( 501) 775 187.4 8.7e-47 NP_000684 (OMIM: 600463,615113) aldehyde dehydroge ( 512) 768 185.8 2.7e-46 XP_011516104 (OMIM: 100670) PREDICTED: aldehyde de ( 517) 763 184.7 6.1e-46 NP_000683 (OMIM: 100670) aldehyde dehydrogenase X, ( 517) 763 184.7 6.1e-46 NP_003879 (OMIM: 603687) retinal dehydrogenase 2 i ( 518) 758 183.5 1.4e-45 NP_001193826 (OMIM: 603687) retinal dehydrogenase ( 497) 752 182.1 3.4e-45 XP_011507596 (OMIM: 602733) PREDICTED: 4-trimethyl ( 424) 715 173.6 1.1e-42 NP_000681 (OMIM: 100650,610251) aldehyde dehydroge ( 517) 716 173.9 1.1e-42 NP_001071 (OMIM: 271980,610045) succinate-semialde ( 535) 705 171.3 6.5e-42 XP_011536288 (OMIM: 613584) PREDICTED: mitochondri ( 777) 679 165.4 5.8e-40 XP_016874378 (OMIM: 613584) PREDICTED: mitochondri ( 777) 679 165.4 5.8e-40 NP_001029345 (OMIM: 613584) mitochondrial 10-formy ( 923) 679 165.4 6.8e-40 NP_733798 (OMIM: 603687) retinal dehydrogenase 2 i ( 422) 649 158.4 3.9e-38 NP_001257294 (OMIM: 600249) cytosolic 10-formyltet ( 801) 627 153.4 2.4e-36 XP_011510657 (OMIM: 600249) PREDICTED: cytosolic 1 ( 902) 627 153.5 2.6e-36 NP_036322 (OMIM: 600249) cytosolic 10-formyltetrah ( 902) 627 153.5 2.6e-36 XP_006713544 (OMIM: 600249) PREDICTED: cytosolic 1 ( 902) 627 153.5 2.6e-36 NP_001257293 (OMIM: 600249) cytosolic 10-formyltet ( 912) 627 153.5 2.7e-36 NP_001191818 (OMIM: 100650,610251) aldehyde dehydr ( 470) 610 149.5 2.1e-35 NP_001188306 (OMIM: 107323,266100) alpha-aminoadip ( 511) 558 137.5 9.1e-32 NP_001173 (OMIM: 107323,266100) alpha-aminoadipic ( 539) 558 137.6 9.6e-32 NP_739577 (OMIM: 606467) aldehyde dehydrogenase fa ( 433) 550 135.7 2.8e-31 XP_016861103 (OMIM: 600249) PREDICTED: cytosolic 1 ( 828) 462 115.5 6.3e-25 XP_016861102 (OMIM: 600249) PREDICTED: cytosolic 1 ( 838) 462 115.5 6.4e-25 NP_001280744 (OMIM: 600463,615113) aldehyde dehydr ( 405) 439 110.2 1.3e-23 XP_011541719 (OMIM: 107323,266100) PREDICTED: alph ( 404) 425 107.0 1.2e-22 XP_016864982 (OMIM: 107323,266100) PREDICTED: alph ( 404) 425 107.0 1.2e-22 NP_001189333 (OMIM: 107323,266100) alpha-aminoadip ( 475) 406 102.6 2.8e-21 NP_001154976 (OMIM: 239510,606811) delta-1-pyrroli ( 503) 342 87.9 7.9e-17 NP_003739 (OMIM: 239510,606811) delta-1-pyrroline- ( 563) 342 87.9 8.8e-17 NP_733844 (OMIM: 239510,606811) delta-1-pyrroline- ( 563) 342 87.9 8.8e-17 NP_733797 (OMIM: 603687) retinal dehydrogenase 2 i ( 480) 323 83.5 1.6e-15 NP_733936 (OMIM: 271980,610045) succinate-semialde ( 548) 287 75.3 5.5e-13 XP_011536290 (OMIM: 613584) PREDICTED: mitochondri ( 622) 283 74.4 1.2e-12 NP_001180409 (OMIM: 606467) aldehyde dehydrogenase ( 437) 256 68.1 6.2e-11 NP_001306147 (OMIM: 239510,606811) delta-1-pyrroli ( 512) 248 66.3 2.6e-10 XP_011524743 (OMIM: 613358) PREDICTED: aldehyde de ( 773) 243 65.2 8.4e-10 XP_011524744 (OMIM: 613358) PREDICTED: aldehyde de ( 773) 243 65.2 8.4e-10 NP_699160 (OMIM: 613358) aldehyde dehydrogenase fa ( 802) 243 65.2 8.7e-10 NP_001317079 (OMIM: 100660) aldehyde dehydrogenase ( 380) 210 57.6 8.2e-08 XP_011522033 (OMIM: 100660) PREDICTED: aldehyde de ( 380) 210 57.6 8.2e-08 NP_000682 (OMIM: 100660) aldehyde dehydrogenase, d ( 453) 210 57.6 9.7e-08 NP_001128639 (OMIM: 100660) aldehyde dehydrogenase ( 453) 210 57.6 9.7e-08 NP_001128640 (OMIM: 100660) aldehyde dehydrogenase ( 453) 210 57.6 9.7e-08 >>NP_005580 (OMIM: 603178,614105) methylmalonate-semiald (535 aa) initn: 3520 init1: 3520 opt: 3520 Z-score: 4369.7 bits: 818.2 E(85289): 0 Smith-Waterman score: 3520; 100.0% identity (100.0% similar) in 535 aa overlap (1-535:1-535) 10 20 30 40 50 60 pF1KE6 MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 NPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 KLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 GIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 QHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKEN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 TLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLIT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 PQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 PVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLP 430 440 450 460 470 480 490 500 510 520 530 pF1KE6 MFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR 490 500 510 520 530 >>NP_001265522 (OMIM: 603178,614105) methylmalonate-semi (522 aa) initn: 2787 init1: 2787 opt: 2791 Z-score: 3464.5 bits: 650.7 E(85289): 3.1e-186 Smith-Waterman score: 3406; 97.6% identity (97.6% similar) in 535 aa overlap (1-535:1-522) 10 20 30 40 50 60 pF1KE6 MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 NPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIA ::::::::::::::::::::::::::::::::::::::::::: :::: NP_001 NPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQ-------------KEIA 70 80 90 100 130 140 150 160 170 180 pF1KE6 KLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCA 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE6 GIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHG 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE6 QHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKEN 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE6 TLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLIT 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE6 PQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFG 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE6 PVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLP 410 420 430 440 450 460 490 500 510 520 530 pF1KE6 MFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR 470 480 490 500 510 520 >>NP_001265523 (OMIM: 603178,614105) methylmalonate-semi (381 aa) initn: 2552 init1: 2552 opt: 2552 Z-score: 3169.9 bits: 595.8 E(85289): 7.9e-170 Smith-Waterman score: 2552; 100.0% identity (100.0% similar) in 381 aa overlap (155-535:1-381) 130 140 150 160 170 180 pF1KE6 LEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAP :::::::::::::::::::::::::::::: NP_001 MMGETMPSITKDMDLYSYRLPLGVCAGIAP 10 20 30 190 200 210 220 230 240 pF1KE6 FNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEA 40 50 60 70 80 90 250 260 270 280 290 300 pF1KE6 VNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQ 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE6 LVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAK 160 170 180 190 200 210 370 380 390 400 410 420 pF1KE6 ERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLV 220 230 240 250 260 270 430 440 450 460 470 480 pF1KE6 VLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSF 280 290 300 310 320 330 490 500 510 520 530 pF1KE6 TGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR 340 350 360 370 380 >>XP_016876820 (OMIM: 603178,614105) PREDICTED: methylma (381 aa) initn: 2552 init1: 2552 opt: 2552 Z-score: 3169.9 bits: 595.8 E(85289): 7.9e-170 Smith-Waterman score: 2552; 100.0% identity (100.0% similar) in 381 aa overlap (155-535:1-381) 130 140 150 160 170 180 pF1KE6 LEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAP :::::::::::::::::::::::::::::: XP_016 MMGETMPSITKDMDLYSYRLPLGVCAGIAP 10 20 30 190 200 210 220 230 240 pF1KE6 FNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEA 40 50 60 70 80 90 250 260 270 280 290 300 pF1KE6 VNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQ 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE6 LVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAK 160 170 180 190 200 210 370 380 390 400 410 420 pF1KE6 ERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLV 220 230 240 250 260 270 430 440 450 460 470 480 pF1KE6 VLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSF 280 290 300 310 320 330 490 500 510 520 530 pF1KE6 TGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR 340 350 360 370 380 >>NP_000687 (OMIM: 602733) 4-trimethylaminobutyraldehyde (518 aa) initn: 689 init1: 371 opt: 800 Z-score: 991.7 bits: 193.2 E(85289): 1.7e-48 Smith-Waterman score: 800; 30.5% identity (62.1% similar) in 515 aa overlap (10-512:3-507) 10 20 30 40 50 pF1KE6 MAALLAAAAVRARILQVSSKVKS-SPTWYSASSFSSSVPTVKL-FIGGKFVESKSDKWID .:: . .: ..: :. .: : .. : . : . :: :: . . . NP_000 MFLRAGLAALSPLLRSLRPSPVAAMSTGTFVVSQPLNYRGGARVEPADASGTE 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 -IHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLK .:::..::. . . :.. :. . : :: :.. : . : ..::. ..:.: NP_000 KAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRERED 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 EIAKLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLG ::: . ...::.. .:. :. . : .:. .... : :: . .. :. : ::: NP_000 EIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFG-YTRREPLG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 VCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNI ::.::. .:.: .: : :..:::....::: .: ...:::.. ...:.: : .:. NP_000 VCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE6 IHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDAN ..: . .:.:.:::. .::.:: .: :.: ... : : ..:.:. ... : . NP_000 VQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCD 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE6 KENTLNQLVGAAFGAAGQRCMALSTAVLVGEA--KKWLPELVEHAKNLRVNAGDQPGAD- .:... . : : . :: : .: :.: . :. :.:.... :.. :: : NP_000 MNNAVKGALMANFLTQGQVCCN-GTRVFVQKEILDKFTEEVVKQTQ--RIKIGDPLLEDT 300 310 320 330 340 360 370 380 390 400 410 pF1KE6 -LGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVK---GYENGNFVGPTIISNVKPN .::::. ::: ... . ..::..: : : : ..: .. : ...: . . NP_000 RMGPLINRPHLERVLGFVKVAKEQGAKVLCGG-DIYVPEDPKLKDGYYMRPCVLTNCRDD 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE6 MTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVG ::: ::::::::. .: .: :... .:.. .: ....:: . :.. . ...: NP_000 MTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCF 410 420 430 440 450 460 480 490 500 510 520 pF1KE6 VNVPI--PVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAV .: :: :: : : ..: : : :. :..:.::::. NP_000 INNYNVSPVELP---FGGYKKSGFGREN--GRVTIEYYSQLKTVCVEMGDVESAF 470 480 490 500 510 530 pF1KE6 VMPTMGR >>NP_072090 (OMIM: 606467) aldehyde dehydrogenase family (487 aa) initn: 651 init1: 203 opt: 780 Z-score: 967.3 bits: 188.6 E(85289): 3.8e-47 Smith-Waterman score: 780; 31.3% identity (64.9% similar) in 479 aa overlap (43-513:13-484) 20 30 40 50 60 70 pF1KE6 RILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVP :: :::. .: .:: ..:.:.:: ::: NP_072 MAGTNALLMLENFIDGKFLPCSS--YIDSYDPSTGEVYCRVP 10 20 30 40 80 90 100 110 120 130 pF1KE6 QATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLA .. : :..::. . ..:::.:.. : :..:: . .:....:.:.:. . .:::::: NP_072 NSGKDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLA 50 60 70 80 90 100 140 150 160 170 180 190 pF1KE6 DAEG-DVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMI :. :. :..: . : . .: :. : :.:: . :.:.:.: .. NP_072 LARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYL 110 120 130 140 150 160 200 210 220 230 240 250 pF1KE6 PLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNF-ICD : . ::. ::: . :::: . .. .: :::. .:.: :..::. : :. . . NP_072 LTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVS 170 180 190 200 210 220 260 270 280 290 300 310 pF1KE6 HPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAF ::.. :::.::. ..: : . .. : :... ..:.:: .... ::: .. . : ..: NP_072 HPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSF 230 240 250 260 270 280 320 330 340 350 360 pF1KE6 GAAGQRCMALSTAVLVGEA--KKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVC . :. :. : ..: .. ...: ..:: ... .:. ..: ...: ::. :.: NP_072 ANQGEICLCTSR-IFVQKSIYSEFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVR 290 300 310 320 330 370 380 390 400 410 420 pF1KE6 NLIDSGTKEGASIL----LDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLV . . . :::.: .: .. ... . : :. ::.:...: . :. ::::::: NP_072 SYVKRALAEGAQIWCGEGVDKLSLPARN-QAGYFMLPTVITDIKDESCCMTEEIFGPVTC 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE6 VLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSF :. .. .:.:. .:: :: .......: . ... :. .. : : .: . : . : NP_072 VVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNL-PF 400 410 420 430 440 450 490 500 510 520 530 pF1KE6 TGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR : .:: : . .:.. .:.:..:::: NP_072 GGMKSSGIGREG--AKDSYDFFTEIKTITVKH 460 470 480 >>NP_000680 (OMIM: 100640) retinal dehydrogenase 1 [Homo (501 aa) initn: 554 init1: 222 opt: 775 Z-score: 960.9 bits: 187.4 E(85289): 8.7e-47 Smith-Waterman score: 775; 30.4% identity (63.9% similar) in 493 aa overlap (37-521:18-501) 10 20 30 40 50 60 pF1KE6 AAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNE . .:.::.... .: : : . . ::::.: NP_000 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEE 10 20 30 40 70 80 90 100 110 120 pF1KE6 VIGRVPQATKAEMDAAIASCKRAFPA---WADTSVLSRQQVLLRYQQLIKENLKEIAKLI . .: .. : ..: :. . ..:: : .. : ..: . .::... .: . NP_000 ELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATME 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE6 TLEQGKTLADAEGDVFRG-LQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGI ... :: ..: . . : ...... . .. ..:.:.: : .. :. . :.:::. : NP_000 SMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIP-IDGNFFTYTRHEPIGVCGQI 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE6 APFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQH :.::: .. .: . :. :::: ..::.:..: ... .:.:....: : :..::. : NP_000 IPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYG 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE6 EAVNF-ICDHPDIKAISFVGSNKAGEYIFER-GSRHGKRVQANMGAKNHGVVMPDANKEN ... : .: :: ..:.::...:. : : :. . ::: ..:.:. .:. ::. .: NP_000 PTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDN 230 240 250 260 270 280 310 320 330 340 350 pF1KE6 TLNQLVGAAFGAAGQRCMALSTAVLVGEA--KKWLPELVEHAKNLRVNAGDQPGADLGPL ... ..: :: :.: : ..: :. ... . ::.::. .. ::. :: NP_000 AVEFAHHGVFYHQGQCCIAASR-IFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQ 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE6 ITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEI : . ... .::.:: ::::.. : ::: :: ::..::: .: :::: NP_000 IDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGY----FVQPTVFSNVTDEMRIAKEEI 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE6 FGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVP :::: ... ..::..:. .::. :: ....:: . : . ...: : :: : NP_000 FGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNC-YGVV 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE6 LPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR . : : . : :. :. :.. ::..::.: . ..... NP_000 SAQCPFGGFKMS--GNGRELGEYGFHEYTEVKTVTVKISQKNS 470 480 490 500 >>NP_000684 (OMIM: 600463,615113) aldehyde dehydrogenase (512 aa) initn: 654 init1: 215 opt: 768 Z-score: 952.1 bits: 185.8 E(85289): 2.7e-46 Smith-Waterman score: 768; 31.8% identity (63.9% similar) in 485 aa overlap (37-513:29-504) 10 20 30 40 50 60 pF1KE6 AAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNE : .:.::.... :::: : . ::.: : NP_000 MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTRE 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 VIGRVPQATKAEMDAAIASCKRAFP---AWADTSVLSRQQVLLRYQQLIKENLKEIAKLI : .: .. : ..: :. . . :: : ..::: ..: . .:.... .: : NP_000 QICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALE 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 TLEQGKTLADAEGDVFRG-LQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGI :.. :: . : ..: ...... . .. ..:.:.:. .. .. . :.:::..: NP_000 TMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPT-DDNVVCFTRHEPIGVCGAI 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE6 APFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQH .:.::: .. .: . :. ::::...::.:..: ... :..:....: : :..::. : NP_000 TPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFG 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE6 EAVNF-ICDHPDIKAISFVGSNKAGEYIFERGSRHG-KRVQANMGAKNHGVVMPDANKEN .:. : .::.:. :.:.::...:. . : .:: . ::: ..:.:: .: ::. . NP_000 PTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDL 240 250 260 270 280 290 310 320 330 340 350 pF1KE6 TLNQLVGAAFGAAGQRCMALSTAVLVGEA--KKWLPELVEHAKNLRVNAGDQPGADLGPL ... ..: :: : : : :.: : .... . ::.::. :. . .. :: NP_000 AVECAHQGVFFNQGQCCTAASR-VFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQ 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE6 ITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEI : . ... .::.:: ::::.. : .. :: :. ::..:.: :: :::: NP_000 IDQKQFDKILELIESGKKEGAKLECGGSAMEDKGL----FIKPTVFSEVTDNMRIAKEEI 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE6 FGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVP :::: .:. ....:.:. .:.. :: .:.:: : : : : .. : : .: . NP_000 FGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNAL- 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE6 LPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR . : : . : :. :. .. ::..::.: NP_000 YAQAPFGGFKMS--GNGRELGEYALAEYTEVKTVTIKLGDKNP 480 490 500 510 >>XP_011516104 (OMIM: 100670) PREDICTED: aldehyde dehydr (517 aa) initn: 637 init1: 205 opt: 763 Z-score: 945.8 bits: 184.7 E(85289): 6.1e-46 Smith-Waterman score: 763; 29.5% identity (63.5% similar) in 526 aa overlap (4-521:1-517) 10 20 30 40 50 60 pF1KE6 MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIH .: : : :: . :: . . .. ..: .:::.... .. : : . XP_011 MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTV 10 20 30 40 50 70 80 90 100 110 pF1KE6 NPATNEVIGRVPQATKAEMDAAIASCKRAF---PAWADTSVLSRQQVLLRYQQLIKENLK ::.:.::::.: .. .:..: :. . ..:: : .. : ..: : .:.... XP_011 NPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 EIAKLITLEQGKTLADAEG-DVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPL .:.: ::..:: . .. . :. . ..: .. . .. :.:.: . . .. . :. XP_011 YLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIP-MDGQHFCFTRHEPV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 GVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLN :::. : :.::: .. : . :.. ::: .:: .:..: ... ::.:....: : :..: XP_011 GVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVN 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE6 IIHGQHEAVNF-ICDHPDIKAISFVGSNKAGEYIFER-GSRHGKRVQANMGAKNHGVVMP :: : ... : .: :. ..:.::...:. : . :. . ::: ..:.:. ..:. XP_011 IITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE6 DANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEA--KKWLPELVEHAKNLRVNAGDQPG ::. :....: : : :: : : : . .: :. ...: . ::.::. .:. . XP_011 DADMEHAVEQCHEALFFNMGQCCCAGSRT-FVEESIYNEFLERTVEKAKQRKVGNPFELD 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE6 ADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMT .. :: . . ::: . :. : ::::..: :... .:. :. ::....:. .: XP_011 TQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGF----FIKPTVFGGVQDDMR 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE6 CYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVN :::::::: ... . ..:... .::. :: ..:.:: . : ... ...: : :: XP_011 IAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVN 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE6 VPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPT . . : : . : :. :..:.. ::..::.: . .... XP_011 T-YNIVTCHTPFGGFKES--GNGRELGEDGLKAYTEVKTVTIKVPQKNS 480 490 500 510 pF1KE6 MGR >>NP_000683 (OMIM: 100670) aldehyde dehydrogenase X, mit (517 aa) initn: 637 init1: 205 opt: 763 Z-score: 945.8 bits: 184.7 E(85289): 6.1e-46 Smith-Waterman score: 763; 29.5% identity (63.5% similar) in 526 aa overlap (4-521:1-517) 10 20 30 40 50 60 pF1KE6 MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIH .: : : :: . :: . . .. ..: .:::.... .. : : . NP_000 MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTV 10 20 30 40 50 70 80 90 100 110 pF1KE6 NPATNEVIGRVPQATKAEMDAAIASCKRAF---PAWADTSVLSRQQVLLRYQQLIKENLK ::.:.::::.: .. .:..: :. . ..:: : .. : ..: : .:.... NP_000 NPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 EIAKLITLEQGKTLADAEG-DVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPL .:.: ::..:: . .. . :. . ..: .. . .. :.:.: . . .. . :. NP_000 YLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIP-MDGQHFCFTRHEPV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 GVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLN :::. : :.::: .. : . :.. ::: .:: .:..: ... ::.:....: : :..: NP_000 GVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVN 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE6 IIHGQHEAVNF-ICDHPDIKAISFVGSNKAGEYIFER-GSRHGKRVQANMGAKNHGVVMP :: : ... : .: :. ..:.::...:. : . :. . ::: ..:.:. ..:. NP_000 IITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE6 DANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEA--KKWLPELVEHAKNLRVNAGDQPG ::. :....: : : :: : : : . .: :. ...: . ::.::. .:. . NP_000 DADMEHAVEQCHEALFFNMGQCCCAGSRT-FVEESIYNEFLERTVEKAKQRKVGNPFELD 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE6 ADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMT .. :: . . ::: . :. : ::::..: :... .:. :. ::....:. .: NP_000 TQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGF----FIKPTVFGGVQDDMR 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE6 CYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVN :::::::: ... . ..:... .::. :: ..:.:: . : ... ...: : :: NP_000 IAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVN 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE6 VPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPT . . : : . : :. :..:.. ::..::.: . .... NP_000 T-YNIVTCHTPFGGFKES--GNGRELGEDGLKAYTEVKTVTIKVPQKNS 480 490 500 510 pF1KE6 MGR 535 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 12:55:34 2016 done: Tue Nov 8 12:55:36 2016 Total Scan time: 9.520 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]