FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6208, 193 aa 1>>>pF1KE6208 193 - 193 aa - 193 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9155+/-0.000385; mu= 15.0478+/- 0.024 mean_var=60.0014+/-12.086, 0's: 0 Z-trim(111.4): 42 B-trim: 251 in 1/49 Lambda= 0.165575 statistics sampled from 19908 (19950) to 19908 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.613), E-opt: 0.2 (0.234), width: 16 Scan time: 4.460 The best scores are: opt bits E(85289) NP_005820 (OMIM: 602416) AP-3 complex subunit sigm ( 193) 1263 310.0 1.5e-84 NP_001275 (OMIM: 601507) AP-3 complex subunit sigm ( 193) 1089 268.5 4.8e-72 NP_001002924 (OMIM: 601507) AP-3 complex subunit s ( 171) 964 238.6 4.3e-63 NP_001305022 (OMIM: 601507) AP-3 complex subunit s ( 162) 873 216.8 1.4e-56 XP_016864513 (OMIM: 601507) PREDICTED: AP-3 comple ( 262) 873 217.0 2.1e-56 XP_011541438 (OMIM: 601507) PREDICTED: AP-3 comple ( 262) 873 217.0 2.1e-56 NP_001305023 (OMIM: 601507) AP-3 complex subunit s ( 157) 685 171.9 4.6e-43 NP_001305019 (OMIM: 601507) AP-3 complex subunit s ( 125) 567 143.7 1.2e-34 NP_001305020 (OMIM: 601507) AP-3 complex subunit s ( 169) 527 134.2 1.1e-31 XP_016864514 (OMIM: 601507) PREDICTED: AP-3 comple ( 238) 527 134.3 1.5e-31 XP_016885415 (OMIM: 300629) PREDICTED: AP-1 comple ( 189) 354 92.9 3.4e-19 NP_001274 (OMIM: 603531,609313) AP-1 complex subun ( 158) 353 92.6 3.4e-19 XP_016885414 (OMIM: 300629) PREDICTED: AP-1 comple ( 202) 354 92.9 3.6e-19 XP_011543901 (OMIM: 300629) PREDICTED: AP-1 comple ( 202) 354 92.9 3.6e-19 NP_004060 (OMIM: 600740,602242) AP-2 complex subun ( 142) 352 92.3 3.7e-19 NP_001288007 (OMIM: 600740,602242) AP-2 complex su ( 156) 350 91.9 5.6e-19 NP_001259000 (OMIM: 300629) AP-1 complex subunit s ( 160) 350 91.9 5.7e-19 NP_001034658 (OMIM: 615781,616106) AP-1 complex su ( 154) 349 91.6 6.5e-19 NP_003907 (OMIM: 300629) AP-1 complex subunit sigm ( 157) 349 91.7 6.6e-19 XP_005274671 (OMIM: 300629) PREDICTED: AP-1 comple ( 195) 349 91.7 7.9e-19 NP_001288010 (OMIM: 600740,602242) AP-2 complex su ( 144) 345 90.7 1.2e-18 NP_001288005 (OMIM: 600740,602242) AP-2 complex su ( 158) 345 90.7 1.3e-18 XP_011524726 (OMIM: 600740,602242) PREDICTED: AP-2 ( 158) 343 90.2 1.8e-18 XP_011524725 (OMIM: 600740,602242) PREDICTED: AP-2 ( 172) 343 90.2 1.9e-18 NP_001241657 (OMIM: 607243,614067) AP-4 complex su ( 144) 340 89.5 2.7e-18 NP_001121598 (OMIM: 607243,614067) AP-4 complex su ( 144) 340 89.5 2.7e-18 NP_001241658 (OMIM: 607243,614067) AP-4 complex su ( 144) 340 89.5 2.7e-18 NP_001241656 (OMIM: 607243,614067) AP-4 complex su ( 149) 236 64.6 8.5e-11 NP_009008 (OMIM: 607243,614067) AP-4 complex subun ( 159) 236 64.7 9e-11 XP_011534673 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 236 64.7 9e-11 XP_005267350 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 236 64.7 9e-11 XP_011534674 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 236 64.7 9e-11 XP_011508902 (OMIM: 615781,616106) PREDICTED: AP-1 ( 108) 222 61.2 6.6e-10 NP_001241655 (OMIM: 607243,614067) AP-4 complex su ( 135) 214 59.4 3e-09 NP_057513 (OMIM: 615526) coatomer subunit zeta-2 [ ( 210) 188 53.3 3.2e-07 NP_001258664 (OMIM: 615472) coatomer subunit zeta- ( 160) 166 47.9 9.7e-06 NP_057141 (OMIM: 615472) coatomer subunit zeta-1 i ( 177) 166 48.0 1.1e-05 XP_016874486 (OMIM: 615472) PREDICTED: coatomer su ( 180) 166 48.0 1.1e-05 NP_001258665 (OMIM: 615472) coatomer subunit zeta- ( 185) 166 48.0 1.1e-05 NP_067586 (OMIM: 600740,602242) AP-2 complex subun ( 104) 153 44.7 5.9e-05 NP_001258663 (OMIM: 615472) coatomer subunit zeta- ( 154) 133 40.0 0.0022 >>NP_005820 (OMIM: 602416) AP-3 complex subunit sigma-2 (193 aa) initn: 1263 init1: 1263 opt: 1263 Z-score: 1639.0 bits: 310.0 E(85289): 1.5e-84 Smith-Waterman score: 1263; 100.0% identity (100.0% similar) in 193 aa overlap (1-193:1-193) 10 20 30 40 50 60 pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG 130 140 150 160 170 180 190 pF1KE6 DLNIKVPNLSQFV ::::::::::::: NP_005 DLNIKVPNLSQFV 190 >>NP_001275 (OMIM: 601507) AP-3 complex subunit sigma-1 (193 aa) initn: 1107 init1: 1089 opt: 1089 Z-score: 1414.4 bits: 268.5 E(85289): 4.8e-72 Smith-Waterman score: 1089; 84.4% identity (94.8% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD ::.:::.::::::::: .::: . :. ::::.::::::: :::.:.::::::: :::::: NP_001 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL :::::::::::::::::::::::::::::::::::::::::::::::::::.:::: :: NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG :.:::::::::::::::.::.:::.:::::.::..:::::::::::.:::::::::::: NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG 130 140 150 160 170 180 190 pF1KE6 DLNIKVPNLSQFV :..:::::: .: NP_001 DISIKVPNLPSFK 190 >>NP_001002924 (OMIM: 601507) AP-3 complex subunit sigma (171 aa) initn: 975 init1: 957 opt: 964 Z-score: 1253.8 bits: 238.6 E(85289): 4.3e-63 Smith-Waterman score: 964; 86.3% identity (95.8% similar) in 168 aa overlap (25-192:3-170) 10 20 30 40 50 60 pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD :. ::::.::::::: :::.:.::::::: :::::: NP_001 MSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 10 20 30 70 80 90 100 110 120 pF1KE6 YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL :::::::::::::::::::::::::::::::::::::::::::::::::::.:::: :: NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE6 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG :.:::::::::::::::.::.:::.:::::.::..:::::::::::.:::::::::::: NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG 100 110 120 130 140 150 190 pF1KE6 DLNIKVPNLSQFV :..:::::: .: NP_001 DISIKVPNLPSFK 160 170 >>NP_001305022 (OMIM: 601507) AP-3 complex subunit sigma (162 aa) initn: 870 init1: 870 opt: 873 Z-score: 1136.6 bits: 216.8 E(85289): 1.4e-56 Smith-Waterman score: 873; 82.3% identity (91.8% similar) in 158 aa overlap (1-158:1-158) 10 20 30 40 50 60 pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD ::.:::.::::::::: .::: . :. ::::.::::::: :::.:.::::::: :::::: NP_001 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL :::::::::::::::::::::::::::::::::::::::::::::::::::.:::: :: NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG :.:::::::::::::::.::.:::.::::: . .: NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSETFIFQSPRQDR 130 140 150 160 190 pF1KE6 DLNIKVPNLSQFV >>XP_016864513 (OMIM: 601507) PREDICTED: AP-3 complex su (262 aa) initn: 870 init1: 870 opt: 873 Z-score: 1133.6 bits: 217.0 E(85289): 2.1e-56 Smith-Waterman score: 873; 82.3% identity (91.8% similar) in 158 aa overlap (1-158:101-258) 10 20 30 pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQ ::.:::.::::::::: .::: . :. ::: XP_016 GRIAGEITRRGSRARPRPGPQCPPGRPGTAMIKAILIFNNHGKPRLSKFYQPYSEDTQQQ 80 90 100 110 120 130 40 50 60 70 80 90 pF1KE6 IVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLI :.::::::: :::.:.::::::: :::::: ::::::::::::::::::::::::::::: XP_016 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI 140 150 160 170 180 190 100 110 120 130 140 150 pF1KE6 QVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKS ::::::::::::::::::::::.:::: :: :.:::::::::::::::.::.:::.:::: XP_016 QVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS 200 210 220 230 240 250 160 170 180 190 pF1KE6 EGGLSAAPARAVSAVKNINLPEIPRNINIGDLNIKVPNLSQFV : . .: XP_016 ETFIFQSPRQDR 260 >>XP_011541438 (OMIM: 601507) PREDICTED: AP-3 complex su (262 aa) initn: 870 init1: 870 opt: 873 Z-score: 1133.6 bits: 217.0 E(85289): 2.1e-56 Smith-Waterman score: 873; 82.3% identity (91.8% similar) in 158 aa overlap (1-158:101-258) 10 20 30 pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQ ::.:::.::::::::: .::: . :. ::: XP_011 GRIAGEITRRGSRARPRPGPQCPPGRPGTAMIKAILIFNNHGKPRLSKFYQPYSEDTQQQ 80 90 100 110 120 130 40 50 60 70 80 90 pF1KE6 IVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLI :.::::::: :::.:.::::::: :::::: ::::::::::::::::::::::::::::: XP_011 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI 140 150 160 170 180 190 100 110 120 130 140 150 pF1KE6 QVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKS ::::::::::::::::::::::.:::: :: :.:::::::::::::::.::.:::.:::: XP_011 QVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS 200 210 220 230 240 250 160 170 180 190 pF1KE6 EGGLSAAPARAVSAVKNINLPEIPRNINIGDLNIKVPNLSQFV : . .: XP_011 ETFIFQSPRQDR 260 >>NP_001305023 (OMIM: 601507) AP-3 complex subunit sigma (157 aa) initn: 891 init1: 685 opt: 685 Z-score: 894.1 bits: 171.9 E(85289): 4.6e-43 Smith-Waterman score: 821; 68.8% identity (77.1% similar) in 192 aa overlap (1-192:1-156) 10 20 30 40 50 60 pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD ::.:::.::::::::: .::: . :. ::::.::::::: :::.:.::::::: :::::: NP_001 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL :::::::::::::::::::::::::::::::::::::::::::::::::::.::. NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKA---- 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG ::..:::::::::::.:::::::::::: NP_001 --------------------------------GLAGAPARAVSAVKNMNLPEIPRNINIG 120 130 140 190 pF1KE6 DLNIKVPNLSQFV :..:::::: .: NP_001 DISIKVPNLPSFK 150 >>NP_001305019 (OMIM: 601507) AP-3 complex subunit sigma (125 aa) initn: 691 init1: 567 opt: 567 Z-score: 743.2 bits: 143.7 E(85289): 1.2e-34 Smith-Waterman score: 567; 85.1% identity (97.0% similar) in 101 aa overlap (92-192:24-124) 70 80 90 100 110 120 pF1KE6 KLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYILQ :::::::::::::::::::::.:::: :: NP_001 MIKAILIFNNHGKPRLSKFYQPYVFVETLDKCFENVCELDLIFHVDKVHNILA 10 20 30 40 50 130 140 150 160 170 180 pF1KE6 EVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIGD :.:::::::::::::::.::.:::.:::::.::..:::::::::::.::::::::::::: NP_001 EMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGD 60 70 80 90 100 110 190 pF1KE6 LNIKVPNLSQFV ..:::::: .: NP_001 ISIKVPNLPSFK 120 >>NP_001305020 (OMIM: 601507) AP-3 complex subunit sigma (169 aa) initn: 918 init1: 527 opt: 527 Z-score: 689.7 bits: 134.2 E(85289): 1.1e-31 Smith-Waterman score: 869; 72.4% identity (82.3% similar) in 192 aa overlap (1-192:1-168) 10 20 30 40 50 60 pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD ::.:::.::::::::: .::: . :. ::::.::::::: :::.:.::::::: :::::: NP_001 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL ::::::::::::::::::::::::::::::: : :: NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQV------------------------HNIL 70 80 90 130 140 150 160 170 180 pF1KE6 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG :.:::::::::::::::.::.:::.:::::.::..:::::::::::.:::::::::::: NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG 100 110 120 130 140 150 190 pF1KE6 DLNIKVPNLSQFV :..:::::: .: NP_001 DISIKVPNLPSFK 160 >>XP_016864514 (OMIM: 601507) PREDICTED: AP-3 complex su (238 aa) initn: 527 init1: 527 opt: 527 Z-score: 687.5 bits: 134.3 E(85289): 1.5e-31 Smith-Waterman score: 653; 67.7% identity (76.6% similar) in 158 aa overlap (1-158:101-234) 10 20 30 pF1KE6 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQ ::.:::.::::::::: .::: . :. ::: XP_016 GRIAGEITRRGSRARPRPGPQCPPGRPGTAMIKAILIFNNHGKPRLSKFYQPYSEDTQQQ 80 90 100 110 120 130 40 50 60 70 80 90 pF1KE6 IVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLI :.::::::: :::.:.::::::: :::::: ::::::::::::::::::::::::::::: XP_016 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI 140 150 160 170 180 190 100 110 120 130 140 150 pF1KE6 QVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKS :: : :: :.:::::::::::::::.::.:::.:::: XP_016 QV------------------------HNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS 200 210 220 160 170 180 190 pF1KE6 EGGLSAAPARAVSAVKNINLPEIPRNINIGDLNIKVPNLSQFV : . .: XP_016 ETFIFQSPRQDR 230 193 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:05:46 2016 done: Tue Nov 8 11:05:47 2016 Total Scan time: 4.460 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]