FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3663, 196 aa 1>>>pF1KE3663 196 - 196 aa - 196 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8064+/-0.000262; mu= 7.2287+/- 0.016 mean_var=111.0539+/-22.256, 0's: 0 Z-trim(123.2): 16 B-trim: 78 in 1/56 Lambda= 0.121705 statistics sampled from 42450 (42468) to 42450 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.825), E-opt: 0.2 (0.498), width: 16 Scan time: 6.000 The best scores are: opt bits E(85289) NP_055180 (OMIM: 158590,608014,608673) heat shock ( 196) 1382 252.1 4.1e-67 NP_001531 (OMIM: 602195,606595,608634) heat shock ( 205) 395 78.9 6.3e-15 NP_001317308 (OMIM: 123590,608810,613763,613869,61 ( 108) 243 52.0 4e-07 NP_001876 (OMIM: 123590,608810,613763,613869,61518 ( 175) 245 52.5 4.7e-07 NP_001276737 (OMIM: 123590,608810,613763,613869,61 ( 175) 245 52.5 4.7e-07 NP_001276736 (OMIM: 123590,608810,613763,613869,61 ( 175) 245 52.5 4.7e-07 XP_011540910 (OMIM: 123590,608810,613763,613869,61 ( 175) 245 52.5 4.7e-07 NP_653218 (OMIM: 610695) heat shock protein beta-6 ( 160) 238 51.2 1e-06 XP_005261150 (OMIM: 123580,604219) PREDICTED: alph ( 136) 215 47.2 1.5e-05 NP_000385 (OMIM: 123580,604219) alpha-crystallin A ( 173) 215 47.2 1.8e-05 NP_001532 (OMIM: 602179) heat shock protein beta-2 ( 182) 206 45.6 5.5e-05 XP_011539551 (OMIM: 610692) PREDICTED: heat shock ( 263) 184 41.9 0.0011 NP_055239 (OMIM: 610692) heat shock protein beta-7 ( 170) 180 41.1 0.0012 XP_011539552 (OMIM: 610692) PREDICTED: heat shock ( 262) 181 41.3 0.0016 NP_006299 (OMIM: 604624,613376) heat shock protein ( 150) 173 39.8 0.0026 >>NP_055180 (OMIM: 158590,608014,608673) heat shock prot (196 aa) initn: 1382 init1: 1382 opt: 1382 Z-score: 1325.9 bits: 252.1 E(85289): 4.1e-67 Smith-Waterman score: 1382; 100.0% identity (100.0% similar) in 196 aa overlap (1-196:1-196) 10 20 30 40 50 60 pF1KE3 MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGES 130 140 150 160 170 180 190 pF1KE3 SFNNELPQDSQEVTCT :::::::::::::::: NP_055 SFNNELPQDSQEVTCT 190 >>NP_001531 (OMIM: 602195,606595,608634) heat shock prot (205 aa) initn: 441 init1: 303 opt: 395 Z-score: 389.0 bits: 78.9 E(85289): 6.3e-15 Smith-Waterman score: 405; 39.6% identity (62.0% similar) in 187 aa overlap (1-176:1-174) 10 20 30 40 50 pF1KE3 MADGQMPFSC-HYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSA :.. ..::: . :: ::::: :::.:..::. .:.. : .: .:. NP_001 MTERRVPFSLLRGPSW---DPFRDWYPHSRLFDQAFGLPRLPEE----WSQWL---GGSS 10 20 30 40 50 60 70 80 90 100 pF1KE3 WPGTLRSGMVPRGPTATARFGVPAEGR----------TPPPFPGEPWKVCVNVHSFKPEE ::: .: .: . . ..:: .: . .. :.: ..:. : :.: NP_001 WPGYVRP--LPPAAIESPAVAAPAYSRALSRQLSSGVSEIRHTADRWRVSLDVNHFAPDE 60 70 80 90 100 110 120 130 140 150 160 pF1KE3 LMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAP : :::::: ::..:::::.:.: : .:. ::.: :: :::. : .:::::: : .::: NP_001 LTVKTKDGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAP 110 120 130 140 150 160 170 180 190 pF1KE3 QVPPYSTFGESSFNNELPQDSQEVTCT .: .: NP_001 -MPKLATQSNEITIPVTFESRAQLGGPEAAKSDETAAK 170 180 190 200 >>NP_001317308 (OMIM: 123590,608810,613763,613869,615184 (108 aa) initn: 224 init1: 224 opt: 243 Z-score: 248.9 bits: 52.0 E(85289): 4e-07 Smith-Waterman score: 243; 45.3% identity (81.3% similar) in 75 aa overlap (96-170:8-82) 70 80 90 100 110 120 pF1KE3 SGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVEVSGKH ..: ..:. :.:::: ::. .:: ::: NP_001 MRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKH 10 20 30 130 140 150 160 170 180 pF1KE3 EEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGESSFNNE ::.:.: :..:..: .: ..::.:::.:. .::: .:.: ...:. NP_001 EERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITRE 40 50 60 70 80 90 190 pF1KE3 LPQDSQEVTCT NP_001 EKPAVTAAPKK 100 >>NP_001876 (OMIM: 123590,608810,613763,613869,615184) a (175 aa) initn: 273 init1: 224 opt: 245 Z-score: 247.7 bits: 52.5 E(85289): 4.7e-07 Smith-Waterman score: 284; 35.2% identity (61.2% similar) in 165 aa overlap (6-170:1-149) 10 20 30 40 50 60 pF1KE3 MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAW : .. :.: .:: :: :::.:. :: . .:: .: .: NP_001 MDIAIHHP-WIRR-PFFPFHSPSRLFDQFFGEHLLESDL--------FPTSTSLS 10 20 30 40 70 80 90 100 110 120 pF1KE3 PGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVE : :: :.:. : . : . . . ..: ..:. :.:::: ::. .: NP_001 PFYLRPPSFLRAPS---WFDT---GLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIE 50 60 70 80 90 130 140 150 160 170 180 pF1KE3 VSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGES : :::::.:.: :..:..: .: ..::.:::.:. .::: .:.: ...:. NP_001 VHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTI 100 110 120 130 140 150 190 pF1KE3 SFNNELPQDSQEVTCT NP_001 PITREEKPAVTAAPKK 160 170 >>NP_001276737 (OMIM: 123590,608810,613763,613869,615184 (175 aa) initn: 273 init1: 224 opt: 245 Z-score: 247.7 bits: 52.5 E(85289): 4.7e-07 Smith-Waterman score: 284; 35.2% identity (61.2% similar) in 165 aa overlap (6-170:1-149) 10 20 30 40 50 60 pF1KE3 MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAW : .. :.: .:: :: :::.:. :: . .:: .: .: NP_001 MDIAIHHP-WIRR-PFFPFHSPSRLFDQFFGEHLLESDL--------FPTSTSLS 10 20 30 40 70 80 90 100 110 120 pF1KE3 PGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVE : :: :.:. : . : . . . ..: ..:. :.:::: ::. .: NP_001 PFYLRPPSFLRAPS---WFDT---GLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIE 50 60 70 80 90 130 140 150 160 170 180 pF1KE3 VSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGES : :::::.:.: :..:..: .: ..::.:::.:. .::: .:.: ...:. NP_001 VHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTI 100 110 120 130 140 150 190 pF1KE3 SFNNELPQDSQEVTCT NP_001 PITREEKPAVTAAPKK 160 170 >>NP_001276736 (OMIM: 123590,608810,613763,613869,615184 (175 aa) initn: 273 init1: 224 opt: 245 Z-score: 247.7 bits: 52.5 E(85289): 4.7e-07 Smith-Waterman score: 284; 35.2% identity (61.2% similar) in 165 aa overlap (6-170:1-149) 10 20 30 40 50 60 pF1KE3 MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAW : .. :.: .:: :: :::.:. :: . .:: .: .: NP_001 MDIAIHHP-WIRR-PFFPFHSPSRLFDQFFGEHLLESDL--------FPTSTSLS 10 20 30 40 70 80 90 100 110 120 pF1KE3 PGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVE : :: :.:. : . : . . . ..: ..:. :.:::: ::. .: NP_001 PFYLRPPSFLRAPS---WFDT---GLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIE 50 60 70 80 90 130 140 150 160 170 180 pF1KE3 VSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGES : :::::.:.: :..:..: .: ..::.:::.:. .::: .:.: ...:. NP_001 VHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTI 100 110 120 130 140 150 190 pF1KE3 SFNNELPQDSQEVTCT NP_001 PITREEKPAVTAAPKK 160 170 >>XP_011540910 (OMIM: 123590,608810,613763,613869,615184 (175 aa) initn: 273 init1: 224 opt: 245 Z-score: 247.7 bits: 52.5 E(85289): 4.7e-07 Smith-Waterman score: 284; 35.2% identity (61.2% similar) in 165 aa overlap (6-170:1-149) 10 20 30 40 50 60 pF1KE3 MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAW : .. :.: .:: :: :::.:. :: . .:: .: .: XP_011 MDIAIHHP-WIRR-PFFPFHSPSRLFDQFFGEHLLESDL--------FPTSTSLS 10 20 30 40 70 80 90 100 110 120 pF1KE3 PGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVE : :: :.:. : . : . . . ..: ..:. :.:::: ::. .: XP_011 PFYLRPPSFLRAPS---WFDT---GLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIE 50 60 70 80 90 130 140 150 160 170 180 pF1KE3 VSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGES : :::::.:.: :..:..: .: ..::.:::.:. .::: .:.: ...:. XP_011 VHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTI 100 110 120 130 140 150 190 pF1KE3 SFNNELPQDSQEVTCT XP_011 PITREEKPAVTAAPKK 160 170 >>NP_653218 (OMIM: 610695) heat shock protein beta-6 [Ho (160 aa) initn: 249 init1: 192 opt: 238 Z-score: 241.6 bits: 51.2 E(85289): 1e-06 Smith-Waterman score: 247; 35.9% identity (60.5% similar) in 167 aa overlap (13-173:9-155) 10 20 30 40 50 pF1KE3 MADGQMPFSCHYPSRLRRD--PFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSS :: ::: :. .::.:. :: . .:.: : .. NP_653 MEIPVPVQPSWLRRASAPLPGLSAPGRLFDQRFGEGLLEAELAALCP-------TT 10 20 30 40 60 70 80 90 100 110 pF1KE3 AWPGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGY : ::. : :.: ::.. ::. ..: ..:. :.:::. ::. . NP_653 LAPYYLRAPSVAL-PVAQ----VPTD-------PGH-FSVLLDVKHFSPEEIAVKVVGEH 50 60 70 80 90 120 130 140 150 160 170 pF1KE3 VEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEA-P---QVPPY ::: ..:::. .: :.:...: .. .:: :::..: ..:::::.: :.: : :.:: NP_653 VEVHARHEERPDEHGFVAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQAAPASAQAPPP 100 110 120 130 140 150 180 190 pF1KE3 STFGESSFNNELPQDSQEVTCT NP_653 AAAK 160 >>XP_005261150 (OMIM: 123580,604219) PREDICTED: alpha-cr (136 aa) initn: 229 init1: 198 opt: 215 Z-score: 220.9 bits: 47.2 E(85289): 1.5e-05 Smith-Waterman score: 215; 37.8% identity (78.4% similar) in 74 aa overlap (98-171:36-109) 70 80 90 100 110 120 pF1KE3 MVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVEVSGKHEE . ..:. :.::.: ::..: .::. :::.: XP_005 GDSHRPPKALPHLVCGRRGRQVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNE 10 20 30 40 50 60 130 140 150 160 170 180 pF1KE3 KQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGESSFNNELP .:.. : .:..: .. .::..:: .. ::: .:.: . .:.. XP_005 RQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVS 70 80 90 100 110 120 190 pF1KE3 QDSQEVTCT XP_005 REEKPTSAPSS 130 >>NP_000385 (OMIM: 123580,604219) alpha-crystallin A cha (173 aa) initn: 233 init1: 198 opt: 215 Z-score: 219.3 bits: 47.2 E(85289): 1.8e-05 Smith-Waterman score: 227; 31.9% identity (61.8% similar) in 144 aa overlap (28-171:20-146) 10 20 30 40 50 60 pF1KE3 MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAW :::.:. :: : :: :: :::. NP_000 MDVTIQHPWFKRTLGPFYPSRLFDQFFGEGLFEYDL--------LPFLSSTI 10 20 30 40 70 80 90 100 110 120 pF1KE3 PGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVE :... .. :. .: :. . . . ..:. :.::.: ::..: .:: NP_000 SPYYRQSLF----RTVLDSGI-SEVRSDR----DKFVIFLDVKHFSPEDLTVKVQDDFVE 50 60 70 80 90 130 140 150 160 170 180 pF1KE3 VSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGES . :::.:.:.. : .:..: .. .::..:: .. ::: .:.: . .:.. NP_000 IHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHA 100 110 120 130 140 150 190 pF1KE3 SFNNELPQDSQEVTCT NP_000 ERAIPVSREEKPTSAPSS 160 170 196 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 02:37:02 2016 done: Mon Nov 7 02:37:03 2016 Total Scan time: 6.000 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]