FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2236, 476 aa 1>>>pF1KE2236 476 - 476 aa - 476 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9796+/-0.000317; mu= 14.7623+/- 0.020 mean_var=74.6764+/-15.038, 0's: 0 Z-trim(117.1): 76 B-trim: 79 in 1/49 Lambda= 0.148417 statistics sampled from 28811 (28889) to 28811 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.704), E-opt: 0.2 (0.339), width: 16 Scan time: 10.090 The best scores are: opt bits E(85289) NP_002416 (OMIM: 185260) stromelysin-2 preproprote ( 476) 3286 712.7 5.4e-205 NP_002413 (OMIM: 185250,614466) stromelysin-1 prep ( 477) 2651 576.8 4.6e-164 NP_002417 (OMIM: 601046) macrophage metalloelastas ( 470) 1633 358.8 1.9e-98 NP_004762 (OMIM: 604629,612529) matrix metalloprot ( 483) 1442 317.9 4e-86 NP_002418 (OMIM: 250400,600108,602111) collagenase ( 471) 1009 225.2 3.1e-58 NP_002412 (OMIM: 120353,226600,606963) interstitia ( 469) 967 216.2 1.6e-55 NP_002415 (OMIM: 120355) neutrophil collagenase is ( 467) 909 203.8 8.7e-52 NP_005931 (OMIM: 185261) stromelysin-3 preproprote ( 488) 880 197.6 6.7e-50 XP_011541138 (OMIM: 120355) PREDICTED: neutrophil ( 377) 859 193.0 1.2e-48 XP_016873260 (OMIM: 120355) PREDICTED: neutrophil ( 444) 859 193.0 1.4e-48 XP_011541137 (OMIM: 120355) PREDICTED: neutrophil ( 444) 859 193.0 1.4e-48 NP_001291370 (OMIM: 120355) neutrophil collagenase ( 444) 859 193.0 1.4e-48 NP_001291371 (OMIM: 120355) neutrophil collagenase ( 444) 859 193.0 1.4e-48 XP_011541136 (OMIM: 120355) PREDICTED: neutrophil ( 476) 859 193.1 1.5e-48 NP_002420 (OMIM: 601807,611543) matrix metalloprot ( 508) 848 190.7 8e-48 NP_002414 (OMIM: 178990) matrilysin preproprotein ( 267) 835 187.8 3.1e-47 NP_001139410 (OMIM: 120353,226600,606963) intersti ( 403) 836 188.1 3.9e-47 XP_016874798 (OMIM: 601807,611543) PREDICTED: matr ( 366) 692 157.3 6.8e-38 NP_004521 (OMIM: 120360,259600) 72 kDa type IV col ( 660) 638 145.8 3.5e-34 NP_001121363 (OMIM: 120360,259600) 72 kDa type IV ( 610) 619 141.7 5.4e-33 NP_068573 (OMIM: 605470) matrix metalloproteinase- ( 261) 600 137.5 4.3e-32 NP_004985 (OMIM: 120361,613073) matrix metalloprot ( 707) 603 138.3 6.7e-32 NP_001289439 (OMIM: 120360,259600) 72 kDa type IV ( 584) 599 137.4 1e-31 NP_001289438 (OMIM: 120360,259600) 72 kDa type IV ( 584) 599 137.4 1e-31 NP_001289437 (OMIM: 120360,259600) 72 kDa type IV ( 584) 599 137.4 1e-31 XP_011526802 (OMIM: 604871) PREDICTED: matrix meta ( 556) 590 135.5 3.7e-31 XP_016883087 (OMIM: 604871) PREDICTED: matrix meta ( 614) 590 135.5 4e-31 NP_006681 (OMIM: 604871) matrix metalloproteinase- ( 645) 590 135.5 4.2e-31 XP_016874797 (OMIM: 601807,611543) PREDICTED: matr ( 387) 582 133.7 8.8e-31 XP_011518521 (OMIM: 605470) PREDICTED: matrix meta ( 191) 577 132.5 9.9e-31 XP_016874796 (OMIM: 602285) PREDICTED: matrix meta ( 434) 544 125.6 2.7e-28 NP_004986 (OMIM: 277950,600754) matrix metalloprot ( 582) 544 125.6 3.6e-28 NP_057239 (OMIM: 602285) matrix metalloproteinase- ( 603) 544 125.6 3.7e-28 XP_011536657 (OMIM: 602285) PREDICTED: matrix meta ( 519) 535 123.7 1.2e-27 XP_011536659 (OMIM: 602285) PREDICTED: matrix meta ( 519) 535 123.7 1.2e-27 XP_011536658 (OMIM: 602285) PREDICTED: matrix meta ( 519) 535 123.7 1.2e-27 NP_671724 (OMIM: 608416,616749) matrix metalloprot ( 569) 455 106.6 1.9e-22 XP_016880552 (OMIM: 608417) PREDICTED: matrix meta ( 378) 449 105.2 3.2e-22 XP_016880553 (OMIM: 608417) PREDICTED: matrix meta ( 378) 449 105.2 3.2e-22 XP_016880551 (OMIM: 608417) PREDICTED: matrix meta ( 378) 449 105.2 3.2e-22 XP_011523533 (OMIM: 608417) PREDICTED: matrix meta ( 390) 449 105.2 3.3e-22 NP_116568 (OMIM: 608417) matrix metalloproteinase- ( 393) 449 105.2 3.3e-22 XP_011523532 (OMIM: 608417) PREDICTED: matrix meta ( 418) 449 105.2 3.5e-22 XP_011523529 (OMIM: 608417) PREDICTED: matrix meta ( 435) 449 105.3 3.6e-22 XP_011523530 (OMIM: 608417) PREDICTED: matrix meta ( 435) 449 105.3 3.6e-22 XP_011523531 (OMIM: 608417) PREDICTED: matrix meta ( 435) 449 105.3 3.6e-22 XP_011523528 (OMIM: 608417) PREDICTED: matrix meta ( 435) 449 105.3 3.6e-22 NP_077278 (OMIM: 608417) matrix metalloproteinase- ( 520) 449 105.3 4.3e-22 XP_016880550 (OMIM: 608417) PREDICTED: matrix meta ( 409) 433 101.8 3.7e-21 XP_011523534 (OMIM: 608417) PREDICTED: matrix meta ( 494) 433 101.8 4.4e-21 >>NP_002416 (OMIM: 185260) stromelysin-2 preproprotein [ (476 aa) initn: 3286 init1: 3286 opt: 3286 Z-score: 3801.3 bits: 712.7 E(85289): 5.4e-205 Smith-Waterman score: 3286; 100.0% identity (100.0% similar) in 476 aa overlap (1-476:1-476) 10 20 30 40 50 60 pF1KE2 MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 430 440 450 460 470 >>NP_002413 (OMIM: 185250,614466) stromelysin-1 prepropr (477 aa) initn: 2726 init1: 2443 opt: 2651 Z-score: 3066.4 bits: 576.8 E(85289): 4.6e-164 Smith-Waterman score: 2651; 78.2% identity (92.0% similar) in 477 aa overlap (1-476:1-477) 10 20 30 40 50 pF1KE2 MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQF-RRKDSNLI : : .:.:::. :::::::.:::. ::.. .:.:.:::.::.:.:::::: :::::. . NP_002 MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 VKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVN ::::. ::::::::::::::.::::::::::::::::::: .:::.:::::::::::::: NP_002 VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 YTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHS ::::::.::::::.:::::::::::::::::::::::::::::::.:::::: :::::. NP_002 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 LAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLY ::::: ::::. :: ::::::.::.:..:::::::::::.:::::::::::::::::::: NP_002 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 NSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIS .:.:.:..:::::::.::::::::::: : : :::::. :: ::.:::::::::.: NP_002 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE2 TLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEF ::::: :.::::.:::.: . :::.::::.::::::: .::::::.:.: :::::::.: NP_002 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE2 WAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQ ::::::::.:::::::::::::::.::::::.:::::.:::::. ::::::::. .::: NP_002 WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE2 GFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC :::. ::.::::.. :.:::.. :::::::.::::.::::::. ::: :::::::.: NP_002 GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 430 440 450 460 470 >>NP_002417 (OMIM: 601046) macrophage metalloelastase pr (470 aa) initn: 1672 init1: 794 opt: 1633 Z-score: 1888.5 bits: 358.8 E(85289): 1.9e-98 Smith-Waterman score: 1633; 49.6% identity (76.2% similar) in 478 aa overlap (2-476:1-470) 10 20 30 40 50 pF1KE2 MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKD-VKQFRRKDS-NL :.. ...:: . .: ::..... : .: ....::::.:.:: . . . : : :: NP_002 MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNL 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 IVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIV . .::: ::.::::.:::.:::.:::.:. :::::::: :: .:: : ::: ..:::: NP_002 MKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRIN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 NYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGH :::::. :. :: ::.::..:: .:::: ::.. : :::.. :: ::::..::: : NP_002 NYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 SLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPL ::::. :: :. :: :::.:: :: ..::::::.:.::.:::::: ::.. .:.:.: NP_002 ILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 YNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAI :. .... :::: ::. ::::::: : . . : :..:: :: ::: :::::. NP_002 YK-YVDINTFRLSADDIRGIQSLYGDPKENQRLP------NPDNSE-PALCDPNLSFDAV 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 STLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNE .:. .. .:::::.:: . :. .:::..::.::: ..::::...:. ::.:: .. NP_002 TTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDK 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 FWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSME .: : . . . .::..::..::: ..:::::: . . .::::. ..:::.:: : :. NP_002 YWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMD 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 QGFPRLIADDFPGVEPKVDAVLQAFG-FFYFFSGSSQFEFDPNARMVTHILKSNSWLHC :.:.::. .: :. ::.:::. . . ..:::.::.:::.: . .:. ::::::. : NP_002 PGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC 420 430 440 450 460 470 >>NP_004762 (OMIM: 604629,612529) matrix metalloproteina (483 aa) initn: 1326 init1: 764 opt: 1442 Z-score: 1667.3 bits: 317.9 E(85289): 4e-86 Smith-Waterman score: 1442; 45.6% identity (71.5% similar) in 478 aa overlap (4-476:9-483) 10 20 30 40 50 pF1KE2 MMHLAFLVLLCLPVCSAYP--LSGAAKEEDSNKDLAQQYLEKYY-NLE-KDVKQF :: .... : .: : .... . .: ::: ::.::: : : ... .. NP_004 MKVLPASGLAVFLIMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKYYTNKEGHQIGEM 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 RRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKT . :: ...::. .: :.::.:::::: :..:..:::::::::... ::: :::.:. NP_004 VARGSNSMIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPGEPKWKKN 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 HLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFY ::::: .:::.. ::.:.: ::..: ..::.: :. ::::::::: .::: : NP_004 TLTYRISKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDSY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 SFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANT :::: .::::. :: :: :: :::. :::: ..: ::: :::::.::.::: ::.. NP_004 PFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGTNGFNLFTVAAHEFGHALGLAHSTDP 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 EALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDP ::::: :. . . :.: .:::.:::.:::: . .: .: . : .: :: NP_004 SALMYPTYK-YKNPYGFHLPKDDVKGIQALYGPRKVFLGKPTLPHAPHHKPS-IPDLCDS 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 ALSFDAISTLRGEYLFFKDRYFWRRS-HWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDT . ::::.. : : :.:::: ::::. : . :.. .:.: : .:::::: : : NP_004 SSSFDAVTMLGKELLLFKDRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGT 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 VFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRF ...::: ..: :: ..: : :: :. .::: ...::::: .: .:: ::..:.:. . NP_004 AYFFKGPHYWITRGFQMQ-GPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSY 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 DENSQSMEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKS :: ...::. .:. ..: ::. ..::... :..::::: . ...: . . :. ..:: NP_004 DERKRKMEKDYPKNTEEEFSGVNGQIDAAVELNGYIYFFSGPKTYKYDTEKEDVVSVVKS 420 430 440 450 460 470 pF1KE2 NSWLHC .::. : NP_004 SSWIGC 480 >>NP_002418 (OMIM: 250400,600108,602111) collagenase 3 p (471 aa) initn: 1638 init1: 865 opt: 1009 Z-score: 1166.4 bits: 225.2 E(85289): 3.1e-58 Smith-Waterman score: 1637; 49.7% identity (76.3% similar) in 481 aa overlap (2-476:1-471) 10 20 30 40 50 pF1KE2 MMH---LAFLVLLCLPVCSAYPLSGAAKEED-SNKDL--AQQYLEKYYNLEKDVKQFRRK :: :: ...: : : :: ... :.: :..:: :..::..::. . . .... NP_002 MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKEN 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 DSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLT .. ...... ::.:.::::::::: .::.::.::::::::::... :: :: : .:: NP_002 AASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 YRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFD :::::::::. .. :..:..::.::: .::::.:.::..: :::::::..::::::: :: NP_002 YRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFD 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 GPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEAL ::. ::::.::::. :: :::::: :: ...: :::::::::.:::::: :: . :: NP_002 GPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGAL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 MYPLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALS :.:.: ..: ..: : .:::.:::::::: . :.: :. . : ::::.:: NP_002 MFPIY-TYTGKSHFMLPDDDVQGIQSLYGP---GDEDP------NPKHPKTPDKCDPSLS 240 250 260 270 280 300 310 320 330 340 350 pF1KE2 FDAISTLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIF .:::..:::: ..::::.::: . . :. : ..::: ::. .::::: :.: .::: NP_002 LDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIF 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE2 KGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENS .: .:::. : .. :::. : ::.: ..::.::: .. :: .:.... ::.:... NP_002 RGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTN 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE2 QSMEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWL . :.. .:::: .::::. ::::: . :..:::.: :::.. . ..... .:: : NP_002 HIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSIL 410 420 430 440 450 460 pF1KE2 HC : NP_002 WC 470 >>NP_002412 (OMIM: 120353,226600,606963) interstitial co (469 aa) initn: 1691 init1: 772 opt: 967 Z-score: 1117.8 bits: 216.2 E(85289): 1.6e-55 Smith-Waterman score: 1722; 52.3% identity (78.5% similar) in 474 aa overlap (6-476:7-466) 10 20 30 40 50 pF1KE2 MMHLAFLVLLCLPVCS-AYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQF-RRKDSN .:.:: : : ..: . ..:.: ::.:.::::::::..: .: .:..:. NP_002 MHSFPPLLLLLFWGVVSHSFPATLETQEQDV--DLVQKYLEKYYNLKNDGRQVEKRRNSG 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 LIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRI .:.:.. ::.:.::.:::: :..::.::..::::::::..: : :.:..::::::: NP_002 PVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 VNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPG :::::::: :: :::::...: .::::::... ::.:::::::. .: : ::::: NP_002 ENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 HSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYP .::::. ::::. :: :::.::.::.. :: :::::::::::: ::.. ::::: NP_002 GNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYP 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 LYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDA :.: .. .:.:::..:::..:: ...:. : : . : :: :.::: NP_002 ---SYTFSGDVQLAQDDIDGIQAIYG----RSQNPVQPI-----GPQTPKACDSKLTFDA 240 250 260 270 280 300 310 320 330 340 350 pF1KE2 ISTLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGN :.:.::: .:::::.. : . . :: :...::.:::.::. :.:::: .:: : .:::: NP_002 ITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGN 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE2 EFWAIRGNEVQAGYPRGIHT-LGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQS ..::..:..: :::. :.. .::: :...::::.:... :::::.:.::::.:: ..: NP_002 KYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRS 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE2 MEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC :. :.:..:: ::::. :::::.. :::::: :. :..:::... . . :.:::..: NP_002 MDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 410 420 430 440 450 460 NP_002 RKN >>NP_002415 (OMIM: 120355) neutrophil collagenase isofor (467 aa) initn: 1557 init1: 716 opt: 909 Z-score: 1050.7 bits: 203.8 E(85289): 8.7e-52 Smith-Waterman score: 1614; 50.2% identity (74.1% similar) in 474 aa overlap (4-476:7-464) 10 20 30 40 50 pF1KE2 MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKD-S : ::.:: . . .:.:.: .::. : .:.::::.:.: .. : ::. . NP_002 MFSLKTLPFLLLLHVQISKAFPVS--SKEK--NTKTVQDYLEKFYQLPSNQYQSTRKNGT 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 NLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYR :.::.:.. ::.:.::.:::: . .::..:.:::::::: : : :: :::..:.:::: NP_002 NVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 IVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGP : ::::.: . :. ::. :...: ..:: :.:. .::::: :.: ..::: :::: NP_002 IRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGP 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 GHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMY . ::::. :: :. :: ::: .: ::. ... :::::::::.:::::: ::.. :::: NP_002 NGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMY 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 PLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFD : : .: : ... : :::..:::..:: . .:. :: : : :::.:.:: NP_002 PNY-AFRETSNYSLPQDDIDGIQAIYG----LSSNPIQPT-----GPSTPKPCDPSLTFD 240 250 260 270 280 300 310 320 330 340 350 pF1KE2 AISTLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKG ::.::::: ::::::::::: . :...:: ::::::. ..:::: .:: .:.::: NP_002 AITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKG 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE2 NEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQS :..::. : .. :::. : . ::: ... ::::: ..:::::. :..::.:.. : NP_002 NQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVF--YRSKTYFFVNDQFWRYDNQRQF 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE2 MEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC :: :.:. :. :::.: :::::.: ::. ::: . :: :. ::.. ..:.::.: NP_002 MEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNC 410 420 430 440 450 460 NP_002 RYG >>NP_005931 (OMIM: 185261) stromelysin-3 preproprotein [ (488 aa) initn: 780 init1: 352 opt: 880 Z-score: 1016.9 bits: 197.6 E(85289): 6.7e-50 Smith-Waterman score: 880; 41.3% identity (63.0% similar) in 395 aa overlap (86-459:75-460) 60 70 80 90 100 pF1KE2 SNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPK-------- .: ::::::: . : . : NP_005 RRGPQPWHAALPSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGR 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE2 WRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEH :.:: :::::. . .: .. : ... .::::: .::::::....::.:::::.:: : NP_005 WEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMIDFARYWH 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE2 GDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWT-EDASGTNLFLVAAHELGHSLGLF :: ::::: ::::. : ::.::: :: :: : .::.:. :::::.:: ::: NP_005 GDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQ 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE2 HSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPP-PA-STEEP-LVPTKSVPSGS :.. ..::: .:. :. :: :: :.: ::: : :. ... : : : .. .. NP_005 HTTAAKALMSAFYTFRYPLS---LSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNE 230 240 250 260 270 280 290 300 310 320 330 pF1KE2 EMPAKCD-PA----LSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEFH-LISAFWPSLPS : . : : ::::.::.::: .::: . :: . .: . : : : .::: NP_005 IAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPS 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE2 YLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIR-KIDAA-VSDKE .:::.: ... ...:.: ..:. :.. : : . ::. .: . :: : : NP_005 PVDAAFE-DAQGHIWFFQGAQYWVYDGEKPVLG-PAPLTELGL---VRFPVHAALVWGPE 350 360 370 380 390 400 410 420 430 440 450 pF1KE2 KKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQ-AFGFFYFFSGSSQ :.: ::: . :::: ... ... :: : :. :: ..::..: : :. ::. : NP_005 KNKIYFFRGRDYWRFHPSTRRVDSPVPRR-ATDWRGVPSEIDAAFQDADGYAYFLRGRLY 400 410 420 430 440 450 460 470 pF1KE2 FEFDPNARMVTHILKSNSWLHC ..::: NP_005 WKFDPVKVKALEGFPRLVGPDFFGCAEPANTFL 460 470 480 >>XP_011541138 (OMIM: 120355) PREDICTED: neutrophil coll (377 aa) initn: 1181 init1: 716 opt: 859 Z-score: 994.3 bits: 193.0 E(85289): 1.2e-48 Smith-Waterman score: 1144; 53.1% identity (75.3% similar) in 320 aa overlap (37-355:45-354) 10 20 30 40 50 60 pF1KE2 LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKD-SNLIVKKIQG ::::.:.: .. : ::. .:.::.:.. XP_011 KIQKLFSTRPSQKPTRCSHLILDFPASRIDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKE 20 30 40 50 60 70 70 80 90 100 110 120 pF1KE2 MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLP ::.:.::.:::: . .::..:.:::::::: : : :: :::..:.::::: ::::.: XP_011 MQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLS 80 90 100 110 120 130 130 140 150 160 170 180 pF1KE2 RDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYP . :. ::. :...: ..:: :.:. .::::: :.: ..::: ::::. ::::. XP_011 EAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQ 140 150 160 170 180 190 190 200 210 220 230 240 pF1KE2 PGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTEL :: :. :: ::: .: ::. ... :::::::::.:::::: ::.. ::::: : .: : XP_011 PGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNY-AFRET 200 210 220 230 240 250 250 260 270 280 290 300 pF1KE2 AQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEY ... : :::..:::..:: . .:. :: : : :::.:.::::.::::: XP_011 SNYSLPQDDIDGIQAIYG----LSSNPIQPT-----GPSTPKPCDPSLTFDAITTLRGEI 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 LFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGN ::::::::::: . :...:: ::::::. ..:::: .:: .:.:: XP_011 LFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKDMITKDNSWS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 EVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLI XP_011 QVIPKAYQVPFQE 370 >>XP_016873260 (OMIM: 120355) PREDICTED: neutrophil coll (444 aa) initn: 1557 init1: 716 opt: 859 Z-score: 993.2 bits: 193.0 E(85289): 1.4e-48 Smith-Waterman score: 1564; 51.2% identity (74.6% similar) in 441 aa overlap (37-476:13-441) 10 20 30 40 50 60 pF1KE2 LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKD-SNLIVKKIQG ::::.:.: .. : ::. .:.::.:.. XP_016 MQQIPQEKSINDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKE 10 20 30 40 70 80 90 100 110 120 pF1KE2 MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLP ::.:.::.:::: . .::..:.:::::::: : : :: :::..:.::::: ::::.: XP_016 MQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLS 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE2 RDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYP . :. ::. :...: ..:: :.:. .::::: :.: ..::: ::::. ::::. XP_016 EAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQ 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE2 PGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTEL :: :. :: ::: .: ::. ... :::::::::.:::::: ::.. ::::: : .: : XP_016 PGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNY-AFRET 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE2 AQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEY ... : :::..:::..:: . .:. :: : : :::.:.::::.::::: XP_016 SNYSLPQDDIDGIQAIYG----LSSNPIQPT-----GPSTPKPCDPSLTFDAITTLRGEI 230 240 250 260 270 310 320 330 340 350 360 pF1KE2 LFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGN ::::::::::: . :...:: ::::::. ..:::: .:: .:.::::..::. : XP_016 LFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGY 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE2 EVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLI .. :::. : . ::: ... ::::: ..:::::. :..::.:.. : :: :.:. : XP_016 DILQGYPKDISNYGFPSSVQAIDAAVF--YRSKTYFFVNDQFWRYDNQRQFMEPGYPKSI 340 350 360 370 380 390 430 440 450 460 470 pF1KE2 ADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC . :::.: :::::.: ::. ::: . :: :. ::.. ..:.::.: XP_016 SGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG 400 410 420 430 440 476 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 15:38:05 2016 done: Mon Nov 7 15:38:07 2016 Total Scan time: 10.090 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]