FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6215, 265 aa 1>>>pF1KE6215 265 - 265 aa - 265 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2985+/-0.000343; mu= 15.0832+/- 0.021 mean_var=66.6564+/-13.011, 0's: 0 Z-trim(114.6): 65 B-trim: 35 in 1/54 Lambda= 0.157092 statistics sampled from 24485 (24550) to 24485 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.68), E-opt: 0.2 (0.288), width: 16 Scan time: 6.400 The best scores are: opt bits E(85289) NP_000366 (OMIM: 263700,606938) uroporphyrinogen-I ( 265) 1743 403.6 1.9e-112 NP_001310965 (OMIM: 263700,606938) uroporphyrinoge ( 292) 1454 338.2 1.1e-92 XP_016872099 (OMIM: 263700,606938) PREDICTED: urop ( 301) 1444 335.9 5.2e-92 XP_016872100 (OMIM: 263700,606938) PREDICTED: urop ( 301) 1444 335.9 5.2e-92 XP_016872101 (OMIM: 263700,606938) PREDICTED: urop ( 262) 1438 334.5 1.2e-91 XP_005270197 (OMIM: 263700,606938) PREDICTED: urop ( 223) 1437 334.2 1.2e-91 XP_011538429 (OMIM: 263700,606938) PREDICTED: urop ( 234) 1437 334.3 1.3e-91 NP_001310966 (OMIM: 263700,606938) uroporphyrinoge ( 265) 1137 266.3 4.1e-71 NP_001310968 (OMIM: 263700,606938) uroporphyrinoge ( 139) 862 203.8 1.4e-52 NP_001310967 (OMIM: 263700,606938) uroporphyrinoge ( 238) 864 204.4 1.6e-52 >>NP_000366 (OMIM: 263700,606938) uroporphyrinogen-III s (265 aa) initn: 1743 init1: 1743 opt: 1743 Z-score: 2139.9 bits: 403.6 E(85289): 1.9e-112 Smith-Waterman score: 1743; 100.0% identity (100.0% similar) in 265 aa overlap (1-265:1-265) 10 20 30 40 50 60 pF1KE6 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPVS 190 200 210 220 230 240 250 260 pF1KE6 CTAESPTPQALATGIRKALQPHGCC ::::::::::::::::::::::::: NP_000 CTAESPTPQALATGIRKALQPHGCC 250 260 >>NP_001310965 (OMIM: 263700,606938) uroporphyrinogen-II (292 aa) initn: 1482 init1: 1451 opt: 1454 Z-score: 1785.3 bits: 338.2 E(85289): 1.1e-92 Smith-Waterman score: 1679; 90.8% identity (90.8% similar) in 292 aa overlap (1-265:1-292) 10 20 30 40 50 60 pF1KE6 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL 130 140 150 160 170 180 190 200 210 220 pF1KE6 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIK-------------------- :::::::::::::::::::::::::::::::::::::::: NP_001 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKTQGPQHPKKNCLQLEPLRKD 190 200 210 220 230 240 230 240 250 260 pF1KE6 -------FAAIGPTTARALAAQGLPVSCTAESPTPQALATGIRKALQPHGCC ::::::::::::::::::::::::::::::::::::::::::::: NP_001 CTDTAVMFAAIGPTTARALAAQGLPVSCTAESPTPQALATGIRKALQPHGCC 250 260 270 280 290 >>XP_016872099 (OMIM: 263700,606938) PREDICTED: uroporph (301 aa) initn: 1441 init1: 1441 opt: 1444 Z-score: 1772.9 bits: 335.9 E(85289): 5.2e-92 Smith-Waterman score: 1444; 92.6% identity (93.9% similar) in 244 aa overlap (1-242:1-242) 10 20 30 40 50 60 pF1KE6 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPV- :::::::::::::::::::::::::::::::::::::::: :: . : :. XP_016 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKTQ--GPQHPKKNCLQLEPLR 190 200 210 220 230 240 250 260 pF1KE6 -SCTAESPTPQALATGIRKALQPHGCC .:: XP_016 KDCTDTAVMVSTSLGPSSPCPSPEPGDSRSGWQTDESVDAEVFCTLRSWARIGQCCHFYK 240 250 260 270 280 290 >>XP_016872100 (OMIM: 263700,606938) PREDICTED: uroporph (301 aa) initn: 1441 init1: 1441 opt: 1444 Z-score: 1772.9 bits: 335.9 E(85289): 5.2e-92 Smith-Waterman score: 1444; 92.6% identity (93.9% similar) in 244 aa overlap (1-242:1-242) 10 20 30 40 50 60 pF1KE6 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPV- :::::::::::::::::::::::::::::::::::::::: :: . : :. XP_016 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKTQ--GPQHPKKNCLQLEPLR 190 200 210 220 230 240 250 260 pF1KE6 -SCTAESPTPQALATGIRKALQPHGCC .:: XP_016 KDCTDTAVMVSTSLGPSSPCPSPEPGDSRSGWQTDESVDAEVFCTLRSWARIGQCCHFYK 240 250 260 270 280 290 >>XP_016872101 (OMIM: 263700,606938) PREDICTED: uroporph (262 aa) initn: 1438 init1: 1438 opt: 1438 Z-score: 1766.4 bits: 334.5 E(85289): 1.2e-91 Smith-Waterman score: 1438; 99.5% identity (100.0% similar) in 221 aa overlap (1-221:1-221) 10 20 30 40 50 60 pF1KE6 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPVS ::::::::::::::::::::::::::::::::::::::::. XP_016 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKLLDGGELLKKFMQGRNKGSH 190 200 210 220 230 240 250 260 pF1KE6 CTAESPTPQALATGIRKALQPHGCC XP_016 RNLRAKVKCNWPPRPRGASSEN 250 260 >>XP_005270197 (OMIM: 263700,606938) PREDICTED: uroporph (223 aa) initn: 1437 init1: 1437 opt: 1437 Z-score: 1766.2 bits: 334.2 E(85289): 1.2e-91 Smith-Waterman score: 1437; 100.0% identity (100.0% similar) in 220 aa overlap (1-220:1-220) 10 20 30 40 50 60 pF1KE6 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPVS :::::::::::::::::::::::::::::::::::::::: XP_005 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKKHP 190 200 210 220 250 260 pF1KE6 CTAESPTPQALATGIRKALQPHGCC >>XP_011538429 (OMIM: 263700,606938) PREDICTED: uroporph (234 aa) initn: 1437 init1: 1437 opt: 1437 Z-score: 1765.9 bits: 334.3 E(85289): 1.3e-91 Smith-Waterman score: 1437; 100.0% identity (100.0% similar) in 220 aa overlap (1-220:1-220) 10 20 30 40 50 60 pF1KE6 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPVS :::::::::::::::::::::::::::::::::::::::: XP_011 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKIEELELQWASWALR 190 200 210 220 230 250 260 pF1KE6 CTAESPTPQALATGIRKALQPHGCC >>NP_001310966 (OMIM: 263700,606938) uroporphyrinogen-II (265 aa) initn: 1061 init1: 1061 opt: 1137 Z-score: 1397.7 bits: 266.3 E(85289): 4.1e-71 Smith-Waterman score: 1435; 81.5% identity (81.5% similar) in 292 aa overlap (1-265:1-265) 10 20 30 40 50 60 pF1KE6 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL :::::::::::: ::::::::::::::::::::: NP_001 NAEKLAEYICSR---------------------------IAMESITVYQTVAHPGIQGNL 130 140 150 190 200 210 220 pF1KE6 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIK-------------------- :::::::::::::::::::::::::::::::::::::::: NP_001 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKTQGPQHPKKNCLQLEPLRKD 160 170 180 190 200 210 230 240 250 260 pF1KE6 -------FAAIGPTTARALAAQGLPVSCTAESPTPQALATGIRKALQPHGCC ::::::::::::::::::::::::::::::::::::::::::::: NP_001 CTDTAVMFAAIGPTTARALAAQGLPVSCTAESPTPQALATGIRKALQPHGCC 220 230 240 250 260 >>NP_001310968 (OMIM: 263700,606938) uroporphyrinogen-II (139 aa) initn: 876 init1: 862 opt: 862 Z-score: 1065.0 bits: 203.8 E(85289): 1.4e-52 Smith-Waterman score: 862; 99.2% identity (99.2% similar) in 133 aa overlap (1-133:1-133) 10 20 30 40 50 60 pF1KE6 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL ::::::::::: : NP_001 NAEKLAEYICSSEEVKGIF 130 >>NP_001310967 (OMIM: 263700,606938) uroporphyrinogen-II (238 aa) initn: 1549 init1: 864 opt: 864 Z-score: 1064.0 bits: 204.4 E(85289): 1.6e-52 Smith-Waterman score: 1499; 89.8% identity (89.8% similar) in 265 aa overlap (1-265:1-238) 10 20 30 40 50 60 pF1KE6 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL :::::::::::: ::::::::::::::::::::: NP_001 NAEKLAEYICSR---------------------------IAMESITVYQTVAHPGIQGNL 130 140 150 190 200 210 220 230 240 pF1KE6 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPVS 160 170 180 190 200 210 250 260 pF1KE6 CTAESPTPQALATGIRKALQPHGCC ::::::::::::::::::::::::: NP_001 CTAESPTPQALATGIRKALQPHGCC 220 230 265 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:09:30 2016 done: Tue Nov 8 11:09:30 2016 Total Scan time: 6.400 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]