FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4464, 486 aa 1>>>pF1KE4464 486 - 486 aa - 486 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9465+/-0.000396; mu= 15.0398+/- 0.025 mean_var=79.7091+/-16.616, 0's: 0 Z-trim(112.2): 25 B-trim: 1010 in 1/52 Lambda= 0.143655 statistics sampled from 20991 (21008) to 20991 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.609), E-opt: 0.2 (0.246), width: 16 Scan time: 7.890 The best scores are: opt bits E(85289) XP_016870616 (OMIM: 610558) PREDICTED: target of r ( 486) 3186 670.3 3.4e-192 NP_077022 (OMIM: 610558) target of rapamycin compl ( 486) 3186 670.3 3.4e-192 XP_016870615 (OMIM: 610558) PREDICTED: target of r ( 522) 2130 451.4 2.8e-126 NP_001006618 (OMIM: 610558) target of rapamycin co ( 522) 2130 451.4 2.8e-126 NP_001006620 (OMIM: 610558) target of rapamycin co ( 475) 2121 449.5 9.3e-126 NP_001006619 (OMIM: 610558) target of rapamycin co ( 323) 2115 448.2 1.6e-125 XP_011517308 (OMIM: 610558) PREDICTED: target of r ( 533) 2079 440.9 4.3e-123 XP_011517311 (OMIM: 610558) PREDICTED: target of r ( 370) 1113 240.6 5.8e-63 XP_011517310 (OMIM: 610558) PREDICTED: target of r ( 482) 1113 240.6 7.3e-63 XP_011517309 (OMIM: 610558) PREDICTED: target of r ( 522) 1113 240.6 7.8e-63 XP_011517307 (OMIM: 610558) PREDICTED: target of r ( 569) 1113 240.7 8.4e-63 NP_001006621 (OMIM: 610558) target of rapamycin co ( 330) 1073 232.3 1.7e-60 NP_001006622 (OMIM: 610558) target of rapamycin co ( 330) 1073 232.3 1.7e-60 XP_011517312 (OMIM: 610558) PREDICTED: target of r ( 330) 1073 232.3 1.7e-60 >>XP_016870616 (OMIM: 610558) PREDICTED: target of rapam (486 aa) initn: 3186 init1: 3186 opt: 3186 Z-score: 3571.4 bits: 670.3 E(85289): 3.4e-192 Smith-Waterman score: 3186; 100.0% identity (100.0% similar) in 486 aa overlap (1-486:1-486) 10 20 30 40 50 60 pF1KE4 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 MKEILLKAVKRRKGSQKVSGSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKEILLKAVKRRKGSQKVSGSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 TTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 YLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKE 430 440 450 460 470 480 pF1KE4 KKSGQQ :::::: XP_016 KKSGQQ >>NP_077022 (OMIM: 610558) target of rapamycin complex 2 (486 aa) initn: 3186 init1: 3186 opt: 3186 Z-score: 3571.4 bits: 670.3 E(85289): 3.4e-192 Smith-Waterman score: 3186; 100.0% identity (100.0% similar) in 486 aa overlap (1-486:1-486) 10 20 30 40 50 60 pF1KE4 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 MKEILLKAVKRRKGSQKVSGSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 MKEILLKAVKRRKGSQKVSGSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 TTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 TTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 YLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 YLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKE 430 440 450 460 470 480 pF1KE4 KKSGQQ :::::: NP_077 KKSGQQ >>XP_016870615 (OMIM: 610558) PREDICTED: target of rapam (522 aa) initn: 2114 init1: 2114 opt: 2130 Z-score: 2388.2 bits: 451.4 E(85289): 2.8e-126 Smith-Waterman score: 3077; 93.1% identity (93.1% similar) in 518 aa overlap (1-482:1-518) 10 20 30 40 50 60 pF1KE4 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT 250 260 270 280 290 300 310 320 pF1KE4 MKEILLKAVKRRKGSQKVSG------------------------------------SRAD :::::::::::::::::::: :::: XP_016 MKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRAD 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE4 GVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKAS 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE4 TKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVL 430 440 450 460 470 480 450 460 470 480 pF1KE4 KVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ :::::::::::::::::::::::::::::::::::::: XP_016 KVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ 490 500 510 520 >>NP_001006618 (OMIM: 610558) target of rapamycin comple (522 aa) initn: 2114 init1: 2114 opt: 2130 Z-score: 2388.2 bits: 451.4 E(85289): 2.8e-126 Smith-Waterman score: 3077; 93.1% identity (93.1% similar) in 518 aa overlap (1-482:1-518) 10 20 30 40 50 60 pF1KE4 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT 250 260 270 280 290 300 310 320 pF1KE4 MKEILLKAVKRRKGSQKVSG------------------------------------SRAD :::::::::::::::::::: :::: NP_001 MKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRAD 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE4 GVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKAS 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE4 TKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVL 430 440 450 460 470 480 450 460 470 480 pF1KE4 KVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ :::::::::::::::::::::::::::::::::::::: NP_001 KVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ 490 500 510 520 >>NP_001006620 (OMIM: 610558) target of rapamycin comple (475 aa) initn: 2869 init1: 2114 opt: 2121 Z-score: 2378.7 bits: 449.5 E(85289): 9.3e-126 Smith-Waterman score: 2859; 91.8% identity (94.9% similar) in 486 aa overlap (1-486:1-475) 10 20 30 40 50 60 pF1KE4 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 MKEILLKAVKRRKGSQKVSGSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRF :::::::::::::::::::: . .:..:. ..:. :. :. . .: .: NP_001 MKEILLKAVKRRKGSQKVSGPQYR--LEKQSEPNVAV--DLDSTLESQS-------AWEF 310 320 330 340 370 380 390 400 410 420 pF1KE4 TTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLT . .::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLVRENSISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLT 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE4 YLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKE 410 420 430 440 450 460 pF1KE4 KKSGQQ :::::: NP_001 KKSGQQ 470 >>NP_001006619 (OMIM: 610558) target of rapamycin comple (323 aa) initn: 2115 init1: 2115 opt: 2115 Z-score: 2374.5 bits: 448.2 E(85289): 1.6e-125 Smith-Waterman score: 2115; 99.7% identity (100.0% similar) in 321 aa overlap (1-321:1-321) 10 20 30 40 50 60 pF1KE4 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 MKEILLKAVKRRKGSQKVSGSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRF ::::::::::::::::::::. NP_001 MKEILLKAVKRRKGSQKVSGACD 310 320 >>XP_011517308 (OMIM: 610558) PREDICTED: target of rapam (533 aa) initn: 2079 init1: 2079 opt: 2079 Z-score: 2330.9 bits: 440.9 E(85289): 4.3e-123 Smith-Waterman score: 2985; 90.9% identity (90.9% similar) in 518 aa overlap (16-486:16-533) 10 20 30 40 50 60 pF1KE4 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE ::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL 70 80 90 100 110 120 130 140 150 160 pF1KE4 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGK-------------- :::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKHCSSLCRIIMNKCF 130 140 150 160 170 180 170 180 190 pF1KE4 ---------------------------------GHVGTTATKKIDVYLPLHSSQDRLLPM ::::::::::::::::::::::::::: XP_011 LQSLALNSSLQRKSLKTLQKSMKPPRNVANSEKGHVGTTATKKIDVYLPLHSSQDRLLPM 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE4 TVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEP 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE4 IHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRK 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE4 GSQKVSGSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSQKVSGSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKV 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE4 EIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFE 430 440 450 460 470 480 440 450 460 470 480 pF1KE4 SDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ 490 500 510 520 530 >>XP_011517311 (OMIM: 610558) PREDICTED: target of rapam (370 aa) initn: 2107 init1: 1113 opt: 1113 Z-score: 1251.3 bits: 240.6 E(85289): 5.8e-63 Smith-Waterman score: 2011; 87.0% identity (87.2% similar) in 368 aa overlap (1-321:1-368) 10 20 30 40 50 60 pF1KE4 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL 70 80 90 100 110 120 130 140 150 160 pF1KE4 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGK-------------- :::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKHCSSLCRIIMNKCF 130 140 150 160 170 180 170 180 190 pF1KE4 ---------------------------------GHVGTTATKKIDVYLPLHSSQDRLLPM ::::::::::::::::::::::::::: XP_011 LQSLALNSSLQRKSLKTLQKSMKPPRNVANSEKGHVGTTATKKIDVYLPLHSSQDRLLPM 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE4 TVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEP 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE4 IHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRK 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE4 GSQKVSGSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKV :::::::. XP_011 GSQKVSGACD 370 >>XP_011517310 (OMIM: 610558) PREDICTED: target of rapam (482 aa) initn: 1397 init1: 1113 opt: 1113 Z-score: 1249.6 bits: 240.6 E(85289): 7.3e-63 Smith-Waterman score: 2230; 77.0% identity (79.7% similar) in 482 aa overlap (1-395:1-482) 10 20 30 40 50 60 pF1KE4 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL 70 80 90 100 110 120 130 140 150 160 pF1KE4 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGK-------------- :::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKHCSSLCRIIMNKCF 130 140 150 160 170 180 170 180 190 pF1KE4 ---------------------------------GHVGTTATKKIDVYLPLHSSQDRLLPM ::::::::::::::::::::::::::: XP_011 LQSLALNSSLQRKSLKTLQKSMKPPRNVANSEKGHVGTTATKKIDVYLPLHSSQDRLLPM 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE4 TVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEP 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE4 IHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRK 310 320 330 340 350 360 320 330 pF1KE4 GSQKVSG------------------------------------SRADGVFEEDSQIDIAT ::::::: ::::::::::::::::: XP_011 GSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRADGVFEEDSQIDIAT 370 380 390 400 410 420 340 350 360 370 380 390 pF1KE4 VQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPV----TNQKASTKFWIKQKP ::::::::::::::::::::::::::::: . . ... :. :.. . :. . . : XP_011 VQDMLSSHHYKSFKVSMIHRLRFTTDVQLDVVYQPLRFLPLGPDLTSEFVPTQSYKQPLP 430 440 450 460 470 480 400 410 420 430 440 450 pF1KE4 ISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESR :. XP_011 IN >>XP_011517309 (OMIM: 610558) PREDICTED: target of rapam (522 aa) initn: 1868 init1: 1113 opt: 1113 Z-score: 1249.0 bits: 240.6 E(85289): 7.8e-63 Smith-Waterman score: 2728; 83.6% identity (86.4% similar) in 529 aa overlap (1-482:1-518) 10 20 30 40 50 60 pF1KE4 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL 70 80 90 100 110 120 130 140 150 160 pF1KE4 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGK-------------- :::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKHCSSLCRIIMNKCF 130 140 150 160 170 180 170 180 190 pF1KE4 ---------------------------------GHVGTTATKKIDVYLPLHSSQDRLLPM ::::::::::::::::::::::::::: XP_011 LQSLALNSSLQRKSLKTLQKSMKPPRNVANSEKGHVGTTATKKIDVYLPLHSSQDRLLPM 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE4 TVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEP 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE4 IHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRK 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE4 GSQKVSGSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKV ::::::: . .:..:. ..:. :. :. . .: .: . .:::::: XP_011 GSQKVSGPQYR--LEKQSEPNVAV--DLDSTLESQS-------AWEFCLVRENSISGDKV 370 380 390 400 380 390 400 410 420 430 pF1KE4 EIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFE 410 420 430 440 450 460 440 450 460 470 480 pF1KE4 SDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ 470 480 490 500 510 520 486 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:56:31 2016 done: Sun Nov 6 00:56:32 2016 Total Scan time: 7.890 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]