FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1377, 526 aa 1>>>pF1KE1377 526 - 526 aa - 526 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.0027+/-0.000397; mu= 2.6172+/- 0.025 mean_var=260.5869+/-55.775, 0's: 0 Z-trim(120.3): 87 B-trim: 0 in 0/54 Lambda= 0.079451 statistics sampled from 35198 (35359) to 35198 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.732), E-opt: 0.2 (0.415), width: 16 Scan time: 7.240 The best scores are: opt bits E(85289) XP_011507882 (OMIM: 233710,608515) PREDICTED: neut ( 526) 3521 417.0 7e-116 NP_000424 (OMIM: 233710,608515) neutrophil cytosol ( 526) 3521 417.0 7e-116 NP_001121123 (OMIM: 233710,608515) neutrophil cyto ( 526) 3521 417.0 7e-116 XP_011507883 (OMIM: 233710,608515) PREDICTED: neut ( 526) 3521 417.0 7e-116 NP_001177723 (OMIM: 233710,608515) neutrophil cyto ( 481) 2417 290.4 8.1e-78 NP_001177718 (OMIM: 233710,608515) neutrophil cyto ( 445) 2186 263.9 7.2e-70 XP_005245264 (OMIM: 233710,608515) PREDICTED: neut ( 490) 2186 264.0 7.7e-70 NP_001242996 (OMIM: 611255) NADPH oxidase activato ( 476) 526 73.7 1.4e-12 NP_006638 (OMIM: 611255) NADPH oxidase activator 1 ( 483) 526 73.7 1.4e-12 XP_011516460 (OMIM: 611255) PREDICTED: NADPH oxida ( 447) 389 57.9 7.3e-08 NP_001242997 (OMIM: 611255) NADPH oxidase activato ( 427) 386 57.6 8.9e-08 >>XP_011507882 (OMIM: 233710,608515) PREDICTED: neutroph (526 aa) initn: 3521 init1: 3521 opt: 3521 Z-score: 2201.5 bits: 417.0 E(85289): 7e-116 Smith-Waterman score: 3521; 99.6% identity (100.0% similar) in 526 aa overlap (1-526:1-526) 10 20 30 40 50 60 pF1KE1 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 CEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 RLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 TVVMKTQPGLPYSQVRDMVSKKLELRLEQTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: XP_011 TVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE 430 440 450 460 470 480 490 500 510 520 pF1KE1 GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV :::::::::::::::::::::::::::::::::::::::::::::: XP_011 GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV 490 500 510 520 >>NP_000424 (OMIM: 233710,608515) neutrophil cytosol fac (526 aa) initn: 3521 init1: 3521 opt: 3521 Z-score: 2201.5 bits: 417.0 E(85289): 7e-116 Smith-Waterman score: 3521; 99.6% identity (100.0% similar) in 526 aa overlap (1-526:1-526) 10 20 30 40 50 60 pF1KE1 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 CEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 RLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 TVVMKTQPGLPYSQVRDMVSKKLELRLEQTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: NP_000 TVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE 430 440 450 460 470 480 490 500 510 520 pF1KE1 GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV :::::::::::::::::::::::::::::::::::::::::::::: NP_000 GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV 490 500 510 520 >>NP_001121123 (OMIM: 233710,608515) neutrophil cytosol (526 aa) initn: 3521 init1: 3521 opt: 3521 Z-score: 2201.5 bits: 417.0 E(85289): 7e-116 Smith-Waterman score: 3521; 99.6% identity (100.0% similar) in 526 aa overlap (1-526:1-526) 10 20 30 40 50 60 pF1KE1 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 CEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 RLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 TVVMKTQPGLPYSQVRDMVSKKLELRLEQTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: NP_001 TVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE 430 440 450 460 470 480 490 500 510 520 pF1KE1 GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV :::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV 490 500 510 520 >>XP_011507883 (OMIM: 233710,608515) PREDICTED: neutroph (526 aa) initn: 3521 init1: 3521 opt: 3521 Z-score: 2201.5 bits: 417.0 E(85289): 7e-116 Smith-Waterman score: 3521; 99.6% identity (100.0% similar) in 526 aa overlap (1-526:1-526) 10 20 30 40 50 60 pF1KE1 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 CEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 RLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 TVVMKTQPGLPYSQVRDMVSKKLELRLEQTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: XP_011 TVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE 430 440 450 460 470 480 490 500 510 520 pF1KE1 GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV :::::::::::::::::::::::::::::::::::::::::::::: XP_011 GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV 490 500 510 520 >>NP_001177723 (OMIM: 233710,608515) neutrophil cytosol (481 aa) initn: 3207 init1: 2416 opt: 2417 Z-score: 1518.1 bits: 290.4 E(85289): 8.1e-78 Smith-Waterman score: 3121; 91.1% identity (91.4% similar) in 526 aa overlap (1-526:1-481) 10 20 30 40 50 60 pF1KE1 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 CEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVG :: ::::::::::::: NP_001 CE---------------------------------------------KQKLYEPVVIPVG 130 190 200 210 220 230 240 pF1KE1 RLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE1 EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE1 IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE1 TVVMKTQPGLPYSQVRDMVSKKLELRLEQTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: NP_001 TVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY 320 330 340 350 360 370 430 440 450 460 470 480 pF1KE1 CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE 380 390 400 410 420 430 490 500 510 520 pF1KE1 GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV :::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV 440 450 460 470 480 >>NP_001177718 (OMIM: 233710,608515) neutrophil cytosol (445 aa) initn: 2186 init1: 2186 opt: 2186 Z-score: 1375.4 bits: 263.9 E(85289): 7.2e-70 Smith-Waterman score: 2819; 84.4% identity (84.6% similar) in 526 aa overlap (1-526:1-445) 10 20 30 40 50 60 pF1KE1 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 CEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVG ::: NP_001 CEV--------------------------------------------------------- 190 200 210 220 230 240 pF1KE1 RLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL :::::::::::::::::::::::::::::::::::: NP_001 ------------------------VASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL 130 140 150 250 260 270 280 290 300 pF1KE1 EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE1 IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE1 TVVMKTQPGLPYSQVRDMVSKKLELRLEQTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: NP_001 TVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE1 CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE 340 350 360 370 380 390 490 500 510 520 pF1KE1 GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV :::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV 400 410 420 430 440 >>XP_005245264 (OMIM: 233710,608515) PREDICTED: neutroph (490 aa) initn: 3277 init1: 2186 opt: 2186 Z-score: 1374.9 bits: 264.0 E(85289): 7.7e-70 Smith-Waterman score: 3209; 93.0% identity (93.2% similar) in 526 aa overlap (1-526:1-490) 10 20 30 40 50 60 pF1KE1 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 CEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVG ::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVW------------- 130 140 150 160 190 200 210 220 230 240 pF1KE1 RLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL ::::::::::::::::::::::::::::::::::::: XP_005 -----------------------VVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL 170 180 190 200 250 260 270 280 290 300 pF1KE1 EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE1 IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE1 TVVMKTQPGLPYSQVRDMVSKKLELRLEQTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: XP_005 TVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY 330 340 350 360 370 380 430 440 450 460 470 480 pF1KE1 CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE 390 400 410 420 430 440 490 500 510 520 pF1KE1 GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV :::::::::::::::::::::::::::::::::::::::::::::: XP_005 GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV 450 460 470 480 490 >>NP_001242996 (OMIM: 611255) NADPH oxidase activator 1 (476 aa) initn: 717 init1: 526 opt: 526 Z-score: 346.7 bits: 73.7 E(85289): 1.4e-12 Smith-Waterman score: 722; 31.9% identity (53.9% similar) in 521 aa overlap (2-511:3-453) 10 20 30 40 50 pF1KE1 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKA :: . . :. :. :.:. :: :: ::.: : .:.::: ::.. . . : .: NP_001 MASLGDLVRAWHLGAQAVDRGDWARALHLFSGVPAPPARLCFNAGCVHLLAGDPEAALRA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 FTRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLF : .....: .::..::::. .: ... :..:. :: ::::. ::: :::.::: NP_001 FDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQLRGHAAIDYTQLGLRFKLQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 ACEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPV : :::.:.: . : .: .: : : : . .:.:.. : .. : .: NP_001 AWEVLHNVASAQCQLGLWTEAASSLREAMSKWPEGSLNGLDSALDQVQRRGSLPPRQVPR 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 GRLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRA :..:::.. .. .: :.:::: ::::.. .:. : : :::. : . . :. NP_001 GEVFRPHRWHLKHLEPVDFLGKAKVVASAIPDDQGWGVRPQQPQG------PGANHDARS 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 LEGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVEL : .. :. : : .: : : ... .. NP_001 LIMDSPRAGTHQGP-LDAETEV-----------GADRCTSTAYQ---------------- 240 250 260 300 310 320 330 340 350 pF1KE1 RIHPQQQPQEESSPQSDIPAPPSSKAPGRPQLS-PGQKQKEEPKEVKL-----SVPMPYT .:.:: : : :: : :: : .. :: :.: . : :. : NP_001 ----EQRPQVE---QVGKQAPLS---PGLPAMGGPGPGPCEDPAGAGGAGAGGSEPL-VT 270 280 290 300 310 360 370 380 390 400 410 pF1KE1 LKVHYKYTVVMKTQPGLPYSQVRDMVSKKLELRLEQTKLSY-RPRDSNELVPLSED-SMK . :. .::..... : :..: .... : . . .::: : .... ::. :. :.. NP_001 VTVQCAFTVALRARRGADLSSLRALLGQALPHQAQLGQLSYLAPGEDGHWVPIPEEESLQ 320 330 340 350 360 370 420 430 440 450 460 pF1KE1 DAWGQVKNYC---LTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSY :: : : : : :... : .: : :: : :: NP_001 RAW-QDAAACPRGLQLQCRGAGG---------------------RPVL---YQVVAQHSY 380 390 400 410 470 480 490 500 510 520 pF1KE1 EATQPEDLEFQEGDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV : :::: :..:: . :: .:.. ::::.: :..::::: :: NP_001 SAQGPEDLGFRQGDTVDVLCEVDQAWLEGHCDGRIGIFPKCFVVPAGPRMSGAPGRLPRS 420 430 440 450 460 470 NP_001 QQGDQP >>NP_006638 (OMIM: 611255) NADPH oxidase activator 1 iso (483 aa) initn: 703 init1: 526 opt: 526 Z-score: 346.6 bits: 73.7 E(85289): 1.4e-12 Smith-Waterman score: 698; 31.4% identity (53.2% similar) in 528 aa overlap (2-511:3-460) 10 20 30 40 50 pF1KE1 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKA :: . . :. :. :.:. :: :: ::.: : .:.::: ::.. . . : .: NP_006 MASLGDLVRAWHLGAQAVDRGDWARALHLFSGVPAPPARLCFNAGCVHLLAGDPEAALRA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 FTRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLF : .....: .::..::::. .: ... :..:. :: ::::. ::: :::.::: NP_006 FDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQLRGHAAIDYTQLGLRFKLQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 ACEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPV : :::.:.: . : .: .: : : : . .:.:.. : .. : .: NP_006 AWEVLHNVASAQCQLGLWTEAASSLREAMSKWPEGSLNGLDSALDQVQRRGSLPPRQVPR 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 GRLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRA :..:::.. .. .: :.:::: ::::.. .:. : : :::. : . . :. NP_006 GEVFRPHRWHLKHLEPVDFLGKAKVVASAIPDDQGWGVRPQQPQG------PGANHDARS 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 LEGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVEL : .. :. : : .: : : ... .. NP_006 LIMDSPRAGTHQGP-LDAETEV-----------GADRCTSTAYQ---------------- 240 250 260 300 310 320 330 340 350 pF1KE1 RIHPQQQPQEESSPQSDIPAPPSSKAPGRPQLS-PGQKQKEEPKEVKL-----SVPMPYT .:.:: : : :: : :: : .. :: :.: . : :. : NP_006 ----EQRPQVE---QVGKQAPLS---PGLPAMGGPGPGPCEDPAGAGGAGAGGSEPL-VT 270 280 290 300 310 360 370 380 390 400 410 pF1KE1 LKVHYKYTVVMKTQPGLPYSQVRDMVSKKLELRLEQTKLSY-RPRDSNELVPLSED-SMK . :. .::..... : :..: .... : . . .::: : .... ::. :. :.. NP_006 VTVQCAFTVALRARRGADLSSLRALLGQALPHQAQLGQLSYLAPGEDGHWVPIPEEESLQ 320 330 340 350 360 370 420 430 440 450 460 pF1KE1 DAWGQVKNYC---LTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSY :: : : : : :... : .: : :: : :: NP_006 RAW-QDAAACPRGLQLQCRGAGG---------------------RPVL---YQVVAQHSY 380 390 400 410 470 480 490 500 510 520 pF1KE1 EATQPEDLEFQEGDIILVLSK-------VNEEWLEGECKGKVGIFPKVFVEDCATTDLES : :::: :..:: . :: . :.. ::::.: :..::::: :: NP_006 SAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGPRMSGA 420 430 440 450 460 470 pF1KE1 TRREV NP_006 PGRLPRSQQGDQP 480 >>XP_011516460 (OMIM: 611255) PREDICTED: NADPH oxidase a (447 aa) initn: 585 init1: 357 opt: 389 Z-score: 262.2 bits: 57.9 E(85289): 7.3e-08 Smith-Waterman score: 536; 30.3% identity (50.4% similar) in 528 aa overlap (2-511:3-424) 10 20 30 40 50 pF1KE1 MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKA :: . . :. :. :.:. :: :: ::.: : .:.::: ::.. . . : .: XP_011 MASLGDLVRAWHLGAQAVDRGDWARALHLFSGVPAPPARLCFNAGCVHLLAGDPEAALRA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 FTRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLF : .....: .::..::::. .: ... :..:. :: ::::. ::: :::.::: XP_011 FDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQLRGHAAIDYTQLGLRFKLQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 ACEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPV : :::.:.: .:. ::.: : : :.. ..: : : XP_011 AWEVLHNVA----------SAQCQLGLWTEAASSLREA-MSK-----W----------PE 130 140 150 180 190 200 210 220 230 pF1KE1 GRLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRA : : : . : : .. ::::.. .:. : : :::. : . . :. XP_011 GSL---NGLDSA-------LDQVQVVASAIPDDQGWGVRPQQPQG------PGANHDARS 160 170 180 190 240 250 260 270 280 290 pF1KE1 LEGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVEL : .. :. : : .: : : ... .. XP_011 LIMDSPRAGTHQGP-LDAETEV-----------GADRCTSTAYQ---------------- 200 210 220 230 300 310 320 330 340 350 pF1KE1 RIHPQQQPQEESSPQSDIPAPPSSKAPGRPQLS-PGQKQKEEPKEVKL-----SVPMPYT .:.:: : : :: : :: : .. :: :.: . : :. : XP_011 ----EQRPQVE---QVGKQAPLS---PGLPAMGGPGPGPCEDPAGAGGAGAGGSEPL-VT 240 250 260 270 360 370 380 390 400 410 pF1KE1 LKVHYKYTVVMKTQPGLPYSQVRDMVSKKLELRLEQTKLSY-RPRDSNELVPLSED-SMK . :. .::..... : :..: .... : . . .::: : .... ::. :. :.. XP_011 VTVQCAFTVALRARRGADLSSLRALLGQALPHQAQLGQLSYLAPGEDGHWVPIPEEESLQ 280 290 300 310 320 330 420 430 440 450 460 pF1KE1 DAWGQVKNYC---LTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSY :: : : : : :... : .: : :: : :: XP_011 RAW-QDAAACPRGLQLQCRGAGG---------------------RPVL---YQVVAQHSY 340 350 360 370 470 480 490 500 510 520 pF1KE1 EATQPEDLEFQEGDIILVLSK-------VNEEWLEGECKGKVGIFPKVFVEDCATTDLES : :::: :..:: . :: . :.. ::::.: :..::::: :: XP_011 SAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGPRMSGA 380 390 400 410 420 430 pF1KE1 TRREV XP_011 PGRLPRSQQGDQP 440 526 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 02:49:35 2016 done: Mon Nov 7 02:49:36 2016 Total Scan time: 7.240 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]