FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6419, 496 aa 1>>>pF1KE6419 496 - 496 aa - 496 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8804+/-0.00044; mu= 20.3773+/- 0.027 mean_var=61.2191+/-12.516, 0's: 0 Z-trim(111.6): 26 B-trim: 1207 in 2/47 Lambda= 0.163920 statistics sampled from 20209 (20235) to 20209 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.6), E-opt: 0.2 (0.237), width: 16 Scan time: 6.440 The best scores are: opt bits E(85289) NP_005031 (OMIM: 176785) lysosomal Pro-X carboxype ( 496) 3420 817.6 0 NP_955450 (OMIM: 176785) lysosomal Pro-X carboxype ( 517) 3062 733.0 5e-211 XP_005274150 (OMIM: 176785) PREDICTED: lysosomal P ( 391) 2709 649.4 5.3e-186 NP_001306143 (OMIM: 176785) lysosomal Pro-X carbox ( 391) 2709 649.4 5.3e-186 NP_037511 (OMIM: 610537) dipeptidyl peptidase 2 pr ( 492) 1259 306.6 1.1e-82 XP_011516902 (OMIM: 610537) PREDICTED: dipeptidyl ( 484) 1134 277.0 8.4e-74 XP_011516901 (OMIM: 610537) PREDICTED: dipeptidyl ( 514) 1134 277.0 8.8e-74 XP_016870141 (OMIM: 610537) PREDICTED: dipeptidyl ( 436) 953 234.2 5.9e-61 XP_016870140 (OMIM: 610537) PREDICTED: dipeptidyl ( 458) 828 204.6 4.9e-52 XP_005266132 (OMIM: 610537) PREDICTED: dipeptidyl ( 565) 771 191.2 6.6e-48 XP_006717146 (OMIM: 610537) PREDICTED: dipeptidyl ( 509) 465 118.8 3.7e-26 XP_016865651 (OMIM: 607169) PREDICTED: thymus-spec ( 454) 410 105.8 2.8e-22 NP_005856 (OMIM: 607169) thymus-specific serine pr ( 514) 410 105.8 3.1e-22 XP_016865653 (OMIM: 607169) PREDICTED: thymus-spec ( 357) 347 90.8 7e-18 XP_016865652 (OMIM: 607169) PREDICTED: thymus-spec ( 417) 347 90.8 7.9e-18 XP_016865650 (OMIM: 607169) PREDICTED: thymus-spec ( 488) 283 75.8 3.2e-13 XP_016865654 (OMIM: 607169) PREDICTED: thymus-spec ( 257) 201 56.2 1.3e-07 >>NP_005031 (OMIM: 176785) lysosomal Pro-X carboxypeptid (496 aa) initn: 3420 init1: 3420 opt: 3420 Z-score: 4367.5 bits: 817.6 E(85289): 0 Smith-Waterman score: 3420; 100.0% identity (100.0% similar) in 496 aa overlap (1-496:1-496) 10 20 30 40 50 60 pF1KE6 MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 EHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 GGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 WDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 WDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 LPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 YQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 NIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRH 430 440 450 460 470 480 490 pF1KE6 MKNWIRDFYDSAGKQH :::::::::::::::: NP_005 MKNWIRDFYDSAGKQH 490 >>NP_955450 (OMIM: 176785) lysosomal Pro-X carboxypeptid (517 aa) initn: 3406 init1: 3062 opt: 3062 Z-score: 3909.7 bits: 733.0 E(85289): 5e-211 Smith-Waterman score: 3368; 95.9% identity (95.9% similar) in 517 aa overlap (1-496:1-517) 10 20 30 40 50 pF1KE6 MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQK---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKALAA 10 20 30 40 50 60 60 70 80 90 pF1KE6 -----------------VDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWF ::::::::::::::::::::::::::::::::::::::::::: NP_955 GQLHICIIQLNHYKTPLVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWF 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE6 CNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 CNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIK 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE6 HLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 HLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFM 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE6 KIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 KIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWI 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE6 SETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 SETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSG 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE6 QVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 QVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWG 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE6 VRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 VRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDL 430 440 450 460 470 480 460 470 480 490 pF1KE6 RTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH ::::::::::::::::::::::::::::::::::::: NP_955 RTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH 490 500 510 >>XP_005274150 (OMIM: 176785) PREDICTED: lysosomal Pro-X (391 aa) initn: 2709 init1: 2709 opt: 2709 Z-score: 3460.2 bits: 649.4 E(85289): 5.3e-186 Smith-Waterman score: 2709; 100.0% identity (100.0% similar) in 391 aa overlap (106-496:1-391) 80 90 100 110 120 130 pF1KE6 DKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNS :::::::::::::::::::::::::::::: XP_005 MWDVAEELKAMLVFAEHRYYGESLPFGDNS 10 20 30 140 150 160 170 180 190 pF1KE6 FKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHM 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE6 VVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQ 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE6 WLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKN 160 170 180 190 200 210 320 330 340 350 360 370 pF1KE6 PNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNG 220 230 240 250 260 270 380 390 400 410 420 430 pF1KE6 VDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGG 280 290 300 310 320 330 440 450 460 470 480 490 pF1KE6 GVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQ 340 350 360 370 380 390 pF1KE6 H : XP_005 H >>NP_001306143 (OMIM: 176785) lysosomal Pro-X carboxypep (391 aa) initn: 2709 init1: 2709 opt: 2709 Z-score: 3460.2 bits: 649.4 E(85289): 5.3e-186 Smith-Waterman score: 2709; 100.0% identity (100.0% similar) in 391 aa overlap (106-496:1-391) 80 90 100 110 120 130 pF1KE6 DKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNS :::::::::::::::::::::::::::::: NP_001 MWDVAEELKAMLVFAEHRYYGESLPFGDNS 10 20 30 140 150 160 170 180 190 pF1KE6 FKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHM 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE6 VVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQ 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE6 WLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKN 160 170 180 190 200 210 320 330 340 350 360 370 pF1KE6 PNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNG 220 230 240 250 260 270 380 390 400 410 420 430 pF1KE6 VDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGG 280 290 300 310 320 330 440 450 460 470 480 490 pF1KE6 GVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQ 340 350 360 370 380 390 pF1KE6 H : NP_001 H >>NP_037511 (OMIM: 610537) dipeptidyl peptidase 2 prepro (492 aa) initn: 1202 init1: 425 opt: 1259 Z-score: 1605.6 bits: 306.6 E(85289): 1.1e-82 Smith-Waterman score: 1286; 42.4% identity (69.9% similar) in 488 aa overlap (15-486:4-474) 10 20 30 40 50 60 pF1KE6 MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHF :::: . : ::: : .. : ... .:::..::: NP_037 MGSAPWAPVLLL----ALGLRGLQAGARRAPD--PGFQERFFQQRLDHF 10 20 30 40 70 80 90 100 110 pF1KE6 GFNTV--KTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLV .:. ::: ::.::.:..: .. : :.::::::::. : ::..:. ..: : :.:: NP_037 NFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLV 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 FAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGG ::::::::.::::: .: . . : ..:: ::::::::::.. :.: . ::.. :.::.:: NP_037 FAEHRYYGKSLPFGAQSTQRG-HTELLTVEQALADFAELLRALRRDL-GAQDAPAIAFGG 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 SYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIH ::::::.:..::::::.:.::::::::. : . :.. ::.::. ..:.:..... NP_037 SYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVR 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 RSWDAINRLSNTGS--GLQWLTGALHLCSPLTSQ-DIQHLKDWISETWVNLAMVDYPYAS ... :. : :. ..: :. :.::... :. .: . .... :::.:::: . NP_037 EAFRQIKDLFLQGAYDTVRWEFGT---CQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPT 230 240 250 260 270 300 310 320 330 340 350 pF1KE6 NFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLG .:: :::: :.:: :. : .:.. . .. .. :: ::. .: .: . : NP_037 DFLGPLPANPVKVGCDRL----LSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCAD 280 290 300 310 320 330 360 370 380 390 400 pF1KE6 TLG---------WSYQACTEVVMPFCTNGVDDMFE--PHSWNLKELSDDCFQQWGVRPRP : :.::::::. . : .:.: ::: : . .:.. :.. ::: ::: NP_037 PTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRY--CLDTWGVWPRP 340 350 360 370 380 390 410 420 430 440 450 460 pF1KE6 SWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNA .:. : . : .. . .::.::::.::::.:::. .... ...::::. ::::::::... NP_037 DWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHP 400 410 420 430 440 450 470 480 490 pF1KE6 LDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH :: ::. ::.::. . .:.. NP_037 EDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 460 470 480 490 >>XP_011516902 (OMIM: 610537) PREDICTED: dipeptidyl pept (484 aa) initn: 1072 init1: 425 opt: 1134 Z-score: 1445.9 bits: 277.0 E(85289): 8.4e-74 Smith-Waterman score: 1161; 43.0% identity (71.4% similar) in 423 aa overlap (78-486:55-466) 50 60 70 80 90 100 pF1KE6 YSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMW .: .. : :.::::::::. : ::..:. XP_011 PGALLPAASGPLQLRALRQQDLPSALPGVGFWVRGEGPIFFYTGNEGDVWAFANNSAFVA 30 40 50 60 70 80 110 120 130 140 150 160 pF1KE6 DVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPG ..: : :.::::::::::.::::: .: . . : ..:: ::::::::::.. :.: . : XP_011 ELAAERGALLVFAEHRYYGKSLPFGAQSTQRG-HTELLTVEQALADFAELLRALRRDL-G 90 100 110 120 130 140 170 180 190 200 210 220 pF1KE6 AENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFR :.. :.::.::::::::.:..::::::.:.::::::::. : . :.. ::.::. XP_011 AQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFE 150 160 170 180 190 200 230 240 250 260 270 280 pF1KE6 KSGPHCSESIHRSWDAINRLSNTGS--GLQWLTGALHLCSPLTSQ-DIQHLKDWISETWV ..:.:........ :. : :. ..: :. :.::... :. .: . .... XP_011 GQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGT---CQPLSDEKDLTQLFMFARNAFT 210 220 230 240 250 290 300 310 320 330 340 pF1KE6 NLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCL :::.:::: ..:: :::: :.:: :. : .:.. . .. .. :: ::. .: XP_011 VLAMMDYPYPTDFLGPLPANPVKVGCDRL----LSEAQRITGLRALAGLVYNASGSEHCY 260 270 280 290 300 310 350 360 370 380 390 pF1KE6 NISETATSSLGTLG---------WSYQACTEVVMPFCTNGVDDMFE--PHSWNLKELSDD .: . : : :.::::::. . : .:.: ::: : . .:.. XP_011 DIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQ--RY 320 330 340 350 360 370 400 410 420 430 440 450 pF1KE6 CFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEG :.. ::: :::.:. : . : .. . .::.::::.::::.:::. .... ...::::. : XP_011 CLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGG 380 390 400 410 420 430 460 470 480 490 pF1KE6 AHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH :::::::... :: ::. ::.::. . .:.. XP_011 AHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 440 450 460 470 480 >>XP_011516901 (OMIM: 610537) PREDICTED: dipeptidyl pept (514 aa) initn: 1099 init1: 425 opt: 1134 Z-score: 1445.6 bits: 277.0 E(85289): 8.8e-74 Smith-Waterman score: 1161; 43.0% identity (71.4% similar) in 423 aa overlap (78-486:85-496) 50 60 70 80 90 100 pF1KE6 YSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMW .: .. : :.::::::::. : ::..:. XP_011 PGALLPAASGPLQLRALRQQDLPSALPGVGFWVRGEGPIFFYTGNEGDVWAFANNSAFVA 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE6 DVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPG ..: : :.::::::::::.::::: .: . . : ..:: ::::::::::.. :.: . : XP_011 ELAAERGALLVFAEHRYYGKSLPFGAQSTQRG-HTELLTVEQALADFAELLRALRRDL-G 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 AENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFR :.. :.::.::::::::.:..::::::.:.::::::::. : . :.. ::.::. XP_011 AQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFE 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE6 KSGPHCSESIHRSWDAINRLSNTGS--GLQWLTGALHLCSPLTSQ-DIQHLKDWISETWV ..:.:........ :. : :. ..: :. :.::... :. .: . .... XP_011 GQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGT---CQPLSDEKDLTQLFMFARNAFT 240 250 260 270 280 290 300 310 320 330 340 pF1KE6 NLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCL :::.:::: ..:: :::: :.:: :. : .:.. . .. .. :: ::. .: XP_011 VLAMMDYPYPTDFLGPLPANPVKVGCDRL----LSEAQRITGLRALAGLVYNASGSEHCY 290 300 310 320 330 340 350 360 370 380 390 pF1KE6 NISETATSSLGTLG---------WSYQACTEVVMPFCTNGVDDMFE--PHSWNLKELSDD .: . : : :.::::::. . : .:.: ::: : . .:.. XP_011 DIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQ--RY 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE6 CFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEG :.. ::: :::.:. : . : .. . .::.::::.::::.:::. .... ...::::. : XP_011 CLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGG 410 420 430 440 450 460 460 470 480 490 pF1KE6 AHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH :::::::... :: ::. ::.::. . .:.. XP_011 AHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 470 480 490 500 510 >>XP_016870141 (OMIM: 610537) PREDICTED: dipeptidyl pept (436 aa) initn: 882 init1: 362 opt: 953 Z-score: 1215.3 bits: 234.2 E(85289): 5.9e-61 Smith-Waterman score: 953; 40.9% identity (67.7% similar) in 406 aa overlap (15-404:4-394) 10 20 30 40 50 60 pF1KE6 MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHF :::: . : ::: : .. : ... .:::..::: XP_016 MGSAPWAPVLL----LALGLRGLQAGARRAP--DPGFQERFFQQRLDHF 10 20 30 40 70 80 90 100 110 pF1KE6 GFNTV--KTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLV .:. ::: ::.::.:..: .. : :.::::::::. : ::..:. ..: : :.:: XP_016 NFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLV 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 FAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGG ::::::::.::::: .: . . : ..:: ::::::::::.. :.: . ::.. :.::.:: XP_016 FAEHRYYGKSLPFGAQSTQRG-HTELLTVEQALADFAELLRALRRDL-GAQDAPAIAFGG 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 SYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIH ::::::.:..::::::.:.::::::::. : . :.. ::.::. ..:.:..... XP_016 SYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVR 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 RSWDAINRLSNTGS--GLQWLTGALHLCSPLTSQ-DIQHLKDWISETWVNLAMVDYPYAS ... :. : :. ..: :. :.::... :. .: . .... :::.:::: . XP_016 EAFRQIKDLFLQGAYDTVRWEFGT---CQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPT 230 240 250 260 270 300 310 320 330 340 350 pF1KE6 NFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLG .:: :::: :.:: :. : .:.. . .. .. :: ::. .: .: . : XP_016 DFLGPLPANPVKVGCDRL----LSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCAD 280 290 300 310 320 330 360 370 380 390 400 pF1KE6 TLG---------WSYQACTEVVMPFCTNGVDDMFE--PHSWNLKELSDDCFQQWGVRPRP : :.::::::. . : .:.: ::: : . .:.. :.. :. .. .: XP_016 PTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRSQSRQQHHLLQREP 340 350 360 370 380 390 410 420 430 440 450 460 pF1KE6 SWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNA XP_016 GPLGRGRDSEEPECLSHRRHHPGGSAPPRPQSLPPRRSCFRG 400 410 420 430 >>XP_016870140 (OMIM: 610537) PREDICTED: dipeptidyl pept (458 aa) initn: 779 init1: 362 opt: 828 Z-score: 1055.2 bits: 204.6 E(85289): 4.9e-52 Smith-Waterman score: 828; 41.3% identity (69.2% similar) in 341 aa overlap (78-404:85-416) 50 60 70 80 90 100 pF1KE6 YSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMW .: .. : :.::::::::. : ::..:. XP_016 PGALLPAASGPLQLRALRQQDLPSALPGVGFWVRGEGPIFFYTGNEGDVWAFANNSAFVA 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE6 DVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPG ..: : :.::::::::::.::::: .: . . : ..:: ::::::::::.. :.: . : XP_016 ELAAERGALLVFAEHRYYGKSLPFGAQSTQRG-HTELLTVEQALADFAELLRALRRDL-G 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 AENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFR :.. :.::.::::::::.:..::::::.:.::::::::. : . :.. ::.::. XP_016 AQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFE 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE6 KSGPHCSESIHRSWDAINRLSNTGS--GLQWLTGALHLCSPLTSQ-DIQHLKDWISETWV ..:.:........ :. : :. ..: :. :.::... :. .: . .... XP_016 GQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGT---CQPLSDEKDLTQLFMFARNAFT 240 250 260 270 280 290 300 310 320 330 340 pF1KE6 NLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCL :::.:::: ..:: :::: :.:: :. : .:.. . .. .. :: ::. .: XP_016 VLAMMDYPYPTDFLGPLPANPVKVGCDRL----LSEAQRITGLRALAGLVYNASGSEHCY 290 300 310 320 330 340 350 360 370 380 390 pF1KE6 NISETATSSLGTLG---------WSYQACTEVVMPFCTNGVDDMFE--PHSWNLKELSDD .: . : : :.::::::. . : .:.: ::: : . .:.. :.. XP_016 DIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRSQS 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE6 CFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEG :. .. .: XP_016 RQQHHLLQREPGPLGRGRDSEEPECLSHRRHHPGGSAPPRPQSLPPRRSCFRG 410 420 430 440 450 >>XP_005266132 (OMIM: 610537) PREDICTED: dipeptidyl pept (565 aa) initn: 1198 init1: 425 opt: 771 Z-score: 981.0 bits: 191.2 E(85289): 6.6e-48 Smith-Waterman score: 1110; 37.6% identity (62.0% similar) in 524 aa overlap (52-486:35-547) 30 40 50 60 70 pF1KE6 LRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTV--KTFNQRYLVADKYW .:::..:::.:. ::: ::.::.:..: XP_005 PWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFW 10 20 30 40 50 60 80 90 100 110 120 130 pF1KE6 KKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDS .. : :.::::::::. : ::..:. ..: : :.::::::::::.::::: .: . . XP_005 VRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRG 70 80 90 100 110 120 140 150 160 170 pF1KE6 RHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGG--------------------- : ..:: ::::::::::.. :.: . ::.. :.::.:: XP_005 -HTELLTVEQALADFAELLRALRRDL-GAQDAPAIAFGGRKPSHLSSQPPAQLGCAATLA 130 140 150 160 170 180 180 pF1KE6 ----------------------------------------------------SYGGMLAA ::::::.: XP_005 AFPSESCTRTWPRVGICGSQKCRPPCGTCGPLRRKRGNGVLGAAALTLCPSPSYGGMLSA 190 200 210 220 230 240 190 200 210 220 230 240 pF1KE6 WFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINR ..::::::.:.::::::::. : . :.. ::.::. ..:.:........ :. XP_005 YLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKD 250 260 270 280 290 300 250 260 270 280 290 300 pF1KE6 LSNTGS--GLQWLTGALHLCSPLTSQ-DIQHLKDWISETWVNLAMVDYPYASNFLQPLPA : :. ..: :. :.::... :. .: . .... :::.:::: ..:: :::: XP_005 LFLQGAYDTVRWEFGT---CQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPA 310 320 330 340 350 310 320 330 340 350 pF1KE6 WPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLG----- :.:: :. : .:.. . .. .. :: ::. .: .: . : : XP_005 NPVKVGCDRL----LSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGP 360 370 380 390 400 410 360 370 380 390 400 410 pF1KE6 ----WSYQACTEVVMPFCTNGVDDMFE--PHSWNLKELSDDCFQQWGVRPRPSWITTMYG :.::::::. . : .:.: ::: : . .:.. :.. ::: :::.:. : . XP_005 DARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRY--CLDTWGVWPRPDWLLTSFW 420 430 440 450 460 470 420 430 440 450 460 470 pF1KE6 GKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLL : .. . .::.::::.::::.:::. .... ...::::. ::::::::... :: ::. XP_005 GGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVE 480 490 500 510 520 530 480 490 pF1KE6 ARSLEVRHMKNWIRDFYDSAGKQH ::.::. . .:.. XP_005 ARKLEATIIGEWVKAARREQQPALRGGPRLSL 540 550 560 496 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:06:35 2016 done: Tue Nov 8 13:06:36 2016 Total Scan time: 6.440 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]