FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1122, 433 aa 1>>>pF1KE1122 433 - 433 aa - 433 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.9169+/-0.000324; mu= 2.3854+/- 0.020 mean_var=222.6722+/-45.530, 0's: 0 Z-trim(122.9): 11 B-trim: 42 in 1/60 Lambda= 0.085949 statistics sampled from 41847 (41862) to 41847 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.794), E-opt: 0.2 (0.491), width: 16 Scan time: 11.840 The best scores are: opt bits E(85289) NP_001317669 (OMIM: 611053) iporin isoform 2 [Homo ( 638) 655 93.7 1.4e-18 NP_055621 (OMIM: 611053) iporin isoform 1 [Homo sa (1516) 655 94.0 2.8e-18 NP_001129471 (OMIM: 611053) iporin isoform 1 [Homo (1516) 655 94.0 2.8e-18 >>NP_001317669 (OMIM: 611053) iporin isoform 2 [Homo sap (638 aa) initn: 976 init1: 655 opt: 655 Z-score: 454.3 bits: 93.7 E(85289): 1.4e-18 Smith-Waterman score: 725; 39.8% identity (58.4% similar) in 399 aa overlap (14-371:114-501) 10 20 30 40 pF1KE1 MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKA :::::. ::...:: :..:::..:. :: NP_001 QDPFSLTEKPPAEFCLSPDGSSEAISIDLLQKKGLVKAVNIAVDLIVAHFGTSRDPGVKA 90 100 110 120 130 140 50 60 70 80 90 100 pF1KE1 QLGDSRLSPDVGHLVLTTLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSS .::.: .::.:::::: ::::..:.. :::: : :.: :::.. ::::::::.. : : NP_001 KLGNSSVSPNVGHLVLKYLCPAVRAVLEDGLKAFVLDVIIGQRKNMPWSVVEASTQLGPS 150 160 170 180 190 200 110 120 130 140 150 160 pF1KE1 TRSLGTLYSQVSRLAPLSSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGF :. : ::..::.. :.: ::.:::::::: ..::.::. : . ... : : :: NP_001 TKVLHGLYNKVSQFPELTSHTMRFNAFILGLLNIRSLEFWFNHLYNHEDIIQTHYQPWGF 210 220 230 240 250 260 170 180 190 pF1KE1 FSLARGGCPSLSTELLLLLQPLSVLTFHLDLLFEH------------------------- .: :. ::.: :::::::::..: : :::::.: NP_001 LSAAHTVCPGLFEELLLLLQPLALLPFSLDLLFQHRLLQSGQQQRQHKELLRVSQDLLLS 270 280 290 300 310 320 200 210 220 230 240 250 pF1KE1 -HHHLPLGPPQAPAPPGPPPALQQTMQAM---LHFGGRLAQSLRGTSKEA-ASDPSDSPN : : :. .. :: : .. ::. . . : . : :. : NP_001 AHSTLQLARARGQEGPGDVDRAAQGERVKGVGASEGGEEEEEEEETEEVAEAAGGSGRAR 330 340 350 360 370 380 260 270 280 290 300 pF1KE1 LPTPGS--WWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEE--GAQERPLPTDEMAP :. :: :: :.:.:: .:. :: ::. : ....:. :: : . : NP_001 WARGGQAGWWYQLMQSSQVYIDGSIEG---SRFPRGSSNSSSEKKKGAGGGGPP--QAPP 390 400 410 420 430 310 320 330 340 350 360 pF1KE1 GRGLWLGRLFGVPGGPAENENGALKSRRP-SSWL--PPTVSVLALVKRGAPPEMP--SPQ : : . :. . :: .: :: .: :. :: :::: ..:. : : :: NP_001 PR---EGVVEGAEACPASEE--ALGRERGWPFWMGSPPD-SVLAELRRSREREGPAASPA 440 450 460 470 480 490 370 380 390 400 410 420 pF1KE1 ELE--ASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEG : : :: : NP_001 ENEEGASEPSPGGIKWGHLFGSRKAQREARPTNRLPSDWLSLDKSMFQLVAQTVGSRREP 500 510 520 530 540 550 >>NP_055621 (OMIM: 611053) iporin isoform 1 [Homo sapien (1516 aa) initn: 943 init1: 655 opt: 655 Z-score: 449.1 bits: 94.0 E(85289): 2.8e-18 Smith-Waterman score: 725; 39.8% identity (58.4% similar) in 399 aa overlap (14-371:992-1379) 10 20 30 40 pF1KE1 MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKA :::::. ::...:: :..:::..:. :: NP_055 QDPFSLTEKPPAEFCLSPDGSSEAISIDLLQKKGLVKAVNIAVDLIVAHFGTSRDPGVKA 970 980 990 1000 1010 1020 50 60 70 80 90 100 pF1KE1 QLGDSRLSPDVGHLVLTTLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSS .::.: .::.:::::: ::::..:.. :::: : :.: :::.. ::::::::.. : : NP_055 KLGNSSVSPNVGHLVLKYLCPAVRAVLEDGLKAFVLDVIIGQRKNMPWSVVEASTQLGPS 1030 1040 1050 1060 1070 1080 110 120 130 140 150 160 pF1KE1 TRSLGTLYSQVSRLAPLSSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGF :. : ::..::.. :.: ::.:::::::: ..::.::. : . ... : : :: NP_055 TKVLHGLYNKVSQFPELTSHTMRFNAFILGLLNIRSLEFWFNHLYNHEDIIQTHYQPWGF 1090 1100 1110 1120 1130 1140 170 180 190 pF1KE1 FSLARGGCPSLSTELLLLLQPLSVLTFHLDLLFEH------------------------- .: :. ::.: :::::::::..: : :::::.: NP_055 LSAAHTVCPGLFEELLLLLQPLALLPFSLDLLFQHRLLQSGQQQRQHKELLRVSQDLLLS 1150 1160 1170 1180 1190 1200 200 210 220 230 240 250 pF1KE1 -HHHLPLGPPQAPAPPGPPPALQQTMQAM---LHFGGRLAQSLRGTSKEA-ASDPSDSPN : : :. .. :: : .. ::. . . : . : :. : NP_055 AHSTLQLARARGQEGPGDVDRAAQGERVKGVGASEGGEEEEEEEETEEVAEAAGGSGRAR 1210 1220 1230 1240 1250 1260 260 270 280 290 300 pF1KE1 LPTPGS--WWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEE--GAQERPLPTDEMAP :. :: :: :.:.:: .:. :: ::. : ....:. :: : . : NP_055 WARGGQAGWWYQLMQSSQVYIDGSIEG---SRFPRGSSNSSSEKKKGAGGGGPP--QAPP 1270 1280 1290 1300 1310 310 320 330 340 350 360 pF1KE1 GRGLWLGRLFGVPGGPAENENGALKSRRP-SSWL--PPTVSVLALVKRGAPPEMP--SPQ : : . :. . :: .: :: .: :. :: :::: ..:. : : :: NP_055 PR---EGVVEGAEACPASEE--ALGRERGWPFWMGSPPD-SVLAELRRSREREGPAASPA 1320 1330 1340 1350 1360 1370 370 380 390 400 410 420 pF1KE1 ELE--ASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEG : : :: : NP_055 ENEEGASEPSPGGIKWGHLFGSRKAQREARPTNRLPSDWLSLDKSMFQLVAQTVGSRREP 1380 1390 1400 1410 1420 1430 >>NP_001129471 (OMIM: 611053) iporin isoform 1 [Homo sap (1516 aa) initn: 943 init1: 655 opt: 655 Z-score: 449.1 bits: 94.0 E(85289): 2.8e-18 Smith-Waterman score: 725; 39.8% identity (58.4% similar) in 399 aa overlap (14-371:992-1379) 10 20 30 40 pF1KE1 MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKA :::::. ::...:: :..:::..:. :: NP_001 QDPFSLTEKPPAEFCLSPDGSSEAISIDLLQKKGLVKAVNIAVDLIVAHFGTSRDPGVKA 970 980 990 1000 1010 1020 50 60 70 80 90 100 pF1KE1 QLGDSRLSPDVGHLVLTTLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSS .::.: .::.:::::: ::::..:.. :::: : :.: :::.. ::::::::.. : : NP_001 KLGNSSVSPNVGHLVLKYLCPAVRAVLEDGLKAFVLDVIIGQRKNMPWSVVEASTQLGPS 1030 1040 1050 1060 1070 1080 110 120 130 140 150 160 pF1KE1 TRSLGTLYSQVSRLAPLSSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGF :. : ::..::.. :.: ::.:::::::: ..::.::. : . ... : : :: NP_001 TKVLHGLYNKVSQFPELTSHTMRFNAFILGLLNIRSLEFWFNHLYNHEDIIQTHYQPWGF 1090 1100 1110 1120 1130 1140 170 180 190 pF1KE1 FSLARGGCPSLSTELLLLLQPLSVLTFHLDLLFEH------------------------- .: :. ::.: :::::::::..: : :::::.: NP_001 LSAAHTVCPGLFEELLLLLQPLALLPFSLDLLFQHRLLQSGQQQRQHKELLRVSQDLLLS 1150 1160 1170 1180 1190 1200 200 210 220 230 240 250 pF1KE1 -HHHLPLGPPQAPAPPGPPPALQQTMQAM---LHFGGRLAQSLRGTSKEA-ASDPSDSPN : : :. .. :: : .. ::. . . : . : :. : NP_001 AHSTLQLARARGQEGPGDVDRAAQGERVKGVGASEGGEEEEEEEETEEVAEAAGGSGRAR 1210 1220 1230 1240 1250 1260 260 270 280 290 300 pF1KE1 LPTPGS--WWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEE--GAQERPLPTDEMAP :. :: :: :.:.:: .:. :: ::. : ....:. :: : . : NP_001 WARGGQAGWWYQLMQSSQVYIDGSIEG---SRFPRGSSNSSSEKKKGAGGGGPP--QAPP 1270 1280 1290 1300 1310 310 320 330 340 350 360 pF1KE1 GRGLWLGRLFGVPGGPAENENGALKSRRP-SSWL--PPTVSVLALVKRGAPPEMP--SPQ : : . :. . :: .: :: .: :. :: :::: ..:. : : :: NP_001 PR---EGVVEGAEACPASEE--ALGRERGWPFWMGSPPD-SVLAELRRSREREGPAASPA 1320 1330 1340 1350 1360 1370 370 380 390 400 410 420 pF1KE1 ELE--ASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEG : : :: : NP_001 ENEEGASEPSPGGIKWGHLFGSRKAQREARPTNRLPSDWLSLDKSMFQLVAQTVGSRREP 1380 1390 1400 1410 1420 1430 433 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 02:55:53 2016 done: Mon Nov 7 02:55:54 2016 Total Scan time: 11.840 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]