FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1304, 289 aa 1>>>pF1KE1304 289 - 289 aa - 289 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4680+/-0.000347; mu= 14.2646+/- 0.022 mean_var=62.6905+/-13.157, 0's: 0 Z-trim(114.6): 15 B-trim: 538 in 1/55 Lambda= 0.161984 statistics sampled from 24554 (24560) to 24554 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.669), E-opt: 0.2 (0.288), width: 16 Scan time: 6.750 The best scores are: opt bits E(85289) NP_066952 (OMIM: 179030) inorganic pyrophosphatase ( 289) 2036 484.2 1.2e-136 NP_789845 (OMIM: 609988) inorganic pyrophosphatase ( 334) 1162 280.0 4.3e-75 NP_789842 (OMIM: 609988) inorganic pyrophosphatase ( 232) 644 158.9 8.6e-39 NP_008834 (OMIM: 609988) inorganic pyrophosphatase ( 305) 642 158.4 1.5e-38 NP_789843 (OMIM: 609988) inorganic pyrophosphatase ( 168) 449 113.2 3.4e-25 >>NP_066952 (OMIM: 179030) inorganic pyrophosphatase [Ho (289 aa) initn: 2036 init1: 2036 opt: 2036 Z-score: 2574.0 bits: 484.2 E(85289): 1.2e-136 Smith-Waterman score: 2036; 100.0% identity (100.0% similar) in 289 aa overlap (1-289:1-289) 10 20 30 40 50 60 pF1KE1 MSGFSTEERAAPFSLEYRVFLKNEKGQYISPFHDIPIYADKDVFHMVVEVPRWSNAKMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 MSGFSTEERAAPFSLEYRVFLKNEKGQYISPFHDIPIYADKDVFHMVVEVPRWSNAKMEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 ATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 DVCEIGSKVCARGEIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYNDINDVKRLKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 DVCEIGSKVCARGEIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYNDINDVKRLKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GYLEATVDWFRRYKVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 GYLEATVDWFRRYKVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGI 190 200 210 220 230 240 250 260 270 280 pF1KE1 SCMNTTLSESPFKCDPDAARAIVDALPPPCESACTVPTDVDKWFHHQKN ::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 SCMNTTLSESPFKCDPDAARAIVDALPPPCESACTVPTDVDKWFHHQKN 250 260 270 280 >>NP_789845 (OMIM: 609988) inorganic pyrophosphatase 2, (334 aa) initn: 1274 init1: 1133 opt: 1162 Z-score: 1469.2 bits: 280.0 E(85289): 4.3e-75 Smith-Waterman score: 1269; 61.5% identity (83.2% similar) in 291 aa overlap (1-272:32-322) 10 20 30 pF1KE1 MSGFSTEERAAPFSLEYRVFLKNEKGQYIS :. . ::::. : : .::.:.:: :.::: NP_789 SALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYIS 10 20 30 40 50 60 40 50 60 70 pF1KE1 PFHDIPIYAD-----------------KDVFHMVVEVPRWSNAKMEIATKDPLNPIKQDV ::::::. .. ...:.:.::.:::.:::::::::.:.::::: : NP_789 PFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQYV 70 80 90 100 110 120 80 90 100 110 120 130 pF1KE1 KKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPIDVCEIGSKVCARG : ::::::::.:::::::::::..::::::: ..:: :.: ::::::::::::::. . : NP_789 KDGKLRYVANIFPYKGYIWNYGTLPQTWEDPHEKDKSTNCFGDNDPIDVCEIGSKILSCG 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE1 EIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYNDINDVKRLKPGYLEATVDWFRRY :.: ::.:::::.:::::::::.::::..::.:....::.:::..::::::::..::: : NP_789 EVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRLY 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE1 KVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGISCMNTTLSESPFK :::::::::.::::.:::.: ::...:::::. ::::. :: :: .:.: :. .:.:::. NP_789 KVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFR 250 260 270 280 290 300 260 270 280 pF1KE1 CDPDAARAIVDALP--PPCESACTVPTDVDKWFHHQKN : . ::..:... : :: NP_789 CTQEEARSLVESVSSSPNKESNEEEQVWHFLGK 310 320 330 >>NP_789842 (OMIM: 609988) inorganic pyrophosphatase 2, (232 aa) initn: 781 init1: 640 opt: 644 Z-score: 817.4 bits: 158.9 E(85289): 8.6e-39 Smith-Waterman score: 644; 59.9% identity (86.8% similar) in 152 aa overlap (124-272:69-220) 100 110 120 130 140 150 pF1KE1 YGAIPQTWEDPGHNDKHTGCCGDNDPIDVCEIGSK-VCARGEIIGVKVLGILAMIDEGET ...:: . . ::.: ::.:::::.:::::: NP_789 ERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEILSCGEVIHVKILGILALIDEGET 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE1 DWKVIAINVDDPDAANYNDINDVKRLKPGYLEATVDWFRRYKVPDGKPENEFAFNAEFKD :::.::::..::.:....::.:::..::::::::..::: ::::::::::.::::.:::. NP_789 DWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKN 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE1 KDFAIDIIKSTHDHWKALVTKKTNGKGISCMNTTLSESPFKCDPDAARAIVDALP--PPC : ::...:::::. ::::. :: :: .:.: :. .:.:::.: . ::..:... : NP_789 KAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNK 160 170 180 190 200 210 280 pF1KE1 ESACTVPTDVDKWFHHQKN :: NP_789 ESNEEEQVWHFLGK 220 230 >-- initn: 148 init1: 148 opt: 155 Z-score: 199.8 bits: 44.6 E(85289): 0.00022 Smith-Waterman score: 155; 59.5% identity (81.1% similar) in 37 aa overlap (1-37:32-68) 10 20 30 pF1KE1 MSGFSTEERAAPFSLEYRVFLKNEKGQYIS :. . ::::. : : .::.:.:: :.::: NP_789 SALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYIS 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 PFHDIPIYADKDVFHMVVEVPRWSNAKMEIATKDPLNPIKQDVKKGKLRYVANLFPYKGY ::::::. NP_789 PFHDIPLKVNSKEILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDV 70 80 90 100 110 120 >>NP_008834 (OMIM: 609988) inorganic pyrophosphatase 2, (305 aa) initn: 1105 init1: 640 opt: 642 Z-score: 813.0 bits: 158.4 E(85289): 1.5e-38 Smith-Waterman score: 1031; 54.3% identity (74.2% similar) in 291 aa overlap (1-272:32-293) 10 20 30 pF1KE1 MSGFSTEERAAPFSLEYRVFLKNEKGQYIS :. . ::::. : : .::.:.:: :.::: NP_008 SALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYIS 10 20 30 40 50 60 40 50 60 70 pF1KE1 PFHDIPIYAD-----------------KDVFHMVVEVPRWSNAKMEIATKDPLNPIKQDV ::::::. .. ...:.:.::.:::.:::::::::.:.::::: : NP_008 PFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQYV 70 80 90 100 110 120 80 90 100 110 120 130 pF1KE1 KKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPIDVCEIGSKVCARG : ::::::::.:::::::::::..:: : : : NP_008 KDGKLRYVANIFPYKGYIWNYGTLPQ--------------------ILSC---------G 130 140 150 140 150 160 170 180 190 pF1KE1 EIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYNDINDVKRLKPGYLEATVDWFRRY :.: ::.:::::.:::::::::.::::..::.:....::.:::..::::::::..::: : NP_008 EVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRLY 160 170 180 190 200 210 200 210 220 230 240 250 pF1KE1 KVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGISCMNTTLSESPFK :::::::::.::::.:::.: ::...:::::. ::::. :: :: .:.: :. .:.:::. NP_008 KVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFR 220 230 240 250 260 270 260 270 280 pF1KE1 CDPDAARAIVDALP--PPCESACTVPTDVDKWFHHQKN : . ::..:... : :: NP_008 CTQEEARSLVESVSSSPNKESNEEEQVWHFLGK 280 290 300 >>NP_789843 (OMIM: 609988) inorganic pyrophosphatase 2, (168 aa) initn: 480 init1: 435 opt: 449 Z-score: 573.4 bits: 113.2 E(85289): 3.4e-25 Smith-Waterman score: 449; 57.0% identity (80.7% similar) in 114 aa overlap (164-272:43-156) 140 150 160 170 180 190 pF1KE1 EIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYN---DINDVKRLKPGYLEATVDWF : . :: .:.:::..::::::::..:: NP_789 PAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFNIDDVKKFKPGYLEATLNWF 20 30 40 50 60 70 200 210 220 230 240 250 pF1KE1 RRYKVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGISCMNTTLSES : ::::::::::.::::.:::.: ::...:::::. ::::. :: :: .:.: :. .:.: NP_789 RLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDS 80 90 100 110 120 130 260 270 280 pF1KE1 PFKCDPDAARAIVDALP--PPCESACTVPTDVDKWFHHQKN ::.: . ::..:... : :: NP_789 PFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK 140 150 160 289 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 02:56:33 2016 done: Mon Nov 7 02:56:34 2016 Total Scan time: 6.750 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]