FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6229, 193 aa 1>>>pF1KE6229 193 - 193 aa - 193 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1479+/-0.000376; mu= 13.4204+/- 0.023 mean_var=54.3114+/-10.797, 0's: 0 Z-trim(110.8): 42 B-trim: 0 in 0/53 Lambda= 0.174032 statistics sampled from 19201 (19247) to 19201 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.614), E-opt: 0.2 (0.226), width: 16 Scan time: 4.760 The best scores are: opt bits E(85289) NP_001275 (OMIM: 601507) AP-3 complex subunit sigm ( 193) 1260 324.3 7.3e-89 NP_001002924 (OMIM: 601507) AP-3 complex subunit s ( 171) 1102 284.7 5.7e-77 NP_005820 (OMIM: 602416) AP-3 complex subunit sigm ( 193) 1089 281.4 6.1e-76 NP_001305022 (OMIM: 601507) AP-3 complex subunit s ( 162) 994 257.5 7.9e-69 XP_016864513 (OMIM: 601507) PREDICTED: AP-3 comple ( 262) 994 257.6 1.2e-68 XP_011541438 (OMIM: 601507) PREDICTED: AP-3 comple ( 262) 994 257.6 1.2e-68 NP_001305023 (OMIM: 601507) AP-3 complex subunit s ( 157) 775 202.5 2.8e-52 NP_001305019 (OMIM: 601507) AP-3 complex subunit s ( 125) 657 172.9 1.9e-43 NP_001305020 (OMIM: 601507) AP-3 complex subunit s ( 169) 608 160.6 1.2e-39 XP_016864514 (OMIM: 601507) PREDICTED: AP-3 comple ( 238) 608 160.7 1.7e-39 NP_004060 (OMIM: 600740,602242) AP-2 complex subun ( 142) 365 99.6 2.4e-21 NP_001288007 (OMIM: 600740,602242) AP-2 complex su ( 156) 359 98.1 7.6e-21 NP_001288010 (OMIM: 600740,602242) AP-2 complex su ( 144) 358 97.8 8.4e-21 NP_001288005 (OMIM: 600740,602242) AP-2 complex su ( 158) 358 97.8 9.1e-21 XP_011524726 (OMIM: 600740,602242) PREDICTED: AP-2 ( 158) 352 96.3 2.6e-20 XP_011524725 (OMIM: 600740,602242) PREDICTED: AP-2 ( 172) 352 96.4 2.8e-20 NP_001259000 (OMIM: 300629) AP-1 complex subunit s ( 160) 348 95.3 5.3e-20 XP_016885415 (OMIM: 300629) PREDICTED: AP-1 comple ( 189) 347 95.1 7.3e-20 XP_016885414 (OMIM: 300629) PREDICTED: AP-1 comple ( 202) 347 95.1 7.7e-20 XP_011543901 (OMIM: 300629) PREDICTED: AP-1 comple ( 202) 347 95.1 7.7e-20 NP_003907 (OMIM: 300629) AP-1 complex subunit sigm ( 157) 344 94.3 1e-19 NP_001274 (OMIM: 603531,609313) AP-1 complex subun ( 158) 343 94.1 1.2e-19 XP_005274671 (OMIM: 300629) PREDICTED: AP-1 comple ( 195) 342 93.9 1.8e-19 NP_001241657 (OMIM: 607243,614067) AP-4 complex su ( 144) 336 92.3 3.9e-19 NP_001241658 (OMIM: 607243,614067) AP-4 complex su ( 144) 336 92.3 3.9e-19 NP_001121598 (OMIM: 607243,614067) AP-4 complex su ( 144) 336 92.3 3.9e-19 NP_001034658 (OMIM: 615781,616106) AP-1 complex su ( 154) 321 88.6 5.6e-18 NP_001241656 (OMIM: 607243,614067) AP-4 complex su ( 149) 233 66.5 2.4e-11 XP_011534674 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 233 66.5 2.6e-11 XP_011534673 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 233 66.5 2.6e-11 NP_009008 (OMIM: 607243,614067) AP-4 complex subun ( 159) 233 66.5 2.6e-11 XP_005267350 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 233 66.5 2.6e-11 NP_001241655 (OMIM: 607243,614067) AP-4 complex su ( 135) 213 61.4 7.2e-10 XP_011508902 (OMIM: 615781,616106) PREDICTED: AP-1 ( 108) 207 59.9 1.7e-09 NP_057513 (OMIM: 615526) coatomer subunit zeta-2 [ ( 210) 186 54.7 1.2e-07 NP_067586 (OMIM: 600740,602242) AP-2 complex subun ( 104) 158 47.6 8.2e-06 NP_001258664 (OMIM: 615472) coatomer subunit zeta- ( 160) 154 46.6 2.4e-05 NP_057141 (OMIM: 615472) coatomer subunit zeta-1 i ( 177) 154 46.6 2.6e-05 XP_016874486 (OMIM: 615472) PREDICTED: coatomer su ( 180) 154 46.6 2.7e-05 NP_001258665 (OMIM: 615472) coatomer subunit zeta- ( 185) 154 46.7 2.8e-05 >>NP_001275 (OMIM: 601507) AP-3 complex subunit sigma-1 (193 aa) initn: 1260 init1: 1260 opt: 1260 Z-score: 1716.4 bits: 324.3 E(85289): 7.3e-89 Smith-Waterman score: 1260; 100.0% identity (100.0% similar) in 193 aa overlap (1-193:1-193) 10 20 30 40 50 60 pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG 130 140 150 160 170 180 190 pF1KE6 DISIKVPNLPSFK ::::::::::::: NP_001 DISIKVPNLPSFK 190 >>NP_001002924 (OMIM: 601507) AP-3 complex subunit sigma (171 aa) initn: 1102 init1: 1102 opt: 1102 Z-score: 1502.8 bits: 284.7 E(85289): 5.7e-77 Smith-Waterman score: 1102; 100.0% identity (100.0% similar) in 170 aa overlap (24-193:2-171) 10 20 30 40 50 60 pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD ::::::::::::::::::::::::::::::::::::: NP_001 MSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 10 20 30 70 80 90 100 110 120 pF1KE6 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE6 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG 100 110 120 130 140 150 190 pF1KE6 DISIKVPNLPSFK ::::::::::::: NP_001 DISIKVPNLPSFK 160 170 >>NP_005820 (OMIM: 602416) AP-3 complex subunit sigma-2 (193 aa) initn: 1107 init1: 1089 opt: 1089 Z-score: 1484.3 bits: 281.4 E(85289): 6.1e-76 Smith-Waterman score: 1089; 84.4% identity (94.8% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD ::.:::.::::::::: .::: . :. ::::.::::::: :::.:.::::::: :::::: NP_005 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL :::::::::::::::::::::::::::::::::::::::::::::::::::.:::: :: NP_005 YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG :.:::::::::::::::.::.:::.:::::.::..:::::::::::.:::::::::::: NP_005 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG 130 140 150 160 170 180 190 pF1KE6 DISIKVPNLPSFK :..:::::: .: NP_005 DLNIKVPNLSQFV 190 >>NP_001305022 (OMIM: 601507) AP-3 complex subunit sigma (162 aa) initn: 990 init1: 990 opt: 994 Z-score: 1356.6 bits: 257.5 E(85289): 7.9e-69 Smith-Waterman score: 994; 96.2% identity (98.1% similar) in 158 aa overlap (1-158:1-158) 10 20 30 40 50 60 pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG :::::::::::::::::::::::::::::::. . .: NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSETFIFQSPRQDR 130 140 150 160 190 pF1KE6 DISIKVPNLPSFK >>XP_016864513 (OMIM: 601507) PREDICTED: AP-3 complex su (262 aa) initn: 990 init1: 990 opt: 994 Z-score: 1353.3 bits: 257.6 E(85289): 1.2e-68 Smith-Waterman score: 994; 96.2% identity (98.1% similar) in 158 aa overlap (1-158:101-258) 10 20 30 pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQ :::::::::::::::::::::::::::::: XP_016 GRIAGEITRRGSRARPRPGPQCPPGRPGTAMIKAILIFNNHGKPRLSKFYQPYSEDTQQQ 80 90 100 110 120 130 40 50 60 70 80 90 pF1KE6 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI 140 150 160 170 180 190 100 110 120 130 140 150 pF1KE6 QVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS 200 210 220 230 240 250 160 170 180 190 pF1KE6 EAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK :. . .: XP_016 ETFIFQSPRQDR 260 >>XP_011541438 (OMIM: 601507) PREDICTED: AP-3 complex su (262 aa) initn: 990 init1: 990 opt: 994 Z-score: 1353.3 bits: 257.6 E(85289): 1.2e-68 Smith-Waterman score: 994; 96.2% identity (98.1% similar) in 158 aa overlap (1-158:101-258) 10 20 30 pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQ :::::::::::::::::::::::::::::: XP_011 GRIAGEITRRGSRARPRPGPQCPPGRPGTAMIKAILIFNNHGKPRLSKFYQPYSEDTQQQ 80 90 100 110 120 130 40 50 60 70 80 90 pF1KE6 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI 140 150 160 170 180 190 100 110 120 130 140 150 pF1KE6 QVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS 200 210 220 230 240 250 160 170 180 190 pF1KE6 EAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK :. . .: XP_011 ETFIFQSPRQDR 260 >>NP_001305023 (OMIM: 601507) AP-3 complex subunit sigma (157 aa) initn: 793 init1: 775 opt: 775 Z-score: 1059.7 bits: 202.5 E(85289): 2.8e-52 Smith-Waterman score: 957; 81.3% identity (81.3% similar) in 193 aa overlap (1-193:1-157) 10 20 30 40 50 60 pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDK----- 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG ::::::::::::::::::::::::::::: NP_001 -------------------------------AGLAGAPARAVSAVKNMNLPEIPRNINIG 120 130 140 190 pF1KE6 DISIKVPNLPSFK ::::::::::::: NP_001 DISIKVPNLPSFK 150 >>NP_001305019 (OMIM: 601507) AP-3 complex subunit sigma (125 aa) initn: 801 init1: 657 opt: 657 Z-score: 901.2 bits: 172.9 E(85289): 1.9e-43 Smith-Waterman score: 669; 64.8% identity (64.8% similar) in 193 aa overlap (1-193:1-125) 10 20 30 40 50 60 pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD ::::::::::::::::::::::: NP_001 MIKAILIFNNHGKPRLSKFYQPY------------------------------------- 10 20 70 80 90 100 110 120 pF1KE6 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL ::::::::::::::::::::::::::::: NP_001 -------------------------------VFVETLDKCFENVCELDLIFHVDKVHNIL 30 40 50 130 140 150 160 170 180 pF1KE6 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG 60 70 80 90 100 110 190 pF1KE6 DISIKVPNLPSFK ::::::::::::: NP_001 DISIKVPNLPSFK 120 >>NP_001305020 (OMIM: 601507) AP-3 complex subunit sigma (169 aa) initn: 608 init1: 608 opt: 608 Z-score: 832.6 bits: 160.6 E(85289): 1.2e-39 Smith-Waterman score: 1036; 87.6% identity (87.6% similar) in 193 aa overlap (1-193:1-169) 10 20 30 40 50 60 pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL :::::::::::::::::::::::::::::::: :::: NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQV------------------------HNIL 70 80 90 130 140 150 160 170 180 pF1KE6 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG 100 110 120 130 140 150 190 pF1KE6 DISIKVPNLPSFK ::::::::::::: NP_001 DISIKVPNLPSFK 160 >>XP_016864514 (OMIM: 601507) PREDICTED: AP-3 complex su (238 aa) initn: 608 init1: 608 opt: 608 Z-score: 830.2 bits: 160.7 E(85289): 1.7e-39 Smith-Waterman score: 770; 81.0% identity (82.9% similar) in 158 aa overlap (1-158:101-234) 10 20 30 pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQ :::::::::::::::::::::::::::::: XP_016 GRIAGEITRRGSRARPRPGPQCPPGRPGTAMIKAILIFNNHGKPRLSKFYQPYSEDTQQQ 80 90 100 110 120 130 40 50 60 70 80 90 pF1KE6 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI 140 150 160 170 180 190 100 110 120 130 140 150 pF1KE6 QVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS :: :::::::::::::::::::::::::::::::::: XP_016 QV------------------------HNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS 200 210 220 160 170 180 190 pF1KE6 EAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK :. . .: XP_016 ETFIFQSPRQDR 230 193 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:17:01 2016 done: Tue Nov 8 11:17:02 2016 Total Scan time: 4.760 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]