FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6730, 809 aa 1>>>pF1KE6730 809 - 809 aa - 809 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.1102+/-0.000422; mu= -9.7560+/- 0.026 mean_var=439.6571+/-91.333, 0's: 0 Z-trim(123.4): 103 B-trim: 806 in 1/60 Lambda= 0.061167 statistics sampled from 42988 (43106) to 42988 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.789), E-opt: 0.2 (0.505), width: 16 Scan time: 11.480 The best scores are: opt bits E(85289) NP_001107572 (OMIM: 616667) seizure 6-like protein ( 809) 5675 515.6 3.4e-145 XP_016878624 (OMIM: 616667) PREDICTED: seizure 6-l ( 739) 4721 431.4 6.9e-120 NP_036542 (OMIM: 616667) seizure 6-like protein 2 ( 853) 4525 414.2 1.2e-114 NP_001230262 (OMIM: 616667) seizure 6-like protein ( 879) 4525 414.2 1.3e-114 NP_001230261 (OMIM: 616667) seizure 6-like protein ( 923) 4525 414.2 1.3e-114 NP_001107571 (OMIM: 616667) seizure 6-like protein ( 840) 3941 362.6 4e-99 NP_963869 (OMIM: 616667) seizure 6-like protein 2 ( 910) 3941 362.7 4.2e-99 XP_005255309 (OMIM: 616667) PREDICTED: seizure 6-l ( 859) 3473 321.3 1.1e-86 NP_001092105 (OMIM: 616666) seizure protein 6 homo ( 993) 2401 226.8 3.7e-58 NP_001277131 (OMIM: 616666) seizure protein 6 homo ( 869) 2352 222.4 6.6e-57 NP_849191 (OMIM: 616666) seizure protein 6 homolog ( 994) 2352 222.5 7.3e-57 NP_066938 (OMIM: 607021) seizure 6-like protein is (1024) 2347 222.0 1e-56 NP_001171702 (OMIM: 607021) seizure 6-like protein (1023) 2343 221.7 1.3e-56 XP_006724258 (OMIM: 607021) PREDICTED: seizure 6-l (1022) 2335 221.0 2.1e-56 XP_011522619 (OMIM: 616666) PREDICTED: seizure pro ( 964) 2271 215.3 1e-54 XP_011522617 (OMIM: 616666) PREDICTED: seizure pro (1073) 2269 215.2 1.2e-54 NP_001171703 (OMIM: 607021) seizure 6-like protein (1013) 2128 202.7 6.6e-51 NP_001171704 (OMIM: 607021) seizure 6-like protein (1011) 2123 202.3 9e-51 XP_005261496 (OMIM: 607021) PREDICTED: seizure 6-l (1012) 2118 201.8 1.2e-50 NP_001171706 (OMIM: 607021) seizure 6-like protein ( 948) 1847 177.9 1.8e-43 XP_011528341 (OMIM: 607021) PREDICTED: seizure 6-l ( 957) 1844 177.6 2.2e-43 XP_011528340 (OMIM: 607021) PREDICTED: seizure 6-l ( 958) 1844 177.6 2.2e-43 XP_011528339 (OMIM: 607021) PREDICTED: seizure 6-l ( 959) 1844 177.6 2.2e-43 XP_016884189 (OMIM: 607021) PREDICTED: seizure 6-l ( 958) 1661 161.5 1.6e-38 XP_016884188 (OMIM: 607021) PREDICTED: seizure 6-l ( 959) 1661 161.5 1.6e-38 XP_005261497 (OMIM: 607021) PREDICTED: seizure 6-l ( 960) 1661 161.5 1.6e-38 NP_001171705 (OMIM: 607021) seizure 6-like protein ( 949) 1660 161.4 1.7e-38 XP_011533056 (OMIM: 608397) PREDICTED: CUB and sus (2238) 748 81.2 5.4e-14 XP_011515117 (OMIM: 608399) PREDICTED: CUB and sus (2173) 687 75.8 2.2e-12 XP_011533055 (OMIM: 608397) PREDICTED: CUB and sus (2595) 655 73.1 1.8e-11 XP_016869220 (OMIM: 608397) PREDICTED: CUB and sus (3327) 655 73.2 2.2e-11 XP_011533054 (OMIM: 608397) PREDICTED: CUB and sus (3549) 655 73.2 2.3e-11 NP_150094 (OMIM: 608397) CUB and sushi domain-cont (3564) 655 73.2 2.3e-11 XP_016855682 (OMIM: 608398) PREDICTED: CUB and sus (2294) 648 72.4 2.5e-11 XP_016855681 (OMIM: 608398) PREDICTED: CUB and sus (2315) 648 72.4 2.5e-11 XP_016855680 (OMIM: 608398) PREDICTED: CUB and sus (2973) 648 72.5 3e-11 XP_016855679 (OMIM: 608398) PREDICTED: CUB and sus (3362) 648 72.6 3.3e-11 NP_443128 (OMIM: 608398) CUB and sushi domain-cont (3487) 648 72.6 3.4e-11 XP_016855678 (OMIM: 608398) PREDICTED: CUB and sus (3506) 648 72.6 3.4e-11 XP_016855683 (OMIM: 608398) PREDICTED: CUB and sus (3566) 648 72.6 3.5e-11 XP_016855677 (OMIM: 608398) PREDICTED: CUB and sus (3567) 648 72.6 3.5e-11 XP_016855676 (OMIM: 608398) PREDICTED: CUB and sus (3606) 648 72.6 3.5e-11 XP_016855675 (OMIM: 608398) PREDICTED: CUB and sus (3607) 648 72.6 3.5e-11 XP_016855674 (OMIM: 608398) PREDICTED: CUB and sus (3607) 648 72.6 3.5e-11 NP_001268885 (OMIM: 608398) CUB and sushi domain-c (3631) 648 72.6 3.5e-11 XP_016868500 (OMIM: 608399) PREDICTED: CUB and sus (3507) 509 60.3 1.7e-07 XP_016868498 (OMIM: 608399) PREDICTED: CUB and sus (3637) 509 60.3 1.7e-07 XP_016868501 (OMIM: 608399) PREDICTED: CUB and sus (3463) 506 60.0 2e-07 NP_443132 (OMIM: 608399) CUB and sushi domain-cont (3538) 506 60.0 2.1e-07 XP_016868499 (OMIM: 608399) PREDICTED: CUB and sus (3577) 506 60.1 2.1e-07 >>NP_001107572 (OMIM: 616667) seizure 6-like protein 2 i (809 aa) initn: 5675 init1: 5675 opt: 5675 Z-score: 2727.8 bits: 515.6 E(85289): 3.4e-145 Smith-Waterman score: 5675; 99.9% identity (99.9% similar) in 809 aa overlap (1-809:1-809) 10 20 30 40 50 60 pF1KE6 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP ::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 PVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 AGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 QLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGW 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 RTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE6 GVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE6 LLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGS 730 740 750 760 770 780 790 800 pF1KE6 HSYSPITVESDFSNPLYEAGDTREYEVSI ::::::::::::::::::::::::::::: NP_001 HSYSPITVESDFSNPLYEAGDTREYEVSI 790 800 >>XP_016878624 (OMIM: 616667) PREDICTED: seizure 6-like (739 aa) initn: 4721 init1: 4721 opt: 4721 Z-score: 2273.3 bits: 431.4 E(85289): 6.9e-120 Smith-Waterman score: 5048; 91.3% identity (91.3% similar) in 809 aa overlap (1-809:1-739) 10 20 30 40 50 60 pF1KE6 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP ::::::::::: XP_016 RRGPEMGYLPG------------------------------------------------- 70 130 140 150 160 170 180 pF1KE6 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPP ::::::::::::::::::::::::::::::::::::::: XP_016 ---------------------PPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPP 80 90 100 110 190 200 210 220 230 240 pF1KE6 RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH 120 130 140 150 160 170 250 260 270 280 290 300 pF1KE6 NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLS 180 190 200 210 220 230 310 320 330 340 350 360 pF1KE6 PVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV 240 250 260 270 280 290 370 380 390 400 410 420 pF1KE6 TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEP 300 310 320 330 340 350 430 440 450 460 470 480 pF1KE6 AGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLA 360 370 380 390 400 410 490 500 510 520 530 540 pF1KE6 QLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGW 420 430 440 450 460 470 550 560 570 580 590 600 pF1KE6 RTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANG 480 490 500 510 520 530 610 620 630 640 650 660 pF1KE6 HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNP 540 550 560 570 580 590 670 680 690 700 710 720 pF1KE6 GVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEE 600 610 620 630 640 650 730 740 750 760 770 780 pF1KE6 LLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGS 660 670 680 690 700 710 790 800 pF1KE6 HSYSPITVESDFSNPLYEAGDTREYEVSI ::::::::::::::::::::::::::::: XP_016 HSYSPITVESDFSNPLYEAGDTREYEVSI 720 730 >>NP_036542 (OMIM: 616667) seizure 6-like protein 2 isof (853 aa) initn: 5009 init1: 4525 opt: 4525 Z-score: 2179.0 bits: 414.2 E(85289): 1.2e-114 Smith-Waterman score: 4837; 85.1% identity (88.3% similar) in 848 aa overlap (13-809:13-853) 10 20 30 40 50 60 pF1KE6 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL :::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 RRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV-RGAGPT- ::::::::::: : :. : .:. .. .. .: : . .. :.. .: : . NP_036 RRGPEMGYLPG----PPLG-PEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVE 70 80 90 100 110 120 130 140 pF1KE6 APELLTPP----------------PGTTAPPPPSP------------ASPGPP-LGPEG- .:.: .: :: . :. : : :.:. NP_036 SPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLL 120 130 140 150 160 170 150 160 170 180 pF1KE6 ------GEEETTTTIITTTTVTTTVTSP-------------AYLLSCGFPPRPAHGDVSV :: .. . :. . :: ::::::::::::::::::: NP_036 ANSSMLGEGQVLRS--PTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGDVSV 180 190 200 210 220 230 190 200 210 220 230 240 pF1KE6 TDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVS 240 250 260 270 280 290 250 260 270 280 290 300 pF1KE6 PEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 PEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMD 300 310 320 330 340 350 310 320 330 340 350 360 pF1KE6 DVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 DVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRP 360 370 380 390 400 410 370 380 390 400 410 420 pF1KE6 GALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 GALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDW 420 430 440 450 460 470 430 440 450 460 470 480 pF1KE6 PQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 PQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRR 480 490 500 510 520 530 490 500 510 520 530 540 pF1KE6 RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLI 540 550 560 570 580 590 550 560 570 580 590 600 pF1KE6 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 600 610 620 630 640 650 610 620 630 640 650 660 pF1KE6 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 660 670 680 690 700 710 670 680 690 700 710 720 pF1KE6 LYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 LYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEV 720 730 740 750 760 770 730 740 750 760 770 780 pF1KE6 TQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVE 780 790 800 810 820 830 790 800 pF1KE6 SDFSNPLYEAGDTREYEVSI :::::::::::::::::::: NP_036 SDFSNPLYEAGDTREYEVSI 840 850 >>NP_001230262 (OMIM: 616667) seizure 6-like protein 2 i (879 aa) initn: 5177 init1: 4525 opt: 4525 Z-score: 2178.9 bits: 414.2 E(85289): 1.3e-114 Smith-Waterman score: 4874; 86.4% identity (86.4% similar) in 841 aa overlap (83-809:39-879) 60 70 80 90 100 110 pF1KE6 ELLHGALLRRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV :::::::::::::::::::::::::::::: NP_001 PPPPQLLFLILLSCPWIQGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV 10 20 30 40 50 60 120 130 140 150 160 170 pF1KE6 RGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSP-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVL 70 80 90 100 110 120 pF1KE6 ------------------------------------------------------------ NP_001 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 130 140 150 160 170 180 pF1KE6 ----------------------------------------------------AYLLSCGF :::::::: NP_001 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF 190 200 210 220 230 240 180 190 200 210 220 230 pF1KE6 PPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGT 250 260 270 280 290 300 240 250 260 270 280 290 pF1KE6 IHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP 310 320 330 340 350 360 300 310 320 330 340 350 pF1KE6 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG 370 380 390 400 410 420 360 370 380 390 400 410 pF1KE6 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS 430 440 450 460 470 480 420 430 440 450 460 470 pF1KE6 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV 490 500 510 520 530 540 480 490 500 510 520 530 pF1KE6 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEW 550 560 570 580 590 600 540 550 560 570 580 590 pF1KE6 GWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIA 610 620 630 640 650 660 600 610 620 630 640 650 pF1KE6 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCL 670 680 690 700 710 720 660 670 680 690 700 710 pF1KE6 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY 730 740 750 760 770 780 720 730 740 750 760 770 pF1KE6 EELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS 790 800 810 820 830 840 780 790 800 pF1KE6 GSHSYSPITVESDFSNPLYEAGDTREYEVSI ::::::::::::::::::::::::::::::: NP_001 GSHSYSPITVESDFSNPLYEAGDTREYEVSI 850 860 870 >>NP_001230261 (OMIM: 616667) seizure 6-like protein 2 i (923 aa) initn: 5661 init1: 4525 opt: 4525 Z-score: 2178.6 bits: 414.2 E(85289): 1.3e-114 Smith-Waterman score: 4874; 86.4% identity (86.4% similar) in 841 aa overlap (83-809:83-923) 60 70 80 90 100 110 pF1KE6 ELLHGALLRRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV :::::::::::::::::::::::::::::: NP_001 ELLHGALLRRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 RGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSP-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVL 120 130 140 150 160 170 pF1KE6 ------------------------------------------------------------ NP_001 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 180 190 200 210 220 230 pF1KE6 ----------------------------------------------------AYLLSCGF :::::::: NP_001 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF 240 250 260 270 280 290 180 190 200 210 220 230 pF1KE6 PPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGT 300 310 320 330 340 350 240 250 260 270 280 290 pF1KE6 IHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP 360 370 380 390 400 410 300 310 320 330 340 350 pF1KE6 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG 420 430 440 450 460 470 360 370 380 390 400 410 pF1KE6 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS 480 490 500 510 520 530 420 430 440 450 460 470 pF1KE6 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV 540 550 560 570 580 590 480 490 500 510 520 530 pF1KE6 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEW 600 610 620 630 640 650 540 550 560 570 580 590 pF1KE6 GWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIA 660 670 680 690 700 710 600 610 620 630 640 650 pF1KE6 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCL 720 730 740 750 760 770 660 670 680 690 700 710 pF1KE6 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY 780 790 800 810 820 830 720 730 740 750 760 770 pF1KE6 EELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS 840 850 860 870 880 890 780 790 800 pF1KE6 GSHSYSPITVESDFSNPLYEAGDTREYEVSI ::::::::::::::::::::::::::::::: NP_001 GSHSYSPITVESDFSNPLYEAGDTREYEVSI 900 910 920 >-- initn: 563 init1: 563 opt: 563 Z-score: 289.0 bits: 64.6 E(85289): 2.3e-09 Smith-Waterman score: 563; 98.8% identity (98.8% similar) in 82 aa overlap (1-82:1-82) 10 20 30 40 50 60 pF1KE6 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP ::::::::::::: :::::::: NP_001 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 70 80 90 100 110 120 >>NP_001107571 (OMIM: 616667) seizure 6-like protein 2 i (840 aa) initn: 4421 init1: 3937 opt: 3941 Z-score: 1900.6 bits: 362.6 E(85289): 4e-99 Smith-Waterman score: 4722; 83.6% identity (86.8% similar) in 848 aa overlap (13-809:13-840) 10 20 30 40 50 60 pF1KE6 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 RRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV-RGAGPT- ::::::::::: : :. : .:. .. .. .: : . .. :.. .: : . NP_001 RRGPEMGYLPG----PPLG-PEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVE 70 80 90 100 110 120 130 140 pF1KE6 APELLTPP----------------PGTTAPPPPSP------------ASPGPP-LGPEG- .:.: .: :: . :. : : :.:. NP_001 SPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLL 120 130 140 150 160 170 150 160 170 180 pF1KE6 ------GEEETTTTIITTTTVTTTVTSP-------------AYLLSCGFPPRPAHGDVSV :: .. . :. . :: ::::::::::::::::::: NP_001 ANSSMLGEGQVLRS--PTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGDVSV 180 190 200 210 220 230 190 200 210 220 230 240 pF1KE6 TDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVS 240 250 260 270 280 290 250 260 270 280 290 300 pF1KE6 PEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMD 300 310 320 330 340 350 310 320 330 340 350 360 pF1KE6 DVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRP 360 370 380 390 400 410 370 380 390 400 410 420 pF1KE6 GALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDW 420 430 440 450 460 470 430 440 450 460 470 480 pF1KE6 PQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRR 480 490 500 510 520 530 490 500 510 520 530 540 pF1KE6 RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLI 540 550 560 570 580 590 550 560 570 580 590 600 pF1KE6 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 600 610 620 630 640 650 610 620 630 640 650 660 pF1KE6 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 660 670 680 690 700 710 670 680 690 700 710 720 pF1KE6 LYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEV ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV------------- 720 730 740 750 760 730 740 750 760 770 780 pF1KE6 TQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVE 770 780 790 800 810 820 790 800 pF1KE6 SDFSNPLYEAGDTREYEVSI :::::::::::::::::::: NP_001 SDFSNPLYEAGDTREYEVSI 830 840 >>NP_963869 (OMIM: 616667) seizure 6-like protein 2 isof (910 aa) initn: 5073 init1: 3937 opt: 3941 Z-score: 1900.2 bits: 362.7 E(85289): 4.2e-99 Smith-Waterman score: 4759; 84.9% identity (84.9% similar) in 841 aa overlap (83-809:83-910) 60 70 80 90 100 110 pF1KE6 ELLHGALLRRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV :::::::::::::::::::::::::::::: NP_963 ELLHGALLRRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 RGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSP-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 RGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVL 120 130 140 150 160 170 pF1KE6 ------------------------------------------------------------ NP_963 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 180 190 200 210 220 230 pF1KE6 ----------------------------------------------------AYLLSCGF :::::::: NP_963 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF 240 250 260 270 280 290 180 190 200 210 220 230 pF1KE6 PPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 PPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGT 300 310 320 330 340 350 240 250 260 270 280 290 pF1KE6 IHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 IHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP 360 370 380 390 400 410 300 310 320 330 340 350 pF1KE6 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG 420 430 440 450 460 470 360 370 380 390 400 410 pF1KE6 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS 480 490 500 510 520 530 420 430 440 450 460 470 pF1KE6 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV 540 550 560 570 580 590 480 490 500 510 520 530 pF1KE6 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEW 600 610 620 630 640 650 540 550 560 570 580 590 pF1KE6 GWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 GWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIA 660 670 680 690 700 710 600 610 620 630 640 650 pF1KE6 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCL 720 730 740 750 760 770 660 670 680 690 700 710 pF1KE6 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV-- 780 790 800 810 820 830 720 730 740 750 760 770 pF1KE6 EELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS ::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 -----------TQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS 840 850 860 870 780 790 800 pF1KE6 GSHSYSPITVESDFSNPLYEAGDTREYEVSI ::::::::::::::::::::::::::::::: NP_963 GSHSYSPITVESDFSNPLYEAGDTREYEVSI 880 890 900 910 >-- initn: 563 init1: 563 opt: 563 Z-score: 289.1 bits: 64.6 E(85289): 2.3e-09 Smith-Waterman score: 563; 98.8% identity (98.8% similar) in 82 aa overlap (1-82:1-82) 10 20 30 40 50 60 pF1KE6 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP ::::::::::::: :::::::: NP_963 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 70 80 90 100 110 120 >>XP_005255309 (OMIM: 616667) PREDICTED: seizure 6-like (859 aa) initn: 4744 init1: 3473 opt: 3473 Z-score: 1677.3 bits: 321.3 E(85289): 1.1e-86 Smith-Waterman score: 4255; 78.7% identity (78.8% similar) in 841 aa overlap (83-809:83-859) 60 70 80 90 100 110 pF1KE6 ELLHGALLRRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV :::::::::::::::::::::::::::::: XP_005 ELLHGALLRRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 RGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSP-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVL 120 130 140 150 160 170 pF1KE6 ------------------------------------------------------------ XP_005 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 180 190 200 210 220 230 pF1KE6 ----------------------------------------------------AYLLSCGF :::::::: XP_005 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF 240 250 260 270 280 290 180 190 200 210 220 230 pF1KE6 PPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGT 300 310 320 330 340 350 240 250 260 270 280 290 pF1KE6 IHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP 360 370 380 390 400 410 300 310 320 330 340 350 pF1KE6 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG 420 430 440 450 460 470 360 370 380 390 400 410 pF1KE6 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS 480 490 500 510 520 530 420 430 440 450 460 470 pF1KE6 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV 540 550 560 570 580 590 480 490 500 510 520 530 pF1KE6 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEW 600 610 620 630 640 650 540 550 560 570 580 590 pF1KE6 GWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIA 660 670 680 690 700 710 600 610 620 630 640 650 pF1KE6 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCL :::::::::::::::::::::::::::::::::::::::::::::::::::::. XP_005 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCAF------ 720 730 740 750 760 660 670 680 690 700 710 pF1KE6 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY :: XP_005 ----------------------------------------------------------AY 720 730 740 750 760 770 pF1KE6 EELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS 770 780 790 800 810 820 780 790 800 pF1KE6 GSHSYSPITVESDFSNPLYEAGDTREYEVSI ::::::::::::::::::::::::::::::: XP_005 GSHSYSPITVESDFSNPLYEAGDTREYEVSI 830 840 850 >-- initn: 563 init1: 563 opt: 563 Z-score: 289.5 bits: 64.5 E(85289): 2.2e-09 Smith-Waterman score: 563; 98.8% identity (98.8% similar) in 82 aa overlap (1-82:1-82) 10 20 30 40 50 60 pF1KE6 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP ::::::::::::: :::::::: XP_005 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 70 80 90 100 110 120 >>NP_001092105 (OMIM: 616666) seizure protein 6 homolog (993 aa) initn: 2159 init1: 1155 opt: 2401 Z-score: 1165.2 bits: 226.8 E(85289): 3.7e-58 Smith-Waterman score: 2401; 50.2% identity (78.4% similar) in 644 aa overlap (171-809:352-993) 150 160 170 180 190 200 pF1KE6 GPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVTDLHPGGTATF :::::: :: :::.:::.::.:::::.: : NP_001 VIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARF 330 340 350 360 370 380 210 220 230 240 250 260 pF1KE6 HCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNL :: .::::.: . : :::.:.: :... : :.:.:::.:.::: :::::: : . :: NP_001 HCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNL 390 400 410 420 430 440 270 280 290 300 310 pF1KE6 TCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS-DMDDVPERGLISD ::.:..:: ::.:::::::.::: ::.:::..:.: . .: .::: ... .: .::.:. NP_001 TCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSS 450 460 470 480 490 500 320 330 340 350 360 370 pF1KE6 AQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLP .. ..::: ... . ..::.:::.. .:. ::. .:: ... : : :. . ::: : NP_001 GKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDP 510 520 530 540 550 560 380 390 400 410 420 430 pF1KE6 GYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDC ::.:: . :::::: .:.::.:::::.:.:.::... :::::::.::. :. :::: NP_001 GYTLEQGS--IIIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDC 570 580 590 600 610 440 450 460 470 480 490 pF1KE6 VWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLT .:::::.:.:::.:....: . ::.::..::: .::::.: ::. . .:..: :.: NP_001 IWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVT 620 630 640 650 660 670 500 510 520 530 540 550 pF1KE6 LQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCE .:::. :: : ::::.:: :::::::::::: ::.. :. .:..:::.:::: NP_001 IQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCY 680 690 700 710 720 730 560 570 580 590 600 610 pF1KE6 PGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRC :::...::..: :::::.:: :.::.. .: :::.. ...: :. ::::. ::: : NP_001 PGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYIC 740 750 760 770 780 790 620 630 640 650 660 670 pF1KE6 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCAL-KYEPCLNPGVPENGYQTLYKHHYQAG :. : :...:::..:..:.::::::.::: : . .:: . ..:::: .. :. . :: NP_001 DQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAG 800 810 820 830 840 850 680 690 700 710 720 730 pF1KE6 ESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVA-YEELLDNRKLEVTQTTDPSR ...: : :. : :...: :::::::.:.. ::.:..: . . ..:.:.:... : NP_001 ATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASS 860 870 880 890 900 910 740 750 760 770 780 790 pF1KE6 QLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHS--YSPITVESDFSNP :.....: ::.::: ...: .:::.:...::::: . . . :. ::.:: :.:: NP_001 TLDAAHIAAAIFLPLVAMVLLVGGVYFYFSRLQGKSSLQLPRPRPRPYNRITIESAFDNP 920 930 940 950 960 970 800 pF1KE6 LYEAGDTREYEVSI ::.:.:::::::: NP_001 TYETGETREYEVSI 980 990 >>NP_001277131 (OMIM: 616666) seizure protein 6 homolog (869 aa) initn: 2029 init1: 1155 opt: 2352 Z-score: 1142.6 bits: 222.4 E(85289): 6.6e-57 Smith-Waterman score: 2352; 49.6% identity (78.1% similar) in 635 aa overlap (171-800:227-859) 150 160 170 180 190 200 pF1KE6 GPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVTDLHPGGTATF :::::: :: :::.:::.::.:::::.: : NP_001 VIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARF 200 210 220 230 240 250 210 220 230 240 250 260 pF1KE6 HCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNL :: .::::.: . : :::.:.: :... : :.:.:::.:.::: :::::: : . :: NP_001 HCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNL 260 270 280 290 300 310 270 280 290 300 310 pF1KE6 TCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS-DMDDVPERGLISD ::.:..:: ::.:::::::.::: ::.:::..:.: . .: .::: ... .: .::.:. NP_001 TCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSS 320 330 340 350 360 370 320 330 340 350 360 370 pF1KE6 AQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLP .. ..::: ... . ..::.:::.. .:. ::. .:: ... : : :. . ::: : NP_001 GKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDP 380 390 400 410 420 430 380 390 400 410 420 430 pF1KE6 GYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDC ::.:: . :::::: .:.::.:::::.:.:.::... :::::::.::. :. :::: NP_001 GYTLEQGSI--IIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDC 440 450 460 470 480 490 440 450 460 470 480 490 pF1KE6 VWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLT .:::::.:.:::.:....: . ::.::..::: .::::.: ::. . .:..: :.: NP_001 IWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVT 500 510 520 530 540 550 500 510 520 530 540 550 pF1KE6 LQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCE .:::. :: : ::::.:: :::::::::::: ::.. :. .:..:::.:::: NP_001 IQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCY 560 570 580 590 600 610 560 570 580 590 600 610 pF1KE6 PGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRC :::...::..: :::::.:: :.::.. .: :::.. ...: :. ::::. ::: : NP_001 PGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYIC 620 630 640 650 660 670 620 630 640 650 660 670 pF1KE6 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCAL-KYEPCLNPGVPENGYQTLYKHHYQAG :. : :...:::..:..:.::::::.::: : . .:: . ..:::: .. :. . :: NP_001 DQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAG 680 690 700 710 720 730 680 690 700 710 720 730 pF1KE6 ESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVA-YEELLDNRKLEVTQTTDPSR ...: : :. : :...: :::::::.:.. ::.:..: . . ..:.:.:... : NP_001 ATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASS 740 750 760 770 780 790 740 750 760 770 780 790 pF1KE6 QLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHS--YSPITVESDFSNP :.....: ::.::: ...: .:::.:...::::: . . . :. ::.:: :.:: NP_001 TLDAAHIAAAIFLPLVAMVLLVGGVYFYFSRLQGKSSLQLPRPRPRPYNRITIESAFDNP 800 810 820 830 840 850 800 pF1KE6 LYEAGDTREYEVSI ::.: NP_001 TYETGSLSFAGDERI 860 809 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 15:47:49 2016 done: Tue Nov 8 15:47:50 2016 Total Scan time: 11.480 Total Display time: 0.210 Function used was FASTA [36.3.4 Apr, 2011]