FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1452, 249 aa 1>>>pF1KE1452 249 - 249 aa - 249 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.4389+/-0.000317; mu= 5.4952+/- 0.020 mean_var=131.5051+/-25.763, 0's: 0 Z-trim(119.7): 25 B-trim: 0 in 0/56 Lambda= 0.111841 statistics sampled from 33930 (33955) to 33930 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.752), E-opt: 0.2 (0.398), width: 16 Scan time: 7.220 The best scores are: opt bits E(85289) NP_006254 (OMIM: 600654) proteasome activator comp ( 249) 1634 274.2 1.5e-73 NP_001268457 (OMIM: 600654) proteasome activator c ( 233) 1468 247.4 1.6e-65 NP_788955 (OMIM: 600654) proteasome activator comp ( 250) 1468 247.4 1.7e-65 NP_001268458 (OMIM: 600654) proteasome activator c ( 236) 1025 175.9 5.4e-44 NP_005780 (OMIM: 605129) proteasome activator comp ( 254) 679 120.1 3.7e-27 NP_001253974 (OMIM: 605129) proteasome activator c ( 265) 657 116.6 4.5e-26 NP_002809 (OMIM: 602161) proteasome activator comp ( 239) 547 98.8 9.1e-21 XP_006720276 (OMIM: 602161) PREDICTED: proteasome ( 162) 542 97.9 1.1e-20 NP_001317158 (OMIM: 605129) proteasome activator c ( 193) 498 90.9 1.8e-18 NP_789839 (OMIM: 605129) proteasome activator comp ( 267) 396 74.5 2.1e-13 >>NP_006254 (OMIM: 600654) proteasome activator complex (249 aa) initn: 1634 init1: 1634 opt: 1634 Z-score: 1441.5 bits: 274.2 E(85289): 1.5e-73 Smith-Waterman score: 1634; 100.0% identity (100.0% similar) in 249 aa overlap (1-249:1-249) 10 20 30 40 50 60 pF1KE1 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKP 190 200 210 220 230 240 pF1KE1 RGETKGMIY ::::::::: NP_006 RGETKGMIY >>NP_001268457 (OMIM: 600654) proteasome activator compl (233 aa) initn: 1468 init1: 1468 opt: 1468 Z-score: 1297.2 bits: 247.4 E(85289): 1.6e-65 Smith-Waterman score: 1468; 100.0% identity (100.0% similar) in 223 aa overlap (1-223:1-223) 10 20 30 40 50 60 pF1KE1 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKP ::::::::::::::::::::::::::::::::::::::::::: NP_001 RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYVRRLCYMTSS 190 200 210 220 230 pF1KE1 RGETKGMIY >>NP_788955 (OMIM: 600654) proteasome activator complex (250 aa) initn: 1468 init1: 1468 opt: 1468 Z-score: 1296.7 bits: 247.4 E(85289): 1.7e-65 Smith-Waterman score: 1468; 100.0% identity (100.0% similar) in 223 aa overlap (1-223:1-223) 10 20 30 40 50 60 pF1KE1 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_788 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_788 LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_788 IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKP ::::::::::::::::::::::::::::::::::::::::::: NP_788 RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYVRRQGQGRGGQRQLSQA 190 200 210 220 230 240 pF1KE1 RGETKGMIY NP_788 THSLTLQARG 250 >>NP_001268458 (OMIM: 600654) proteasome activator compl (236 aa) initn: 1021 init1: 1021 opt: 1025 Z-score: 910.8 bits: 175.9 E(85289): 5.4e-44 Smith-Waterman score: 1519; 94.8% identity (94.8% similar) in 249 aa overlap (1-249:1-236) 10 20 30 40 50 60 pF1KE1 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE ::::::::::::::::::::::::::::::::: :::::::::::::: NP_001 IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQ-------------LEGFHTQISKYFSE 130 140 150 160 190 200 210 220 230 240 pF1KE1 RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKP 170 180 190 200 210 220 pF1KE1 RGETKGMIY ::::::::: NP_001 RGETKGMIY 230 >>NP_005780 (OMIM: 605129) proteasome activator complex (254 aa) initn: 672 init1: 473 opt: 679 Z-score: 608.6 bits: 120.1 E(85289): 3.7e-27 Smith-Waterman score: 679; 40.9% identity (74.2% similar) in 252 aa overlap (2-249:3-254) 10 20 30 40 50 pF1KE1 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKA ..:.:. :.. ::: ::: . ...:.:....::::. :::.::::: :: .:..... NP_005 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 PLDIPVPDPVKEKEKEE--RKKQQEKEDKDEKKKGEDEDKG--PPCGPVNCNEKIVVLLQ ...:::::. .... .:. :: ... . : : : .. :...: ... NP_005 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 RLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQIS ..::::. .::. : : :.:: ::::::::::::..::.. . ..... .. ::: NP_005 KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 KYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFE .:. :. :.: :: ::: :::. : :.:: :: ..::.. :.:: :..:.:.::::.: NP_005 RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE 190 200 210 220 230 240 240 pF1KE1 KLKKPRGETKGMIY :.:.::. . .: NP_005 KIKRPRSSNAETLY 250 >>NP_001253974 (OMIM: 605129) proteasome activator compl (265 aa) initn: 672 init1: 473 opt: 657 Z-score: 589.1 bits: 116.6 E(85289): 4.5e-26 Smith-Waterman score: 657; 41.5% identity (73.9% similar) in 241 aa overlap (13-249:25-265) 10 20 30 40 pF1KE1 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPA ::: ::: . ...:.:....::::. :::.::::: NP_001 MEKWILKKIKYLQSGGLSASYYSYKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPI 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 LNEANLSNLKAPLDIPVPDPVKEKEKEE--RKKQQEKEDKDEKKKGEDEDKG--PPCGPV :: .:..... ...:::::. .... .:. :: ... . : : : . NP_001 LNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGML 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE1 NCNEKIVVLLQRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLH . :...: .....::::. .::. : : :.:: ::::::::::::..::.. . ... NP_001 KSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVE 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE1 TKLEGFHTQISKYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYA .. .. :::.:. :. :.: :: ::: :::. : :.:: :: ..::.. :.:: :. NP_001 SEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYV 190 200 210 220 230 240 230 240 pF1KE1 VLYDIILKNFEKLKKPRGETKGMIY .:.:.::::.::.:.::. . .: NP_001 TLHDMILKNIEKIKRPRSSNAETLY 250 260 >>NP_002809 (OMIM: 602161) proteasome activator complex (239 aa) initn: 763 init1: 536 opt: 547 Z-score: 493.9 bits: 98.8 E(85289): 9.1e-21 Smith-Waterman score: 736; 48.0% identity (74.0% similar) in 246 aa overlap (4-249:7-239) 10 20 30 40 50 pF1KE1 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNL .:.. ::. .:.:::..: ..:..: ..:.:: :. .:.: .:: :.:..: NP_002 MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 KAPLDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRL .::::::.::: . .. : ::..:: . :: . :::.. :: . NP_002 RAPLDIPIPDPPPKDDEMETDKQEKKEVHK-------------CGFLPGNEKVLSLLALV 70 80 90 100 120 130 140 150 160 170 pF1KE1 KPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKY :::. . :. :: ::.: ::.:::::.::::.::::.: .....::.:.:.: :::: NP_002 KPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKY 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 FSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKL ::::::::.::.:. :: ::: :::: ::: : ..: ::...: :: :: :: .:.::. NP_002 FSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKI 170 180 190 200 210 220 240 pF1KE1 KKPRGETKGMIY .:.:: : .: NP_002 VNPKGEEKPSMY 230 >>XP_006720276 (OMIM: 602161) PREDICTED: proteasome acti (162 aa) initn: 555 init1: 536 opt: 542 Z-score: 492.0 bits: 97.9 E(85289): 1.1e-20 Smith-Waterman score: 542; 53.3% identity (75.8% similar) in 165 aa overlap (85-249:4-162) 60 70 80 90 100 110 pF1KE1 SNLKAPLDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLL ::.:::. . :: . :::.. :: XP_006 METDKQEKKEVHK------CGFLPGNEKVLSLL 10 20 120 130 140 150 160 170 pF1KE1 QRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQI .:::. . :. :: ::.: ::.:::::.::::.::::.: .....::.:.:.: : XP_006 ALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTI 30 40 50 60 70 80 180 190 200 210 220 230 pF1KE1 SKYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNF :::::::::::.::.:. :: ::: :::: ::: : ..: ::...: :: :: :: .:. XP_006 SKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNL 90 100 110 120 130 140 240 pF1KE1 EKLKKPRGETKGMIY ::. .:.:: : .: XP_006 EKIVNPKGEEKPSMY 150 160 >>NP_001317158 (OMIM: 605129) proteasome activator compl (193 aa) initn: 506 init1: 473 opt: 498 Z-score: 452.5 bits: 90.9 E(85289): 1.8e-18 Smith-Waterman score: 498; 39.9% identity (71.5% similar) in 193 aa overlap (61-249:1-193) 40 50 60 70 80 pF1KE1 SYFPKKISELDAFLKEPALNEANLSNLKAPLDIPVPDPVKEKEKEE--RKKQQEKEDKDE ...:::::. .... .:. :: NP_001 MNLPVPDPILLTNSHDGLDGPTYKKRRLDE 10 20 30 90 100 110 120 130 140 pF1KE1 KKKGEDEDKG--PPCGPVNCNEKIVVLLQRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGN ... . : : : .. :...: .....::::. .::. : : :.:: :::::::: NP_001 CEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGN 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE1 NFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSERGDAVTKAAKQPHVGDYRQLVHELDE ::::..::.. . ..... .. :::.:. :. :.: :: ::: :::. : :.:: NP_001 NFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDE 100 110 120 130 140 150 210 220 230 240 pF1KE1 AEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKPRGETKGMIY :: ..::.. :.:: :..:.:.::::.::.:.::. . .: NP_001 KEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY 160 170 180 190 >>NP_789839 (OMIM: 605129) proteasome activator complex (267 aa) initn: 644 init1: 392 opt: 396 Z-score: 361.5 bits: 74.5 E(85289): 2.1e-13 Smith-Waterman score: 643; 38.9% identity (70.6% similar) in 265 aa overlap (2-249:3-267) 10 20 30 40 50 pF1KE1 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKA ..:.:. :.. ::: ::: . ...:.:....::::. :::.::::: :: .:..... NP_789 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 PLDIPVPDPVKEKEKEE--RKKQQEKEDKDEKKKGEDEDKG--PPCGPVNCNEKIVVLLQ ...:::::. .... .:. :: ... . : : : .. :...: ... NP_789 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE 70 80 90 100 110 120 120 130 140 150 160 pF1KE1 RLKPEIKDVIEQLNL-------------VTTWLQLQIPRIEDGNNFGVAVQEKVFELMTS ..::::. .::. : : :.:: ::::::::::::..::.. . . NP_789 KVKPEIRLLIEKCNTPSGKGPHICFDLQVKMWVQLLIPRIEDGNNFGVSIQEETVAELRT 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE1 LHTKLEGFHTQISKYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNA .... .. :::.:. :. :.: :: ::: :::. : :.:: :: ..::.. :.:: NP_789 VESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQ 190 200 210 220 230 240 230 240 pF1KE1 YAVLYDIILKNFEKLKKPRGETKGMIY :..:.:.::::.::.:.::. . .: NP_789 YVTLHDMILKNIEKIKRPRSSNAETLY 250 260 249 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 03:06:20 2016 done: Mon Nov 7 03:06:21 2016 Total Scan time: 7.220 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]