FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3583, 418 aa 1>>>pF1KE3583 418 - 418 aa - 418 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2914+/-0.000395; mu= 13.5665+/- 0.025 mean_var=107.2646+/-21.958, 0's: 0 Z-trim(114.1): 181 B-trim: 683 in 1/53 Lambda= 0.123836 statistics sampled from 23508 (23700) to 23508 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.645), E-opt: 0.2 (0.278), width: 16 Scan time: 9.090 The best scores are: opt bits E(85289) NP_006494 (OMIM: 602707) 26S protease regulatory s ( 418) 2693 492.0 1.2e-138 NP_694546 (OMIM: 602707) 26S protease regulatory s ( 387) 2227 408.7 1.3e-113 NP_002793 (OMIM: 602706) 26S protease regulatory s ( 440) 1311 245.1 2.5e-64 XP_016876959 (OMIM: 602706) PREDICTED: 26S proteas ( 367) 1296 242.4 1.4e-63 NP_001317141 (OMIM: 602706) 26S protease regulator ( 367) 1296 242.4 1.4e-63 NP_001186092 (OMIM: 601681) 26S protease regulator ( 398) 1052 198.8 2e-50 NP_002796 (OMIM: 601681) 26S protease regulatory s ( 406) 1052 198.8 2e-50 NP_002797 (OMIM: 602708) 26S protease regulatory s ( 403) 1029 194.7 3.5e-49 NP_002795 (OMIM: 186852) 26S protease regulatory s ( 439) 1018 192.8 1.5e-48 XP_016873515 (OMIM: 186852) PREDICTED: 26S proteas ( 461) 977 185.5 2.4e-46 NP_002794 (OMIM: 154365) 26S protease regulatory s ( 433) 960 182.4 1.9e-45 XP_016876961 (OMIM: 602708) PREDICTED: 26S proteas ( 288) 886 169.1 1.3e-41 NP_009057 (OMIM: 167320,601023,613954,616687) tran ( 806) 654 127.9 8.8e-29 XP_011523903 (OMIM: 604581,610246,614487) PREDICTE ( 730) 630 123.6 1.6e-27 NP_006787 (OMIM: 604581,610246,614487) AFG3-like p ( 797) 630 123.6 1.7e-27 NP_001230075 (OMIM: 602426) nuclear valosin-contai ( 667) 605 119.1 3.3e-26 XP_011542502 (OMIM: 602426) PREDICTED: nuclear val ( 765) 605 119.2 3.7e-26 XP_011542501 (OMIM: 602426) PREDICTED: nuclear val ( 765) 605 119.2 3.7e-26 XP_011542500 (OMIM: 602426) PREDICTED: nuclear val ( 777) 605 119.2 3.7e-26 XP_016856871 (OMIM: 602426) PREDICTED: nuclear val ( 839) 605 119.2 3.9e-26 XP_016856870 (OMIM: 602426) PREDICTED: nuclear val ( 839) 605 119.2 3.9e-26 XP_011542498 (OMIM: 602426) PREDICTED: nuclear val ( 883) 605 119.2 4.1e-26 XP_016856869 (OMIM: 602426) PREDICTED: nuclear val ( 889) 605 119.2 4.1e-26 XP_016856867 (OMIM: 602426) PREDICTED: nuclear val ( 917) 605 119.2 4.2e-26 XP_016879087 (OMIM: 602783,607259) PREDICTED: para ( 561) 584 115.3 3.9e-25 XP_016879086 (OMIM: 602783,607259) PREDICTED: para ( 618) 584 115.3 4.2e-25 NP_003110 (OMIM: 602783,607259) paraplegin isoform ( 795) 584 115.4 5.1e-25 XP_006721327 (OMIM: 602783,607259) PREDICTED: para ( 809) 584 115.4 5.1e-25 XP_016856875 (OMIM: 602426) PREDICTED: nuclear val ( 738) 572 113.3 2.1e-24 NP_996671 (OMIM: 602426) nuclear valosin-containin ( 750) 572 113.3 2.1e-24 NP_001230076 (OMIM: 602426) nuclear valosin-contai ( 765) 572 113.3 2.2e-24 XP_016856872 (OMIM: 602426) PREDICTED: nuclear val ( 812) 572 113.3 2.3e-24 NP_002524 (OMIM: 602426) nuclear valosin-containin ( 856) 572 113.3 2.4e-24 XP_016856868 (OMIM: 602426) PREDICTED: nuclear val ( 890) 572 113.3 2.4e-24 NP_001304728 (OMIM: 613940,616577) spermatogenesis ( 695) 558 110.7 1.1e-23 XP_011529981 (OMIM: 613940,616577) PREDICTED: sper ( 790) 558 110.8 1.3e-23 XP_016863317 (OMIM: 613940,616577) PREDICTED: sper ( 819) 558 110.8 1.3e-23 NP_001332785 (OMIM: 613940,616577) spermatogenesis ( 892) 558 110.8 1.4e-23 NP_660208 (OMIM: 613940,616577) spermatogenesis-as ( 893) 558 110.8 1.4e-23 XP_016863319 (OMIM: 613940,616577) PREDICTED: sper ( 593) 544 108.2 5.7e-23 NP_001303242 (OMIM: 601498,614862,614863,616617) p ( 892) 542 108.0 1e-22 XP_016863318 (OMIM: 613940,616577) PREDICTED: sper ( 765) 541 107.7 1e-22 XP_011512963 (OMIM: 601498,614862,614863,616617) P ( 952) 542 108.0 1.1e-22 XP_016863316 (OMIM: 613940,616577) PREDICTED: sper ( 823) 541 107.8 1.1e-22 NP_000278 (OMIM: 601498,614862,614863,616617) pero ( 980) 542 108.0 1.1e-22 XP_016863315 (OMIM: 613940,616577) PREDICTED: sper ( 859) 541 107.8 1.1e-22 XP_011529980 (OMIM: 613940,616577) PREDICTED: sper ( 916) 541 107.8 1.2e-22 XP_016863314 (OMIM: 613940,616577) PREDICTED: sper ( 917) 541 107.8 1.2e-22 XP_016867808 (OMIM: 214100,234580,601539,602136) P ( 700) 537 107.0 1.5e-22 NP_001269607 (OMIM: 214100,234580,601539,602136) p (1075) 537 107.1 2.2e-22 >>NP_006494 (OMIM: 602707) 26S protease regulatory subun (418 aa) initn: 2693 init1: 2693 opt: 2693 Z-score: 2610.4 bits: 492.0 E(85289): 1.2e-138 Smith-Waterman score: 2693; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KE3 MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 IKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 IKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTID 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 RELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 VELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 GEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDL 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK 370 380 390 400 410 >>NP_694546 (OMIM: 602707) 26S protease regulatory subun (387 aa) initn: 2208 init1: 2208 opt: 2227 Z-score: 2161.0 bits: 408.7 E(85289): 1.3e-113 Smith-Waterman score: 2425; 92.6% identity (92.6% similar) in 418 aa overlap (1-418:1-387) 10 20 30 40 50 60 pF1KE3 MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEY ::::::::::::::::::::::::::::::::::::::::::::: NP_694 MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYK--------------- 10 20 30 40 70 80 90 100 110 120 pF1KE3 IKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTID :::::::::::::::::::::::::::::::::::::::::::: NP_694 ----------------EEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTID 50 60 70 80 130 140 150 160 170 180 pF1KE3 RELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 RELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREA 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE3 VELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 VELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYL 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE3 GEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 GEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFD 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE3 QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDL 270 280 290 300 310 320 370 380 390 400 410 pF1KE3 EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK 330 340 350 360 370 380 >>NP_002793 (OMIM: 602706) 26S protease regulatory subun (440 aa) initn: 1255 init1: 1226 opt: 1311 Z-score: 1275.7 bits: 245.1 E(85289): 2.5e-64 Smith-Waterman score: 1311; 50.7% identity (83.2% similar) in 369 aa overlap (46-412:64-432) 20 30 40 50 60 70 pF1KE3 PALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQ--KNLKKEFL ::.. ..: ..::.:.... : :... NP_002 GKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQE 40 50 60 70 80 90 80 90 100 110 120 130 pF1KE3 HAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALH . . .: ... :. .: . : .:.: :::....::..:: ::: .:..::.:. :: :. NP_002 EERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLN 100 110 120 130 140 150 140 150 160 170 180 190 pF1KE3 KHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQ .. .:.. :: ..: . .. .. :. ::::::.: : ::..:.::::::: : :.. NP_002 HKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEE 160 170 180 190 200 210 200 210 220 230 240 250 pF1KE3 IGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRL .:: ::.::..::::: :::.::::::..:.:.:.::::::..:::::.::..::..::. NP_002 MGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRV 220 230 240 250 260 270 260 270 280 290 300 310 pF1KE3 AKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNR :.:.::.:.::::::::.:::.:...:..::.:: .::::::.::::. .::::::::: NP_002 AEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNR 280 290 300 310 320 330 320 330 340 350 360 370 pF1KE3 ADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGA .::::::.::::.::::::::::.. :. ::. ::.:.:...: :.: . : .::: NP_002 IETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGA 340 350 360 370 380 390 380 390 400 410 pF1KE3 DINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK ::..:: :.:..:.:: :. : .::.:. ..:. : .. NP_002 DIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL 400 410 420 430 440 >>XP_016876959 (OMIM: 602706) PREDICTED: 26S protease re (367 aa) initn: 1255 init1: 1226 opt: 1296 Z-score: 1262.4 bits: 242.4 E(85289): 1.4e-63 Smith-Waterman score: 1296; 51.3% identity (83.6% similar) in 359 aa overlap (56-412:1-359) 30 40 50 60 70 80 pF1KE3 GLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQ--KNLKKEFLHAQEEVKRIQ ..::.:.... : :... . . .: .. XP_016 MEEEFIRNQEQMKPLEEKQEEERSKVDDLR 10 20 30 90 100 110 120 130 140 pF1KE3 SIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVL . :. .: . : .:.: :::....::..:: ::: .:..::.:. :: :... .:.. :: XP_016 GTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVL 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE3 PPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVL ..: . .. .. :. ::::::.: : ::..:.::::::: : :...:: ::.::. XP_016 MDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVI 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE3 MYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIF .::::: :::.::::::..:.:.:.::::::..:::::.::..::..::.:.:.::.:.: XP_016 LYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVF 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE3 IDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLR :::::::.:::.:...:..::.:: .::::::.::::. .::::::::: .::::::.: XP_016 IDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIR 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE3 PGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESG :::.::::::::::.. :. ::. ::.:.:...: :.: . : .:::::..:: :.: XP_016 PGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAG 280 290 300 310 320 330 390 400 410 pF1KE3 MLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK ..:.:: :. : .::.:. ..:. : .. XP_016 LMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL 340 350 360 >>NP_001317141 (OMIM: 602706) 26S protease regulatory su (367 aa) initn: 1255 init1: 1226 opt: 1296 Z-score: 1262.4 bits: 242.4 E(85289): 1.4e-63 Smith-Waterman score: 1296; 51.3% identity (83.6% similar) in 359 aa overlap (56-412:1-359) 30 40 50 60 70 80 pF1KE3 GLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQ--KNLKKEFLHAQEEVKRIQ ..::.:.... : :... . . .: .. NP_001 MEEEFIRNQEQMKPLEEKQEEERSKVDDLR 10 20 30 90 100 110 120 130 140 pF1KE3 SIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVL . :. .: . : .:.: :::....::..:: ::: .:..::.:. :: :... .:.. :: NP_001 GTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVL 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE3 PPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVL ..: . .. .. :. ::::::.: : ::..:.::::::: : :...:: ::.::. NP_001 MDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVI 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE3 MYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIF .::::: :::.::::::..:.:.:.::::::..:::::.::..::..::.:.:.::.:.: NP_001 LYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVF 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE3 IDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLR :::::::.:::.:...:..::.:: .::::::.::::. .::::::::: .::::::.: NP_001 IDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIR 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE3 PGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESG :::.::::::::::.. :. ::. ::.:.:...: :.: . : .:::::..:: :.: NP_001 PGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAG 280 290 300 310 320 330 390 400 410 pF1KE3 MLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK ..:.:: :. : .::.:. ..:. : .. NP_001 LMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL 340 350 360 >>NP_001186092 (OMIM: 601681) 26S protease regulatory su (398 aa) initn: 1003 init1: 1003 opt: 1052 Z-score: 1026.3 bits: 198.8 E(85289): 2e-50 Smith-Waterman score: 1054; 43.5% identity (71.8% similar) in 379 aa overlap (48-414:14-390) 20 30 40 50 60 70 pF1KE3 LSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQ- : : .: . ..:...::.. :.:: NP_001 MELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRR--LQAQR 10 20 30 40 80 90 100 110 120 pF1KE3 -----------EEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLK ::.. .: .:. ..:.:.. ..: ... : . ..:: . . NP_001 NELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVT 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE3 PNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPL :: :::.. : .: .:: ..: . .. .. :: : :::.: : .:..:..:::. NP_001 PNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPV 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE3 THFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPR : ::.. .:: :.:::.::::: :::.::.:::::: .:::: :::.:::..::: : NP_001 KHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGAR 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE3 MVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNV :::..: .:.:.::.:::.::::.:...:... .:.: :::: .::::::.:::. . :. NP_001 MVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNI 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE3 KVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVA :::::::: : :: :::::::.::::::: :... . :.. . ::::.. ..:. . NP_001 KVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAE 290 300 310 320 330 340 370 380 390 400 410 pF1KE3 RPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK :::.....: :.:: :.:: : : .::: : :..:: ... NP_001 LMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK 350 360 370 380 390 >>NP_002796 (OMIM: 601681) 26S protease regulatory subun (406 aa) initn: 1045 init1: 1003 opt: 1052 Z-score: 1026.2 bits: 198.8 E(85289): 2e-50 Smith-Waterman score: 1073; 42.5% identity (70.8% similar) in 400 aa overlap (27-414:1-398) 10 20 30 40 50 60 pF1KE3 MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEY ... ::: .::. . : : .: . NP_002 MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLI 10 20 30 70 80 90 100 pF1KE3 IKDEQKNLKKEFLHAQ------------EEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTG ..:...::.. :.:: ::.. .: .:. ..:.:.. ..: NP_002 VNDKSQNLRR--LQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPE 40 50 60 70 80 90 110 120 130 140 150 160 pF1KE3 SNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIG ... : . ..:: . . :: :::.. : .: .:: ..: . .. .. :: : :: NP_002 GKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIG 100 110 120 130 140 150 170 180 190 200 210 220 pF1KE3 GMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFI :.: : .:..:..:::. : ::.. .:: :.:::.::::: :::.::.:::::: .:: NP_002 GLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFI 160 170 180 190 200 210 230 240 250 260 270 280 pF1KE3 RVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRI :: :::.:::..::: ::::..: .:.:.::.:::.::::.:...:... .:.: :::: NP_002 RVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRT 220 230 240 250 260 270 290 300 310 320 330 340 pF1KE3 LLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTI .::::::.:::. . :.:::::::: : :: :::::::.::::::: :... . :.. NP_002 MLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIH 280 290 300 310 320 330 350 360 370 380 390 400 pF1KE3 TSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIK . ::::.. ..:. . :::.....: :.:: :.:: : : .::: : :.. NP_002 SRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQ 340 350 360 370 380 390 410 pF1KE3 KDEQEHEFYK :: ... NP_002 KDSEKNMSIKKLWK 400 >>NP_002797 (OMIM: 602708) 26S protease regulatory subun (403 aa) initn: 1025 init1: 975 opt: 1029 Z-score: 1004.0 bits: 194.7 E(85289): 3.5e-49 Smith-Waterman score: 1029; 41.6% identity (72.9% similar) in 387 aa overlap (33-418:17-401) 10 20 30 40 50 60 pF1KE3 EIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIK .:.: . : . ::: .. : .. . . .. NP_002 MAIPGIPYERRLLIMADPRD-KALQDYRKKLLEHKE-IDGRLKELR 10 20 30 40 70 80 90 100 110 120 pF1KE3 DEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRE .. :.: :.. ......: .::. ..:. :. . .. :: .:.: : : .:. NP_002 EQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKS 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE3 LLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVE :::.. ::: . ... :: :.: .. .. .. .: :..:::.. : .:.::..: NP_002 KLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIE 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE3 LPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGE ::::. ::....:: ::.: :.::::: :::.::.::: . :..::.: .:.::.:: NP_002 LPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGE 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE3 GPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQN . :..:..: :... : :::.::::::. .::. :.::::.:: :.:::::::::: NP_002 SARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTL 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE3 VNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLED ::.:::::: :::::::::::::::::.. ::... . :.. .. .. :.: : NP_002 HRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEA 290 300 310 320 330 340 370 380 390 400 410 pF1KE3 YVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEF-YK : : ..:::. ..: :.::.:.: .. .:. .:: :: . : . . : .. :: NP_002 IVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV 350 360 370 380 390 400 >>NP_002795 (OMIM: 186852) 26S protease regulatory subun (439 aa) initn: 959 init1: 959 opt: 1018 Z-score: 992.8 bits: 192.8 E(85289): 1.5e-48 Smith-Waterman score: 1049; 40.2% identity (72.5% similar) in 400 aa overlap (38-417:39-438) 10 20 30 40 50 60 pF1KE3 VEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKN :.. .: . :..:..... . . : . NP_002 SPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQA 10 20 30 40 50 60 70 80 90 100 pF1KE3 LKKEFLHAQEEVKRIQSIPLVIGQFLEA--VDQNT------------------AIVGSTT .: .. . .:..: ...: .... .: :: : :.. ..: NP_002 MKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTST 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 GSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADI ..:.. ... .: : :::. :...: : ....:: : :: . . :..: .:.:: NP_002 RQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDI 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 GGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAF ::.: : ::. ::. ::..: : ....::.::.::::::::: :::.::.: : .: :.: NP_002 GGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATF 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE3 IRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQR ....: ..:: ..:.: ..:::.: ::::.::.::::::.:::.:::::.. ..:::::: NP_002 LKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQR 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE3 ILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFST .::::::.:::. :..:::: ::::.: ::::::: ::::::::::.:... . :.. NP_002 TMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQI 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE3 ITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVI . :::.: .:. :. . : ..::. ...: :.::.:.:.. . .:. .. : NP_002 HSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQ 370 380 390 400 410 420 410 pF1KE3 KKDEQEHEFYK : . . ..: NP_002 AKKKANLQYYA 430 >>XP_016873515 (OMIM: 186852) PREDICTED: 26S protease re (461 aa) initn: 929 init1: 929 opt: 977 Z-score: 953.0 bits: 185.5 E(85289): 2.4e-46 Smith-Waterman score: 1008; 42.2% identity (73.5% similar) in 370 aa overlap (38-385:39-408) 10 20 30 40 50 60 pF1KE3 VEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKN :.. .: . :..:..... . . : . XP_016 SPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQA 10 20 30 40 50 60 70 80 90 100 pF1KE3 LKKEFLHAQEEVKRIQSIPLVIGQFLEA--VDQNT------------------AIVGSTT .: .. . .:..: ...: .... .: :: : :.. ..: XP_016 MKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTST 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 GSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADI ..:.. ... .: : :::. :...: : ....:: : :: . . :..: .:.:: XP_016 RQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDI 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 GGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAF ::.: : ::. ::. ::..: : ....::.::.::::::::: :::.::.: : .: :.: XP_016 GGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATF 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE3 IRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQR ....: ..:: ..:.: ..:::.: ::::.::.::::::.:::.:::::.. ..:::::: XP_016 LKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQR 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE3 ILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFST .::::::.:::. :..:::: ::::.: ::::::: ::::::::::.:... . :.. XP_016 TMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQI 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE3 ITSKMNLSEEVDLEDYVARPDKISGADINSICQE--SGMLAVRENRYIVLAKDFEKAYKT . :::.: .:. :. . : ..::. ...: : ::.: XP_016 HSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAVSGQLGWVRCFVPSCPLPGQDGGIW 370 380 390 400 410 420 410 pF1KE3 VIKKDEQEHEFYK XP_016 LVETAEGRGLSLREPGKAFRRSDLDSVCPGCRA 430 440 450 460 418 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 03:06:49 2016 done: Mon Nov 7 03:06:51 2016 Total Scan time: 9.090 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]