FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1342, 187 aa 1>>>pF1KE1342 187 - 187 aa - 187 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9513+/-0.000297; mu= 14.6798+/- 0.019 mean_var=61.2562+/-12.543, 0's: 0 Z-trim(116.0): 9 B-trim: 125 in 1/56 Lambda= 0.163870 statistics sampled from 26872 (26881) to 26872 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.71), E-opt: 0.2 (0.315), width: 16 Scan time: 5.910 The best scores are: opt bits E(85289) NP_000782 (OMIM: 126060,613839) dihydrofolate redu ( 187) 1256 304.9 4.8e-83 NP_001182572 (OMIM: 616588) dihydrofolate reductas ( 187) 1130 275.1 4.4e-74 NP_789785 (OMIM: 616588) dihydrofolate reductase, ( 187) 1130 275.1 4.4e-74 XP_011510839 (OMIM: 616588) PREDICTED: dihydrofola ( 187) 1130 275.1 4.4e-74 NP_001277283 (OMIM: 126060,613839) dihydrofolate r ( 135) 904 221.6 4.1e-58 NP_001277286 (OMIM: 126060,613839) dihydrofolate r ( 129) 825 202.9 1.7e-52 >>NP_000782 (OMIM: 126060,613839) dihydrofolate reductas (187 aa) initn: 1256 init1: 1256 opt: 1256 Z-score: 1611.9 bits: 304.9 E(85289): 4.8e-83 Smith-Waterman score: 1256; 100.0% identity (100.0% similar) in 187 aa overlap (1-187:1-187) 10 20 30 40 50 60 pF1KE1 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF 130 140 150 160 170 180 pF1KE1 EVYEKND ::::::: NP_000 EVYEKND >>NP_001182572 (OMIM: 616588) dihydrofolate reductase, m (187 aa) initn: 1130 init1: 1130 opt: 1130 Z-score: 1450.9 bits: 275.1 E(85289): 4.4e-74 Smith-Waterman score: 1130; 93.4% identity (96.2% similar) in 183 aa overlap (5-187:5-187) 10 20 30 40 50 60 pF1KE1 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS :::::::::::::::::::: :::::::::::::::::::::::::::::.::::: NP_001 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS ::::::::: ::::::::::::::::::::.:::::::::::.:::::::::.::::::: NP_001 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF :::::::: :::::::::::::::::::: :::::::::::::::::::::: : ::::: NP_001 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF 130 140 150 160 170 180 pF1KE1 EVYEKND :: ::.: NP_001 EVCEKDD >>NP_789785 (OMIM: 616588) dihydrofolate reductase, mito (187 aa) initn: 1130 init1: 1130 opt: 1130 Z-score: 1450.9 bits: 275.1 E(85289): 4.4e-74 Smith-Waterman score: 1130; 93.4% identity (96.2% similar) in 183 aa overlap (5-187:5-187) 10 20 30 40 50 60 pF1KE1 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS :::::::::::::::::::: :::::::::::::::::::::::::::::.::::: NP_789 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS ::::::::: ::::::::::::::::::::.:::::::::::.:::::::::.::::::: NP_789 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF :::::::: :::::::::::::::::::: :::::::::::::::::::::: : ::::: NP_789 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF 130 140 150 160 170 180 pF1KE1 EVYEKND :: ::.: NP_789 EVCEKDD >>XP_011510839 (OMIM: 616588) PREDICTED: dihydrofolate r (187 aa) initn: 1130 init1: 1130 opt: 1130 Z-score: 1450.9 bits: 275.1 E(85289): 4.4e-74 Smith-Waterman score: 1130; 93.4% identity (96.2% similar) in 183 aa overlap (5-187:5-187) 10 20 30 40 50 60 pF1KE1 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS :::::::::::::::::::: :::::::::::::::::::::::::::::.::::: XP_011 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS ::::::::: ::::::::::::::::::::.:::::::::::.:::::::::.::::::: XP_011 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF :::::::: :::::::::::::::::::: :::::::::::::::::::::: : ::::: XP_011 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF 130 140 150 160 170 180 pF1KE1 EVYEKND :: ::.: XP_011 EVCEKDD >>NP_001277283 (OMIM: 126060,613839) dihydrofolate reduc (135 aa) initn: 904 init1: 904 opt: 904 Z-score: 1164.2 bits: 221.6 E(85289): 4.1e-58 Smith-Waterman score: 904; 100.0% identity (100.0% similar) in 135 aa overlap (53-187:1-135) 30 40 50 60 70 80 pF1KE1 LPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKE :::::::::::::::::::::::::::::: NP_001 MGKKTWFSIPEKNRPLKGRINLVLSRELKE 10 20 30 90 100 110 120 130 140 pF1KE1 PPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQD 40 50 60 70 80 90 150 160 170 180 pF1KE1 FESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND ::::::::::::::::::::::::::::::::::::::::::::: NP_001 FESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 100 110 120 130 >>NP_001277286 (OMIM: 126060,613839) dihydrofolate reduc (129 aa) initn: 825 init1: 825 opt: 825 Z-score: 1063.6 bits: 202.9 E(85289): 1.7e-52 Smith-Waterman score: 825; 100.0% identity (100.0% similar) in 123 aa overlap (1-123:1-123) 10 20 30 40 50 60 pF1KE1 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF ::: NP_001 VYKIPRCSL 187 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 03:08:33 2016 done: Mon Nov 7 03:08:34 2016 Total Scan time: 5.910 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]