FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6304, 443 aa 1>>>pF1KE6304 443 - 443 aa - 443 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3854+/-0.000332; mu= 17.5608+/- 0.021 mean_var=76.0766+/-15.053, 0's: 0 Z-trim(116.1): 12 B-trim: 22 in 1/53 Lambda= 0.147045 statistics sampled from 27038 (27050) to 27038 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.691), E-opt: 0.2 (0.317), width: 16 Scan time: 8.610 The best scores are: opt bits E(85289) NP_001294 (OMIM: 220110,256000,602125) protoheme I ( 443) 3007 647.3 2.3e-185 XP_016863520 (OMIM: 146500,607426,609825) PREDICTE ( 303) 193 50.2 8.8e-06 XP_011530169 (OMIM: 146500,607426,609825) PREDICTE ( 371) 193 50.3 1e-05 XP_011530168 (OMIM: 146500,607426,609825) PREDICTE ( 395) 193 50.3 1.1e-05 NP_056512 (OMIM: 146500,607426,609825) 4-hydroxybe ( 421) 193 50.3 1.1e-05 XP_011530165 (OMIM: 146500,607426,609825) PREDICTE ( 422) 193 50.3 1.1e-05 XP_011530164 (OMIM: 146500,607426,609825) PREDICTE ( 450) 193 50.3 1.2e-05 XP_011530162 (OMIM: 146500,607426,609825) PREDICTE ( 455) 193 50.3 1.2e-05 XP_011530161 (OMIM: 146500,607426,609825) PREDICTE ( 464) 193 50.3 1.2e-05 XP_011530159 (OMIM: 146500,607426,609825) PREDICTE ( 471) 193 50.3 1.2e-05 XP_011530157 (OMIM: 146500,607426,609825) PREDICTE ( 489) 193 50.4 1.3e-05 >>NP_001294 (OMIM: 220110,256000,602125) protoheme IX fa (443 aa) initn: 3007 init1: 3007 opt: 3007 Z-score: 3448.7 bits: 647.3 E(85289): 2.3e-185 Smith-Waterman score: 3007; 99.8% identity (100.0% similar) in 443 aa overlap (1-443:1-443) 10 20 30 40 50 60 pF1KE6 MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 VTQLNRSHNQQVRPKPEPVASPFLEKTSSGQAKAEIYEMRPLSPPSLSLSRKPNEKELIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTQLNRSHNQQVRPKPEPVASPFLEKTSSGQAKAEIYEMRPLSPPSLSLSRKPNEKELIE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 LEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILAQLSKIKLTALVVSTTAAGFALA ::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::: NP_001 LEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILARLSKIKLTALVVSTTAAGFALA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 PGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 TCCAVPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TCCAVPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 TAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 CLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLP 370 380 390 400 410 420 430 440 pF1KE6 LLLLLMLTCKRPSGGGDAGPPPS ::::::::::::::::::::::: NP_001 LLLLLMLTCKRPSGGGDAGPPPS 430 440 >>XP_016863520 (OMIM: 146500,607426,609825) PREDICTED: 4 (303 aa) initn: 148 init1: 109 opt: 193 Z-score: 224.8 bits: 50.2 E(85289): 8.8e-06 Smith-Waterman score: 193; 31.5% identity (56.8% similar) in 162 aa overlap (172-320:26-176) 150 160 170 180 190 pF1KE6 RWKEMKLQVYDLPGILAQLSKIKLTALVVSTTAAGFALAPGPF-DWPCFLLTSVGTG--L : . :.: :: : :: ..:. ::: : XP_016 MMTFAIAVYGDVVKGLGTWLLYLPCTWSIGLAAEPGCFPDW--YMLSLFGTGAIL 10 20 30 40 50 200 210 220 230 240 250 pF1KE6 ASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGV--- :. .::.... .:....:: :::.. :.:: .: . . : :.::: XP_016 MRGAGCTINDMWDQDYDKKVTRTANRPIAAGDIS-----TFQSFVFLGGQLTLALGVLLC 60 70 80 90 100 260 270 280 290 300 310 pF1KE6 -NPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAI---PPVMGWTAATGSLDAGA : . ::: ...: : .:::: : ..: ..::.: :: : .. XP_016 LNYYSIALGAGSLLLVIT-YPLMKRISY---WPQLALGLTFNWGALLGWSAIKGSCDPSV 110 120 130 140 150 160 320 330 340 350 360 pF1KE6 FL---LGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLS : ..:.... XP_016 CLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSL 170 180 190 200 210 220 >>XP_011530169 (OMIM: 146500,607426,609825) PREDICTED: 4 (371 aa) initn: 148 init1: 109 opt: 193 Z-score: 223.6 bits: 50.3 E(85289): 1e-05 Smith-Waterman score: 193; 31.5% identity (56.8% similar) in 162 aa overlap (172-320:26-176) 150 160 170 180 190 pF1KE6 RWKEMKLQVYDLPGILAQLSKIKLTALVVSTTAAGFALAPGPF-DWPCFLLTSVGTG--L : . :.: :: : :: ..:. ::: : XP_011 MMTFAIAVYGDVVKGLGTWLLYLPCTWSIGLAAEPGCFPDW--YMLSLFGTGAIL 10 20 30 40 50 200 210 220 230 240 250 pF1KE6 ASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGV--- :. .::.... .:....:: :::.. :.:: .: . . : :.::: XP_011 MRGAGCTINDMWDQDYDKKVTRTANRPIAAGDIS-----TFQSFVFLGGQLTLALGVLLC 60 70 80 90 100 260 270 280 290 300 310 pF1KE6 -NPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAI---PPVMGWTAATGSLDAGA : . ::: ...: : .:::: : ..: ..::.: :: : .. XP_011 LNYYSIALGAGSLLLVIT-YPLMKRISY---WPQLALGLTFNWGALLGWSAIKGSCDPSV 110 120 130 140 150 160 320 330 340 350 360 pF1KE6 FL---LGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLS : ..:.... XP_011 CLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSL 170 180 190 200 210 220 >>XP_011530168 (OMIM: 146500,607426,609825) PREDICTED: 4 (395 aa) initn: 177 init1: 109 opt: 193 Z-score: 223.2 bits: 50.3 E(85289): 1.1e-05 Smith-Waterman score: 193; 31.5% identity (56.8% similar) in 162 aa overlap (172-320:144-294) 150 160 170 180 190 pF1KE6 RWKEMKLQVYDLPGILAQLSKIKLTALVVSTTAAGFALAPGPF-DWPCFLLTSVGTG--L : . :.: :: : :: ..:. ::: : XP_011 VDSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDW--YMLSLFGTGAIL 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE6 ASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGV--- :. .::.... .:....:: :::.. :.:: .: . . : :.::: XP_011 MRGAGCTINDMWDQDYDKKVTRTANRPIAAGDIS-----TFQSFVFLGGQLTLALGVLLC 180 190 200 210 220 260 270 280 290 300 310 pF1KE6 -NPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAI---PPVMGWTAATGSLDAGA : . ::: ...: : .:::: : ..: ..::.: :: : .. XP_011 LNYYSIALGAGSLLLVIT-YPLMKRISY---WPQLALGLTFNWGALLGWSAIKGSCDPSV 230 240 250 260 270 280 320 330 340 350 360 pF1KE6 FL---LGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLS : ..:.... XP_011 CLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSL 290 300 310 320 330 340 >>NP_056512 (OMIM: 146500,607426,609825) 4-hydroxybenzoa (421 aa) initn: 177 init1: 109 opt: 193 Z-score: 222.8 bits: 50.3 E(85289): 1.1e-05 Smith-Waterman score: 193; 31.5% identity (56.8% similar) in 162 aa overlap (172-320:144-294) 150 160 170 180 190 pF1KE6 RWKEMKLQVYDLPGILAQLSKIKLTALVVSTTAAGFALAPGPF-DWPCFLLTSVGTG--L : . :.: :: : :: ..:. ::: : NP_056 VDSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDW--YMLSLFGTGAIL 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE6 ASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGV--- :. .::.... .:....:: :::.. :.:: .: . . : :.::: NP_056 MRGAGCTINDMWDQDYDKKVTRTANRPIAAGDIS-----TFQSFVFLGGQLTLALGVLLC 180 190 200 210 220 260 270 280 290 300 310 pF1KE6 -NPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAI---PPVMGWTAATGSLDAGA : . ::: ...: : .:::: : ..: ..::.: :: : .. NP_056 LNYYSIALGAGSLLLVIT-YPLMKRISY---WPQLALGLTFNWGALLGWSAIKGSCDPSV 230 240 250 260 270 280 320 330 340 350 360 pF1KE6 FL---LGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLS : ..:.... NP_056 CLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSL 290 300 310 320 330 340 >>XP_011530165 (OMIM: 146500,607426,609825) PREDICTED: 4 (422 aa) initn: 177 init1: 109 opt: 193 Z-score: 222.8 bits: 50.3 E(85289): 1.1e-05 Smith-Waterman score: 193; 31.5% identity (56.8% similar) in 162 aa overlap (172-320:144-294) 150 160 170 180 190 pF1KE6 RWKEMKLQVYDLPGILAQLSKIKLTALVVSTTAAGFALAPGPF-DWPCFLLTSVGTG--L : . :.: :: : :: ..:. ::: : XP_011 VDSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDW--YMLSLFGTGAIL 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE6 ASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGV--- :. .::.... .:....:: :::.. :.:: .: . . : :.::: XP_011 MRGAGCTINDMWDQDYDKKVTRTANRPIAAGDIS-----TFQSFVFLGGQLTLALGVLLC 180 190 200 210 220 260 270 280 290 300 310 pF1KE6 -NPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAI---PPVMGWTAATGSLDAGA : . ::: ...: : .:::: : ..: ..::.: :: : .. XP_011 LNYYSIALGAGSLLLVIT-YPLMKRISY---WPQLALGLTFNWGALLGWSAIKGSCDPSV 230 240 250 260 270 280 320 330 340 350 360 pF1KE6 FL---LGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLS : ..:.... XP_011 CLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSL 290 300 310 320 330 340 >>XP_011530164 (OMIM: 146500,607426,609825) PREDICTED: 4 (450 aa) initn: 177 init1: 109 opt: 193 Z-score: 222.4 bits: 50.3 E(85289): 1.2e-05 Smith-Waterman score: 193; 31.5% identity (56.8% similar) in 162 aa overlap (172-320:144-294) 150 160 170 180 190 pF1KE6 RWKEMKLQVYDLPGILAQLSKIKLTALVVSTTAAGFALAPGPF-DWPCFLLTSVGTG--L : . :.: :: : :: ..:. ::: : XP_011 VDSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDW--YMLSLFGTGAIL 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE6 ASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGV--- :. .::.... .:....:: :::.. :.:: .: . . : :.::: XP_011 MRGAGCTINDMWDQDYDKKVTRTANRPIAAGDIS-----TFQSFVFLGGQLTLALGVLLC 180 190 200 210 220 260 270 280 290 300 310 pF1KE6 -NPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAI---PPVMGWTAATGSLDAGA : . ::: ...: : .:::: : ..: ..::.: :: : .. XP_011 LNYYSIALGAGSLLLVIT-YPLMKRISY---WPQLALGLTFNWGALLGWSAIKGSCDPSV 230 240 250 260 270 280 320 330 340 350 360 pF1KE6 FL---LGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLS : ..:.... XP_011 CLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSL 290 300 310 320 330 340 >>XP_011530162 (OMIM: 146500,607426,609825) PREDICTED: 4 (455 aa) initn: 177 init1: 109 opt: 193 Z-score: 222.3 bits: 50.3 E(85289): 1.2e-05 Smith-Waterman score: 193; 31.5% identity (56.8% similar) in 162 aa overlap (172-320:144-294) 150 160 170 180 190 pF1KE6 RWKEMKLQVYDLPGILAQLSKIKLTALVVSTTAAGFALAPGPF-DWPCFLLTSVGTG--L : . :.: :: : :: ..:. ::: : XP_011 VDSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDW--YMLSLFGTGAIL 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE6 ASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGV--- :. .::.... .:....:: :::.. :.:: .: . . : :.::: XP_011 MRGAGCTINDMWDQDYDKKVTRTANRPIAAGDIS-----TFQSFVFLGGQLTLALGVLLC 180 190 200 210 220 260 270 280 290 300 310 pF1KE6 -NPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAI---PPVMGWTAATGSLDAGA : . ::: ...: : .:::: : ..: ..::.: :: : .. XP_011 LNYYSIALGAGSLLLVIT-YPLMKRISY---WPQLALGLTFNWGALLGWSAIKGSCDPSV 230 240 250 260 270 280 320 330 340 350 360 pF1KE6 FL---LGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLS : ..:.... XP_011 CLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSL 290 300 310 320 330 340 >>XP_011530161 (OMIM: 146500,607426,609825) PREDICTED: 4 (464 aa) initn: 177 init1: 109 opt: 193 Z-score: 222.2 bits: 50.3 E(85289): 1.2e-05 Smith-Waterman score: 193; 31.5% identity (56.8% similar) in 162 aa overlap (172-320:144-294) 150 160 170 180 190 pF1KE6 RWKEMKLQVYDLPGILAQLSKIKLTALVVSTTAAGFALAPGPF-DWPCFLLTSVGTG--L : . :.: :: : :: ..:. ::: : XP_011 VDSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDW--YMLSLFGTGAIL 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE6 ASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGV--- :. .::.... .:....:: :::.. :.:: .: . . : :.::: XP_011 MRGAGCTINDMWDQDYDKKVTRTANRPIAAGDIS-----TFQSFVFLGGQLTLALGVLLC 180 190 200 210 220 260 270 280 290 300 310 pF1KE6 -NPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAI---PPVMGWTAATGSLDAGA : . ::: ...: : .:::: : ..: ..::.: :: : .. XP_011 LNYYSIALGAGSLLLVIT-YPLMKRISY---WPQLALGLTFNWGALLGWSAIKGSCDPSV 230 240 250 260 270 280 320 330 340 350 360 pF1KE6 FL---LGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLS : ..:.... XP_011 CLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSL 290 300 310 320 330 340 >>XP_011530159 (OMIM: 146500,607426,609825) PREDICTED: 4 (471 aa) initn: 177 init1: 109 opt: 193 Z-score: 222.1 bits: 50.3 E(85289): 1.2e-05 Smith-Waterman score: 193; 31.5% identity (56.8% similar) in 162 aa overlap (172-320:144-294) 150 160 170 180 190 pF1KE6 RWKEMKLQVYDLPGILAQLSKIKLTALVVSTTAAGFALAPGPF-DWPCFLLTSVGTG--L : . :.: :: : :: ..:. ::: : XP_011 VDSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDW--YMLSLFGTGAIL 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE6 ASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGV--- :. .::.... .:....:: :::.. :.:: .: . . : :.::: XP_011 MRGAGCTINDMWDQDYDKKVTRTANRPIAAGDIS-----TFQSFVFLGGQLTLALGVLLC 180 190 200 210 220 260 270 280 290 300 310 pF1KE6 -NPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAI---PPVMGWTAATGSLDAGA : . ::: ...: : .:::: : ..: ..::.: :: : .. XP_011 LNYYSIALGAGSLLLVIT-YPLMKRISY---WPQLALGLTFNWGALLGWSAIKGSCDPSV 230 240 250 260 270 280 320 330 340 350 360 pF1KE6 FL---LGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLS : ..:.... XP_011 CLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSL 290 300 310 320 330 340 443 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:55:16 2016 done: Tue Nov 8 11:55:17 2016 Total Scan time: 8.610 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]