FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4455, 475 aa 1>>>pF1KE4455 475 - 475 aa - 475 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8721+/-0.000456; mu= 19.8920+/- 0.028 mean_var=68.2188+/-14.237, 0's: 0 Z-trim(110.1): 18 B-trim: 0 in 0/48 Lambda= 0.155282 statistics sampled from 18392 (18403) to 18392 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.563), E-opt: 0.2 (0.216), width: 16 Scan time: 7.830 The best scores are: opt bits E(85289) NP_001157289 (OMIM: 270400,602858) 7-dehydrocholes ( 475) 3371 764.8 0 NP_001351 (OMIM: 270400,602858) 7-dehydrocholester ( 475) 3371 764.8 0 XP_011543079 (OMIM: 270400,602858) PREDICTED: 7-de ( 456) 2277 519.7 6.5e-147 NP_003264 (OMIM: 603414) delta(14)-sterol reductas ( 418) 546 131.9 3.3e-30 XP_011542487 (OMIM: 169400,215140,600024,613471) P ( 615) 425 104.9 6.4e-22 NP_919424 (OMIM: 169400,215140,600024,613471) lami ( 615) 425 104.9 6.4e-22 NP_002287 (OMIM: 169400,215140,600024,613471) lami ( 615) 425 104.9 6.4e-22 XP_005273182 (OMIM: 169400,215140,600024,613471) P ( 573) 357 89.7 2.3e-17 NP_001264162 (OMIM: 603414) delta(14)-sterol reduc ( 391) 349 87.8 6e-17 >>NP_001157289 (OMIM: 270400,602858) 7-dehydrocholestero (475 aa) initn: 3371 init1: 3371 opt: 3371 Z-score: 4082.9 bits: 764.8 E(85289): 0 Smith-Waterman score: 3371; 100.0% identity (100.0% similar) in 475 aa overlap (1-475:1-475) 10 20 30 40 50 60 pF1KE4 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 430 440 450 460 470 >>NP_001351 (OMIM: 270400,602858) 7-dehydrocholesterol r (475 aa) initn: 3371 init1: 3371 opt: 3371 Z-score: 4082.9 bits: 764.8 E(85289): 0 Smith-Waterman score: 3371; 100.0% identity (100.0% similar) in 475 aa overlap (1-475:1-475) 10 20 30 40 50 60 pF1KE4 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 430 440 450 460 470 >>XP_011543079 (OMIM: 270400,602858) PREDICTED: 7-dehydr (456 aa) initn: 2277 init1: 2277 opt: 2277 Z-score: 2758.6 bits: 519.7 E(85289): 6.5e-147 Smith-Waterman score: 2277; 100.0% identity (100.0% similar) in 321 aa overlap (1-321:1-321) 10 20 30 40 50 60 pF1KE4 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL ::::::::::::::::::::: XP_011 HFGWYLGWGDCVWLPYLYTLQKRTRRQGVCQRQSWGLTPGRWAPEPTLLSSPWAKHRLTP 310 320 330 340 350 360 >>NP_003264 (OMIM: 603414) delta(14)-sterol reductase is (418 aa) initn: 864 init1: 427 opt: 546 Z-score: 663.3 bits: 131.9 E(85289): 3.3e-30 Smith-Waterman score: 901; 37.6% identity (63.8% similar) in 431 aa overlap (46-475:22-418) 20 30 40 50 60 70 pF1KE4 DGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDI :::. : ......: . : :: ... NP_003 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASL 10 20 30 40 50 80 90 100 110 120 130 pF1KE4 VTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVT : : .: .: .: :. :. .:. :: .::. . :: NP_003 -PG---LEVLW--SP----RALLLWLAWLGLQAALY---------LLPAR--KVAEGQEL 60 70 80 90 140 150 160 170 180 190 pF1KE4 PAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFA .: :::.:: .:: :: .. . . . . . .:: . :.. .. : : NP_003 KDKSRLRYPINGFQALVLTALL--VGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFL 100 110 120 130 140 200 210 220 230 240 250 pF1KE4 MVKGYFFPTSA-RDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLS ..:. :.:: .:: .:....: :.:::: .:::: : . :::...:.::::. NP_003 YMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRIC-FFDFKYFCELRPGLIGWVLINLA 150 160 170 180 190 200 260 270 280 290 300 310 pF1KE4 FAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWL . :. ::.. . :: ::: .: .:: : .:.: : :.:: :: ::..:..:: .:. NP_003 LLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWV 210 220 230 240 250 260 320 330 340 350 360 370 pF1KE4 PYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRK :. :.::. .:..:: :. : : . :.. .:::::: :: ::. ::.. . . : . NP_003 PFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLE 270 280 290 300 310 320 380 390 400 410 420 430 pF1KE4 PKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYII . ..: :. ::::::.::..:: ::.:::. .::. : :: .:::::::.. NP_003 ------TISTATGR----KLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLL 330 340 350 360 370 440 450 460 470 pF1KE4 YMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF :.. ::.:: :::..: .::: :..: ::::..: :. NP_003 YFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY 380 390 400 410 >>XP_011542487 (OMIM: 169400,215140,600024,613471) PREDI (615 aa) initn: 881 init1: 355 opt: 425 Z-score: 514.6 bits: 104.9 E(85289): 6.4e-22 Smith-Waterman score: 911; 35.0% identity (65.0% similar) in 449 aa overlap (31-475:203-615) 10 20 30 40 50 pF1KE4 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFA-PFIVYYFIM :: ... :. . .::..:. : ... ... XP_011 EEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLE-FGGVPGVFLIMFGLPVFLFLLLL 180 190 200 210 220 230 60 70 80 90 100 110 pF1KE4 ACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCH : : . .: ... : ..: .. .: :: .:::.: XP_011 MCKQKDPSL----LNFPPPLPALYELWET------RVFGVYLLWFLIQVLFY-------- 240 250 260 270 120 130 140 150 160 170 pF1KE4 KFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIP .:: .: . ::. : ::..::. :..:: . .. :.. ...... XP_011 -LLP--IGKVVEGTPLIDGRRLKYRLNGFYAFILTSAV--IGTSLFQGVEFHYVYSHFLQ 280 290 300 310 320 180 190 200 210 220 230 pF1KE4 LLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFF . :... ..:.. .... : . . .:: :....: :.::::: ::.: : XP_011 FALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGT-FDLKYFC 330 340 350 360 370 380 240 250 260 270 280 290 pF1KE4 NGRPGIVAWTLINLSFAAKQRELHSHVTN--AMVLVNVLQAIYVIDFFWNETWYLKTIDI . :::...:..::: . . ....... ::.::: .: .::.: .::: : :.:: XP_011 ELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDI 390 400 410 420 430 440 300 310 320 330 340 350 pF1KE4 CHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQ :: ::..:..:: ::.:..:..:..::: :: ..: : : ...: : :: ::: :: : XP_011 IHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQ 450 460 470 480 490 500 360 370 380 390 400 410 pF1KE4 KDLFRRTDGRCLIWGRKPKVIEC-SYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSL :. ::.. . ::. . . .. :. .:::::.:: .:: ::.:::. .: XP_011 KNAFRKNPS-------DPKLAHLKTIHTSTGK----NLLVSGWWGFVRHPNYLGDLIMAL 510 520 530 540 550 420 430 440 450 460 470 pF1KE4 AYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF :. : :: .:.::::::::...::.:: :::..: .::: ::.: ::::..: :. XP_011 AWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY 560 570 580 590 600 610 >>NP_919424 (OMIM: 169400,215140,600024,613471) lamin-B (615 aa) initn: 881 init1: 355 opt: 425 Z-score: 514.6 bits: 104.9 E(85289): 6.4e-22 Smith-Waterman score: 911; 35.0% identity (65.0% similar) in 449 aa overlap (31-475:203-615) 10 20 30 40 50 pF1KE4 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFA-PFIVYYFIM :: ... :. . .::..:. : ... ... NP_919 EEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLE-FGGVPGVFLIMFGLPVFLFLLLL 180 190 200 210 220 230 60 70 80 90 100 110 pF1KE4 ACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCH : : . .: ... : ..: .. .: :: .:::.: NP_919 MCKQKDPSL----LNFPPPLPALYELWET------RVFGVYLLWFLIQVLFY-------- 240 250 260 270 120 130 140 150 160 170 pF1KE4 KFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIP .:: .: . ::. : ::..::. :..:: . .. :.. ...... NP_919 -LLP--IGKVVEGTPLIDGRRLKYRLNGFYAFILTSAV--IGTSLFQGVEFHYVYSHFLQ 280 290 300 310 320 180 190 200 210 220 230 pF1KE4 LLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFF . :... ..:.. .... : . . .:: :....: :.::::: ::.: : NP_919 FALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGT-FDLKYFC 330 340 350 360 370 380 240 250 260 270 280 290 pF1KE4 NGRPGIVAWTLINLSFAAKQRELHSHVTN--AMVLVNVLQAIYVIDFFWNETWYLKTIDI . :::...:..::: . . ....... ::.::: .: .::.: .::: : :.:: NP_919 ELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDI 390 400 410 420 430 440 300 310 320 330 340 350 pF1KE4 CHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQ :: ::..:..:: ::.:..:..:..::: :: ..: : : ...: : :: ::: :: : NP_919 IHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQ 450 460 470 480 490 500 360 370 380 390 400 410 pF1KE4 KDLFRRTDGRCLIWGRKPKVIEC-SYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSL :. ::.. . ::. . . .. :. .:::::.:: .:: ::.:::. .: NP_919 KNAFRKNPS-------DPKLAHLKTIHTSTGK----NLLVSGWWGFVRHPNYLGDLIMAL 510 520 530 540 550 420 430 440 450 460 470 pF1KE4 AYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF :. : :: .:.::::::::...::.:: :::..: .::: ::.: ::::..: :. NP_919 AWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY 560 570 580 590 600 610 >>NP_002287 (OMIM: 169400,215140,600024,613471) lamin-B (615 aa) initn: 881 init1: 355 opt: 425 Z-score: 514.6 bits: 104.9 E(85289): 6.4e-22 Smith-Waterman score: 911; 35.0% identity (65.0% similar) in 449 aa overlap (31-475:203-615) 10 20 30 40 50 pF1KE4 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFA-PFIVYYFIM :: ... :. . .::..:. : ... ... NP_002 EEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLE-FGGVPGVFLIMFGLPVFLFLLLL 180 190 200 210 220 230 60 70 80 90 100 110 pF1KE4 ACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCH : : . .: ... : ..: .. .: :: .:::.: NP_002 MCKQKDPSL----LNFPPPLPALYELWET------RVFGVYLLWFLIQVLFY-------- 240 250 260 270 120 130 140 150 160 170 pF1KE4 KFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIP .:: .: . ::. : ::..::. :..:: . .. :.. ...... NP_002 -LLP--IGKVVEGTPLIDGRRLKYRLNGFYAFILTSAV--IGTSLFQGVEFHYVYSHFLQ 280 290 300 310 320 180 190 200 210 220 230 pF1KE4 LLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFF . :... ..:.. .... : . . .:: :....: :.::::: ::.: : NP_002 FALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGT-FDLKYFC 330 340 350 360 370 380 240 250 260 270 280 290 pF1KE4 NGRPGIVAWTLINLSFAAKQRELHSHVTN--AMVLVNVLQAIYVIDFFWNETWYLKTIDI . :::...:..::: . . ....... ::.::: .: .::.: .::: : :.:: NP_002 ELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDI 390 400 410 420 430 440 300 310 320 330 340 350 pF1KE4 CHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQ :: ::..:..:: ::.:..:..:..::: :: ..: : : ...: : :: ::: :: : NP_002 IHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQ 450 460 470 480 490 500 360 370 380 390 400 410 pF1KE4 KDLFRRTDGRCLIWGRKPKVIEC-SYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSL :. ::.. . ::. . . .. :. .:::::.:: .:: ::.:::. .: NP_002 KNAFRKNPS-------DPKLAHLKTIHTSTGK----NLLVSGWWGFVRHPNYLGDLIMAL 510 520 530 540 550 420 430 440 450 460 470 pF1KE4 AYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF :. : :: .:.::::::::...::.:: :::..: .::: ::.: ::::..: :. NP_002 AWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY 560 570 580 590 600 610 >>XP_005273182 (OMIM: 169400,215140,600024,613471) PREDI (573 aa) initn: 767 init1: 355 opt: 357 Z-score: 432.6 bits: 89.7 E(85289): 2.3e-17 Smith-Waterman score: 736; 31.8% identity (58.6% similar) in 447 aa overlap (31-475:203-573) 10 20 30 40 50 pF1KE4 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFA-PFIVYYFIM :: ... :. . .::..:. : ... ... XP_005 EEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLE-FGGVPGVFLIMFGLPVFLFLLLL 180 190 200 210 220 230 60 70 80 90 100 110 pF1KE4 ACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCH : : . .: ... : ..: .. .: :: .:::.: XP_005 MCKQKDPSL----LNFPPPLPALYELWET------RVFGVYLLWFLIQVLFY-------- 240 250 260 270 120 130 140 150 160 170 pF1KE4 KFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIP .:: .: . ::. : ::..::. :..:: . .. :.. ...... XP_005 -LLP--IGKVVEGTPLIDGRRLKYRLNGFYAFILTSAV--IGTSLFQGVEFHYVYSHFLQ 280 290 300 310 320 180 190 200 210 220 230 pF1KE4 LLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFF . :... ..:.. .... : . . .:: :....: :.::::: ::.: : XP_005 FALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGT-FDLKYFC 330 340 350 360 370 380 240 250 260 270 280 290 pF1KE4 NGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICH . :::...: . : :.:: : XP_005 ELRPGLIGWEAL----------------------------------------LTTMDIIH 390 400 300 310 320 330 340 350 pF1KE4 DHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKD : ::..:..:: ::.:..:..:..::: :: ..: : : ...: : :: ::: :: ::. XP_005 DGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKN 410 420 430 440 450 460 360 370 380 390 400 410 pF1KE4 LFRRTDGRCLIWGRKPKVIEC-SYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAY ::.. . ::. . . .. :. .:::::.:: .:: ::.:::. .::. XP_005 AFRKNPS-------DPKLAHLKTIHTSTGK----NLLVSGWWGFVRHPNYLGDLIMALAW 470 480 490 500 510 420 430 440 450 460 470 pF1KE4 CLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF : :: .:.::::::::...::.:: :::..: .::: ::.: ::::..: :. XP_005 SLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY 520 530 540 550 560 570 >>NP_001264162 (OMIM: 603414) delta(14)-sterol reductase (391 aa) initn: 783 init1: 349 opt: 349 Z-score: 425.2 bits: 87.8 E(85289): 6e-17 Smith-Waterman score: 779; 35.3% identity (59.6% similar) in 431 aa overlap (46-475:22-391) 20 30 40 50 60 70 pF1KE4 DGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDI :::. : ......: . : :: ... NP_001 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASL 10 20 30 40 50 80 90 100 110 120 130 pF1KE4 VTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVT : : .: .: .: :. :. .:. :: .::. . :: NP_001 -PG---LEVLW--SP----RALLLWLAWLGLQAALY---------LLPAR--KVAEGQEL 60 70 80 90 140 150 160 170 180 190 pF1KE4 PAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFA .: :::.:: .:: :: .. . . . . . .:: . :.. .. : : NP_001 KDKSRLRYPINGFQALVLTALL--VGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFL 100 110 120 130 140 200 210 220 230 240 250 pF1KE4 MVKGYFFPTSA-RDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLS ..:. :.:: .:: .:....: :.:::: .:::: : . :::...:.::::. NP_001 YMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRIC-FFDFKYFCELRPGLIGWVLINLA 150 160 170 180 190 200 260 270 280 290 300 310 pF1KE4 FAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWL . :. ::.. . :: ::: .: .:: : .:.: : :.:: :: ::..:..:: .:. NP_001 LLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWV 210 220 230 240 250 260 320 330 340 350 360 370 pF1KE4 PYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRK :. :.::. .:..:: :. : : . ::: : . NP_001 PFTYSLQAQFLLHHPQPLGLPMASVI---------------------------CLINGLE 270 280 290 300 380 390 400 410 420 430 pF1KE4 PKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYII . ..: :. ::::::.::..:: ::.:::. .::. : :: .:::::::.. NP_001 ------TISTATGR----KLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLL 310 320 330 340 350 440 450 460 470 pF1KE4 YMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF :.. ::.:: :::..: .::: :..: ::::..: :. NP_001 YFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY 360 370 380 390 475 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:00:31 2016 done: Sun Nov 6 01:00:32 2016 Total Scan time: 7.830 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]