FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3434, 886 aa 1>>>pF1KE3434 886 - 886 aa - 886 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.9976+/-0.000317; mu= 5.0232+/- 0.020 mean_var=176.3353+/-34.698, 0's: 0 Z-trim(122.1): 209 B-trim: 0 in 0/58 Lambda= 0.096584 statistics sampled from 39481 (39699) to 39481 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.755), E-opt: 0.2 (0.465), width: 16 Scan time: 15.270 The best scores are: opt bits E(85289) NP_001104777 (OMIM: 600126) cAMP-specific 3',5'-cy ( 886) 5902 834.7 0 XP_016882354 (OMIM: 600126) PREDICTED: cAMP-specif ( 885) 5884 832.2 0 NP_001104778 (OMIM: 600126) cAMP-specific 3',5'-cy ( 860) 5164 731.9 3.2e-210 NP_001104779 (OMIM: 600126) cAMP-specific 3',5'-cy ( 825) 5158 731.0 5.5e-210 NP_001230050 (OMIM: 600126) cAMP-specific 3',5'-cy ( 864) 5150 729.9 1.2e-209 XP_011526356 (OMIM: 600126) PREDICTED: cAMP-specif ( 864) 5150 729.9 1.2e-209 XP_011526357 (OMIM: 600126) PREDICTED: cAMP-specif ( 657) 4275 607.9 4.9e-173 NP_006193 (OMIM: 600126) cAMP-specific 3',5'-cycli ( 647) 4147 590.1 1.1e-167 XP_005259990 (OMIM: 600126) PREDICTED: cAMP-specif ( 582) 3873 551.9 3.2e-156 NP_001184150 (OMIM: 600129,606799,614613) cAMP-spe ( 507) 2203 319.2 3.2e-86 NP_001184152 (OMIM: 600129,606799,614613) cAMP-spe ( 518) 2203 319.2 3.2e-86 XP_016865060 (OMIM: 600129,606799,614613) PREDICTE ( 553) 2203 319.2 3.4e-86 XP_016865059 (OMIM: 600129,606799,614613) PREDICTE ( 553) 2203 319.2 3.4e-86 NP_001184151 (OMIM: 600129,606799,614613) cAMP-spe ( 585) 2203 319.2 3.6e-86 XP_011541779 (OMIM: 600129,606799,614613) PREDICTE ( 662) 2203 319.2 4e-86 XP_005248595 (OMIM: 600129,606799,614613) PREDICTE ( 673) 2203 319.2 4.1e-86 NP_006194 (OMIM: 600129,606799,614613) cAMP-specif ( 673) 2203 319.2 4.1e-86 NP_001184149 (OMIM: 600129,606799,614613) cAMP-spe ( 679) 2203 319.2 4.1e-86 NP_001184148 (OMIM: 600129,606799,614613) cAMP-spe ( 687) 2203 319.2 4.1e-86 XP_016865058 (OMIM: 600129,606799,614613) PREDICTE ( 699) 2203 319.2 4.2e-86 XP_005248594 (OMIM: 600129,606799,614613) PREDICTE ( 699) 2203 319.2 4.2e-86 XP_016865057 (OMIM: 600129,606799,614613) PREDICTE ( 738) 2203 319.2 4.4e-86 XP_016865056 (OMIM: 600129,606799,614613) PREDICTE ( 743) 2203 319.2 4.4e-86 NP_001184147 (OMIM: 600129,606799,614613) cAMP-spe ( 745) 2203 319.2 4.4e-86 XP_016865055 (OMIM: 600129,606799,614613) PREDICTE ( 748) 2203 319.2 4.5e-86 XP_011541773 (OMIM: 600129,606799,614613) PREDICTE ( 748) 2203 319.2 4.5e-86 XP_011541775 (OMIM: 600129,606799,614613) PREDICTE ( 748) 2203 319.2 4.5e-86 NP_001159371 (OMIM: 600129,606799,614613) cAMP-spe ( 748) 2203 319.2 4.5e-86 XP_011541772 (OMIM: 600129,606799,614613) PREDICTE ( 797) 2203 319.3 4.7e-86 XP_016865054 (OMIM: 600129,606799,614613) PREDICTE ( 797) 2203 319.3 4.7e-86 XP_011541771 (OMIM: 600129,606799,614613) PREDICTE ( 797) 2203 319.3 4.7e-86 NP_001098101 (OMIM: 600129,606799,614613) cAMP-spe ( 809) 2203 319.3 4.8e-86 NP_001284371 (OMIM: 600127) cAMP-specific 3',5'-cy ( 503) 2174 315.1 5.2e-85 XP_005270982 (OMIM: 600127) PREDICTED: cAMP-specif ( 517) 2174 315.1 5.3e-85 XP_005270981 (OMIM: 600127) PREDICTED: cAMP-specif ( 517) 2174 315.1 5.3e-85 XP_011539868 (OMIM: 600127) PREDICTED: cAMP-specif ( 530) 2174 315.1 5.4e-85 XP_016856935 (OMIM: 600127) PREDICTED: cAMP-specif ( 530) 2174 315.1 5.4e-85 XP_006710743 (OMIM: 600127) PREDICTED: cAMP-specif ( 531) 2174 315.1 5.5e-85 NP_001032416 (OMIM: 600127) cAMP-specific 3',5'-cy ( 564) 2174 315.2 5.7e-85 XP_016856934 (OMIM: 600127) PREDICTED: cAMP-specif ( 597) 2174 315.2 6e-85 NP_001284369 (OMIM: 600127) cAMP-specific 3',5'-cy ( 644) 2174 315.2 6.4e-85 NP_001284370 (OMIM: 600127) cAMP-specific 3',5'-cy ( 661) 2174 315.2 6.6e-85 NP_001032417 (OMIM: 600127) cAMP-specific 3',5'-cy ( 721) 2174 315.2 7.1e-85 NP_002591 (OMIM: 600127) cAMP-specific 3',5'-cycli ( 736) 2174 315.2 7.2e-85 NP_001032418 (OMIM: 600127) cAMP-specific 3',5'-cy ( 736) 2174 315.2 7.2e-85 XP_011526360 (OMIM: 600128) PREDICTED: cAMP-specif ( 481) 2070 300.6 1.2e-80 NP_001092289 (OMIM: 600128) cAMP-specific 3',5'-cy ( 606) 2070 300.7 1.4e-80 XP_011526358 (OMIM: 600128) PREDICTED: cAMP-specif ( 606) 2070 300.7 1.4e-80 NP_001092288 (OMIM: 600128) cAMP-specific 3',5'-cy ( 680) 2070 300.7 1.6e-80 NP_000914 (OMIM: 600128) cAMP-specific 3',5'-cycli ( 712) 2070 300.7 1.6e-80 >>NP_001104777 (OMIM: 600126) cAMP-specific 3',5'-cyclic (886 aa) initn: 5902 init1: 5902 opt: 5902 Z-score: 4450.8 bits: 834.7 E(85289): 0 Smith-Waterman score: 5902; 100.0% identity (100.0% similar) in 886 aa overlap (1-886:1-886) 10 20 30 40 50 60 pF1KE3 MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP 790 800 810 820 830 840 850 860 870 880 pF1KE3 STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT :::::::::::::::::::::::::::::::::::::::::::::: NP_001 STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 850 860 870 880 >>XP_016882354 (OMIM: 600126) PREDICTED: cAMP-specific 3 (885 aa) initn: 4391 init1: 4391 opt: 5884 Z-score: 4437.2 bits: 832.2 E(85289): 0 Smith-Waterman score: 5884; 99.9% identity (99.9% similar) in 886 aa overlap (1-886:1-885) 10 20 30 40 50 60 pF1KE3 MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW :::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::: XP_016 FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSE-TCQQLARETLEELDW 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE3 PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE3 TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE3 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE3 VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE3 LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL 600 610 620 630 640 650 670 680 690 700 710 720 pF1KE3 VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE 660 670 680 690 700 710 730 740 750 760 770 780 pF1KE3 ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT 720 730 740 750 760 770 790 800 810 820 830 840 pF1KE3 QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP 780 790 800 810 820 830 850 860 870 880 pF1KE3 STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT :::::::::::::::::::::::::::::::::::::::::::::: XP_016 STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 840 850 860 870 880 >>NP_001104778 (OMIM: 600126) cAMP-specific 3',5'-cyclic (860 aa) initn: 5150 init1: 5150 opt: 5164 Z-score: 3895.2 bits: 731.9 E(85289): 3.2e-210 Smith-Waterman score: 5164; 95.4% identity (96.7% similar) in 830 aa overlap (59-886:37-860) 30 40 50 60 70 80 pF1KE3 PPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRP--IERADAMDTSDRPGLRTTRMSW : :.:: . .. .: : .: :. NP_001 LGRIPELQLVAFPVAVAAEDEAFLPEPLAPRAPRRPRSPPSSPVFFASPSPTFRR-RLRL 10 20 30 40 50 60 90 100 110 120 130 140 pF1KE3 PSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESF : . : .. ::.: ::::::::::::::::::::::::::::::::::::::: NP_001 LRSCQDLGR-QAWAGAG----FEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESF 70 80 90 100 110 120 150 160 170 180 190 200 pF1KE3 LYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSN 130 140 150 160 170 180 210 220 230 240 250 260 pF1KE3 KRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRML 190 200 210 220 230 240 270 280 290 300 310 320 pF1KE3 NRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPV 250 260 270 280 290 300 330 340 350 360 370 380 pF1KE3 PHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYA 310 320 330 340 350 360 390 400 410 420 430 440 pF1KE3 GGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTH 370 380 390 400 410 420 450 460 470 480 490 500 pF1KE3 VLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH 430 440 450 460 470 480 510 520 530 540 550 560 pF1KE3 LAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVT 490 500 510 520 530 540 570 580 590 600 610 620 pF1KE3 SSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME 550 560 570 580 590 600 630 640 650 660 670 680 pF1KE3 ISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQS 610 620 630 640 650 660 690 700 710 720 730 740 pF1KE3 PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEAL 670 680 690 700 710 720 750 760 770 780 790 800 pF1KE3 DATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAV 730 740 750 760 770 780 810 820 830 840 850 860 pF1KE3 SHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTF 790 800 810 820 830 840 870 880 pF1KE3 GEDTSALPAPGGGGSGGDPT :::::::::::::::::::: NP_001 GEDTSALPAPGGGGSGGDPT 850 860 >>NP_001104779 (OMIM: 600126) cAMP-specific 3',5'-cyclic (825 aa) initn: 5158 init1: 5158 opt: 5158 Z-score: 3891.0 bits: 731.0 E(85289): 5.5e-210 Smith-Waterman score: 5158; 99.6% identity (99.6% similar) in 784 aa overlap (103-886:42-825) 80 90 100 110 120 130 pF1KE3 TSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLV : : ::::::::::::::::::::::::: NP_001 RPPALALPPTGPESLTHFPFSDEDTRRHPPGRSVSFEAENGPTPSPGRSPLDSQASPGLV 20 30 40 50 60 70 140 150 160 170 180 190 pF1KE3 LHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVR 80 90 100 110 120 130 200 210 220 230 240 250 pF1KE3 SNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYR 140 150 160 170 180 190 260 270 280 290 300 310 pF1KE3 SVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQ 200 210 220 230 240 250 320 330 340 350 360 370 pF1KE3 APRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENL 260 270 280 290 300 310 380 390 400 410 420 430 pF1KE3 NKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAY 320 330 340 350 360 370 440 450 460 470 480 490 pF1KE3 HNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSEL 380 390 400 410 420 430 500 510 520 530 540 550 pF1KE3 ALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTL 440 450 460 470 480 490 560 570 580 590 600 610 pF1KE3 LADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAE 500 510 520 530 540 550 620 630 640 650 660 670 pF1KE3 FFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTL 560 570 580 590 600 610 680 690 700 710 720 730 pF1KE3 EDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQE 620 630 640 650 660 670 740 750 760 770 780 790 pF1KE3 ALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVA 680 690 700 710 720 730 800 810 820 830 840 850 pF1KE3 PDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREH 740 750 760 770 780 790 860 870 880 pF1KE3 QAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT :::::::::::::::::::::::::::::::::: NP_001 QAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 800 810 820 >>NP_001230050 (OMIM: 600126) cAMP-specific 3',5'-cyclic (864 aa) initn: 5150 init1: 5150 opt: 5150 Z-score: 3884.6 bits: 729.9 E(85289): 1.2e-209 Smith-Waterman score: 5150; 100.0% identity (100.0% similar) in 779 aa overlap (108-886:86-864) 80 90 100 110 120 130 pF1KE3 GLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGA :::::::::::::::::::::::::::::: NP_001 DPGVPLPPRPTTLPLLIPPRISITRAENDSFEAENGPTPSPGRSPLDSQASPGLVLHAGA 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE3 ATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSL 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE3 LTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEM 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE3 ASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPR 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE3 PSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGL 300 310 320 330 340 350 380 390 400 410 420 430 pF1KE3 NIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLH 360 370 380 390 400 410 440 450 460 470 480 490 pF1KE3 AADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYN 420 430 440 450 460 470 500 510 520 530 540 550 pF1KE3 DESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLK 480 490 500 510 520 530 560 570 580 590 600 610 pF1KE3 TMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQG 540 550 560 570 580 590 620 630 640 650 660 670 pF1KE3 DRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRD 600 610 620 630 640 650 680 690 700 710 720 730 pF1KE3 WYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQ 660 670 680 690 700 710 740 750 760 770 780 790 pF1KE3 GLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFS 720 730 740 750 760 770 800 810 820 830 840 850 pF1KE3 SREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKR 780 790 800 810 820 830 860 870 880 pF1KE3 ACSACAGTFGEDTSALPAPGGGGSGGDPT ::::::::::::::::::::::::::::: NP_001 ACSACAGTFGEDTSALPAPGGGGSGGDPT 840 850 860 >>XP_011526356 (OMIM: 600126) PREDICTED: cAMP-specific 3 (864 aa) initn: 5150 init1: 5150 opt: 5150 Z-score: 3884.6 bits: 729.9 E(85289): 1.2e-209 Smith-Waterman score: 5150; 100.0% identity (100.0% similar) in 779 aa overlap (108-886:86-864) 80 90 100 110 120 130 pF1KE3 GLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGA :::::::::::::::::::::::::::::: XP_011 DPGVPLPPRPTTLPLLIPPRISITRAENDSFEAENGPTPSPGRSPLDSQASPGLVLHAGA 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE3 ATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSL 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE3 LTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEM 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE3 ASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPR 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE3 PSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGL 300 310 320 330 340 350 380 390 400 410 420 430 pF1KE3 NIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLH 360 370 380 390 400 410 440 450 460 470 480 490 pF1KE3 AADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYN 420 430 440 450 460 470 500 510 520 530 540 550 pF1KE3 DESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLK 480 490 500 510 520 530 560 570 580 590 600 610 pF1KE3 TMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQG 540 550 560 570 580 590 620 630 640 650 660 670 pF1KE3 DRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRD 600 610 620 630 640 650 680 690 700 710 720 730 pF1KE3 WYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQ 660 670 680 690 700 710 740 750 760 770 780 790 pF1KE3 GLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFS 720 730 740 750 760 770 800 810 820 830 840 850 pF1KE3 SREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKR 780 790 800 810 820 830 860 870 880 pF1KE3 ACSACAGTFGEDTSALPAPGGGGSGGDPT ::::::::::::::::::::::::::::: XP_011 ACSACAGTFGEDTSALPAPGGGGSGGDPT 840 850 860 >>XP_011526357 (OMIM: 600126) PREDICTED: cAMP-specific 3 (657 aa) initn: 4275 init1: 4275 opt: 4275 Z-score: 3227.6 bits: 607.9 E(85289): 4.9e-173 Smith-Waterman score: 4275; 100.0% identity (100.0% similar) in 643 aa overlap (1-643:1-643) 10 20 30 40 50 60 pF1KE3 MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL ::::::::::::::::::::::::::::::::::::::::::: XP_011 LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVQARGIDGRAQGGFY 610 620 630 640 650 670 680 690 700 710 720 pF1KE3 VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE >>NP_006193 (OMIM: 600126) cAMP-specific 3',5'-cyclic ph (647 aa) initn: 4147 init1: 4147 opt: 4147 Z-score: 3131.3 bits: 590.1 E(85289): 1.1e-167 Smith-Waterman score: 4147; 99.8% identity (100.0% similar) in 626 aa overlap (261-886:22-647) 240 250 260 270 280 290 pF1KE3 ARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTT .::::::::::::::::::::::::::::: NP_006 MPLVDFFCETCSKPWLVGWWDQFKRMLNRELTHLSEMSRSGNQVSEYISTT 10 20 30 40 50 300 310 320 330 340 350 pF1KE3 FLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNS 60 70 80 90 100 110 360 370 380 390 400 410 pF1KE3 NIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRI 120 130 140 150 160 170 420 430 440 450 460 470 pF1KE3 PVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAA 180 190 200 210 220 230 480 490 500 510 520 530 pF1KE3 AIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQR 240 250 260 270 280 290 540 550 560 570 580 590 pF1KE3 QSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA 300 310 320 330 340 350 600 610 620 630 640 650 pF1KE3 DLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIV 360 370 380 390 400 410 660 670 680 690 700 710 pF1KE3 HPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 HPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFE 420 430 440 450 460 470 720 730 740 750 760 770 pF1KE3 LTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASL 480 490 500 510 520 530 780 790 800 810 820 830 pF1KE3 EAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVS 540 550 560 570 580 590 840 850 860 870 880 pF1KE3 EHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 600 610 620 630 640 >>XP_005259990 (OMIM: 600126) PREDICTED: cAMP-specific 3 (582 aa) initn: 3873 init1: 3873 opt: 3873 Z-score: 2925.6 bits: 551.9 E(85289): 3.2e-156 Smith-Waterman score: 3873; 100.0% identity (100.0% similar) in 582 aa overlap (305-886:1-582) 280 290 300 310 320 330 pF1KE3 EMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQ :::::::::::::::::::::::::::::: XP_005 MKEREKQQAPRPRPSQPPPPPVPHLQPMSQ 10 20 30 340 350 360 370 380 390 pF1KE3 ITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCI 40 50 60 70 80 90 400 410 420 430 440 450 pF1KE3 MYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPAL 100 110 120 130 140 150 460 470 480 490 500 510 pF1KE3 DAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLL 160 170 180 190 200 210 520 530 540 550 560 570 pF1KE3 QEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD 220 230 240 250 260 270 580 590 600 610 620 630 pF1KE3 NYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKH 280 290 300 310 320 330 640 650 660 670 680 690 pF1KE3 TASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEE 340 350 360 370 380 390 700 710 720 730 740 750 pF1KE3 SRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEA 400 410 420 430 440 450 760 770 780 790 800 810 pF1KE3 SPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSAL 460 470 480 490 500 510 820 830 840 850 860 870 pF1KE3 ALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALP 520 530 540 550 560 570 880 pF1KE3 APGGGGSGGDPT :::::::::::: XP_005 APGGGGSGGDPT 580 >>NP_001184150 (OMIM: 600129,606799,614613) cAMP-specifi (507 aa) initn: 2480 init1: 2119 opt: 2203 Z-score: 1669.0 bits: 319.2 E(85289): 3.2e-86 Smith-Waterman score: 2462; 74.3% identity (88.0% similar) in 510 aa overlap (257-759:1-491) 230 240 250 260 270 280 pF1KE3 CQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEY :::.:::::::::::::::::::::::::. NP_001 MASNKFKRMLNRELTHLSEMSRSGNQVSEF 10 20 30 290 300 310 320 330 340 pF1KE3 ISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNS ::.::::::.::::::::.::.::.. .:::::.:.::::::.: NP_001 ISNTFLDKQHEVEIPSPTQKEKEKKK-----------------RPMSQISGVKKLMHSSS 40 50 60 70 350 360 370 380 390 400 pF1KE3 LNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLK :.::.::::::::.::..::.:::..:::::..: ... .:.: :: ::. ::::::::: NP_001 LTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLK 80 90 100 110 120 130 410 420 430 440 450 460 pF1KE3 KFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAA :.:::::..::..::::::::::::::..:::::.:::::::.::::.::::::::::: NP_001 TFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAA 140 150 160 170 180 190 470 480 490 500 510 520 pF1KE3 LFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLS .::.:::::::::::::::::::::::::::: :::::::::::::::::.::::::::. NP_001 IFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLT 200 210 220 230 240 250 530 540 550 560 570 580 pF1KE3 KRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNM :.:::::::::::.::::::::::.::::::::::::::::::::::::::::::::.:: NP_001 KKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNM 260 270 280 290 300 310 590 600 610 620 630 640 pF1KE3 VHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFI :::::::::::::.:::::::::: :::.:::::::::::::::::::.::::::::::: NP_001 VHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFI 320 330 340 350 360 370 650 660 670 680 690 700 pF1KE3 DYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDK ::::::::::::::::::::.:::::::::.:: :.: ::::: :.. .: . .: NP_001 DYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEG--RQGQTEK 380 390 400 410 420 430 710 720 730 740 750 pF1KE3 FQFELTLEEEEE---EEISMAQIP----CTAQEALTAQGLSGVEEALDATIAWEASPAQE :::::::::. : :. : .:. :. ...: .: ..: :: . :: .: NP_001 FQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEE 440 450 460 470 480 490 760 770 780 790 800 810 pF1KE3 SLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSP NP_001 ESQPEACVIDDRSPDT 500 886 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 03:14:59 2016 done: Mon Nov 7 03:15:01 2016 Total Scan time: 15.270 Total Display time: 0.240 Function used was FASTA [36.3.4 Apr, 2011]