FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3434, 886 aa 1>>>pF1KE3434 886 - 886 aa - 886 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.3915+/-0.000822; mu= 8.9098+/- 0.050 mean_var=169.8908+/-33.825, 0's: 0 Z-trim(114.3): 75 B-trim: 0 in 0/52 Lambda= 0.098399 statistics sampled from 14796 (14871) to 14796 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.751), E-opt: 0.2 (0.457), width: 16 Scan time: 4.530 The best scores are: opt bits E(32554) CCDS45961.1 PDE4A gene_id:5141|Hs108|chr19 ( 886) 5902 850.0 0 CCDS45962.1 PDE4A gene_id:5141|Hs108|chr19 ( 860) 5164 745.3 1.1e-214 CCDS45963.1 PDE4A gene_id:5141|Hs108|chr19 ( 825) 5158 744.4 1.9e-214 CCDS58649.1 PDE4A gene_id:5141|Hs108|chr19 ( 864) 5150 743.3 4.4e-214 CCDS12238.1 PDE4A gene_id:5141|Hs108|chr19 ( 647) 4147 600.8 2.5e-171 CCDS56370.1 PDE4D gene_id:5144|Hs108|chr5 ( 507) 2203 324.8 2.5e-88 CCDS56369.1 PDE4D gene_id:5144|Hs108|chr5 ( 518) 2203 324.8 2.5e-88 CCDS54858.1 PDE4D gene_id:5144|Hs108|chr5 ( 673) 2203 324.9 3.1e-88 CCDS56371.1 PDE4D gene_id:5144|Hs108|chr5 ( 679) 2203 324.9 3.1e-88 CCDS56372.1 PDE4D gene_id:5144|Hs108|chr5 ( 687) 2203 324.9 3.2e-88 CCDS56373.1 PDE4D gene_id:5144|Hs108|chr5 ( 745) 2203 324.9 3.4e-88 CCDS54859.1 PDE4D gene_id:5144|Hs108|chr5 ( 748) 2203 324.9 3.4e-88 CCDS47213.1 PDE4D gene_id:5144|Hs108|chr5 ( 809) 2203 324.9 3.6e-88 CCDS72802.1 PDE4B gene_id:5142|Hs108|chr1 ( 503) 2174 320.7 4.3e-87 CCDS30743.1 PDE4B gene_id:5142|Hs108|chr1 ( 564) 2174 320.7 4.7e-87 CCDS30742.1 PDE4B gene_id:5142|Hs108|chr1 ( 721) 2174 320.8 5.7e-87 CCDS632.1 PDE4B gene_id:5142|Hs108|chr1 ( 736) 2174 320.8 5.8e-87 CCDS46016.1 PDE4C gene_id:5143|Hs108|chr19 ( 606) 2070 306.0 1.4e-82 CCDS42523.1 PDE4C gene_id:5143|Hs108|chr19 ( 680) 2070 306.0 1.5e-82 CCDS12373.1 PDE4C gene_id:5143|Hs108|chr19 ( 712) 2070 306.0 1.6e-82 CCDS5175.1 PDE7B gene_id:27115|Hs108|chr6 ( 450) 742 117.4 6.1e-26 CCDS34901.1 PDE7A gene_id:5150|Hs108|chr8 ( 456) 720 114.2 5.4e-25 CCDS56538.1 PDE7A gene_id:5150|Hs108|chr8 ( 482) 720 114.3 5.6e-25 CCDS34190.1 PDE8B gene_id:8622|Hs108|chr5 ( 830) 619 100.1 1.8e-20 CCDS34192.1 PDE8B gene_id:8622|Hs108|chr5 ( 788) 612 99.0 3.5e-20 CCDS34191.1 PDE8B gene_id:8622|Hs108|chr5 ( 838) 612 99.1 3.7e-20 CCDS34193.1 PDE8B gene_id:8622|Hs108|chr5 ( 865) 612 99.1 3.8e-20 CCDS4037.1 PDE8B gene_id:8622|Hs108|chr5 ( 885) 612 99.1 3.8e-20 CCDS42947.1 PDE9A gene_id:5152|Hs108|chr21 ( 433) 606 98.0 3.8e-20 CCDS42944.1 PDE9A gene_id:5152|Hs108|chr21 ( 459) 606 98.1 4e-20 CCDS33571.1 PDE9A gene_id:5152|Hs108|chr21 ( 465) 606 98.1 4.1e-20 CCDS42946.1 PDE9A gene_id:5152|Hs108|chr21 ( 466) 606 98.1 4.1e-20 CCDS33570.1 PDE9A gene_id:5152|Hs108|chr21 ( 491) 606 98.1 4.2e-20 CCDS42943.1 PDE9A gene_id:5152|Hs108|chr21 ( 492) 606 98.1 4.3e-20 CCDS42941.1 PDE9A gene_id:5152|Hs108|chr21 ( 507) 606 98.1 4.4e-20 CCDS42945.1 PDE9A gene_id:5152|Hs108|chr21 ( 526) 606 98.1 4.5e-20 CCDS33568.1 PDE9A gene_id:5152|Hs108|chr21 ( 533) 606 98.1 4.5e-20 CCDS33567.1 PDE9A gene_id:5152|Hs108|chr21 ( 540) 606 98.1 4.6e-20 CCDS42942.1 PDE9A gene_id:5152|Hs108|chr21 ( 552) 606 98.1 4.7e-20 CCDS33569.1 PDE9A gene_id:5152|Hs108|chr21 ( 567) 606 98.1 4.8e-20 CCDS13690.1 PDE9A gene_id:5152|Hs108|chr21 ( 593) 606 98.1 5e-20 CCDS74612.1 PDE1A gene_id:5136|Hs108|chr2 ( 501) 548 89.8 1.3e-17 CCDS58741.1 PDE1A gene_id:5136|Hs108|chr2 ( 519) 548 89.9 1.3e-17 CCDS33344.1 PDE1A gene_id:5136|Hs108|chr2 ( 535) 548 89.9 1.4e-17 CCDS2285.1 PDE1A gene_id:5136|Hs108|chr2 ( 545) 548 89.9 1.4e-17 CCDS5437.1 PDE1C gene_id:5137|Hs108|chr7 ( 634) 538 88.5 4.2e-17 CCDS55099.1 PDE1C gene_id:5137|Hs108|chr7 ( 709) 538 88.5 4.6e-17 CCDS55100.1 PDE1C gene_id:5137|Hs108|chr7 ( 769) 538 88.5 4.9e-17 CCDS73477.1 PDE1B gene_id:5153|Hs108|chr12 ( 495) 528 87.0 9.2e-17 CCDS53800.1 PDE1B gene_id:5153|Hs108|chr12 ( 516) 528 87.0 9.5e-17 >>CCDS45961.1 PDE4A gene_id:5141|Hs108|chr19 (886 aa) initn: 5902 init1: 5902 opt: 5902 Z-score: 4533.7 bits: 850.0 E(32554): 0 Smith-Waterman score: 5902; 100.0% identity (100.0% similar) in 886 aa overlap (1-886:1-886) 10 20 30 40 50 60 pF1KE3 MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP 790 800 810 820 830 840 850 860 870 880 pF1KE3 STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT :::::::::::::::::::::::::::::::::::::::::::::: CCDS45 STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 850 860 870 880 >>CCDS45962.1 PDE4A gene_id:5141|Hs108|chr19 (860 aa) initn: 5150 init1: 5150 opt: 5164 Z-score: 3967.7 bits: 745.3 E(32554): 1.1e-214 Smith-Waterman score: 5164; 95.4% identity (96.7% similar) in 830 aa overlap (59-886:37-860) 30 40 50 60 70 80 pF1KE3 PPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRP--IERADAMDTSDRPGLRTTRMSW : :.:: . .. .: : .: :. CCDS45 LGRIPELQLVAFPVAVAAEDEAFLPEPLAPRAPRRPRSPPSSPVFFASPSPTFRR-RLRL 10 20 30 40 50 60 90 100 110 120 130 140 pF1KE3 PSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESF : . : .. ::.: ::::::::::::::::::::::::::::::::::::::: CCDS45 LRSCQDLGR-QAWAGAG----FEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESF 70 80 90 100 110 120 150 160 170 180 190 200 pF1KE3 LYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 LYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSN 130 140 150 160 170 180 210 220 230 240 250 260 pF1KE3 KRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 KRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRML 190 200 210 220 230 240 270 280 290 300 310 320 pF1KE3 NRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 NRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPV 250 260 270 280 290 300 330 340 350 360 370 380 pF1KE3 PHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 PHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYA 310 320 330 340 350 360 390 400 410 420 430 440 pF1KE3 GGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 GGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTH 370 380 390 400 410 420 450 460 470 480 490 500 pF1KE3 VLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 VLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH 430 440 450 460 470 480 510 520 530 540 550 560 pF1KE3 LAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 LAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVT 490 500 510 520 530 540 570 580 590 600 610 620 pF1KE3 SSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 SSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME 550 560 570 580 590 600 630 640 650 660 670 680 pF1KE3 ISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 ISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQS 610 620 630 640 650 660 690 700 710 720 730 740 pF1KE3 PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEAL 670 680 690 700 710 720 750 760 770 780 790 800 pF1KE3 DATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 DATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAV 730 740 750 760 770 780 810 820 830 840 850 860 pF1KE3 SHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 SHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTF 790 800 810 820 830 840 870 880 pF1KE3 GEDTSALPAPGGGGSGGDPT :::::::::::::::::::: CCDS45 GEDTSALPAPGGGGSGGDPT 850 860 >>CCDS45963.1 PDE4A gene_id:5141|Hs108|chr19 (825 aa) initn: 5158 init1: 5158 opt: 5158 Z-score: 3963.3 bits: 744.4 E(32554): 1.9e-214 Smith-Waterman score: 5158; 99.6% identity (99.6% similar) in 784 aa overlap (103-886:42-825) 80 90 100 110 120 130 pF1KE3 TSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLV : : ::::::::::::::::::::::::: CCDS45 RPPALALPPTGPESLTHFPFSDEDTRRHPPGRSVSFEAENGPTPSPGRSPLDSQASPGLV 20 30 40 50 60 70 140 150 160 170 180 190 pF1KE3 LHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 LHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVR 80 90 100 110 120 130 200 210 220 230 240 250 pF1KE3 SNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 SNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYR 140 150 160 170 180 190 260 270 280 290 300 310 pF1KE3 SVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 SVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQ 200 210 220 230 240 250 320 330 340 350 360 370 pF1KE3 APRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 APRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENL 260 270 280 290 300 310 380 390 400 410 420 430 pF1KE3 NKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 NKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAY 320 330 340 350 360 370 440 450 460 470 480 490 pF1KE3 HNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 HNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSEL 380 390 400 410 420 430 500 510 520 530 540 550 pF1KE3 ALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 ALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTL 440 450 460 470 480 490 560 570 580 590 600 610 pF1KE3 LADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 LADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAE 500 510 520 530 540 550 620 630 640 650 660 670 pF1KE3 FFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 FFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTL 560 570 580 590 600 610 680 690 700 710 720 730 pF1KE3 EDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 EDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQE 620 630 640 650 660 670 740 750 760 770 780 790 pF1KE3 ALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 ALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVA 680 690 700 710 720 730 800 810 820 830 840 850 pF1KE3 PDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 PDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREH 740 750 760 770 780 790 860 870 880 pF1KE3 QAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT :::::::::::::::::::::::::::::::::: CCDS45 QAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 800 810 820 >>CCDS58649.1 PDE4A gene_id:5141|Hs108|chr19 (864 aa) initn: 5150 init1: 5150 opt: 5150 Z-score: 3956.9 bits: 743.3 E(32554): 4.4e-214 Smith-Waterman score: 5150; 100.0% identity (100.0% similar) in 779 aa overlap (108-886:86-864) 80 90 100 110 120 130 pF1KE3 GLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGA :::::::::::::::::::::::::::::: CCDS58 DPGVPLPPRPTTLPLLIPPRISITRAENDSFEAENGPTPSPGRSPLDSQASPGLVLHAGA 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE3 ATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 ATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSL 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE3 LTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 LTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEM 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE3 ASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 ASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPR 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE3 PSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 PSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGL 300 310 320 330 340 350 380 390 400 410 420 430 pF1KE3 NIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 NIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLH 360 370 380 390 400 410 440 450 460 470 480 490 pF1KE3 AADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 AADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYN 420 430 440 450 460 470 500 510 520 530 540 550 pF1KE3 DESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 DESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLK 480 490 500 510 520 530 560 570 580 590 600 610 pF1KE3 TMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 TMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQG 540 550 560 570 580 590 620 630 640 650 660 670 pF1KE3 DRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 DRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRD 600 610 620 630 640 650 680 690 700 710 720 730 pF1KE3 WYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 WYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQ 660 670 680 690 700 710 740 750 760 770 780 790 pF1KE3 GLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 GLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFS 720 730 740 750 760 770 800 810 820 830 840 850 pF1KE3 SREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 SREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKR 780 790 800 810 820 830 860 870 880 pF1KE3 ACSACAGTFGEDTSALPAPGGGGSGGDPT ::::::::::::::::::::::::::::: CCDS58 ACSACAGTFGEDTSALPAPGGGGSGGDPT 840 850 860 >>CCDS12238.1 PDE4A gene_id:5141|Hs108|chr19 (647 aa) initn: 4147 init1: 4147 opt: 4147 Z-score: 3189.2 bits: 600.8 E(32554): 2.5e-171 Smith-Waterman score: 4147; 99.8% identity (100.0% similar) in 626 aa overlap (261-886:22-647) 240 250 260 270 280 290 pF1KE3 ARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTT .::::::::::::::::::::::::::::: CCDS12 MPLVDFFCETCSKPWLVGWWDQFKRMLNRELTHLSEMSRSGNQVSEYISTT 10 20 30 40 50 300 310 320 330 340 350 pF1KE3 FLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 FLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNS 60 70 80 90 100 110 360 370 380 390 400 410 pF1KE3 NIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 NIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRI 120 130 140 150 160 170 420 430 440 450 460 470 pF1KE3 PVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 PVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAA 180 190 200 210 220 230 480 490 500 510 520 530 pF1KE3 AIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 AIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQR 240 250 260 270 280 290 540 550 560 570 580 590 pF1KE3 QSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 QSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA 300 310 320 330 340 350 600 610 620 630 640 650 pF1KE3 DLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 DLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIV 360 370 380 390 400 410 660 670 680 690 700 710 pF1KE3 HPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 HPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFE 420 430 440 450 460 470 720 730 740 750 760 770 pF1KE3 LTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 LTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASL 480 490 500 510 520 530 780 790 800 810 820 830 pF1KE3 EAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 EAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVS 540 550 560 570 580 590 840 850 860 870 880 pF1KE3 EHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 EHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 600 610 620 630 640 >>CCDS56370.1 PDE4D gene_id:5144|Hs108|chr5 (507 aa) initn: 2480 init1: 2119 opt: 2203 Z-score: 1699.3 bits: 324.8 E(32554): 2.5e-88 Smith-Waterman score: 2462; 74.3% identity (88.0% similar) in 510 aa overlap (257-759:1-491) 230 240 250 260 270 280 pF1KE3 CQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEY :::.:::::::::::::::::::::::::. CCDS56 MASNKFKRMLNRELTHLSEMSRSGNQVSEF 10 20 30 290 300 310 320 330 340 pF1KE3 ISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNS ::.::::::.::::::::.::.::.. .:::::.:.::::::.: CCDS56 ISNTFLDKQHEVEIPSPTQKEKEKKK-----------------RPMSQISGVKKLMHSSS 40 50 60 70 350 360 370 380 390 400 pF1KE3 LNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLK :.::.::::::::.::..::.:::..:::::..: ... .:.: :: ::. ::::::::: CCDS56 LTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLK 80 90 100 110 120 130 410 420 430 440 450 460 pF1KE3 KFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAA :.:::::..::..::::::::::::::..:::::.:::::::.::::.::::::::::: CCDS56 TFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAA 140 150 160 170 180 190 470 480 490 500 510 520 pF1KE3 LFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLS .::.:::::::::::::::::::::::::::: :::::::::::::::::.::::::::. CCDS56 IFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLT 200 210 220 230 240 250 530 540 550 560 570 580 pF1KE3 KRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNM :.:::::::::::.::::::::::.::::::::::::::::::::::::::::::::.:: CCDS56 KKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNM 260 270 280 290 300 310 590 600 610 620 630 640 pF1KE3 VHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFI :::::::::::::.:::::::::: :::.:::::::::::::::::::.::::::::::: CCDS56 VHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFI 320 330 340 350 360 370 650 660 670 680 690 700 pF1KE3 DYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDK ::::::::::::::::::::.:::::::::.:: :.: ::::: :.. .: . .: CCDS56 DYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEG--RQGQTEK 380 390 400 410 420 430 710 720 730 740 750 pF1KE3 FQFELTLEEEEE---EEISMAQIP----CTAQEALTAQGLSGVEEALDATIAWEASPAQE :::::::::. : :. : .:. :. ...: .: ..: :: . :: .: CCDS56 FQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEE 440 450 460 470 480 490 760 770 780 790 800 810 pF1KE3 SLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSP CCDS56 ESQPEACVIDDRSPDT 500 >>CCDS56369.1 PDE4D gene_id:5144|Hs108|chr5 (518 aa) initn: 2462 init1: 2119 opt: 2203 Z-score: 1699.2 bits: 324.8 E(32554): 2.5e-88 Smith-Waterman score: 2444; 74.3% identity (87.9% similar) in 506 aa overlap (261-759:16-502) 240 250 260 270 280 290 pF1KE3 ARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTT :::::::::::::::::::::::::.::.: CCDS56 MPEANYLLSVSWGYIKFKRMLNRELTHLSEMSRSGNQVSEFISNT 10 20 30 40 300 310 320 330 340 350 pF1KE3 FLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNS :::::.::::::::.::.::.. .:::::.:.::::::.::.:: CCDS56 FLDKQHEVEIPSPTQKEKEKKK-----------------RPMSQISGVKKLMHSSSLTNS 50 60 70 80 360 370 380 390 400 410 pF1KE3 NIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRI .::::::::.::..::.:::..:::::..: ... .:.: :: ::. ::::::::: :.: CCDS56 SIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKI 90 100 110 120 130 140 420 430 440 450 460 470 pF1KE3 PVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAA ::::..::..::::::::::::::..:::::.:::::::.::::.:::::::::::.::. CCDS56 PVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFAS 150 160 170 180 190 200 480 490 500 510 520 530 pF1KE3 AIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQR :::::::::::::::::::::::::::: :::::::::::::::::.::::::::.:.:: CCDS56 AIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQR 210 220 230 240 250 260 540 550 560 570 580 590 pF1KE3 QSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA :::::::::.::::::::::.::::::::::::::::::::::::::::::::.:::::: CCDS56 QSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCA 270 280 290 300 310 320 600 610 620 630 640 650 pF1KE3 DLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIV :::::::::.:::::::::: :::.:::::::::::::::::::.::::::::::::::: CCDS56 DLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIV 330 340 350 360 370 380 660 670 680 690 700 710 pF1KE3 HPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFE ::::::::::::::::.:::::::::.:: :.: ::::: :.. .: . .::::: CCDS56 HPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEG--RQGQTEKFQFE 390 400 410 420 430 440 720 730 740 750 760 pF1KE3 LTLEEEEE---EEISMAQIP----CTAQEALTAQGLSGVEEALDATIAWEASPAQESLEV :::::. : :. : .:. :. ...: .: ..: :: . :: .: CCDS56 LTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQP 450 460 470 480 490 500 770 780 790 800 810 820 pF1KE3 MAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPA CCDS56 EACVIDDRSPDT 510 >>CCDS54858.1 PDE4D gene_id:5144|Hs108|chr5 (673 aa) initn: 2997 init1: 2119 opt: 2203 Z-score: 1697.5 bits: 324.9 E(32554): 3.1e-88 Smith-Waterman score: 3068; 72.1% identity (87.3% similar) in 663 aa overlap (108-759:17-657) 80 90 100 110 120 130 pF1KE3 GLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPG--LVLHA :...:: : :::::: ..::: :.:.: CCDS54 MMHVNNFPFRRHSWICFDVDNGT--SAGRSPLDPMTSPGSGLILQA 10 20 30 40 140 150 160 170 180 190 pF1KE3 GAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNF . . ::::::::::::::::.:::.::::::..:. :..:::::::::::::::.::.:: CCDS54 NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNF 50 60 70 80 90 100 200 210 220 230 240 250 pF1KE3 SLLTNVP--VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRS . :::. .:: ::::. . . :::..::. :.:: ::::::::::.::::.:: .: CCDS54 AALTNLQDRAPS-KRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHS 110 120 130 140 150 160 260 270 280 290 300 310 pF1KE3 VSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQA ::::::.:::::::::::::::::::::::::.::.::::::.::::::::.::.::.. CCDS54 VSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKK- 170 180 190 200 210 220 320 330 340 350 360 370 pF1KE3 PRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLN .:::::.:.::::::.::.::.::::::::.::..::.:::..: CCDS54 ----------------RPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVN 230 240 250 260 380 390 400 410 420 430 pF1KE3 KWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYH ::::..: ... .:.: :: ::. ::::::::: :.:::::..::..::::::::::::: CCDS54 KWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH 270 280 290 300 310 320 440 450 460 470 480 490 pF1KE3 NSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELA :..:::::.:::::::.::::.:::::::::::.::.::::::::::::::::::::::: CCDS54 NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELA 330 340 350 360 370 380 500 510 520 530 540 550 pF1KE3 LMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLL ::::: :::::::::::::::::.::::::::.:.:::::::::::.::::::::::.:: CCDS54 LMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLL 390 400 410 420 430 440 560 570 580 590 600 610 pF1KE3 ADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEF ::::::::::::::::::::::::::::::.:::::::::::::::.:::::::::: :: CCDS54 ADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEF 450 460 470 480 490 500 620 630 640 650 660 670 pF1KE3 FQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLE :.:::::::::::::::::::.:::::::::::::::::::::::::::::::.:::::: CCDS54 FRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE 510 520 530 540 550 560 680 690 700 710 720 pF1KE3 DNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEE---EEISMAQIP--- :::.:: :.: ::::: :.. .: . .::::::::::. : :. : .:. CCDS54 DNREWYQSTIPQSPSPAPDDPEEG--RQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDT 570 580 590 600 610 620 730 740 750 760 770 780 pF1KE3 -CTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQST :. ...: .: ..: :: . :: .: CCDS54 SCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT 630 640 650 660 670 790 800 810 820 830 840 pF1KE3 GSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEV >>CCDS56371.1 PDE4D gene_id:5144|Hs108|chr5 (679 aa) initn: 2997 init1: 2119 opt: 2203 Z-score: 1697.5 bits: 324.9 E(32554): 3.1e-88 Smith-Waterman score: 3068; 72.1% identity (87.3% similar) in 663 aa overlap (108-759:23-663) 80 90 100 110 120 130 pF1KE3 GLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPG--LVLHA :...:: : :::::: ..::: :.:.: CCDS56 MSIIMKPRSRSTSSLRTAEAVCFDVDNGT--SAGRSPLDPMTSPGSGLILQA 10 20 30 40 50 140 150 160 170 180 190 pF1KE3 GAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNF . . ::::::::::::::::.:::.::::::..:. :..:::::::::::::::.::.:: CCDS56 NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNF 60 70 80 90 100 110 200 210 220 230 240 250 pF1KE3 SLLTNVP--VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRS . :::. .:: ::::. . . :::..::. :.:: ::::::::::.::::.:: .: CCDS56 AALTNLQDRAPS-KRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHS 120 130 140 150 160 260 270 280 290 300 310 pF1KE3 VSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQA ::::::.:::::::::::::::::::::::::.::.::::::.::::::::.::.::.. CCDS56 VSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKK- 170 180 190 200 210 220 320 330 340 350 360 370 pF1KE3 PRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLN .:::::.:.::::::.::.::.::::::::.::..::.:::..: CCDS56 ----------------RPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVN 230 240 250 260 270 380 390 400 410 420 430 pF1KE3 KWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYH ::::..: ... .:.: :: ::. ::::::::: :.:::::..::..::::::::::::: CCDS56 KWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH 280 290 300 310 320 330 440 450 460 470 480 490 pF1KE3 NSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELA :..:::::.:::::::.::::.:::::::::::.::.::::::::::::::::::::::: CCDS56 NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELA 340 350 360 370 380 390 500 510 520 530 540 550 pF1KE3 LMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLL ::::: :::::::::::::::::.::::::::.:.:::::::::::.::::::::::.:: CCDS56 LMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLL 400 410 420 430 440 450 560 570 580 590 600 610 pF1KE3 ADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEF ::::::::::::::::::::::::::::::.:::::::::::::::.:::::::::: :: CCDS56 ADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEF 460 470 480 490 500 510 620 630 640 650 660 670 pF1KE3 FQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLE :.:::::::::::::::::::.:::::::::::::::::::::::::::::::.:::::: CCDS56 FRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE 520 530 540 550 560 570 680 690 700 710 720 pF1KE3 DNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEE---EEISMAQIP--- :::.:: :.: ::::: :.. .: . .::::::::::. : :. : .:. CCDS56 DNREWYQSTIPQSPSPAPDDPEEG--RQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDT 580 590 600 610 620 630 730 740 750 760 770 780 pF1KE3 -CTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQST :. ...: .: ..: :: . :: .: CCDS56 SCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT 640 650 660 670 790 800 810 820 830 840 pF1KE3 GSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEV >>CCDS56372.1 PDE4D gene_id:5144|Hs108|chr5 (687 aa) initn: 2997 init1: 2119 opt: 2203 Z-score: 1697.4 bits: 324.9 E(32554): 3.2e-88 Smith-Waterman score: 3071; 71.9% identity (87.1% similar) in 666 aa overlap (105-759:28-671) 80 90 100 110 120 130 pF1KE3 DRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPG--LV : :...:: : :::::: ..::: :. CCDS56 MAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGT--SAGRSPLDPMTSPGSGLI 10 20 30 40 50 140 150 160 170 180 190 pF1KE3 LHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVR :.:. . ::::::::::::::::.:::.::::::..:. :..:::::::::::::::.:: CCDS56 LQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVR 60 70 80 90 100 110 200 210 220 230 240 250 pF1KE3 SNFSLLTNVP--VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQT .::. :::. .:: ::::. . . :::..::. :.:: ::::::::::.::::.:: CCDS56 NNFAALTNLQDRAPS-KRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQT 120 130 140 150 160 170 260 270 280 290 300 310 pF1KE3 YRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREK .:::::::.:::::::::::::::::::::::::.::.::::::.::::::::.::.:: CCDS56 RHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEK 180 190 200 210 220 230 320 330 340 350 360 370 pF1KE3 QQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELE .. .:::::.:.::::::.::.::.::::::::.::..::.::: CCDS56 KK-----------------RPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELE 240 250 260 270 380 390 400 410 420 430 pF1KE3 NLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADV ..:::::..: ... .:.: :: ::. ::::::::: :.:::::..::..:::::::::: CCDS56 DVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADV 280 290 300 310 320 330 440 450 460 470 480 490 pF1KE3 AYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNS ::::..:::::.:::::::.::::.:::::::::::.::.:::::::::::::::::::: CCDS56 AYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNS 340 350 360 370 380 390 500 510 520 530 540 550 pF1KE3 ELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHM :::::::: :::::::::::::::::.::::::::.:.:::::::::::.:::::::::: CCDS56 ELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHM 400 410 420 430 440 450 560 570 580 590 600 610 pF1KE3 TLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIM .::::::::::::::::::::::::::::::::.:::::::::::::::.:::::::::: CCDS56 NLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIM 460 470 480 490 500 510 620 630 640 650 660 670 pF1KE3 AEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILD :::.:::::::::::::::::::.:::::::::::::::::::::::::::::::.::: CCDS56 EEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILD 520 530 540 550 560 570 680 690 700 710 720 pF1KE3 TLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEE---EEISMAQIP ::::::.:: :.: ::::: :.. .: . .::::::::::. : :. : .:. CCDS56 TLEDNREWYQSTIPQSPSPAPDDPEEG--RQGQTEKFQFELTLEEDGESDTEKDSGSQVE 580 590 600 610 620 630 730 740 750 760 770 780 pF1KE3 ----CTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQA :. ...: .: ..: :: . :: .: CCDS56 EDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT 640 650 660 670 680 790 800 810 820 830 840 pF1KE3 QSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTA 886 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 03:14:58 2016 done: Mon Nov 7 03:14:58 2016 Total Scan time: 4.530 Total Display time: 0.240 Function used was FASTA [36.3.4 Apr, 2011]