Result of FASTA (omim) for
pFN21AB9376
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9376, 411 aa
1>>>pF1KB9376 411 - 411 aa - 411 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5447+/-0.000405; mu= 15.9834+/- 0.025
mean_var=68.2936+/-13.831, 0's: 0 Z-trim(111.2): 18 B-trim: 898 in 1/54
Lambda= 0.155197
statistics sampled from 19708 (19725) to 19708 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.579), E-opt: 0.2 (0.231), width: 16
Scan time: 8.000
The best scores are: opt bits E(85289)
NP_001116078 (OMIM: 300257,309060) lysosome-associ ( 411) 2689 611.3 1.3e-174
NP_054701 (OMIM: 300257,309060) lysosome-associate ( 410) 2564 583.3 3.6e-166
NP_002285 (OMIM: 300257,309060) lysosome-associate ( 410) 2547 579.5 5e-165
NP_005552 (OMIM: 153330) lysosome-associated membr ( 417) 877 205.6 1.8e-52
XP_011535796 (OMIM: 153330) PREDICTED: lysosome-as ( 398) 856 200.9 4.6e-51
XP_006713649 (OMIM: 605883) PREDICTED: lysosome-as ( 394) 382 94.8 4.1e-19
XP_005247417 (OMIM: 605883) PREDICTED: lysosome-as ( 418) 382 94.8 4.3e-19
NP_055213 (OMIM: 605883) lysosome-associated membr ( 416) 361 90.1 1.1e-17
NP_001242 (OMIM: 153634) macrosialin isoform A pre ( 354) 240 63.0 1.4e-09
NP_001035148 (OMIM: 153634) macrosialin isoform B ( 327) 238 62.5 1.8e-09
XP_011510990 (OMIM: 605883) PREDICTED: lysosome-as ( 354) 210 56.2 1.4e-07
NP_001186826 (OMIM: 614641) lysosome-associated me ( 236) 140 40.5 0.0053
NP_036393 (OMIM: 614641) lysosome-associated membr ( 280) 140 40.5 0.0062
>>NP_001116078 (OMIM: 300257,309060) lysosome-associated (411 aa)
initn: 2689 init1: 2689 opt: 2689 Z-score: 3255.6 bits: 611.3 E(85289): 1.3e-174
Smith-Waterman score: 2689; 100.0% identity (100.0% similar) in 411 aa overlap (1-411:1-411)
10 20 30 40 50 60
pF1KB9 MVCFRLFPVPGSGLVLVCLVLGAVRSYALELNLTDSENATCLYAKWQMNFTVRYETTNKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVCFRLFPVPGSGLVLVCLVLGAVRSYALELNLTDSENATCLYAKWQMNFTVRYETTNKT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 YKTVTISDHGTVTYNGSICGDDQNGPKIAVQFGPGFSWIANFTKAASTYSIDSVSFSYNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YKTVTISDHGTVTYNGSICGDDQNGPKIAVQFGPGFSWIANFTKAASTYSIDSVSFSYNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 GDNTTFPDAEDKGILTVDELLAIRIPLNDLFRCNSLSTLEKNDVVQHYWDVLVQAFVQNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDNTTFPDAEDKGILTVDELLAIRIPLNDLFRCNSLSTLEKNDVVQHYWDVLVQAFVQNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 TVSTNEFLCDKDKTSTVAPTIHTTVPSPTTTPTPKEKPEAGTYSVNNGNDTCLLATMGLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVSTNEFLCDKDKTSTVAPTIHTTVPSPTTTPTPKEKPEAGTYSVNNGNDTCLLATMGLQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 LNITQDKVASVININPNTTHSTGSCRSHTALLRLNSSTIKYLDFVFAVKNENRFYLKEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNITQDKVASVININPNTTHSTGSCRSHTALLRLNSSTIKYLDFVFAVKNENRFYLKEVN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 ISMYLVNGSVFSIANNNLSYWDAPLGSSYMCNKEQTVSVSGAFQINTFDLRVQPFNVTQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISMYLVNGSVFSIANNNLSYWDAPLGSSYMCNKEQTVSVSGAFQINTFDLRVQPFNVTQG
310 320 330 340 350 360
370 380 390 400 410
pF1KB9 KYSTAEECSADSDLNFLIPVAVGVALGFLIIVVFISYMIGRRKSRTGYQSV
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KYSTAEECSADSDLNFLIPVAVGVALGFLIIVVFISYMIGRRKSRTGYQSV
370 380 390 400 410
>>NP_054701 (OMIM: 300257,309060) lysosome-associated me (410 aa)
initn: 2585 init1: 2438 opt: 2564 Z-score: 3104.3 bits: 583.3 E(85289): 3.6e-166
Smith-Waterman score: 2564; 95.1% identity (98.5% similar) in 411 aa overlap (1-411:1-410)
10 20 30 40 50 60
pF1KB9 MVCFRLFPVPGSGLVLVCLVLGAVRSYALELNLTDSENATCLYAKWQMNFTVRYETTNKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 MVCFRLFPVPGSGLVLVCLVLGAVRSYALELNLTDSENATCLYAKWQMNFTVRYETTNKT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 YKTVTISDHGTVTYNGSICGDDQNGPKIAVQFGPGFSWIANFTKAASTYSIDSVSFSYNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 YKTVTISDHGTVTYNGSICGDDQNGPKIAVQFGPGFSWIANFTKAASTYSIDSVSFSYNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 GDNTTFPDAEDKGILTVDELLAIRIPLNDLFRCNSLSTLEKNDVVQHYWDVLVQAFVQNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 GDNTTFPDAEDKGILTVDELLAIRIPLNDLFRCNSLSTLEKNDVVQHYWDVLVQAFVQNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 TVSTNEFLCDKDKTSTVAPTIHTTVPSPTTTPTPKEKPEAGTYSVNNGNDTCLLATMGLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 TVSTNEFLCDKDKTSTVAPTIHTTVPSPTTTPTPKEKPEAGTYSVNNGNDTCLLATMGLQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 LNITQDKVASVININPNTTHSTGSCRSHTALLRLNSSTIKYLDFVFAVKNENRFYLKEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 LNITQDKVASVININPNTTHSTGSCRSHTALLRLNSSTIKYLDFVFAVKNENRFYLKEVN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 ISMYLVNGSVFSIANNNLSYWDAPLGSSYMCNKEQTVSVSGAFQINTFDLRVQPFNVTQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 ISMYLVNGSVFSIANNNLSYWDAPLGSSYMCNKEQTVSVSGAFQINTFDLRVQPFNVTQG
310 320 330 340 350 360
370 380 390 400 410
pF1KB9 KYSTAEECSADSDLNFLIPVAVGVALGFLIIVVFISYMIGRRKSRTGYQSV
:::::.::: :.: ..:::. ::..:. ::::. :.:.:::::: .:::..
NP_054 KYSTAQECSLDDD-TILIPIIVGAGLSGLIIVIVIAYVIGRRKSYAGYQTL
370 380 390 400 410
>>NP_002285 (OMIM: 300257,309060) lysosome-associated me (410 aa)
initn: 2545 init1: 2441 opt: 2547 Z-score: 3083.8 bits: 579.5 E(85289): 5e-165
Smith-Waterman score: 2547; 94.4% identity (99.0% similar) in 409 aa overlap (1-409:1-408)
10 20 30 40 50 60
pF1KB9 MVCFRLFPVPGSGLVLVCLVLGAVRSYALELNLTDSENATCLYAKWQMNFTVRYETTNKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MVCFRLFPVPGSGLVLVCLVLGAVRSYALELNLTDSENATCLYAKWQMNFTVRYETTNKT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 YKTVTISDHGTVTYNGSICGDDQNGPKIAVQFGPGFSWIANFTKAASTYSIDSVSFSYNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YKTVTISDHGTVTYNGSICGDDQNGPKIAVQFGPGFSWIANFTKAASTYSIDSVSFSYNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 GDNTTFPDAEDKGILTVDELLAIRIPLNDLFRCNSLSTLEKNDVVQHYWDVLVQAFVQNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GDNTTFPDAEDKGILTVDELLAIRIPLNDLFRCNSLSTLEKNDVVQHYWDVLVQAFVQNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 TVSTNEFLCDKDKTSTVAPTIHTTVPSPTTTPTPKEKPEAGTYSVNNGNDTCLLATMGLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TVSTNEFLCDKDKTSTVAPTIHTTVPSPTTTPTPKEKPEAGTYSVNNGNDTCLLATMGLQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 LNITQDKVASVININPNTTHSTGSCRSHTALLRLNSSTIKYLDFVFAVKNENRFYLKEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LNITQDKVASVININPNTTHSTGSCRSHTALLRLNSSTIKYLDFVFAVKNENRFYLKEVN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 ISMYLVNGSVFSIANNNLSYWDAPLGSSYMCNKEQTVSVSGAFQINTFDLRVQPFNVTQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ISMYLVNGSVFSIANNNLSYWDAPLGSSYMCNKEQTVSVSGAFQINTFDLRVQPFNVTQG
310 320 330 340 350 360
370 380 390 400 410
pF1KB9 KYSTAEECSADSDLNFLIPVAVGVALGFLIIVVFISYMIGRRKSRTGYQSV
:::::..::::.: :::.:.:::.::. ..:.:...:.:: .. ..::.
NP_002 KYSTAQDCSADDD-NFLVPIAVGAALAGVLILVLLAYFIGLKHHHAGYEQF
370 380 390 400 410
>>NP_005552 (OMIM: 153330) lysosome-associated membrane (417 aa)
initn: 776 init1: 289 opt: 877 Z-score: 1062.8 bits: 205.6 E(85289): 1.8e-52
Smith-Waterman score: 877; 36.0% identity (68.3% similar) in 419 aa overlap (10-411:4-417)
10 20 30 40 50
pF1KB9 MVCFRLFPVPGSG-----LVLVCLVLGAVRSYALELNLTDSENAT-CLYAKWQMNFTVRY
:::. :.:. :.:: .. . . .. . :.: :..:... :.: :
NP_005 MAAPGSARRPLLLLLLLLLLGLMHCASAAMFMVKNGNGTACIMANFSAAFSVNY
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 ET-TNKTYKTVTISDHGTVTYNGSICG-DDQNGPKIAVQFGPGFSWIANFTKAASTYSID
.: .. : . . .::. : : :: .. . :.... :: : . :::. :. ::..
NP_005 DTKSGPKNMTFDLPSDATVVLNRSSCGKENTSDPSLVIAFGRGHTLTLNFTRNATRYSVQ
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 SVSFSYNTGDNTTFPDAEDKGILTVDELLAIRIPLNDLFRCNSLSTLEKNDVVQHYWDVL
.:: :: .:. ::.: .: : ::. . :: .. .:: : . .. :.:. :.
NP_005 LMSFVYNLSDTHLFPNASSKEIKTVESITDIRADIDKKYRCVSGTQVHMNNVTVTLHDAT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 VQAFVQNGTVSTNEFLCDKDKTS-TVAPTIHTTVPSPTTTPTPKEKPEAGTYSVNNGNDT
.::...:.. : .: :..:. : :.:: . :::. .:.:: .: . :.:.. : :
NP_005 IQAYLSNSSFSRGETRCEQDRPSPTTAPP---APPSPSPSPVPK-SPSVDKYNVSGTNGT
180 190 200 210 220 230
240 250 260 270 280
pF1KB9 CLLATMGLQLNITQDK-----VASVININPNTTHSTGSCRSHTALLRLNSSTIKYLDFVF
::::.::::::.: .. :. ..::::: : ..::: .: . :.:.: : : :
NP_005 CLLASMGLQLNLTYERKDNTTVTRLLNINPNKTSASGSCGAHLVTLELHSEGTTVLLFQF
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB9 AVK-NENRFYLKEVNISMYLVNGS--VFSIANNNLSYWDAPLGSSYMCNKEQTVSVSGAF
... . .::.:. .... : .. .:. ::..: .: .:.:: :: :. : :. ::
NP_005 GMNASSSRFFLQGIQLNTILPDARDPAFKAANGSLRALQATVGNSYKCNAEEHVRVTKAF
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB9 QINTFDLRVQPFNVTQGKYSTAEECSADSDLNFLIPVAVGVALGFLIIVVFISYMIGRRK
..: : . :: :.: :.....::: : . ..:::.::: ::. :...:.:.:..::..
NP_005 SVNIFKVWVQAFKVEGGQFGSVEECLLDEN-SMLIPIAVGGALAGLVLIVLIAYLVGRKR
360 370 380 390 400
410
pF1KB9 SRTGYQSV
:..:::..
NP_005 SHAGYQTI
410
>>XP_011535796 (OMIM: 153330) PREDICTED: lysosome-associ (398 aa)
initn: 776 init1: 289 opt: 856 Z-score: 1037.7 bits: 200.9 E(85289): 4.6e-51
Smith-Waterman score: 856; 35.7% identity (68.2% similar) in 403 aa overlap (21-411:1-398)
10 20 30 40 50
pF1KB9 MVCFRLFPVPGSGLVLVCLVLGAVRSYALELNLTDSENAT-CLYAKWQMNFTVRYET-TN
.: .. . . .. . :.: :..:... :.: :.: ..
XP_011 MGLMHCASAAMFMVKNGNGTACIMANFSAAFSVNYDTKSG
10 20 30 40
60 70 80 90 100 110
pF1KB9 KTYKTVTISDHGTVTYNGSICG-DDQNGPKIAVQFGPGFSWIANFTKAASTYSIDSVSFS
: . . .::. : : :: .. . :.... :: : . :::. :. ::.. .::
XP_011 PKNMTFDLPSDATVVLNRSSCGKENTSDPSLVIAFGRGHTLTLNFTRNATRYSVQLMSFV
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB9 YNTGDNTTFPDAEDKGILTVDELLAIRIPLNDLFRCNSLSTLEKNDVVQHYWDVLVQAFV
:: .:. ::.: .: : ::. . :: .. .:: : . .. :.:. :. .::..
XP_011 YNLSDTHLFPNASSKEIKTVESITDIRADIDKKYRCVSGTQVHMNNVTVTLHDATIQAYL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB9 QNGTVSTNEFLCDKDKTS-TVAPTIHTTVPSPTTTPTPKEKPEAGTYSVNNGNDTCLLAT
.:.. : .: :..:. : :.:: :::. .:.:: .: . :.:.. : :::::.
XP_011 SNSSFSRGETRCEQDRPSPTTAPPAP---PSPSPSPVPK-SPSVDKYNVSGTNGTCLLAS
170 180 190 200 210
240 250 260 270 280 290
pF1KB9 MGLQLNITQDK-----VASVININPNTTHSTGSCRSHTALLRLNSSTIKYLDFVFAVK-N
::::::.: .. :. ..::::: : ..::: .: . :.:.: : : :... .
XP_011 MGLQLNLTYERKDNTTVTRLLNINPNKTSASGSCGAHLVTLELHSEGTTVLLFQFGMNAS
220 230 240 250 260 270
300 310 320 330 340
pF1KB9 ENRFYLKEVNISMYLVNGS--VFSIANNNLSYWDAPLGSSYMCNKEQTVSVSGAFQINTF
.::.:. .... : .. .:. ::..: .: .:.:: :: :. : :. ::..: :
XP_011 SSRFFLQGIQLNTILPDARDPAFKAANGSLRALQATVGNSYKCNAEEHVRVTKAFSVNIF
280 290 300 310 320 330
350 360 370 380 390 400
pF1KB9 DLRVQPFNVTQGKYSTAEECSADSDLNFLIPVAVGVALGFLIIVVFISYMIGRRKSRTGY
. :: :.: :.....::: : . ..:::.::: ::. :...:.:.:..::..:..::
XP_011 KVWVQAFKVEGGQFGSVEECLLDEN-SMLIPIAVGGALAGLVLIVLIAYLVGRKRSHAGY
340 350 360 370 380 390
410
pF1KB9 QSV
:..
XP_011 QTI
>>XP_006713649 (OMIM: 605883) PREDICTED: lysosome-associ (394 aa)
initn: 266 init1: 81 opt: 382 Z-score: 464.2 bits: 94.8 E(85289): 4.1e-19
Smith-Waterman score: 395; 27.3% identity (60.5% similar) in 377 aa overlap (46-409:51-392)
20 30 40 50 60 70
pF1KB9 LVCLVLGAVRSYALELNLTDSENATCLYAKWQMNFTVRYETTNK--TYKTVTISD--HGT
.: ::. ::. : .:.: : .
XP_006 VQDIKKPVQQPAKQAPHQTLAARFMDGHITFQTAATVKIPTTTPATTKNTATTSPITYTL
30 40 50 60 70 80
80 90 100 110 120
pF1KB9 VTYNGSICGDDQNGPKIAVQFGPG---FSWIANFTKAASTYSIDSVSFSYNTGDNTTFPD
:: ... .. : : ::. .: ..: : : . .: . :..:: ::: :.
XP_006 VTTQATPNNSHTAPPVTEVTVGPSLAPYSLPPTITPPAHTTGTSSSTVSHTTG-NTTQPS
90 100 110 120 130
130 140 150 160 170 180
pF1KB9 AEDKGILTVDELLAIRIPLNDLFRCNSLSTLEKNDVVQHYWDVLVQAFVQNGTVSTNEFL
. :. :.: .:.:. . :. :: ::... .
XP_006 NQT----TLPATLSI--------------ALHKSTTGQKP----VQPTHAPGTTAAAH--
140 150 160 170
190 200 210 220 230 240
pF1KB9 CDKDKTSTVAPTIHTTVPSPTTTPTPKEKPEAGTYSVNNGNDTCLLATMGLQLNITQDKV
. : :.::. .:::.:: .: :. . ..: :.: ::. :. : ::.:: :.:::
XP_006 ---NTTRTAAPA--STVPGPTLAPQPS-SVKTGIYQVLNGSRLCIKAEMGIQL-IVQDKE
180 190 200 210 220
250 260 270 280 290 300
pF1KB9 A-----SVININPNTTHSTGSCRSHTALLRLNSSTIKYLDFVFAVKNENRFYLKEVNISM
. .::.::.:...:.: .. . : :: . .....:. :.:. .:..::. .
XP_006 SVFSPRRYFNIDPNATQASGNCGTRKSNLLLNFQG-GFVNLTFT-KDEESYYISEVGAYL
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB9 YLVNG-SVFSIANNNLSYWDAPLGSSYMCNKEQTVSVSGAFQINTFDLRVQPFNVTQGKY
. . .... .. . .... .: :. : .::....:. .:..: :...: :. . ..
XP_006 TVSDPETIYQGIKHAVVMFQTAVGHSFKCVSEQSLQLSAHLQVKTTDVQLQAFDFEDDHF
290 300 310 320 330 340
370 380 390 400 410
pF1KB9 STAEECSADSDLNFLIPVAVGVALGFLIIVVFISYMIGRRKSRTGYQSV
..:.:: .: . ::::.:... :..... . ...:.. ::.
XP_006 GNADECFSDRN-RREIPVAMGLSITGLLVILLTACLVARKRPSRGYERM
350 360 370 380 390
>>XP_005247417 (OMIM: 605883) PREDICTED: lysosome-associ (418 aa)
initn: 266 init1: 81 opt: 382 Z-score: 463.8 bits: 94.8 E(85289): 4.3e-19
Smith-Waterman score: 395; 27.3% identity (60.5% similar) in 377 aa overlap (46-409:75-416)
20 30 40 50 60 70
pF1KB9 LVCLVLGAVRSYALELNLTDSENATCLYAKWQMNFTVRYETTNK--TYKTVTISD--HGT
.: ::. ::. : .:.: : .
XP_005 VQDIKKPVQQPAKQAPHQTLAARFMDGHITFQTAATVKIPTTTPATTKNTATTSPITYTL
50 60 70 80 90 100
80 90 100 110 120
pF1KB9 VTYNGSICGDDQNGPKIAVQFGPG---FSWIANFTKAASTYSIDSVSFSYNTGDNTTFPD
:: ... .. : : ::. .: ..: : : . .: . :..:: ::: :.
XP_005 VTTQATPNNSHTAPPVTEVTVGPSLAPYSLPPTITPPAHTTGTSSSTVSHTTG-NTTQPS
110 120 130 140 150 160
130 140 150 160 170 180
pF1KB9 AEDKGILTVDELLAIRIPLNDLFRCNSLSTLEKNDVVQHYWDVLVQAFVQNGTVSTNEFL
. :. :.: .:.:. . :. :: ::... .
XP_005 NQT----TLPATLSI--------------ALHKSTTGQKP----VQPTHAPGTTAAAH--
170 180 190
190 200 210 220 230 240
pF1KB9 CDKDKTSTVAPTIHTTVPSPTTTPTPKEKPEAGTYSVNNGNDTCLLATMGLQLNITQDKV
. : :.::. .:::.:: .: :. . ..: :.: ::. :. : ::.:: :.:::
XP_005 ---NTTRTAAPA--STVPGPTLAPQPS-SVKTGIYQVLNGSRLCIKAEMGIQL-IVQDKE
200 210 220 230 240 250
250 260 270 280 290 300
pF1KB9 A-----SVININPNTTHSTGSCRSHTALLRLNSSTIKYLDFVFAVKNENRFYLKEVNISM
. .::.::.:...:.: .. . : :: . .....:. :.:. .:..::. .
XP_005 SVFSPRRYFNIDPNATQASGNCGTRKSNLLLNFQG-GFVNLTFT-KDEESYYISEVGAYL
260 270 280 290 300 310
310 320 330 340 350 360
pF1KB9 YLVNG-SVFSIANNNLSYWDAPLGSSYMCNKEQTVSVSGAFQINTFDLRVQPFNVTQGKY
. . .... .. . .... .: :. : .::....:. .:..: :...: :. . ..
XP_005 TVSDPETIYQGIKHAVVMFQTAVGHSFKCVSEQSLQLSAHLQVKTTDVQLQAFDFEDDHF
320 330 340 350 360 370
370 380 390 400 410
pF1KB9 STAEECSADSDLNFLIPVAVGVALGFLIIVVFISYMIGRRKSRTGYQSV
..:.:: .: . ::::.:... :..... . ...:.. ::.
XP_005 GNADECFSDRN-RREIPVAMGLSITGLLVILLTACLVARKRPSRGYERM
380 390 400 410
>>NP_055213 (OMIM: 605883) lysosome-associated membrane (416 aa)
initn: 199 init1: 76 opt: 361 Z-score: 438.4 bits: 90.1 E(85289): 1.1e-17
Smith-Waterman score: 374; 28.0% identity (60.4% similar) in 379 aa overlap (46-411:75-416)
20 30 40 50 60 70
pF1KB9 LVCLVLGAVRSYALELNLTDSENATCLYAKWQMNFTVRYETTNK--TYKTVTISD--HGT
.: ::. ::. : .:.: : .
NP_055 VQDIKKPVQQPAKQAPHQTLAARFMDGHITFQTAATVKIPTTTPATTKNTATTSPITYTL
50 60 70 80 90 100
80 90 100 110 120
pF1KB9 VTYNGSICGDDQNGPKIAVQFGPG---FSWIANFTKAASTYSIDSVSFSYNTGDNTTFPD
:: ... .. : : ::. .: ..: : : . .: . :..:: ::: :.
NP_055 VTTQATPNNSHTAPPVTEVTVGPSLAPYSLPPTITPPAHTTGTSSSTVSHTTG-NTTQPS
110 120 130 140 150 160
130 140 150 160 170 180
pF1KB9 AEDKGILTVDELLAIRIPLNDLFRCNSLSTLEKNDVVQHYWDVLVQAFVQNGTVSTNEFL
. :. :.: .:.:. . :. :: ::... .
NP_055 NQT----TLPATLSI--------------ALHKSTTGQKP----VQPTHAPGTTAAAH--
170 180 190
190 200 210 220 230 240
pF1KB9 CDKDKTSTVAPTIHTTVPSPTTTPTPKEKPEAGTYSVNNGNDTCLLATMGLQLNITQDK-
. : :.::. .:::.:: .: :. . ..: :.: ::. :. : ::.:: :.:::
NP_055 ---NTTRTAAPA--STVPGPTLAPQPS-SVKTGIYQVLNGSRLCIKAEMGIQL-IVQDKE
200 210 220 230 240 250
250 260 270 280 290 300
pF1KB9 -VAS---VININPNTTHSTGSCRSHTALLRLNSSTIKYLDFVFAVKNENRFYLKEVNISM
: : .::.::.:...:.: .. . : :: . .....:. :.:. .:..::. .
NP_055 SVFSPRRYFNIDPNATQASGNCGTRKSNLLLNFQG-GFVNLTFT-KDEESYYISEVGAYL
260 270 280 290 300 310
310 320 330 340 350 360
pF1KB9 YLVNG-SVFSIANNNLSYWDAPLGSSYMCNKEQTVSVSGAFQINTFDLRVQPFNVTQGKY
. . .... .. . .... .: :. : .::....:. .:..: :...: :. . ..
NP_055 TVSDPETIYQGIKHAVVMFQTAVGHSFKCVSEQSLQLSAHLQVKTTDVQLQAFDFEDDHF
320 330 340 350 360 370
370 380 390 400 410
pF1KB9 STAEECSADSDLNFLIPVAVGVALGFLIIVVFISYMIGRRKSRTGYQSV
....::: :: ....:: ....:. .. . . : : : . .::: .
NP_055 GNVDECS--SDYTIVLPVIGAIVVGLCLMGMGV-YKIRLRCQSSGYQRI
380 390 400 410
>>NP_001242 (OMIM: 153634) macrosialin isoform A precurs (354 aa)
initn: 218 init1: 68 opt: 240 Z-score: 293.1 bits: 63.0 E(85289): 1.4e-09
Smith-Waterman score: 286; 24.4% identity (55.1% similar) in 356 aa overlap (70-411:13-354)
40 50 60 70 80 90
pF1KB9 TCLYAKWQMNFTVRYETTNKTYKTVTISDHGTVTYNGSICGDDQNGPKIAVQFGPGFSWI
: .. .:. :.: : :. . :.:.
NP_001 MRLAVLFSGALLGLLAAQGT--GNDCPHKKSATLL-PSFTVT
10 20 30
100 110 120 130 140 150
pF1KB9 ANFTKAASTYSIDSVSFSYNTGDNTTFPDAEDKGILTVDELLAIRIPLNDLFR--CNSLS
. :....: : ... .: :: . ..: :. . . : . :: .
NP_001 PTVTESTGTTSHRTTKSHKTTTHRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTA
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB9 TLEKNDVVQHYWDVLVQAFVQNGTVSTNEFLCDKDKTSTVAPTIHTTVPSPTTTPTPKEK
: . ... : : ...:..... . . . . : : :. .:.: :
NP_001 TSQGPSTATHS-----PATTSHGNATVHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSK
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB9 PEAGTYSVNNGNDTCLLATMGLQLNI---TQD--KVASVININPNTTHSTGSCR-SHTAL
: :. .::.. :. .:. . :: .. .. .::: :. :::. .: :
NP_001 ETIGDYTWTNGSQPCVHLQAQIQIRVMYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHL
160 170 180 190 200 210
280 290 300 310 320
pF1KB9 LRLNSSTIKYLDFVFAVKNENRF-YLK----EVNISMYLVNGSVFSIANNNLSYWDAPLG
: : .:.: : ... ::. : :.:. . .:: : .: .::::
NP_001 LL--SFPYGHLSFGFMQDLQQKVVYLSYMAVEYNVSFPHAAQWTFSAQNASLRDLQAPLG
220 230 240 250 260 270
330 340 350 360 370 380
pF1KB9 SSYMCNKEQTVSVSGAFQINTFDLRVQPFNVTQ-GKYSTAEECSADSDLNFLIPVAVGVA
.:. :.. ... .: : ... ..::.: .. . : .. . : :: ..:.:. .:.
NP_001 QSFSCSN-SSIILSPAVHLDLLSLRLQAAQLPHTGVFGQSFSC--PSDRSILLPLIIGLI
280 290 300 310 320
390 400 410
pF1KB9 LGFLIIVVFISYMIGRRKSRTGYQSV
: :. .:.:.. : ::. ..::..
NP_001 LLGLLALVLIAFCIIRRRP-SAYQAL
330 340 350
>>NP_001035148 (OMIM: 153634) macrosialin isoform B prec (327 aa)
initn: 194 init1: 68 opt: 238 Z-score: 291.2 bits: 62.5 E(85289): 1.8e-09
Smith-Waterman score: 281; 28.6% identity (58.9% similar) in 224 aa overlap (200-411:110-327)
170 180 190 200 210 220
pF1KB9 DVLVQAFVQNGTVSTNEFLCDKDKTSTVAPTIHTTVPSPTTTPTPKEKPEAGTYSVNNGN
. : : :. .:.: : : :. .::.
NP_001 ATHSPATTSHGNATVHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGS
80 90 100 110 120 130
230 240 250 260 270 280
pF1KB9 DTCLLATMGLQLNI---TQD--KVASVININPNTTHSTGSCR-SHTALLRLNSSTIKYLD
. :. .:. . :: .. .. .::: :. :::. .: :: : .:.
NP_001 QPCVHLQAQIQIRVMYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLL--SFPYGHLS
140 150 160 170 180 190
290 300 310 320 330
pF1KB9 FVFAVKNENRF-YLK----EVNISMYLVNGSVFSIANNNLSYWDAPLGSSYMCNKEQTVS
: : ... ::. : :.:. . .:: : .: .::::.:. :.. ...
NP_001 FGFMQDLQQKVVYLSYMAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCSN-SSII
200 210 220 230 240 250
340 350 360 370 380 390
pF1KB9 VSGAFQINTFDLRVQPFNVTQ-GKYSTAEECSADSDLNFLIPVAVGVALGFLIIVVFISY
.: : ... ..::.: .. . : .. . : :: ..:.:. .:. : :. .:.:..
NP_001 LSPAVHLDLLSLRLQAAQLPHTGVFGQSFSCP--SDRSILLPLIIGLILLGLLALVLIAF
260 270 280 290 300 310
400 410
pF1KB9 MIGRRKSRTGYQSV
: ::. ..::..
NP_001 CIIRRRP-SAYQAL
320
411 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 13:17:44 2016 done: Sat Nov 5 13:17:46 2016
Total Scan time: 8.000 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]