Result of FASTA (omim) for
pFN21AB5459
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5459, 391 aa
1>>>pF1KB5459 391 - 391 aa - 391 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2512+/-0.000352; mu= 12.3079+/- 0.022
mean_var=88.3105+/-18.364, 0's: 0 Z-trim(115.3): 11 B-trim: 883 in 1/55
Lambda= 0.136480
statistics sampled from 25616 (25625) to 25616 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.675), E-opt: 0.2 (0.3), width: 16
Scan time: 8.880
The best scores are: opt bits E(85289)
NP_006463 (OMIM: 606599) thioredoxin-interacting p ( 391) 2628 527.5 2.1e-149
XP_016855574 (OMIM: 606599) PREDICTED: thioredoxin ( 395) 2554 512.9 5.3e-145
NP_001300901 (OMIM: 606599) thioredoxin-interactin ( 336) 2097 422.9 5.6e-118
NP_065852 (OMIM: 612464) arrestin domain-containin ( 414) 946 196.3 1.1e-49
NP_001316599 (OMIM: 612464) arrestin domain-contai ( 194) 550 118.2 1.7e-26
NP_001316601 (OMIM: 612464) arrestin domain-contai ( 194) 550 118.2 1.7e-26
NP_001316600 (OMIM: 612464) arrestin domain-contai ( 194) 550 118.2 1.7e-26
>>NP_006463 (OMIM: 606599) thioredoxin-interacting prote (391 aa)
initn: 2628 init1: 2628 opt: 2628 Z-score: 2803.1 bits: 527.5 E(85289): 2.1e-149
Smith-Waterman score: 2628; 100.0% identity (100.0% similar) in 391 aa overlap (1-391:1-391)
10 20 30 40 50 60
pF1KB5 MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 QQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 QQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 VDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 SARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 HIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 HIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 GLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQD
310 320 330 340 350 360
370 380 390
pF1KB5 SPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
:::::::::::::::::::::::::::::::
NP_006 SPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
370 380 390
>>XP_016855574 (OMIM: 606599) PREDICTED: thioredoxin-int (395 aa)
initn: 2554 init1: 2554 opt: 2554 Z-score: 2724.3 bits: 512.9 E(85289): 5.3e-145
Smith-Waterman score: 2554; 100.0% identity (100.0% similar) in 381 aa overlap (1-381:1-381)
10 20 30 40 50 60
pF1KB5 MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 QQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 VDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 SARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 HIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 GLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQD
310 320 330 340 350 360
370 380 390
pF1KB5 SPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
:::::::::::::::::::::
XP_016 SPIFMYAPEFKFMPPPTYTEVRIVIFTVKFVLSFL
370 380 390
>>NP_001300901 (OMIM: 606599) thioredoxin-interacting pr (336 aa)
initn: 2097 init1: 2097 opt: 2097 Z-score: 2239.1 bits: 422.9 E(85289): 5.6e-118
Smith-Waterman score: 2097; 99.7% identity (100.0% similar) in 310 aa overlap (82-391:27-336)
60 70 80 90 100 110
pF1KB5 AKVLWMQGSQQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLG
:.::::::::::::::::::::::::::::
NP_001 MPPKHSLSHRCILSVTASLMATRFSFPSGENEMVIMRPGNKYEYKFGFELPQGPLG
10 20 30 40 50
120 130 140 150 160 170
pF1KB5 TSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCM
60 70 80 90 100 110
180 190 200 210 220 230
pF1KB5 FIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLT
120 130 140 150 160 170
240 250 260 270 280 290
pF1KB5 QKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILD
180 190 200 210 220 230
300 310 320 330 340 350
pF1KB5 LPLVIGSRSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPLVIGSRSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPL
240 250 260 270 280 290
360 370 380 390
pF1KB5 LDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
::::::::::::::::::::::::::::::::::::::::
NP_001 LDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
300 310 320 330
>>NP_065852 (OMIM: 612464) arrestin domain-containing pr (414 aa)
initn: 1038 init1: 672 opt: 946 Z-score: 1012.9 bits: 196.3 E(85289): 1.1e-49
Smith-Waterman score: 1049; 42.1% identity (70.8% similar) in 401 aa overlap (2-383:1-399)
10 20 30 40 50
pF1KB5 MVMFKKIKSFEVVF---NDPE-KVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLW
... :.::. . : :: . ::.::. :.::: .:: :::...: : : ::: :
NP_065 MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRW
10 20 30 40 50
60 70 80 90 100
pF1KB5 MQ----GS-----QQCKQTSEYLRYEDTLL--LEDQPTGENEMVIMRPGNKYEYKFGFEL
. :: :. . ::. ..: :. .:. ..:. . .. : ..:: :.:::
NP_065 TESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSG-RHEYAFSFEL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB5 PQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKE
:: ::.:::.:..: : ::::: : :: . ::.: : . .:.:::.:..: .. ::
NP_065 PQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKE
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB5 KKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANG
: . : : .: .:.::.:.:::. :. :.: :..:: ::.::::::: ... :.:
NP_065 KTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKG
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB5 QTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGS
. : . : ....::. . :: .: :: :.. . :::: :.:.::::::..::..::.
NP_065 KMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGA
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB5 KKVILDLPLVIGS--RSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHR
..:.::::::. ..:::::..:. : .:.:..:..:. ::::: : .:. :..:
NP_065 MDLFLNLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQR
300 310 320 330 340 350
350 360 370 380 390
pF1KB5 LESPTTPL--LDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
.. .:. ::.. . ..:.: : ::.:.::: :.:.::
NP_065 -RNNLAPVSACDDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
360 370 380 390 400 410
>>NP_001316599 (OMIM: 612464) arrestin domain-containing (194 aa)
initn: 559 init1: 299 opt: 550 Z-score: 596.5 bits: 118.2 E(85289): 1.7e-26
Smith-Waterman score: 550; 43.3% identity (75.6% similar) in 180 aa overlap (208-383:1-179)
180 190 200 210 220 230
pF1KB5 VSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSV
.::::::: ... :.:. : . : ....
NP_001 MVVPKAAIYQTQAFYAKGKMKEVKQLVANL
10 20 30
240 250 260 270 280 290
pF1KB5 RGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIG
::. . :: .: :: :.. . :::: :.:.::::::..::..::. ..:.::::::
NP_001 RGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIG
40 50 60 70 80 90
300 310 320 330 340 350
pF1KB5 S--RSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLES--PTTPLLD
. ..:::::..:. : .:.:..:..:. ::::: : .:. :..: .. :.. :
NP_001 TIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSAC-D
100 110 120 130 140
360 370 380 390
pF1KB5 DMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
:.. . ..:.: : ::.:.::: :.:.::
NP_001 DFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
150 160 170 180 190
>>NP_001316601 (OMIM: 612464) arrestin domain-containing (194 aa)
initn: 559 init1: 299 opt: 550 Z-score: 596.5 bits: 118.2 E(85289): 1.7e-26
Smith-Waterman score: 550; 43.3% identity (75.6% similar) in 180 aa overlap (208-383:1-179)
180 190 200 210 220 230
pF1KB5 VSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSV
.::::::: ... :.:. : . : ....
NP_001 MVVPKAAIYQTQAFYAKGKMKEVKQLVANL
10 20 30
240 250 260 270 280 290
pF1KB5 RGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIG
::. . :: .: :: :.. . :::: :.:.::::::..::..::. ..:.::::::
NP_001 RGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIG
40 50 60 70 80 90
300 310 320 330 340 350
pF1KB5 S--RSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLES--PTTPLLD
. ..:::::..:. : .:.:..:..:. ::::: : .:. :..: .. :.. :
NP_001 TIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSAC-D
100 110 120 130 140
360 370 380 390
pF1KB5 DMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
:.. . ..:.: : ::.:.::: :.:.::
NP_001 DFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
150 160 170 180 190
>>NP_001316600 (OMIM: 612464) arrestin domain-containing (194 aa)
initn: 559 init1: 299 opt: 550 Z-score: 596.5 bits: 118.2 E(85289): 1.7e-26
Smith-Waterman score: 550; 43.3% identity (75.6% similar) in 180 aa overlap (208-383:1-179)
180 190 200 210 220 230
pF1KB5 VSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSV
.::::::: ... :.:. : . : ....
NP_001 MVVPKAAIYQTQAFYAKGKMKEVKQLVANL
10 20 30
240 250 260 270 280 290
pF1KB5 RGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIG
::. . :: .: :: :.. . :::: :.:.::::::..::..::. ..:.::::::
NP_001 RGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIG
40 50 60 70 80 90
300 310 320 330 340 350
pF1KB5 S--RSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLES--PTTPLLD
. ..:::::..:. : .:.:..:..:. ::::: : .:. :..: .. :.. :
NP_001 TIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSAC-D
100 110 120 130 140
360 370 380 390
pF1KB5 DMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
:.. . ..:.: : ::.:.::: :.:.::
NP_001 DFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
150 160 170 180 190
391 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 21:40:12 2016 done: Fri Nov 4 21:40:13 2016
Total Scan time: 8.880 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]