FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3390, 1204 aa 1>>>pF1KE3390 1204 - 1204 aa - 1204 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 16.9403+/-0.000795; mu= -30.5475+/- 0.049 mean_var=1062.4967+/-223.974, 0's: 0 Z-trim(117.7): 1500 B-trim: 0 in 0/56 Lambda= 0.039347 statistics sampled from 28265 (30009) to 28265 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.352), width: 16 Scan time: 15.340 The best scores are: opt bits E(85289) NP_001291672 (OMIM: 616563) STE20-like serine/thre (1204) 7707 455.2 1.1e-126 NP_055535 (OMIM: 616563) STE20-like serine/threoni (1235) 6034 360.3 4.5e-98 XP_011538703 (OMIM: 616563) PREDICTED: STE20-like ( 783) 2245 145.0 1.9e-33 NP_005981 (OMIM: 603919) serine/threonine-protein ( 968) 1690 113.5 6.5e-24 XP_016865277 (OMIM: 603919) PREDICTED: serine/thre ( 860) 1313 92.1 1.7e-17 XP_005260587 (OMIM: 604965,614868) PREDICTED: seri ( 503) 880 67.3 2.9e-10 NP_006273 (OMIM: 604965,614868) serine/threonine-p ( 487) 877 67.1 3.2e-10 XP_005260588 (OMIM: 604965,614868) PREDICTED: seri ( 478) 873 66.8 3.7e-10 XP_005260590 (OMIM: 604965,614868) PREDICTED: seri ( 462) 870 66.6 4.1e-10 NP_001243241 (OMIM: 605030) serine/threonine-prote ( 519) 870 66.7 4.4e-10 XP_016869246 (OMIM: 605030) PREDICTED: serine/thre ( 524) 870 66.7 4.5e-10 XP_011527322 (OMIM: 604965,614868) PREDICTED: seri ( 404) 865 66.3 4.6e-10 XP_011515550 (OMIM: 605030) PREDICTED: serine/thre ( 576) 870 66.8 4.8e-10 XP_016869247 (OMIM: 605030) PREDICTED: serine/thre ( 456) 866 66.4 4.8e-10 XP_016869245 (OMIM: 605030) PREDICTED: serine/thre ( 580) 870 66.8 4.8e-10 NP_006272 (OMIM: 605030) serine/threonine-protein ( 491) 866 66.4 5e-10 XP_016883522 (OMIM: 604965,614868) PREDICTED: seri ( 388) 862 66.1 5e-10 XP_011515553 (OMIM: 605030) PREDICTED: serine/thre ( 522) 866 66.5 5.2e-10 XP_016860859 (OMIM: 604666) PREDICTED: mitogen-act (1188) 854 66.2 1.4e-09 XP_016860858 (OMIM: 604666) PREDICTED: mitogen-act (1196) 854 66.2 1.5e-09 XP_005264120 (OMIM: 604666) PREDICTED: mitogen-act (1260) 854 66.2 1.5e-09 XP_006712932 (OMIM: 604666) PREDICTED: mitogen-act (1189) 847 65.8 1.9e-09 XP_005260589 (OMIM: 604965,614868) PREDICTED: seri ( 474) 831 64.4 1.9e-09 XP_016883519 (OMIM: 604965,614868) PREDICTED: seri ( 474) 831 64.4 1.9e-09 XP_016883520 (OMIM: 604965,614868) PREDICTED: seri ( 474) 831 64.4 1.9e-09 XP_016883518 (OMIM: 604965,614868) PREDICTED: seri ( 474) 831 64.4 1.9e-09 XP_016860852 (OMIM: 604666) PREDICTED: mitogen-act (1253) 847 65.8 2e-09 XP_005264128 (OMIM: 604666) PREDICTED: mitogen-act (1185) 846 65.7 2e-09 XP_005264119 (OMIM: 604666) PREDICTED: mitogen-act (1261) 847 65.8 2e-09 XP_016883521 (OMIM: 604965,614868) PREDICTED: seri ( 458) 828 64.3 2.1e-09 XP_016880194 (OMIM: 609426) PREDICTED: misshapen-l (1341) 842 65.6 2.5e-09 XP_016860860 (OMIM: 604666) PREDICTED: mitogen-act (1186) 839 65.3 2.6e-09 XP_016880195 (OMIM: 609426) PREDICTED: misshapen-l (1323) 840 65.4 2.7e-09 XP_006721599 (OMIM: 609426) PREDICTED: misshapen-l (1324) 840 65.4 2.7e-09 XP_016860853 (OMIM: 604666) PREDICTED: mitogen-act (1249) 839 65.4 2.7e-09 XP_006721595 (OMIM: 609426) PREDICTED: misshapen-l (1360) 840 65.5 2.7e-09 XP_006721594 (OMIM: 609426) PREDICTED: misshapen-l (1361) 840 65.5 2.8e-09 XP_005264121 (OMIM: 604666) PREDICTED: mitogen-act (1258) 832 65.0 3.6e-09 XP_016873585 (OMIM: 603166) PREDICTED: mitogen-act ( 584) 819 63.9 3.6e-09 XP_016876284 (OMIM: 604984) PREDICTED: serine/thre ( 474) 814 63.5 3.8e-09 XP_016880193 (OMIM: 609426) PREDICTED: misshapen-l (1358) 829 64.8 4.2e-09 XP_011543505 (OMIM: 603166) PREDICTED: mitogen-act ( 797) 819 64.0 4.4e-09 NP_001294919 (OMIM: 603166) mitogen-activated prot ( 812) 819 64.0 4.5e-09 NP_004570 (OMIM: 603166) mitogen-activated protein ( 820) 819 64.0 4.5e-09 XP_011517813 (OMIM: 606808,607101) PREDICTED: myos (1009) 819 64.1 5.1e-09 NP_001155036 (OMIM: 610005,617028) TRAF2 and NCK-i (1297) 823 64.5 5.2e-09 NP_001155035 (OMIM: 610005,617028) TRAF2 and NCK-i (1305) 823 64.5 5.2e-09 NP_001155038 (OMIM: 610005,617028) TRAF2 and NCK-i (1268) 822 64.4 5.3e-09 NP_001155032 (OMIM: 610005,617028) TRAF2 and NCK-i (1352) 823 64.5 5.3e-09 NP_001155037 (OMIM: 610005,617028) TRAF2 and NCK-i (1276) 822 64.4 5.3e-09 >>NP_001291672 (OMIM: 616563) STE20-like serine/threonin (1204 aa) initn: 7707 init1: 7707 opt: 7707 Z-score: 2395.1 bits: 455.2 E(85289): 1.1e-126 Smith-Waterman score: 7707; 100.0% identity (100.0% similar) in 1204 aa overlap (1-1204:1-1204) 10 20 30 40 50 60 pF1KE3 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 RELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACIL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 ESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 ENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 FENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 VISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 PIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 DQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 ENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSI 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 SLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 EQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 RDEAKRIKGEQEKELSKFQNMLKNRKKEEQEFVQKQQQELDGSLKKIIQQQKAELANIER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDEAKRIKGEQEKELSKFQNMLKNRKKEEQEFVQKQQQELDGSLKKIIQQQKAELANIER 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 ECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQR 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 YNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQ 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE3 EEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEH 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE3 SQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLH 1150 1160 1170 1180 1190 1200 pF1KE3 STGS :::: NP_001 STGS >>NP_055535 (OMIM: 616563) STE20-like serine/threonine-p (1235 aa) initn: 5971 init1: 5929 opt: 6034 Z-score: 1881.7 bits: 360.3 E(85289): 4.5e-98 Smith-Waterman score: 7635; 97.5% identity (97.5% similar) in 1235 aa overlap (1-1204:1-1235) 10 20 30 40 50 60 pF1KE3 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 RELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACIL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 ESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 ENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 FENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 FENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 VISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 PIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 DQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 ENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSI 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 SLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 EQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRL 850 860 870 880 890 900 910 920 pF1KE3 RDEAKRIKGEQEKELSKFQNMLKNRKKE-------------------------------E :::::::::::::::::::::::::::: : NP_055 RDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQE 910 920 930 940 950 960 930 940 950 960 970 980 pF1KE3 QEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKH 970 980 990 1000 1010 1020 990 1000 1010 1020 1030 1040 pF1KE3 QLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAK 1030 1040 1050 1060 1070 1080 1050 1060 1070 1080 1090 1100 pF1KE3 TRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEA 1090 1100 1110 1120 1130 1140 1110 1120 1130 1140 1150 1160 pF1KE3 NVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 NVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQ 1150 1160 1170 1180 1190 1200 1170 1180 1190 1200 pF1KE3 EVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS ::::::::::::::::::::::::::::::::::: NP_055 EVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS 1210 1220 1230 >>XP_011538703 (OMIM: 616563) PREDICTED: STE20-like seri (783 aa) initn: 4234 init1: 2194 opt: 2245 Z-score: 721.6 bits: 145.0 E(85289): 1.9e-33 Smith-Waterman score: 3926; 60.9% identity (60.9% similar) in 1235 aa overlap (1-1204:1-783) 10 20 30 40 50 60 pF1KE3 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 RELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACIL ::::::::::::::::::::::::::::::: XP_011 RELIAEAKAEVTEEVEDGKEEDEEEETENSL----------------------------- 310 320 330 370 380 390 400 410 420 pF1KE3 ESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIK XP_011 ------------------------------------------------------------ 430 440 450 460 470 480 pF1KE3 ENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQM XP_011 ------------------------------------------------------------ 490 500 510 520 530 540 pF1KE3 FENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKD XP_011 ------------------------------------------------------------ 550 560 570 580 590 600 pF1KE3 VISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEV XP_011 ------------------------------------------------------------ 610 620 630 640 650 660 pF1KE3 PIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADT XP_011 ------------------------------------------------------------ 670 680 690 700 710 720 pF1KE3 DQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG XP_011 ------------------------------------------------------------ 730 740 750 760 770 780 pF1KE3 ENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSI XP_011 ------------------------------------------------------------ 790 800 810 820 830 840 pF1KE3 SLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ---ETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKE 340 350 360 370 380 850 860 870 880 890 900 pF1KE3 EQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRL 390 400 410 420 430 440 910 920 pF1KE3 RDEAKRIKGEQEKELSKFQNMLKNRKKE-------------------------------E :::::::::::::::::::::::::::: : XP_011 RDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQE 450 460 470 480 490 500 930 940 950 960 970 980 pF1KE3 QEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKH 510 520 530 540 550 560 990 1000 1010 1020 1030 1040 pF1KE3 QLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAK 570 580 590 600 610 620 1050 1060 1070 1080 1090 1100 pF1KE3 TRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEA 630 640 650 660 670 680 1110 1120 1130 1140 1150 1160 pF1KE3 NVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQ 690 700 710 720 730 740 1170 1180 1190 1200 pF1KE3 EVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS ::::::::::::::::::::::::::::::::::: XP_011 EVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS 750 760 770 780 >>NP_005981 (OMIM: 603919) serine/threonine-protein kina (968 aa) initn: 3577 init1: 1489 opt: 1690 Z-score: 550.3 bits: 113.5 E(85289): 6.5e-24 Smith-Waterman score: 3102; 46.4% identity (64.9% similar) in 1233 aa overlap (1-1198:1-964) 10 20 30 40 50 pF1KE3 MSFFNFRKIFKLGS-EKKK-KQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSV :.: :::.:..:.. ::.: ..::::.:::.:.. :::.::::::::::::::.::::.. NP_005 MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 LAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDA :::::::.::::::::::.:::.:::.:::: ::::: :.:....:::.:::: :::::: NP_005 LAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 VMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSA .::::.: ::: ::::::.: :.:::.::...::::::::::.:.::.:::.:::::::: NP_005 IMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSA 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 KNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHEL :: .:.:.:::::::::::::::::::: :: :::::::.:::::::::::.:::::::: NP_005 KNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHEL 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 NPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVT-VDSN ::::::::::::.:::: ::.:: .:.:::: :.:: ..: ...:::.::::. . :: NP_005 NPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSN 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 KPIRELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNA : .:::.::::::: ::.:::..: :::.. .. ::. :.. .::. NP_005 KALRELVAEAKAEVMEEIEDGRDEGEEEDAVDA---------------ASTLENH-TQNS 310 320 330 340 360 370 380 390 400 410 pF1KE3 CILESVSEKTERSNSEDKLNSKILNEKPTTD-EPEKAVEDINEHITDAQLEAMTELHDRT :: . : . :: :.:.:.: : .. ...:: .. . ::. NP_005 ------SEVSPPSLNADK----PLEESPSTPLAPSQSQDSVNEPCSQPS-------GDRS 350 360 370 380 420 430 440 450 460 470 pF1KE3 AVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQE .:.. :. :.::.. . . NP_005 L----------------------QTTSPPVVAPGNENGLAVPVP---------------- 390 400 480 490 500 510 520 530 pF1KE3 KQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDK : ::. . ..: : :: NP_005 --------LRKSRPV------SMD----------ARIQ---------------------- 410 420 540 550 560 570 580 590 pF1KE3 TQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGG :::. :.:.: : : .: : NP_005 --------------------VAQE--------------KQVAEQGGDL------SPAA-- 430 440 600 610 620 630 640 650 pF1KE3 TKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSV :. : ..:. :. ::. : NP_005 -------------------NRSQKASQSR--------PN---------SSALE------- 450 660 670 680 690 700 710 pF1KE3 VADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININ .::.: NP_005 -------TLGGE------------------------------------------------ 460 720 730 740 750 760 770 pF1KE3 SDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKD : ::: :: . : . :: .: . :.: . ..:. :: .:. NP_005 ------KLANGSLE------PPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKE 470 480 490 500 510 780 790 800 810 820 830 pF1KE3 SGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRF ::.:... . :::::.::::.:::::::.:::::......: ::.::::::::::::. NP_005 MGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRL 520 530 540 550 560 570 840 850 860 870 880 890 pF1KE3 LQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEH :::::.: : ::..: . : ::. .:::::. .::. .: :.::::.:::: .:..::.: NP_005 LQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQDH 580 590 600 610 620 630 900 910 920 pF1KE3 TNRLRDEAKRIKGEQEKELSKFQNMLKNRKKE---------------------------- . : :.::.::. ::... ..::..:: ::: NP_005 AVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKK 640 650 660 670 680 690 930 940 950 960 970 980 pF1KE3 ---EQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHL ...:: ::...:. ..:.. ... :. . ::::: .::.:.: ::::.::.::..: NP_005 QLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQL 700 710 720 730 740 750 990 1000 1010 1020 1030 1040 pF1KE3 QEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQR ::.:::.:::::::::.:::.::..:::: :::::::::.::.:: :: ::.:::::::: NP_005 QERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQR 760 770 780 790 800 810 1050 1060 1070 1080 1090 1100 pF1KE3 SEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQL ::.::::::.::::.::. .. ..:.:::::. :::::::.::. :.:::::::::. NP_005 SEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLA 820 830 840 850 860 870 1110 1120 1130 1140 1150 1160 pF1KE3 QCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARK :::.:. ::.::::::::::::::::::: ::: :.:.:::::.:::::::.:::.. .: NP_005 QCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQK 880 890 900 910 920 930 1170 1180 1190 1200 pF1KE3 LQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS .:::.:::.. :.:: :::: :. .::.: : NP_005 KREQEMFFKLSEEAECPNPSTPSKAAKFFPYSSADAS 940 950 960 >>XP_016865277 (OMIM: 603919) PREDICTED: serine/threonin (860 aa) initn: 3101 init1: 1235 opt: 1313 Z-score: 435.2 bits: 92.1 E(85289): 1.7e-17 Smith-Waterman score: 2585; 44.1% identity (62.0% similar) in 1125 aa overlap (107-1198:1-856) 80 90 100 110 120 130 pF1KE3 MVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVC .:::: ::::::.::::.: ::: :::::: XP_016 MIEFCPGGAVDAIMLELDRGLTEPQIQVVC 10 20 30 140 150 160 170 180 190 pF1KE3 KQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYW .: :.:::.::...::::::::::.:.::.:::.:::::::::: .:.:.:::::::::: XP_016 RQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYW 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE3 MAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLA :::::::::: :: :::::::.:::::::::::.::::::::::::::::::::.:::: XP_016 MAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLL 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE3 QPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVT-VDSNKPIRELIAEAKAEVTEEV ::.:: .:.:::: :.:: ..: ...:::.::::. . ::: .:::.::::::: ::. XP_016 TPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEI 160 170 180 190 200 210 320 330 340 350 360 370 pF1KE3 EDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDK :::..: :::.. .. ::. :.. .::. :: . : . : XP_016 EDGRDEGEEEDA---------------VDAASTLENH-TQNS------SEVSPPSLNAD- 220 230 240 380 390 400 410 420 430 pF1KE3 LNSKILNEKPTTD-EPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLP : :.:.:.: : .. ...:: .. . ::. XP_016 ---KPLEESPSTPLAPSQSQDSVNEPCSQPS-------GDRSL----------------- 250 260 270 280 440 450 460 470 480 490 pF1KE3 DTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDT .:.. :. :.::.. . . : ::. . XP_016 -----QTTSPPVVAPGNENGLAVPVP------------------------LRKSRPV--- 290 300 500 510 520 530 540 550 pF1KE3 ILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEA ..: : :: XP_016 ---SMD----------ARIQ---------------------------------------- 310 560 570 580 590 600 610 pF1KE3 ADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEG :::. :.:.: : : .: : XP_016 --VAQE--------------KQVAEQGGDL------SPAA-------------------- 320 330 620 630 640 650 660 670 pF1KE3 KNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASK :. : ..:. :. ::. : .::.: XP_016 -NRSQKASQSR--------PN---------SSALE--------------TLGGE------ 340 350 680 690 700 710 720 730 pF1KE3 VTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTET : ::: XP_016 ------------------------------------------------KLANGSLE---- 360 740 750 760 770 780 790 pF1KE3 ILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKK :: . : . :: .: . :.: . ..:. :: .:. ::.:... . :::::. XP_016 --PPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKR 370 380 390 400 410 420 800 810 820 830 840 850 pF1KE3 TRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQ ::::.:::::::.:::::......: ::.::::::::::::.:::::.: : ::..: . XP_016 TRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHEL 430 440 450 460 470 480 860 870 880 890 900 910 pF1KE3 QREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKE : ::. .:::::. .::. .: :.::::.:::: .:..::.:. : :.::.::. ::... XP_016 QLEQMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRD 490 500 510 520 530 540 920 930 940 pF1KE3 LSKFQNMLKNRKKE-------------------------------EQEFVQKQQQELDGS ..::..:: ::: ...:: ::...:. . XP_016 YTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELA 550 560 570 580 590 600 950 960 970 980 990 1000 pF1KE3 LKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQ .:.. ... :. . ::::: .::.:.: ::::.::.::..:::.:::.:::::::::.: XP_016 MKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQ 610 620 630 640 650 660 1010 1020 1030 1040 1050 1060 pF1KE3 RHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINS ::.::..:::: :::::::::.::.:: :: ::.::::::::::.::::::.::::.::. XP_016 RHELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHING 670 680 690 700 710 720 1070 1080 1090 1100 1110 1120 pF1KE3 TATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCH .. ..:.:::::. :::::::.::. :.:::::::::. :::.:. ::.:::::::: XP_016 GGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCH 730 740 750 760 770 780 1130 1140 1150 1160 1170 1180 pF1KE3 LLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLN ::::::::::: ::: :.:.:::::.:::::::.:::.. .: .:::.:::.. :.:: : XP_016 LLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPN 790 800 810 820 830 840 1190 1200 pF1KE3 PSTQSRISKFYPIPSLHSTGS ::: :. .::.: : XP_016 PSTPSKAAKFFPYSSADAS 850 860 >>XP_005260587 (OMIM: 604965,614868) PREDICTED: serine/t (503 aa) initn: 737 init1: 428 opt: 880 Z-score: 305.2 bits: 67.3 E(85289): 2.9e-10 Smith-Waterman score: 880; 32.6% identity (66.7% similar) in 481 aa overlap (12-479:26-487) 10 20 30 40 pF1KE3 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFG .: . :: . . . . .::. .... .::.:..: XP_005 MASFITDVQCLPNGLHILLSSSEPDIGRQLKKLDEDSLTK--QPEEVFDVLEKLGEGSYG 10 20 30 40 50 50 60 70 80 90 100 pF1KE3 KVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWI .:::: .:::. ..: : . ..:. :.. . ::.:. .:: :..:: ... ...::: XP_005 SVYKAIHKETGQIVAIKQVPVESD--LQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWI 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE3 LIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLD ..:.:..:.:. .. .. :::..: .. ..:: .:.::: . ::::.::::::.. . XP_005 VMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTE 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE3 GDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLI : :::::::... : :. .:.. ::::.::::::. .. :. ::.:::::: : XP_005 GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAI 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE3 EMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQL :::: .::. ...:::... : . :::. .: ::.:: ::.:.:: :. . : :..:: XP_005 EMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQL 240 250 260 270 280 290 290 300 310 320 330 pF1KE3 LQHPFV-TVDSNKPIRELIAEA-----KAEVTEEVE---DGKEEDEEEETENSLPIPASK :::::: .. . . .:.:: :: : . ... : : .:..::.: ... . : XP_005 LQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVG 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE3 RASSDLSIASSEEDKLSQNACILESVSEK--TERSNSEDKLNSKILNEKPTTDEPEKA-- . . .::. : . ... . : :.::. . .... : .: : XP_005 DEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSF 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE3 VEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKEN .: .... . :.... . . . .:.. : .:. : : . .: . .. XP_005 LEYFEQKEKENQINSFGK--SVPGPLKNSSDWK------IPQDGDYEFLKSWTVEDLQKR 420 430 440 450 460 460 470 480 490 500 510 pF1KE3 NIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANI ...:. .:.... ..: : :.: XP_005 --LLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF 470 480 490 500 >>NP_006273 (OMIM: 604965,614868) serine/threonine-prote (487 aa) initn: 737 init1: 428 opt: 877 Z-score: 304.4 bits: 67.1 E(85289): 3.2e-10 Smith-Waterman score: 877; 32.6% identity (66.9% similar) in 478 aa overlap (18-479:11-471) 10 20 30 40 50 pF1KE3 MSFFNFRKIFKLGSEKKKKQYEHVKRDL---NPEDFWEIIGELGDGAFGKVYKAQNKETS ..: ... .: .::. .... .::.:..:.:::: .:::. NP_006 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETG 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 VLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVD ..: : . ..:. :.. . ::.:. .:: :..:: ... ...:::..:.:..:.:. NP_006 QIVAIKQVPVESD--LQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 AVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVS .. .. :::..: .. ..:: .:.::: . ::::.::::::.. .: :::::::. NP_006 DIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 AKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHE .. : :. .:.. ::::.::::::. .. :. ::.:::::: ::::: .::. . NP_006 GQLTDTMAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYAD 180 190 200 210 220 240 250 260 270 280 290 pF1KE3 LNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV-TVDS ..:::... : . :::. .: ::.:: ::.:.:: :. . : :..:::::::: .. . NP_006 IHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKG 230 240 250 260 270 280 300 310 320 330 340 pF1KE3 NKPIRELIAEA-----KAEVTEEVE---DGKEEDEEEETENSLPIPASKRASSDLSIASS . .:.:: :: : . ... : : .:..::.: ... . : . . .::. NP_006 VSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVAST 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE3 EEDKLSQNACILESVSEK--TERSNSEDKLNSKILNEKPTTDEPEKA--VEDINEHITDA : . ... . : :.::. . .... : .: : .: .... . NP_006 MTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKEN 350 360 370 380 390 400 410 420 430 440 450 460 pF1KE3 QLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIE :.... . . . .:.. : .:. : : . .: . .. ...:. .: NP_006 QINSFGK--SVPGPLKNSSDWK------IPQDGDYEFLKSWTVEDLQKR--LLALDPMME 410 420 430 440 450 470 480 490 500 510 520 pF1KE3 HNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTK .... ..: : :.: NP_006 QEIEEIRQKYQSKRQPILDAIEAKKRRQQNF 460 470 480 >>XP_005260588 (OMIM: 604965,614868) PREDICTED: serine/t (478 aa) initn: 737 init1: 428 opt: 873 Z-score: 303.3 bits: 66.8 E(85289): 3.7e-10 Smith-Waterman score: 873; 36.5% identity (69.4% similar) in 392 aa overlap (12-392:26-408) 10 20 30 40 pF1KE3 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFG .: . :: . . . . .::. .... .::.:..: XP_005 MASFITDVQCLPNGLHILLSSSEPDIGRQLKKLDEDSLTK--QPEEVFDVLEKLGEGSYG 10 20 30 40 50 50 60 70 80 90 100 pF1KE3 KVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWI .:::: .:::. ..: : . ..:. :.. . ::.:. .:: :..:: ... ...::: XP_005 SVYKAIHKETGQIVAIKQVPVESD--LQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWI 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE3 LIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLD ..:.:..:.:. .. .. :::..: .. ..:: .:.::: . ::::.::::::.. . XP_005 VMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTE 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE3 GDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLI : :::::::... : :. .:.. ::::.::::::. .. :. ::.:::::: : XP_005 GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAI 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE3 EMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQL :::: .::. ...:::... : . :::. .: ::.:: ::.:.:: :. . : :..:: XP_005 EMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQL 240 250 260 270 280 290 290 300 310 320 330 pF1KE3 LQHPFV-TVDSNKPIRELIAEA-----KAEVTEEVE---DGKEEDEEEETENSLPIPASK :::::: .. . . .:.:: :: : . ... : : .:..::.: ... . : XP_005 LQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVG 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE3 RASSDLSIASSEEDKLSQNACILESVSEK--TERSNSEDKLNSKILNEKPTTDEPEKAVE . . .::. : . ... . : :.::. . .... : .: : XP_005 DEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSF 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE3 DINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNI XP_005 LEYFEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFKTSQEQQSGKDICIQNCQGN 420 430 440 450 460 470 >>XP_005260590 (OMIM: 604965,614868) PREDICTED: serine/t (462 aa) initn: 737 init1: 428 opt: 870 Z-score: 302.5 bits: 66.6 E(85289): 4.1e-10 Smith-Waterman score: 870; 36.5% identity (69.7% similar) in 389 aa overlap (18-392:11-392) 10 20 30 40 50 pF1KE3 MSFFNFRKIFKLGSEKKKKQYEHVKRDL---NPEDFWEIIGELGDGAFGKVYKAQNKETS ..: ... .: .::. .... .::.:..:.:::: .:::. XP_005 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETG 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 VLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVD ..: : . ..: .:.. . ::.:. .:: :..:: ... ...:::..:.:..:.:. XP_005 QIVAIKQVPVES--DLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 AVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVS .. .. :::..: .. ..:: .:.::: . ::::.::::::.. .: :::::::. XP_005 DIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 AKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHE .. : :. .:.. ::::.::::::. .. :. ::.:::::: ::::: .::. . XP_005 GQLTDTMAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYAD 180 190 200 210 220 240 250 260 270 280 290 pF1KE3 LNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV-TVDS ..:::... : . :::. .: ::.:: ::.:.:: :. . : :..:::::::: .. . XP_005 IHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKG 230 240 250 260 270 280 300 310 320 330 340 pF1KE3 NKPIRELIAEA-----KAEVTEEVE---DGKEEDEEEETENSLPIPASKRASSDLSIASS . .:.:: :: : . ... : : .:..::.: ... . : . . .::. XP_005 VSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVAST 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE3 EEDKLSQNACILESVSEK--TERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQL : . ... . : :.::. . .... : .: : XP_005 MTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKEN 350 360 370 380 390 400 410 420 430 440 450 460 pF1KE3 EAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHN XP_005 QINSFGKSVPGPLKNSSDWKIPQDGDYEFKTSQEQQSGKDICIQNCQGNLLCRYAF 410 420 430 440 450 460 >>NP_001243241 (OMIM: 605030) serine/threonine-protein k (519 aa) initn: 786 init1: 423 opt: 870 Z-score: 301.9 bits: 66.7 E(85289): 4.4e-10 Smith-Waterman score: 872; 38.6% identity (69.3% similar) in 394 aa overlap (2-375:19-400) 10 20 30 pF1KE3 MSFFNFRKIFKLGSEKKK-KQYEHVKRDL---NPEDFWEIIGE : :. .. : :.:. .. .....: .::. .... . NP_001 MLQLMDSGITICLRNGAASVFKKKEWSTQGEENKQDSKLKKLSEDSLTKQPEEVFDVLEK 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 LGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFY ::.:..:.:.:: .::.. ..: : . ..:. :.. . ::.:. .:: : .:: ... NP_001 LGEGSYGSVFKAIHKESGQVVAIKQVPVESD--LQEIIKEISIMQQCDSPYVVKYYGSYF 70 80 90 100 110 100 110 120 130 140 150 pF1KE3 YENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAG ...:::..:.:..:.:. .. .. : :..: .. :.:: .:.::: . ::::.::: NP_001 KNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAG 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE3 NILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVW :::.. .: :::::::... : :. .:.. ::::.::::::. .. :. ::.: NP_001 NILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIW 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE3 SLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDA ::::: ::::: .::. ...:::... : . :::. .: ::..: ::.:::: :: . NP_001 SLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQ 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE3 RWTTSQLLQHPFVTVDSNKPI---RELIAEA---KAEVTEEVEDGKEEDEEEETENSLP- : :..:::::::. . ::. :.::.:: ::. :: . ::.::. :. : NP_001 RATATQLLQHPFIK--NAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDS 300 310 320 330 340 350 340 350 360 370 380 pF1KE3 ---IPAS------KRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNE . .: ::.: .: . . . .:. .::: . : ::::. NP_001 HTMVKTSVESVGTMRATSTMS--EGAQTMIEHNSTMLES-DLGTMVINSEDEEEEDGTMK 360 370 380 390 400 390 400 410 420 430 440 pF1KE3 KPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVD NP_001 RNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFL 410 420 430 440 450 460 1204 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 20:07:00 2016 done: Mon Nov 7 20:07:02 2016 Total Scan time: 15.340 Total Display time: 0.260 Function used was FASTA [36.3.4 Apr, 2011]