Result of FASTA (omim) for
pFN21AB6862
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6862, 195 aa
1>>>pF1KB6862 195 - 195 aa - 195 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2953+/-0.000295; mu= 14.5113+/- 0.019
mean_var=74.8026+/-15.374, 0's: 0 Z-trim(117.9): 66 B-trim: 111 in 1/54
Lambda= 0.148291
statistics sampled from 30268 (30354) to 30268 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.728), E-opt: 0.2 (0.356), width: 16
Scan time: 5.550
The best scores are: opt bits E(85289)
NP_037390 (OMIM: 606838) apoptosis-associated spec ( 195) 1264 278.9 3.6e-75
NP_660183 (OMIM: 606838) apoptosis-associated spec ( 176) 580 132.5 3.8e-31
NP_690865 (OMIM: 615700) pyrin domain-containing p ( 89) 344 81.8 3.5e-16
NP_127500 (OMIM: 606579,606636,615225) NACHT, LRR (1399) 332 80.1 1.8e-14
NP_055737 (OMIM: 606579,606636,615225) NACHT, LRR (1429) 332 80.1 1.8e-14
NP_127499 (OMIM: 606579,606636,615225) NACHT, LRR (1443) 332 80.1 1.8e-14
NP_127497 (OMIM: 606579,606636,615225) NACHT, LRR (1473) 332 80.1 1.9e-14
NP_001185465 (OMIM: 134610,249100,608107) pyrin is ( 445) 182 47.7 3.3e-05
XP_011518233 (OMIM: 609650) PREDICTED: NACHT, LRR ( 703) 165 44.2 0.0006
XP_016872741 (OMIM: 609650) PREDICTED: NACHT, LRR ( 771) 165 44.2 0.00064
NP_001263629 (OMIM: 609650) NACHT, LRR and PYD dom ( 891) 165 44.2 0.00072
NP_612202 (OMIM: 609650) NACHT, LRR and PYD domain ( 892) 165 44.2 0.00072
XP_016878725 (OMIM: 134610,249100,608107) PREDICTE ( 780) 161 43.3 0.0012
NP_000234 (OMIM: 134610,249100,608107) pyrin isofo ( 781) 161 43.3 0.0012
>>NP_037390 (OMIM: 606838) apoptosis-associated speck-li (195 aa)
initn: 1264 init1: 1264 opt: 1264 Z-score: 1470.5 bits: 278.9 E(85289): 3.6e-75
Smith-Waterman score: 1264; 100.0% identity (100.0% similar) in 195 aa overlap (1-195:1-195)
10 20 30 40 50 60
pF1KB6 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA
130 140 150 160 170 180
190
pF1KB6 LRESQSYLVEDLERS
:::::::::::::::
NP_037 LRESQSYLVEDLERS
190
>>NP_660183 (OMIM: 606838) apoptosis-associated speck-li (176 aa)
initn: 579 init1: 579 opt: 580 Z-score: 680.2 bits: 132.5 E(85289): 3.8e-31
Smith-Waterman score: 1087; 90.3% identity (90.3% similar) in 195 aa overlap (1-195:1-176)
10 20 30 40 50 60
pF1KB6 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA
:::::::::::::::::::::::::::::::: :::::::::
NP_660 LETYGAELTANVLRDMGLQEMAGQLQAATHQG-------------------LHFIDQHRA
70 80 90 100
130 140 150 160 170 180
pF1KB6 ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA
110 120 130 140 150 160
190
pF1KB6 LRESQSYLVEDLERS
:::::::::::::::
NP_660 LRESQSYLVEDLERS
170
>>NP_690865 (OMIM: 615700) pyrin domain-containing prote (89 aa)
initn: 344 init1: 344 opt: 344 Z-score: 411.5 bits: 81.8 E(85289): 3.5e-16
Smith-Waterman score: 344; 64.8% identity (81.8% similar) in 88 aa overlap (1-88:1-88)
10 20 30 40 50 60
pF1KB6 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY
:: :.::: .::::: :::::::.:: .::::::. ::::::: ..: .:::::::. :
NP_690 MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA
: :.:::.. ::::: . : :..:: :
NP_690 YEDYAAELVVAVLRDMRMLEEAARLQRAA
70 80
>>NP_127500 (OMIM: 606579,606636,615225) NACHT, LRR and (1399 aa)
initn: 412 init1: 328 opt: 332 Z-score: 380.8 bits: 80.1 E(85289): 1.8e-14
Smith-Waterman score: 332; 44.5% identity (65.1% similar) in 146 aa overlap (54-192:1243-1385)
30 40 50 60 70 80
pF1KB6 KLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVS-FYLETYGAELTANVL--RDMGLQE
:.: : ::. :. . .: .: :
NP_127 PEEVTFHLYLIPSDCSIRKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVW
1220 1230 1240 1250 1260 1270
90 100 110 120 130
pF1KB6 MA----GQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDAL
: :.:. :: . :: : .: : :::.::.: ::::::.:: .:: :
NP_127 EALVKPGDLMPAT---TLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKL
1280 1290 1300 1310 1320
140 150 160 170 180 190
pF1KB6 YGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS
.:.::..:::. : :: : ::.::::::.. .:. ::: : :::.:.. .:. .:
NP_127 HGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKG
1330 1340 1350 1360 1370 1380
NP_127 SKKGLLPLSS
1390
>>NP_055737 (OMIM: 606579,606636,615225) NACHT, LRR and (1429 aa)
initn: 412 init1: 328 opt: 332 Z-score: 380.7 bits: 80.1 E(85289): 1.8e-14
Smith-Waterman score: 332; 44.5% identity (65.1% similar) in 146 aa overlap (54-192:1273-1415)
30 40 50 60 70 80
pF1KB6 KLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVS-FYLETYGAELTANVL--RDMGLQE
:.: : ::. :. . .: .: :
NP_055 PEEVTFHLYLIPSDCSIRKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVW
1250 1260 1270 1280 1290 1300
90 100 110 120 130
pF1KB6 MA----GQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDAL
: :.:. :: . :: : .: : :::.::.: ::::::.:: .:: :
NP_055 EALVKPGDLMPAT---TLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKL
1310 1320 1330 1340 1350
140 150 160 170 180 190
pF1KB6 YGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS
.:.::..:::. : :: : ::.::::::.. .:. ::: : :::.:.. .:. .:
NP_055 HGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKG
1360 1370 1380 1390 1400 1410
NP_055 SKKGLLPLSS
1420
>>NP_127499 (OMIM: 606579,606636,615225) NACHT, LRR and (1443 aa)
initn: 412 init1: 328 opt: 332 Z-score: 380.6 bits: 80.1 E(85289): 1.8e-14
Smith-Waterman score: 332; 44.5% identity (65.1% similar) in 146 aa overlap (54-192:1287-1429)
30 40 50 60 70 80
pF1KB6 KLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVS-FYLETYGAELTANVL--RDMGLQE
:.: : ::. :. . .: .: :
NP_127 GCRYTVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVW
1260 1270 1280 1290 1300 1310
90 100 110 120 130
pF1KB6 MA----GQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDAL
: :.:. :: . :: : .: : :::.::.: ::::::.:: .:: :
NP_127 EALVKPGDLMPAT---TLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKL
1320 1330 1340 1350 1360 1370
140 150 160 170 180 190
pF1KB6 YGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS
.:.::..:::. : :: : ::.::::::.. .:. ::: : :::.:.. .:. .:
NP_127 HGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKG
1380 1390 1400 1410 1420 1430
NP_127 SKKGLLPLSS
1440
>>NP_127497 (OMIM: 606579,606636,615225) NACHT, LRR and (1473 aa)
initn: 412 init1: 328 opt: 332 Z-score: 380.5 bits: 80.1 E(85289): 1.9e-14
Smith-Waterman score: 332; 44.5% identity (65.1% similar) in 146 aa overlap (54-192:1317-1459)
30 40 50 60 70 80
pF1KB6 KLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVS-FYLETYGAELTANVL--RDMGLQE
:.: : ::. :. . .: .: :
NP_127 GCRYTVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVW
1290 1300 1310 1320 1330 1340
90 100 110 120 130
pF1KB6 MA----GQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDAL
: :.:. :: . :: : .: : :::.::.: ::::::.:: .:: :
NP_127 EALVKPGDLMPAT---TLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKL
1350 1360 1370 1380 1390 1400
140 150 160 170 180 190
pF1KB6 YGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS
.:.::..:::. : :: : ::.::::::.. .:. ::: : :::.:.. .:. .:
NP_127 HGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKG
1410 1420 1430 1440 1450 1460
NP_127 SKKGLLPLSS
1470
>>NP_001185465 (OMIM: 134610,249100,608107) pyrin isofor (445 aa)
initn: 223 init1: 167 opt: 182 Z-score: 214.4 bits: 47.7 E(85289): 3.3e-05
Smith-Waterman score: 185; 32.4% identity (66.7% similar) in 108 aa overlap (6-113:7-105)
10 20 30 40 50
pF1KB6 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSF
: .:..::.:. ...:::.:: .. ... ..::::. . . .. ::..
NP_001 MAKTPSDHLLSTLEELVPYDFEKFKFKLQNTSVQKEHSRIPRSQIQRARPVKMATLLVTY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 YLETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHR
: : :...:: .::: .. . .: .:. :. :: ::..::.: :
NP_001 YGEEYAVQLTLQVLRAINQRLLAEELHRAAIQGR---------PPDTAASPRCHAQEGDP
70 80 90 100 110
120 130 140 150 160 170
pF1KB6 AALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQ
NP_001 VDGTCVRDSCSFPEAVSGHPQASGSRSPGCPRCQDSHERKSPGSLSPQPLPQCKRHLKQV
120 130 140 150 160 170
>>XP_011518233 (OMIM: 609650) PREDICTED: NACHT, LRR and (703 aa)
initn: 162 init1: 94 opt: 165 Z-score: 191.9 bits: 44.2 E(85289): 0.0006
Smith-Waterman score: 165; 32.8% identity (61.2% similar) in 116 aa overlap (4-118:18-130)
10 20 30 40
pF1KB6 MGRARDAILDALENLTAEELKKFKLKLLSV-PLREGYGRIPRGALL
::. .: :::.:. :.::.:. :: .: : .: . :: : :
XP_011 MDQPEAPCSSTGPRLAVARELLLAALEELSQEQLKRFRHKLRDVGP--DGRS-IPWGRLE
10 20 30 40 50
50 60 70 80 90 100
pF1KB6 SMDALDLTDKLVSFYLETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQ
::.::...:..:: . :.. ..:. ...:.::: : : . . . . .
XP_011 RADAVDLAEQLAQFYGPEPALEVARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSE
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB6 SAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSF
: : .. :
XP_011 YKKKYREHVLQLHARVKERNARSVKITKRFTKLLIAPESAAPEEAMGPAEEPEPGRARRS
120 130 140 150 160 170
>>XP_016872741 (OMIM: 609650) PREDICTED: NACHT, LRR and (771 aa)
initn: 162 init1: 94 opt: 165 Z-score: 191.4 bits: 44.2 E(85289): 0.00064
Smith-Waterman score: 165; 32.8% identity (61.2% similar) in 116 aa overlap (4-118:18-130)
10 20 30 40
pF1KB6 MGRARDAILDALENLTAEELKKFKLKLLSV-PLREGYGRIPRGALL
::. .: :::.:. :.::.:. :: .: : .: . :: : :
XP_016 MDQPEAPCSSTGPRLAVARELLLAALEELSQEQLKRFRHKLRDVGP--DGRS-IPWGRLE
10 20 30 40 50
50 60 70 80 90 100
pF1KB6 SMDALDLTDKLVSFYLETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQ
::.::...:..:: . :.. ..:. ...:.::: : : . . . . .
XP_016 RADAVDLAEQLAQFYGPEPALEVARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSE
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB6 SAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSF
: : .. :
XP_016 YKKKYREHVLQLHARVKERNARSVKITKRFTKLLIAPESAAPEEAMGPAEEPEPGRARRS
120 130 140 150 160 170
195 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 00:06:27 2016 done: Sat Nov 5 00:06:28 2016
Total Scan time: 5.550 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]