FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0555, 377 aa 1>>>pF1KE0555 377 - 377 aa - 377 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3608+/-0.000362; mu= 16.0618+/- 0.022 mean_var=58.7403+/-11.929, 0's: 0 Z-trim(112.7): 12 B-trim: 1490 in 2/49 Lambda= 0.167342 statistics sampled from 21736 (21742) to 21736 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.625), E-opt: 0.2 (0.255), width: 16 Scan time: 8.160 The best scores are: opt bits E(85289) NP_005014 (OMIM: 602031) geranylgeranyl transferas ( 377) 2586 632.7 4.2e-181 XP_005272077 (OMIM: 602031) PREDICTED: geranylgera ( 381) 2561 626.7 2.8e-179 XP_011541792 (OMIM: 602031) PREDICTED: geranylgera ( 408) 2556 625.5 6.9e-179 XP_011541794 (OMIM: 602031) PREDICTED: geranylgera ( 285) 1730 426.0 5.3e-119 NP_004573 (OMIM: 179080) geranylgeranyl transferas ( 331) 452 117.5 4.6e-26 NP_002019 (OMIM: 134636) protein farnesyltransfera ( 437) 337 89.7 1.4e-17 >>NP_005014 (OMIM: 602031) geranylgeranyl transferase ty (377 aa) initn: 2586 init1: 2586 opt: 2586 Z-score: 3372.3 bits: 632.7 E(85289): 4.2e-181 Smith-Waterman score: 2586; 100.0% identity (100.0% similar) in 377 aa overlap (1-377:1-377) 10 20 30 40 50 60 pF1KE0 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS 310 320 330 340 350 360 370 pF1KE0 WKTKDSKQCSENVHIST ::::::::::::::::: NP_005 WKTKDSKQCSENVHIST 370 >>XP_005272077 (OMIM: 602031) PREDICTED: geranylgeranyl (381 aa) initn: 2561 init1: 2561 opt: 2561 Z-score: 3339.6 bits: 626.7 E(85289): 2.8e-179 Smith-Waterman score: 2561; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:1-373) 10 20 30 40 50 60 pF1KE0 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS 310 320 330 340 350 360 370 pF1KE0 WKTKDSKQCSENVHIST ::::::::::::: XP_005 WKTKDSKQCSENVESYNQISC 370 380 >>XP_011541792 (OMIM: 602031) PREDICTED: geranylgeranyl (408 aa) initn: 2556 init1: 2556 opt: 2556 Z-score: 3332.6 bits: 625.5 E(85289): 6.9e-179 Smith-Waterman score: 2556; 100.0% identity (100.0% similar) in 372 aa overlap (1-372:1-372) 10 20 30 40 50 60 pF1KE0 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS 310 320 330 340 350 360 370 pF1KE0 WKTKDSKQCSENVHIST :::::::::::: XP_011 WKTKDSKQCSENKEFPGLKDLCFKNIGSYCQELPSRNSVAIHKLNNKV 370 380 390 400 >>XP_011541794 (OMIM: 602031) PREDICTED: geranylgeranyl (285 aa) initn: 1730 init1: 1730 opt: 1730 Z-score: 2257.4 bits: 426.0 E(85289): 5.3e-119 Smith-Waterman score: 1730; 100.0% identity (100.0% similar) in 249 aa overlap (124-372:1-249) 100 110 120 130 140 150 pF1KE0 GFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRA :::::::::::::::::::::::::::::: XP_011 MTYTGLSCLVILGDDLSRVNKEACLAGLRA 10 20 30 160 170 180 190 200 210 pF1KE0 LQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQG 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE0 AGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYS 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE0 FWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLME 160 170 180 190 200 210 340 350 360 370 pF1KE0 ESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST ::::::::::::::::::::::::::::::::::::::: XP_011 ESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENKEFPGLKDLCFKNIGSYCQEL 220 230 240 250 260 270 XP_011 PSRNSVAIHKLNNKV 280 >>NP_004573 (OMIM: 179080) geranylgeranyl transferase ty (331 aa) initn: 463 init1: 252 opt: 452 Z-score: 588.9 bits: 117.5 E(85289): 4.6e-26 Smith-Waterman score: 477; 30.3% identity (60.6% similar) in 317 aa overlap (40-354:39-323) 10 20 30 40 50 60 pF1KE0 AGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNK : : :.. ...:. .:.. .: .:. NP_004 IIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 DDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGL ..:. .: : : ..:: :: . .. : :. .: ... NP_004 EEILAFIKSCQ----------HECG-------GISASIGHDP---------HLLYTLSAV 70 80 90 100 130 140 150 160 170 180 pF1KE0 SCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWS . :. : :... .. . . ...:: ::::: . : : : :: .:: .:.. . NP_004 QILT-LYDSINVIDVNKVVEYVKGLQKEDGSFAGDIWG-EIDTRFSFCAVATLALLGKLD 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE0 GMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIK .....::: .. :..:.:.. : :::.:. .: . : . ..:..: : . . NP_004 AINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNS----DLLG 170 180 190 200 210 250 260 270 280 290 300 pF1KE0 RWCIMRQ--QNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVG : :: ..: .:::.: :.:::.:: :.::.. ... . :: ::.::. ::. .: NP_004 WWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRNFILACQDEETG 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE0 GFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSK ::: : . : .:. ::: ::::. : : :.:.. . .. .:. NP_004 GFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVNPVFCMPEEVLQRVNVQPELVS 280 290 300 310 320 330 370 pF1KE0 QCSENVHIST >>NP_002019 (OMIM: 134636) protein farnesyltransferase s (437 aa) initn: 324 init1: 132 opt: 337 Z-score: 436.9 bits: 89.7 E(85289): 1.4e-17 Smith-Waterman score: 392; 28.4% identity (55.6% similar) in 338 aa overlap (17-336:70-377) 10 20 30 40 pF1KE0 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETS :: . :..: ....: :. : . : :..: NP_002 VETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDAS 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE0 RLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFN : . .. : .:..:: . : : . .: . . . :: : . NP_002 RPWLCYWILHSLELLD--------EPIPQIVATDVCQFLELCQSPEGGFGG--------G 100 110 120 130 140 110 120 130 140 150 160 pF1KE0 PSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSR--VNKEACLAGLRALQLEDGSFCAV :.. : :.: ::.... : :.: . . .:.: : : .:. :::: . NP_002 PGQYP---------HLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFL-M 150 160 170 180 190 170 180 190 200 210 220 pF1KE0 PEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTF :.: :.: .:::. . . : . .. . .: : .....:.. :.:.::: :: NP_002 HVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTF 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE0 CGIASLCLMGKLEEVFSEKELNRIKRWCIMRQ---QNGYHGRPNKPVDTCYSFWVGATLK ::.:.: .. : :. .. : : .: :: ..:..:: :: :: ::::: .. : NP_002 CGLAALVIL-KRERSLNLKSL---LQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLP 260 270 280 290 300 290 300 310 320 pF1KE0 LLK-----------IFQYTNFEKN--RNYILSTQDRLVGGFAKWPDSHPDALHAYFGICG ::. ... :... ..::: . .::. : . : :. . . : NP_002 LLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSG 310 320 330 340 350 360 330 340 350 360 370 pF1KE0 LSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST ::. .. : NP_002 LSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFEELKDE 370 380 390 400 410 420 377 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 03:41:32 2016 done: Mon Nov 7 03:41:33 2016 Total Scan time: 8.160 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]