Result of FASTA (omim) for
pFN21AB8307
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8307, 118 aa
1>>>pF1KB8307 118 - 118 aa - 118 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3820+/-0.000417; mu= 4.0591+/- 0.025
mean_var=177.3027+/-39.801, 0's: 0 Z-trim(116.1): 492 B-trim: 649 in 1/50
Lambda= 0.096320
statistics sampled from 26356 (27058) to 26356 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.721), E-opt: 0.2 (0.317), width: 16
Scan time: 4.760
The best scores are: opt bits E(85289)
NP_665807 (OMIM: 606484) myotrophin [Homo sapiens] ( 118) 787 120.8 5.1e-28
XP_016861517 (OMIM: 611122) PREDICTED: serine/thre ( 687) 225 43.7 0.00048
XP_011531843 (OMIM: 611122) PREDICTED: serine/thre (1027) 225 43.9 0.00062
NP_056014 (OMIM: 611122) serine/threonine-protein (1053) 225 43.9 0.00063
XP_005265053 (OMIM: 611122) PREDICTED: serine/thre (1083) 225 44.0 0.00064
XP_011531842 (OMIM: 611122) PREDICTED: serine/thre (1086) 225 44.0 0.00064
XP_011531845 (OMIM: 611122) PREDICTED: serine/thre (1019) 224 43.8 0.00068
XP_016872190 (OMIM: 607128) PREDICTED: tankyrase-2 ( 506) 216 42.3 0.00095
XP_016860103 (OMIM: 114480,601593) PREDICTED: BRCA ( 675) 217 42.6 0.001
NP_001269472 (OMIM: 114480,601593) BRCA1-associate ( 758) 217 42.6 0.0011
NP_000456 (OMIM: 114480,601593) BRCA1-associated R ( 777) 217 42.7 0.0011
XP_016860102 (OMIM: 114480,601593) PREDICTED: BRCA ( 810) 217 42.7 0.0012
XP_016865167 (OMIM: 605787) PREDICTED: ankyrin rep ( 152) 205 40.1 0.0013
XP_011538517 (OMIM: 607128) PREDICTED: tankyrase-2 ( 695) 212 41.9 0.0017
XP_005248617 (OMIM: 605787) PREDICTED: ankyrin rep ( 245) 205 40.4 0.0018
NP_066956 (OMIM: 180435,601518) 2-5A-dependent rib ( 741) 211 41.8 0.0019
NP_075526 (OMIM: 605787) ankyrin repeat family A p ( 313) 205 40.5 0.002
NP_065789 (OMIM: 615759) kinase D-interacting subs (1771) 216 43.0 0.0021
XP_016872189 (OMIM: 607128) PREDICTED: tankyrase-2 ( 977) 212 42.1 0.0021
XP_016872188 (OMIM: 607128) PREDICTED: tankyrase-2 (1059) 212 42.1 0.0022
XP_016872187 (OMIM: 607128) PREDICTED: tankyrase-2 (1062) 212 42.1 0.0022
XP_016872186 (OMIM: 607128) PREDICTED: tankyrase-2 (1062) 212 42.1 0.0022
NP_079511 (OMIM: 607128) tankyrase-2 [Homo sapiens (1166) 212 42.2 0.0023
XP_016872185 (OMIM: 607128) PREDICTED: tankyrase-2 (1169) 212 42.2 0.0023
XP_011538515 (OMIM: 607128) PREDICTED: tankyrase-2 (1187) 212 42.2 0.0024
XP_005270242 (OMIM: 607128) PREDICTED: tankyrase-2 (1190) 212 42.2 0.0024
XP_011542149 (OMIM: 603303) PREDICTED: tankyrase-1 (1223) 210 41.9 0.0029
XP_011542148 (OMIM: 603303) PREDICTED: tankyrase-1 (1301) 210 42.0 0.003
XP_006716326 (OMIM: 603303) PREDICTED: tankyrase-1 (1316) 210 42.0 0.0031
XP_011542147 (OMIM: 603303) PREDICTED: tankyrase-1 (1316) 210 42.0 0.0031
NP_003738 (OMIM: 603303) tankyrase-1 [Homo sapiens (1327) 210 42.0 0.0031
NP_001139381 (OMIM: 611397) protein TANC1 isoform (1390) 210 42.0 0.0032
XP_011510364 (OMIM: 611397) PREDICTED: protein TAN (1554) 210 42.1 0.0034
XP_016860646 (OMIM: 611397) PREDICTED: protein TAN (1660) 210 42.1 0.0035
XP_006712877 (OMIM: 611397) PREDICTED: protein TAN (1677) 210 42.1 0.0035
XP_016860645 (OMIM: 611397) PREDICTED: protein TAN (1685) 210 42.1 0.0036
XP_011510361 (OMIM: 611397) PREDICTED: protein TAN (1697) 210 42.1 0.0036
XP_016860644 (OMIM: 611397) PREDICTED: protein TAN (1738) 210 42.1 0.0036
XP_011510360 (OMIM: 611397) PREDICTED: protein TAN (1755) 210 42.1 0.0036
XP_016860642 (OMIM: 611397) PREDICTED: protein TAN (1773) 210 42.1 0.0037
XP_016860643 (OMIM: 611397) PREDICTED: protein TAN (1773) 210 42.1 0.0037
XP_016860641 (OMIM: 611397) PREDICTED: protein TAN (1790) 210 42.2 0.0037
XP_016860640 (OMIM: 611397) PREDICTED: protein TAN (1791) 210 42.2 0.0037
XP_006712875 (OMIM: 611397) PREDICTED: protein TAN (1826) 210 42.2 0.0037
XP_016860639 (OMIM: 611397) PREDICTED: protein TAN (1838) 210 42.2 0.0037
XP_016860638 (OMIM: 611397) PREDICTED: protein TAN (1844) 210 42.2 0.0038
XP_011510357 (OMIM: 611397) PREDICTED: protein TAN (1853) 210 42.2 0.0038
XP_016860637 (OMIM: 611397) PREDICTED: protein TAN (1854) 210 42.2 0.0038
XP_016860636 (OMIM: 611397) PREDICTED: protein TAN (1854) 210 42.2 0.0038
XP_006712873 (OMIM: 611397) PREDICTED: protein TAN (1861) 210 42.2 0.0038
>>NP_665807 (OMIM: 606484) myotrophin [Homo sapiens] (118 aa)
initn: 787 init1: 787 opt: 787 Z-score: 624.1 bits: 120.8 E(85289): 5.1e-28
Smith-Waterman score: 787; 100.0% identity (100.0% similar) in 118 aa overlap (1-118:1-118)
10 20 30 40 50 60
pF1KB8 MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGAD
10 20 30 40 50 60
70 80 90 100 110
pF1KB8 INAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 INAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ
70 80 90 100 110
>>XP_016861517 (OMIM: 611122) PREDICTED: serine/threonin (687 aa)
initn: 628 init1: 210 opt: 225 Z-score: 193.6 bits: 43.7 E(85289): 0.00048
Smith-Waterman score: 225; 40.0% identity (66.4% similar) in 110 aa overlap (6-114:45-154)
10 20 30
pF1KB8 MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGG
.. :. ::: :::. . : :::: .
XP_016 ESPAFISKLPQENKSLHSPPSGNVLVRYPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEK
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB8 RKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKT
: ::: :: :. ::.:.:.:.:: .:: :.. .::: :: :..::...:: .
XP_016 RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN
80 90 100 110 120 130
100 110
pF1KB8 VKGPDGLTAFE-ATDNQAIKALLQ
.. . : .. :. :.:.:
XP_016 ARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLS
140 150 160 170 180 190
>>XP_011531843 (OMIM: 611122) PREDICTED: serine/threonin (1027 aa)
initn: 628 init1: 210 opt: 225 Z-score: 191.6 bits: 43.9 E(85289): 0.00062
Smith-Waterman score: 225; 40.0% identity (66.4% similar) in 110 aa overlap (6-114:45-154)
10 20 30
pF1KB8 MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGG
.. :. ::: :::. . : :::: .
XP_011 ESPAFISKLPQENKSLHSPPSGNVLVRYPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEK
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB8 RKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKT
: ::: :: :. ::.:.:.:.:: .:: :.. .::: :: :..::...:: .
XP_011 RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN
80 90 100 110 120 130
100 110
pF1KB8 VKGPDGLTAFE-ATDNQAIKALLQ
.. . : .. :. :.:.:
XP_011 ARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLS
140 150 160 170 180 190
>>NP_056014 (OMIM: 611122) serine/threonine-protein phos (1053 aa)
initn: 628 init1: 210 opt: 225 Z-score: 191.5 bits: 43.9 E(85289): 0.00063
Smith-Waterman score: 225; 40.0% identity (66.4% similar) in 110 aa overlap (6-114:12-121)
10 20 30 40 50
pF1KB8 MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFL
.. :. ::: :::. . : :::: . : ::: :: :. ::.:.:
NP_056 MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 LLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFE-ATDNQAI
.:.:: .:: :.. .::: :: :..::...:: ... . : .. :. :.:.
NP_056 ILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAV
70 80 90 100 110 120
pF1KB8 KALLQ
:
NP_056 KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWA
130 140 150 160 170 180
>>XP_005265053 (OMIM: 611122) PREDICTED: serine/threonin (1083 aa)
initn: 628 init1: 210 opt: 225 Z-score: 191.4 bits: 44.0 E(85289): 0.00064
Smith-Waterman score: 225; 40.0% identity (66.4% similar) in 110 aa overlap (6-114:42-151)
10 20 30
pF1KB8 MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGG
.. :. ::: :::. . : :::: .
XP_005 VEDESPAFISKLPQENKSLHSPPSGNVLPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEK
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB8 RKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKT
: ::: :: :. ::.:.:.:.:: .:: :.. .::: :: :..::...:: .
XP_005 RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN
80 90 100 110 120 130
100 110
pF1KB8 VKGPDGLTAFE-ATDNQAIKALLQ
.. . : .. :. :.:.:
XP_005 ARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLS
140 150 160 170 180 190
>>XP_011531842 (OMIM: 611122) PREDICTED: serine/threonin (1086 aa)
initn: 628 init1: 210 opt: 225 Z-score: 191.4 bits: 44.0 E(85289): 0.00064
Smith-Waterman score: 225; 40.0% identity (66.4% similar) in 110 aa overlap (6-114:45-154)
10 20 30
pF1KB8 MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGG
.. :. ::: :::. . : :::: .
XP_011 ESPAFISKLPQENKSLHSPPSGNVLVRYPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEK
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB8 RKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKT
: ::: :: :. ::.:.:.:.:: .:: :.. .::: :: :..::...:: .
XP_011 RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN
80 90 100 110 120 130
100 110
pF1KB8 VKGPDGLTAFE-ATDNQAIKALLQ
.. . : .. :. :.:.:
XP_011 ARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLS
140 150 160 170 180 190
>>XP_011531845 (OMIM: 611122) PREDICTED: serine/threonin (1019 aa)
initn: 525 init1: 191 opt: 224 Z-score: 190.9 bits: 43.8 E(85289): 0.00068
Smith-Waterman score: 231; 44.1% identity (64.0% similar) in 111 aa overlap (6-113:45-143)
10 20 30
pF1KB8 MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGG
.. :. ::: :::. . : :::: .
XP_011 ESPAFISKLPQENKSLHSPPSGNVLVRYPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEK
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB8 RKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC---VKLLLSKGA
: ::: :: :. ::.:.:.:.:: .:: :.. .::: :: .:: ::::::.::
XP_011 RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAV----ASCSEMVKLLLSRGA
80 90 100 110 120 130
100 110
pF1KB8 DKTVKGPDGLTAFEATDNQAIKALLQ
. ..::. : .::
XP_011 N--------INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASS
140 150 160 170 180
>>XP_016872190 (OMIM: 607128) PREDICTED: tankyrase-2 iso (506 aa)
initn: 420 init1: 193 opt: 216 Z-score: 188.3 bits: 42.3 E(85289): 0.00095
Smith-Waterman score: 216; 38.1% identity (68.6% similar) in 105 aa overlap (13-117:90-193)
10 20 30 40
pF1KB8 MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYA
: : :. . .: .:. .:: ::: :
XP_016 TPLHFAAGNRGQRPLASLQTPPAQPGPTGFGRKDVVEYLLQNGANVQARDDGGLIPLHNA
60 70 80 90 100 110
50 60 70 80 90 100
pF1KB8 ADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGL
. :. :....:: .::: :: :. . ::: :. .:... .::..::. :... ::
XP_016 CSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGR
120 130 140 150 160 170
110
pF1KB8 TAFEATDNQAIKALLQ
::.. .: .: ::.:
XP_016 TALDLADPSA-KAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHL
180 190 200 210 220 230
>>XP_016860103 (OMIM: 114480,601593) PREDICTED: BRCA1-as (675 aa)
initn: 217 init1: 217 opt: 217 Z-score: 187.6 bits: 42.6 E(85289): 0.001
Smith-Waterman score: 217; 37.1% identity (68.6% similar) in 105 aa overlap (13-117:472-576)
10 20 30 40
pF1KB8 MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYA
::. :. . .: : : ..: ::: :
XP_016 SSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEA
450 460 470 480 490 500
50 60 70 80 90 100
pF1KB8 ADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGL
. :.:...:.:: . : .:. .. .:: .:. .:::. :::::: ::.... . ::
XP_016 CNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGL
510 520 530 540 550 560
110
pF1KB8 TAFEATDNQAIKALLQ
. ::....:.::
XP_016 RPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSEL
570 580 590 600 610 620
>>NP_001269472 (OMIM: 114480,601593) BRCA1-associated RI (758 aa)
initn: 217 init1: 217 opt: 217 Z-score: 187.1 bits: 42.6 E(85289): 0.0011
Smith-Waterman score: 217; 37.1% identity (68.6% similar) in 105 aa overlap (13-117:420-524)
10 20 30 40
pF1KB8 MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYA
::. :. . .: : : ..: ::: :
NP_001 SSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEA
390 400 410 420 430 440
50 60 70 80 90 100
pF1KB8 ADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGL
. :.:...:.:: . : .:. .. .:: .:. .:::. :::::: ::.... . ::
NP_001 CNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGL
450 460 470 480 490 500
110
pF1KB8 TAFEATDNQAIKALLQ
. ::....:.::
NP_001 RPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSEL
510 520 530 540 550 560
118 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 02:08:15 2016 done: Sat Nov 5 02:08:15 2016
Total Scan time: 4.760 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]