FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3580, 999 aa 1>>>pF1KE3580 999 - 999 aa - 999 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.7290+/-0.000481; mu= 16.3804+/- 0.030 mean_var=259.7159+/-53.696, 0's: 0 Z-trim(117.2): 501 B-trim: 553 in 2/57 Lambda= 0.079584 statistics sampled from 28318 (29059) to 28318 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.341), width: 16 Scan time: 15.310 The best scores are: opt bits E(85289) NP_001164158 (OMIM: 611141) E3 ubiquitin-protein l (1056) 6832 799.6 0 NP_543151 (OMIM: 611141) E3 ubiquitin-protein liga (1070) 6604 773.4 0 NP_001164157 (OMIM: 611141) E3 ubiquitin-protein l (1066) 6558 768.1 0 XP_011539039 (OMIM: 611141) PREDICTED: E3 ubiquiti (1219) 5942 697.5 1.1e-199 XP_016855850 (OMIM: 611141) PREDICTED: E3 ubiquiti (1094) 5879 690.2 1.6e-197 NP_001164159 (OMIM: 611141) E3 ubiquitin-protein l (1005) 4786 564.6 9.3e-160 XP_016855842 (OMIM: 611141) PREDICTED: E3 ubiquiti (1276) 4443 525.4 7.6e-148 XP_016855855 (OMIM: 611141) PREDICTED: E3 ubiquiti ( 911) 4293 507.9 9.7e-143 XP_006710435 (OMIM: 611141) PREDICTED: E3 ubiquiti (1034) 4195 496.8 2.5e-139 XP_011539044 (OMIM: 611141) PREDICTED: E3 ubiquiti (1183) 4195 496.9 2.7e-139 XP_011539038 (OMIM: 611141) PREDICTED: E3 ubiquiti (1240) 4191 496.4 3.8e-139 XP_016855853 (OMIM: 611141) PREDICTED: E3 ubiquiti (1029) 4061 481.4 1.1e-134 XP_011539043 (OMIM: 611141) PREDICTED: E3 ubiquiti (1184) 3952 469.0 6.8e-131 NP_001164160 (OMIM: 611141) E3 ubiquitin-protein l ( 753) 3659 435.0 7.1e-121 XP_016855843 (OMIM: 611141) PREDICTED: E3 ubiquiti (1264) 3466 413.2 4.4e-114 XP_016855845 (OMIM: 611141) PREDICTED: E3 ubiquiti (1240) 2696 324.8 1.8e-87 XP_016855854 (OMIM: 611141) PREDICTED: E3 ubiquiti ( 932) 2692 324.1 2.1e-87 XP_016855852 (OMIM: 611141) PREDICTED: E3 ubiquiti (1033) 2692 324.2 2.2e-87 XP_016855851 (OMIM: 611141) PREDICTED: E3 ubiquiti (1047) 2692 324.2 2.3e-87 XP_016855849 (OMIM: 611141) PREDICTED: E3 ubiquiti (1134) 2692 324.3 2.4e-87 XP_016855848 (OMIM: 611141) PREDICTED: E3 ubiquiti (1144) 2692 324.3 2.4e-87 XP_016855847 (OMIM: 611141) PREDICTED: E3 ubiquiti (1148) 2692 324.3 2.4e-87 XP_016855846 (OMIM: 611141) PREDICTED: E3 ubiquiti (1232) 2692 324.3 2.5e-87 XP_011539033 (OMIM: 611141) PREDICTED: E3 ubiquiti (1273) 2692 324.3 2.5e-87 XP_016855841 (OMIM: 611141) PREDICTED: E3 ubiquiti (1283) 2692 324.3 2.5e-87 XP_016855840 (OMIM: 611141) PREDICTED: E3 ubiquiti (1291) 2692 324.4 2.5e-87 XP_016855839 (OMIM: 611141) PREDICTED: E3 ubiquiti (1293) 2692 324.4 2.5e-87 XP_016855838 (OMIM: 611141) PREDICTED: E3 ubiquiti (1297) 2692 324.4 2.5e-87 XP_016855844 (OMIM: 611141) PREDICTED: E3 ubiquiti (1241) 2453 296.9 4.5e-79 NP_065825 (OMIM: 608677,615092) E3 ubiquitin-prote (1006) 1674 207.3 3.4e-52 XP_016881362 (OMIM: 608677,615092) PREDICTED: E3 u ( 834) 1179 150.3 3.9e-35 XP_016881363 (OMIM: 608677,615092) PREDICTED: E3 u ( 511) 954 124.2 1.8e-27 XP_016881364 (OMIM: 608677,615092) PREDICTED: E3 u ( 503) 949 123.6 2.7e-27 XP_011524400 (OMIM: 608677,615092) PREDICTED: E3 u ( 516) 759 101.8 1e-20 XP_016863591 (OMIM: 106410,600919) PREDICTED: anky (1838) 521 75.3 3.3e-12 XP_016863600 (OMIM: 106410,600919) PREDICTED: anky (1755) 444 66.5 1.5e-09 XP_016863598 (OMIM: 106410,600919) PREDICTED: anky (1770) 444 66.5 1.5e-09 XP_016863594 (OMIM: 106410,600919) PREDICTED: anky (1810) 444 66.5 1.5e-09 XP_016863584 (OMIM: 106410,600919) PREDICTED: anky (1871) 444 66.5 1.5e-09 XP_016863569 (OMIM: 106410,600919) PREDICTED: anky (1970) 444 66.5 1.6e-09 XP_016863568 (OMIM: 106410,600919) PREDICTED: anky (2006) 444 66.5 1.6e-09 XP_016863566 (OMIM: 106410,600919) PREDICTED: anky (4074) 444 67.0 2.3e-09 XP_016863561 (OMIM: 106410,600919) PREDICTED: anky (4137) 444 67.0 2.3e-09 XP_016863558 (OMIM: 106410,600919) PREDICTED: anky (4175) 444 67.0 2.4e-09 XP_016861517 (OMIM: 611122) PREDICTED: serine/thre ( 687) 425 63.6 4.1e-09 XP_005251814 (OMIM: 600831) PREDICTED: death-assoc ( 839) 425 63.8 4.5e-09 XP_011531848 (OMIM: 611122) PREDICTED: serine/thre ( 997) 425 63.9 5e-09 XP_011531847 (OMIM: 611122) PREDICTED: serine/thre ( 997) 425 63.9 5e-09 XP_011531849 (OMIM: 611122) PREDICTED: serine/thre ( 997) 425 63.9 5e-09 XP_011531844 (OMIM: 611122) PREDICTED: serine/thre (1025) 425 63.9 5e-09 >>NP_001164158 (OMIM: 611141) E3 ubiquitin-protein ligas (1056 aa) initn: 6832 init1: 6832 opt: 6832 Z-score: 4258.5 bits: 799.6 E(85289): 0 Smith-Waterman score: 6832; 99.7% identity (99.9% similar) in 999 aa overlap (1-999:58-1056) 10 20 30 pF1KE3 MGWKPSEARGQSQSFQASGLQPRSLKAARR :::::::::::::::::::::::::::::: NP_001 CPVAQEGLGARSRPRVAPRSLARCGPSSRLMGWKPSEARGQSQSFQASGLQPRSLKAARR 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE3 ATGRPDRSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATGRPDRSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPS 90 100 110 120 130 140 100 110 120 130 140 150 pF1KE3 TPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKC 150 160 170 180 190 200 160 170 180 190 200 210 pF1KE3 RVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRIPLRGIFQGAKVVRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRIPLRGIFQGAKVVRG 210 220 230 240 250 260 220 230 240 250 260 270 pF1KE3 PDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGYKGKVDLKCVGE ::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::: NP_001 PDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGE 270 280 290 300 310 320 280 290 300 310 320 330 pF1KE3 AAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVLREMQEGHGGWNPRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVLREMQEGHGGWNPRM 330 340 350 360 370 380 340 350 360 370 380 390 pF1KE3 AEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGDVVRVIGDLDTVKRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGDVVRVIGDLDTVKRL 390 400 410 420 430 440 400 410 420 430 440 450 pF1KE3 QAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVA 450 460 470 480 490 500 460 470 480 490 500 510 pF1KE3 ERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALGLLRRRPEQVDTKNQGR ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: NP_001 ERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGR 510 520 530 540 550 560 520 530 540 550 560 570 pF1KE3 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 570 580 590 600 610 620 580 590 600 610 620 630 pF1KE3 INSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAGGIVEVLT ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: NP_001 INSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLT 630 640 650 660 670 680 640 650 660 670 680 690 pF1KE3 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 690 700 710 720 730 740 700 710 720 730 740 750 pF1KE3 REVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALH 750 760 770 780 790 800 760 770 780 790 800 810 pF1KE3 VALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYT 810 820 830 840 850 860 820 830 840 850 860 870 pF1KE3 NHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPG 870 880 890 900 910 920 880 890 900 910 920 930 pF1KE3 PEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSKKLRPDGSEVASAAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSKKLRPDGSEVASAAP 930 940 950 960 970 980 940 950 960 970 980 990 pF1KE3 APGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQP 990 1000 1010 1020 1030 1040 pF1KE3 IRDRIQIFV ::::::::: NP_001 IRDRIQIFV 1050 >>NP_543151 (OMIM: 611141) E3 ubiquitin-protein ligase M (1070 aa) initn: 6586 init1: 6586 opt: 6604 Z-score: 4117.0 bits: 773.4 E(85289): 0 Smith-Waterman score: 6794; 98.3% identity (98.5% similar) in 1013 aa overlap (1-999:58-1070) 10 20 30 pF1KE3 MGWKPSEARGQSQSFQASGLQPRSLKAARR :::::::::::::::::::::::::::::: NP_543 CPVAQEGLGARSRPRVAPRSLARCGPSSRLMGWKPSEARGQSQSFQASGLQPRSLKAARR 30 40 50 60 70 80 40 50 60 70 pF1KE3 ATGRPDRSRAA--------------PPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGG ::::::::::: ::::::::::::::::::::::::::::::::::: NP_543 ATGRPDRSRAARPTMDPSAHRSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGG 90 100 110 120 130 140 80 90 100 110 120 130 pF1KE3 VGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 VGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICD 150 160 170 180 190 200 140 150 160 170 180 190 pF1KE3 CCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 CCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRI 210 220 230 240 250 260 200 210 220 230 240 250 pF1KE3 PLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 PLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYR 270 280 290 300 310 320 260 270 280 290 300 310 pF1KE3 VGYKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVL ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 VGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVL 330 340 350 360 370 380 320 330 340 350 360 370 pF1KE3 REMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 REMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGD 390 400 410 420 430 440 380 390 400 410 420 430 pF1KE3 VVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 VVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCL 450 460 470 480 490 500 440 450 460 470 480 490 pF1KE3 VAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALGLL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: NP_543 VAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLL 510 520 530 540 550 560 500 510 520 530 540 550 pF1KE3 RRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 RRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPE 570 580 590 600 610 620 560 570 580 590 600 610 pF1KE3 ATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 ATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAI 630 640 650 660 670 680 620 630 640 650 660 670 pF1KE3 SAGTGAGGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 SAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 690 700 710 720 730 740 680 690 700 710 720 730 pF1KE3 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 750 760 770 780 790 800 740 750 760 770 780 790 pF1KE3 SVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 SVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAV 810 820 830 840 850 860 800 810 820 830 840 850 pF1KE3 ACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 ACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGT 870 880 890 900 910 920 860 870 880 890 900 910 pF1KE3 PNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 PNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSK 930 940 950 960 970 980 920 930 940 950 960 970 pF1KE3 KLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 KLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAP 990 1000 1010 1020 1030 1040 980 990 pF1KE3 CGSALSACPICRQPIRDRIQIFV ::::::::::::::::::::::: NP_543 CGSALSACPICRQPIRDRIQIFV 1050 1060 1070 >>NP_001164157 (OMIM: 611141) E3 ubiquitin-protein ligas (1066 aa) initn: 4839 init1: 4420 opt: 6558 Z-score: 4088.4 bits: 768.1 E(85289): 0 Smith-Waterman score: 6748; 97.9% identity (98.1% similar) in 1013 aa overlap (1-999:58-1066) 10 20 30 pF1KE3 MGWKPSEARGQSQSFQASGLQPRSLKAARR :::::::::::::::::::::::::::::: NP_001 CPVAQEGLGARSRPRVAPRSLARCGPSSRLMGWKPSEARGQSQSFQASGLQPRSLKAARR 30 40 50 60 70 80 40 50 60 70 pF1KE3 ATGRPDRSRAA--------------PPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGG ::::::::::: ::::::::::::::::::::::::::::::::::: NP_001 ATGRPDRSRAARPTMDPSAHRSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGG 90 100 110 120 130 140 80 90 100 110 120 130 pF1KE3 VGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICD 150 160 170 180 190 200 140 150 160 170 180 190 pF1KE3 CCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRI 210 220 230 240 250 260 200 210 220 230 240 250 pF1KE3 PLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYR 270 280 290 300 310 320 260 270 280 290 300 310 pF1KE3 VGYKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVL ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVL 330 340 350 360 370 380 320 330 340 350 360 370 pF1KE3 REMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGD :::::::::::::::: :::::::::::::::::::::::::::::::::::::::: NP_001 REMQEGHGGWNPRMAE----TGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGD 390 400 410 420 430 440 380 390 400 410 420 430 pF1KE3 VVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCL 450 460 470 480 490 500 440 450 460 470 480 490 pF1KE3 VAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALGLL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: NP_001 VAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLL 510 520 530 540 550 560 500 510 520 530 540 550 pF1KE3 RRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPE 570 580 590 600 610 620 560 570 580 590 600 610 pF1KE3 ATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAI 630 640 650 660 670 680 620 630 640 650 660 670 pF1KE3 SAGTGAGGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 690 700 710 720 730 740 680 690 700 710 720 730 pF1KE3 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 750 760 770 780 790 800 740 750 760 770 780 790 pF1KE3 SVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAV 810 820 830 840 850 860 800 810 820 830 840 850 pF1KE3 ACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGT 870 880 890 900 910 920 860 870 880 890 900 910 pF1KE3 PNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSK 930 940 950 960 970 980 920 930 940 950 960 970 pF1KE3 KLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAP 990 1000 1010 1020 1030 1040 980 990 pF1KE3 CGSALSACPICRQPIRDRIQIFV ::::::::::::::::::::::: NP_001 CGSALSACPICRQPIRDRIQIFV 1050 1060 >>XP_011539039 (OMIM: 611141) PREDICTED: E3 ubiquitin-pr (1219 aa) initn: 5938 init1: 5938 opt: 5942 Z-score: 3705.6 bits: 697.5 E(85289): 1.1e-199 Smith-Waterman score: 5951; 89.1% identity (92.4% similar) in 1014 aa overlap (1-999:212-1219) 10 20 30 pF1KE3 MGWKPSEARGQSQSFQASGLQPRSLKAARR .: : :: .. : ..: : : :.:: XP_011 ERRDRPTDGLAGGPAPPSGAGGTETSGQVGVGRVGSPARLEA-SPKVSRHQGCSPGASRR 190 200 210 220 230 240 40 50 60 70 pF1KE3 ATGRPDRSRAAP----PNMDPDPQAG-------VQVGMRVVR-GVDWKWGQQDGGEGGVG :: : .:..: : : : . .:. :. : . : . .: . .. XP_011 PGGRLD-GRTGPEQPGPPWTPLPTGPEQPRPTWTQTPRRACRWACGWCAAWTGSGASRTA 250 260 270 280 290 80 90 100 110 120 130 pF1KE3 TVVELGRHGS--PSTPDRTVVVQWD-QGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIIC . . .: : .. : ..::. .:::. :: . .. :::::::: XP_011 ARAAWARWWSLAATAAPRHPTAQWSCSGTRA--RAPTTAPATR--ARTTCCCVRHPNIIC 300 310 320 330 340 350 140 150 160 170 180 190 pF1KE3 DCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPR 360 370 380 390 400 410 200 210 220 230 240 250 pF1KE3 IPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVY 420 430 440 450 460 470 260 270 280 290 300 310 pF1KE3 RVGYKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDV :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDV 480 490 500 510 520 530 320 330 340 350 360 370 pF1KE3 LREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVG 540 550 560 570 580 590 380 390 400 410 420 430 pF1KE3 DVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSC 600 610 620 630 640 650 440 450 460 470 480 490 pF1KE3 LVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: : XP_011 LVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDL 660 670 680 690 700 710 500 510 520 530 540 550 pF1KE3 LRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQP 720 730 740 750 760 770 560 570 580 590 600 610 pF1KE3 EATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSA 780 790 800 810 820 830 620 630 640 650 660 670 pF1KE3 ISAGTGAGGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKK :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKK 840 850 860 870 880 890 680 690 700 710 720 730 pF1KE3 EDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 900 910 920 930 940 950 740 750 760 770 780 790 pF1KE3 CSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAA 960 970 980 990 1000 1010 800 810 820 830 840 850 pF1KE3 VACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLG 1020 1030 1040 1050 1060 1070 860 870 880 890 900 910 pF1KE3 TPNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVS 1080 1090 1100 1110 1120 1130 920 930 940 950 960 970 pF1KE3 KKLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACA 1140 1150 1160 1170 1180 1190 980 990 pF1KE3 PCGSALSACPICRQPIRDRIQIFV :::::::::::::::::::::::: XP_011 PCGSALSACPICRQPIRDRIQIFV 1200 1210 >>XP_016855850 (OMIM: 611141) PREDICTED: E3 ubiquitin-pr (1094 aa) initn: 6572 init1: 5861 opt: 5879 Z-score: 3667.0 bits: 690.2 E(85289): 1.6e-197 Smith-Waterman score: 6736; 96.0% identity (96.2% similar) in 1037 aa overlap (1-999:58-1094) 10 20 30 pF1KE3 MGWKPSEARGQSQSFQASGLQPRSLKAARR :::::::::::::::::::::::::::::: XP_016 CPVAQEGLGARSRPRVAPRSLARCGPSSRLMGWKPSEARGQSQSFQASGLQPRSLKAARR 30 40 50 60 70 80 40 50 60 70 pF1KE3 ATGRPDRSRAA--------------PPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGG ::::::::::: ::::::::::::::::::::::::::::::::::: XP_016 ATGRPDRSRAARPTMDPSAHRSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGG 90 100 110 120 130 140 80 90 100 110 120 130 pF1KE3 VGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICD 150 160 170 180 190 200 140 150 160 170 180 190 pF1KE3 CCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRI 210 220 230 240 250 260 200 210 220 230 240 250 pF1KE3 PLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYR 270 280 290 300 310 320 260 270 280 290 300 310 pF1KE3 VGYKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVL ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVL 330 340 350 360 370 380 320 330 340 350 360 370 pF1KE3 REMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGD 390 400 410 420 430 440 380 390 400 410 420 430 pF1KE3 VVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCL 450 460 470 480 490 500 440 450 460 470 480 490 pF1KE3 VAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALGLL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_016 VAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLL 510 520 530 540 550 560 500 510 520 530 540 550 pF1KE3 RRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPE 570 580 590 600 610 620 560 570 580 590 600 610 pF1KE3 ATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAI 630 640 650 660 670 680 620 630 640 650 660 670 pF1KE3 SAGTGAGGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 690 700 710 720 730 740 680 690 700 710 720 730 pF1KE3 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 750 760 770 780 790 800 740 750 760 770 780 790 pF1KE3 SVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAV 810 820 830 840 850 860 800 810 820 830 840 850 pF1KE3 ACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGT 870 880 890 900 910 920 860 870 880 890 pF1KE3 PNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCE------------------ :::::::::::::::::::::::::::::::::::::::::: XP_016 PNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEGEWGAPGWGGPASRAAAN 930 940 950 960 970 980 900 910 920 930 940 950 pF1KE3 ------ECARRMKKCIRCQVVVSKKLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEER :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RALLFAECARRMKKCIRCQVVVSKKLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEER 990 1000 1010 1020 1030 1040 960 970 980 990 pF1KE3 ITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV 1050 1060 1070 1080 1090 >>NP_001164159 (OMIM: 611141) E3 ubiquitin-protein ligas (1005 aa) initn: 5195 init1: 4786 opt: 4786 Z-score: 2989.1 bits: 564.6 E(85289): 9.3e-160 Smith-Waterman score: 6206; 92.0% identity (92.1% similar) in 1013 aa overlap (1-999:58-1005) 10 20 30 pF1KE3 MGWKPSEARGQSQSFQASGLQPRSLKAARR :::::::::::::::::::::::::::::: NP_001 CPVAQEGLGARSRPRVAPRSLARCGPSSRLMGWKPSEARGQSQSFQASGLQPRSLKAARR 30 40 50 60 70 80 40 50 60 70 pF1KE3 ATGRPDRSRAA--------------PPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGG ::::::::::: ::::::::::::::::::::::::::::::::::: NP_001 ATGRPDRSRAARPTMDPSAHRSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGG 90 100 110 120 130 140 80 90 100 110 120 130 pF1KE3 VGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICD 150 160 170 180 190 200 140 150 160 170 180 190 pF1KE3 CCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRI 210 220 230 240 250 260 200 210 220 230 240 250 pF1KE3 PLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYR :::::::::::::::::::::::: NP_001 PLRGIFQGAKVVRGPDWEWGSQDG------------------------------------ 270 280 290 260 270 280 290 300 310 pF1KE3 VGYKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVL ::::::::::::::::::::::::::::::: NP_001 -----------------------------KPAELQRRVSADSQPFQHGDKVKCLLDTDVL 300 310 320 320 330 340 350 360 370 pF1KE3 REMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGD 330 340 350 360 370 380 380 390 400 410 420 430 pF1KE3 VVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCL 390 400 410 420 430 440 440 450 460 470 480 490 pF1KE3 VAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALGLL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: NP_001 VAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLL 450 460 470 480 490 500 500 510 520 530 540 550 pF1KE3 RRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPE 510 520 530 540 550 560 560 570 580 590 600 610 pF1KE3 ATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAI 570 580 590 600 610 620 620 630 640 650 660 670 pF1KE3 SAGTGAGGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 630 640 650 660 670 680 680 690 700 710 720 730 pF1KE3 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 690 700 710 720 730 740 740 750 760 770 780 790 pF1KE3 SVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAV 750 760 770 780 790 800 800 810 820 830 840 850 pF1KE3 ACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGT 810 820 830 840 850 860 860 870 880 890 900 910 pF1KE3 PNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSK 870 880 890 900 910 920 920 930 940 950 960 970 pF1KE3 KLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAP 930 940 950 960 970 980 980 990 pF1KE3 CGSALSACPICRQPIRDRIQIFV ::::::::::::::::::::::: NP_001 CGSALSACPICRQPIRDRIQIFV 990 1000 >>XP_016855842 (OMIM: 611141) PREDICTED: E3 ubiquitin-pr (1276 aa) initn: 5127 init1: 4416 opt: 4443 Z-score: 2775.3 bits: 525.4 E(85289): 7.6e-148 Smith-Waterman score: 5634; 83.9% identity (87.2% similar) in 1046 aa overlap (1-974:212-1251) 10 20 30 pF1KE3 MGWKPSEARGQSQSFQASGLQPRSLKAARR .: : :: .. : ..: : : :.:: XP_016 ERRDRPTDGLAGGPAPPSGAGGTETSGQVGVGRVGSPARLEA-SPKVSRHQGCSPGASRR 190 200 210 220 230 240 40 50 60 70 pF1KE3 ATGRPDRSRAAP----PNMDPDPQAG-------VQVGMRVVR-GVDWKWGQQDGGEGGVG :: : .:..: : : : . .:. :. : . : . .: . .. XP_016 PGGRLD-GRTGPEQPGPPWTPLPTGPEQPRPTWTQTPRRACRWACGWCAAWTGSGASRTA 250 260 270 280 290 80 90 100 110 120 130 pF1KE3 TVVELGRHGS--PSTPDRTVVVQWD-QGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIIC . . .: : .. : ..::. .:::. :: . .. :::::::: XP_016 ARAAWARWWSLAATAAPRHPTAQWSCSGTRA--RA--PTTAPATRARTTCCCVRHPNIIC 300 310 320 330 340 350 140 150 160 170 180 190 pF1KE3 DCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPR 360 370 380 390 400 410 200 210 220 230 240 250 pF1KE3 IPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVY 420 430 440 450 460 470 260 270 280 290 300 310 pF1KE3 RVGYKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDV :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDV 480 490 500 510 520 530 320 330 340 350 360 370 pF1KE3 LREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVG 540 550 560 570 580 590 380 390 400 410 420 430 pF1KE3 DVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSC 600 610 620 630 640 650 440 450 460 470 480 490 pF1KE3 LVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: : XP_016 LVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDL 660 670 680 690 700 710 500 510 520 530 540 550 pF1KE3 LRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQP 720 730 740 750 760 770 560 570 580 590 600 610 pF1KE3 EATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSA 780 790 800 810 820 830 620 630 640 650 660 670 pF1KE3 ISAGTGAGGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKK :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKK 840 850 860 870 880 890 680 690 700 710 720 730 pF1KE3 EDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 900 910 920 930 940 950 740 750 760 770 pF1KE3 CSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSR----------------- ::::::::::::::::::::::::::::::::::::::::::: XP_016 CSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRTWGAGCWGCQVPGDASL 960 970 980 990 1000 1010 780 790 800 810 820 pF1KE3 ----------------LQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA :::::::::::::::::::::::::::::::::::::::::::: XP_016 GPAPAPALTGVCPAAQLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA 1020 1030 1040 1050 1060 1070 830 840 850 860 870 880 pF1KE3 EGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPGPEAAECLVCSEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPGPEAAECLVCSEL 1080 1090 1100 1110 1120 1130 890 900 910 pF1KE3 ALLVLFSPCQHRTVCE------------------------ECARRMKKCIRCQVVVSKKL :::::::::::::::: :::::::::::::::::::: XP_016 ALLVLFSPCQHRTVCEGEWGAPGWGGPASRAAANRALLFAECARRMKKCIRCQVVVSKKL 1140 1150 1160 1170 1180 1190 920 930 940 950 960 970 pF1KE3 RPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCG 1200 1210 1220 1230 1240 1250 980 990 pF1KE3 SALSACPICRQPIRDRIQIFV XP_016 SALSACPICRQPIRDRIQIFV 1260 1270 >>XP_016855855 (OMIM: 611141) PREDICTED: E3 ubiquitin-pr (911 aa) initn: 4981 init1: 4270 opt: 4293 Z-score: 2683.6 bits: 507.9 E(85289): 9.7e-143 Smith-Waterman score: 5475; 93.2% identity (93.5% similar) in 886 aa overlap (146-974:1-886) 120 130 140 150 160 170 pF1KE3 HDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFD :::::::::::::::::::::::::::::: XP_016 MRWKCRVCLDYDLCTQCYMHNKHELAHAFD 10 20 30 180 190 200 210 220 230 pF1KE3 RYETAHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RYETAHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWD 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE3 VETGRSVASVTWADGTTNVYRVGYKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVS :::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::: XP_016 VETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVS 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE3 ADSQPFQHGDKVKCLLDTDVLREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADSQPFQHGDKVKCLLDTDVLREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNH 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE3 ETRWTFHPGALTKHHSFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETRWTFHPGALTKHHSFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVF 220 230 240 250 260 270 420 430 440 450 460 470 pF1KE3 GDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPE 280 290 300 310 320 330 480 490 500 510 520 530 pF1KE3 HPGRLVVEVALGNAARALGLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGV :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_016 HPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGV 340 350 360 370 380 390 540 550 560 570 580 590 pF1KE3 DLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALC 400 410 420 430 440 450 600 610 620 630 640 650 pF1KE3 ERGCDVNLPDAHSDTPLHSAISAGTGAGGIVEVLTEVPNIDVTATNSQGFTLLHHASLKG :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: XP_016 ERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKG 460 470 480 490 500 510 660 670 680 690 700 710 pF1KE3 HALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSP 520 530 540 550 560 570 720 730 740 750 760 770 pF1KE3 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 580 590 600 610 620 630 780 790 800 pF1KE3 LSR---------------------------------LQASGLPGSAELTVGAAVACFLAL ::: :::::::::::::::::::::::: XP_016 LSRTWGAGCWGCQVPGDASLGPAPAPALTGVCPAAQLQASGLPGSAELTVGAAVACFLAL 640 650 660 670 680 690 810 820 830 840 850 860 pF1KE3 EGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTN 700 710 720 730 740 750 870 880 890 pF1KE3 LHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCE------------------------ :::::::::::::::::::::::::::::::::::: XP_016 LHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEGEWGAPGWGGPASRAAANRALLFA 760 770 780 790 800 810 900 910 920 930 940 950 pF1KE3 ECARRMKKCIRCQVVVSKKLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECARRMKKCIRCQVVVSKKLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPIC 820 830 840 850 860 870 960 970 980 990 pF1KE3 IDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV :::::::::::::::: XP_016 IDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV 880 890 900 910 >>XP_006710435 (OMIM: 611141) PREDICTED: E3 ubiquitin-pr (1034 aa) initn: 4614 init1: 4195 opt: 4195 Z-score: 2622.3 bits: 496.8 E(85289): 2.5e-139 Smith-Waterman score: 6459; 94.8% identity (95.0% similar) in 1013 aa overlap (1-999:58-1034) 10 20 30 pF1KE3 MGWKPSEARGQSQSFQASGLQPRSLKAARR :::::::::::::::::::::::::::::: XP_006 CPVAQEGLGARSRPRVAPRSLARCGPSSRLMGWKPSEARGQSQSFQASGLQPRSLKAARR 30 40 50 60 70 80 40 50 60 70 pF1KE3 ATGRPDRSRAA--------------PPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGG ::::::::::: ::::::::::::::::::::::::::::::::::: XP_006 ATGRPDRSRAARPTMDPSAHRSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGG 90 100 110 120 130 140 80 90 100 110 120 130 pF1KE3 VGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICD 150 160 170 180 190 200 140 150 160 170 180 190 pF1KE3 CCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRI 210 220 230 240 250 260 200 210 220 230 240 250 pF1KE3 PLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYR 270 280 290 300 310 320 260 270 280 290 300 310 pF1KE3 VGYKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVL ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVL 330 340 350 360 370 380 320 330 340 350 360 370 pF1KE3 REMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGD :::::::::::::::: :::::::: XP_006 REMQEGHGGWNPRMAE------------------------------------HHSFWVGD 390 400 410 380 390 400 410 420 430 pF1KE3 VVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCL 420 430 440 450 460 470 440 450 460 470 480 490 pF1KE3 VAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALGLL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_006 VAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLL 480 490 500 510 520 530 500 510 520 530 540 550 pF1KE3 RRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPE 540 550 560 570 580 590 560 570 580 590 600 610 pF1KE3 ATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAI 600 610 620 630 640 650 620 630 640 650 660 670 pF1KE3 SAGTGAGGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 660 670 680 690 700 710 680 690 700 710 720 730 pF1KE3 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 720 730 740 750 760 770 740 750 760 770 780 790 pF1KE3 SVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAV 780 790 800 810 820 830 800 810 820 830 840 850 pF1KE3 ACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGT 840 850 860 870 880 890 860 870 880 890 900 910 pF1KE3 PNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSK 900 910 920 930 940 950 920 930 940 950 960 970 pF1KE3 KLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAP 960 970 980 990 1000 1010 980 990 pF1KE3 CGSALSACPICRQPIRDRIQIFV ::::::::::::::::::::::: XP_006 CGSALSACPICRQPIRDRIQIFV 1020 1030 >>XP_011539044 (OMIM: 611141) PREDICTED: E3 ubiquitin-pr (1183 aa) initn: 4195 init1: 4195 opt: 4195 Z-score: 2621.7 bits: 496.9 E(85289): 2.7e-139 Smith-Waterman score: 5616; 85.5% identity (88.9% similar) in 1014 aa overlap (1-999:212-1183) 10 20 30 pF1KE3 MGWKPSEARGQSQSFQASGLQPRSLKAARR .: : :: .. : ..: : : :.:: XP_011 ERRDRPTDGLAGGPAPPSGAGGTETSGQVGVGRVGSPARLEA-SPKVSRHQGCSPGASRR 190 200 210 220 230 240 40 50 60 70 pF1KE3 ATGRPDRSRAAP----PNMDPDPQAG-------VQVGMRVVR-GVDWKWGQQDGGEGGVG :: : .:..: : : : . .:. :. : . : . .: . .. XP_011 PGGRLD-GRTGPEQPGPPWTPLPTGPEQPRPTWTQTPRRACRWACGWCAAWTGSGASRTA 250 260 270 280 290 80 90 100 110 120 130 pF1KE3 TVVELGRHGS--PSTPDRTVVVQWD-QGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIIC . . .: : .. : ..::. .:::. :: . .. :::::::: XP_011 ARAAWARWWSLAATAAPRHPTAQWSCSGTRA--RAPTTAPATR--ARTTCCCVRHPNIIC 300 310 320 330 340 350 140 150 160 170 180 190 pF1KE3 DCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPR 360 370 380 390 400 410 200 210 220 230 240 250 pF1KE3 IPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVY 420 430 440 450 460 470 260 270 280 290 300 310 pF1KE3 RVGYKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDV :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDV 480 490 500 510 520 530 320 330 340 350 360 370 pF1KE3 LREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVG ::::::::::::::::: ::::::: XP_011 LREMQEGHGGWNPRMAE------------------------------------HHSFWVG 540 550 380 390 400 410 420 430 pF1KE3 DVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSC 560 570 580 590 600 610 440 450 460 470 480 490 pF1KE3 LVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: : XP_011 LVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDL 620 630 640 650 660 670 500 510 520 530 540 550 pF1KE3 LRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQP 680 690 700 710 720 730 560 570 580 590 600 610 pF1KE3 EATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSA 740 750 760 770 780 790 620 630 640 650 660 670 pF1KE3 ISAGTGAGGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKK :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKK 800 810 820 830 840 850 680 690 700 710 720 730 pF1KE3 EDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 860 870 880 890 900 910 740 750 760 770 780 790 pF1KE3 CSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAA 920 930 940 950 960 970 800 810 820 830 840 850 pF1KE3 VACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLG 980 990 1000 1010 1020 1030 860 870 880 890 900 910 pF1KE3 TPNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVS 1040 1050 1060 1070 1080 1090 920 930 940 950 960 970 pF1KE3 KKLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACA 1100 1110 1120 1130 1140 1150 980 990 pF1KE3 PCGSALSACPICRQPIRDRIQIFV :::::::::::::::::::::::: XP_011 PCGSALSACPICRQPIRDRIQIFV 1160 1170 1180 999 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 03:45:49 2016 done: Mon Nov 7 03:45:51 2016 Total Scan time: 15.310 Total Display time: 0.470 Function used was FASTA [36.3.4 Apr, 2011]